RNAseq (part 3)


The data

In this session we will be reviewing the same data that we used in the first two sessions. This is the data from Christina Leslie’s lab at MSKCC on T-Reg cells and activated T-Reg cells. T-Reg data can be found on the Encode portal here and activated T-Reg data here

I have aligned all FQ to BAM and counted in genes and exons using Rsubread and summariseOverlaps() and then analysed this data for expression changes using DESeq2.

The data

All Gene and Exon counts can be found as .RData obects in data directory

  • Counts in genes can be found at - data/GeneCounts.RData

  • Counts in disjoint exons can be found at - data/ExonCounts.RData

  • Salmon transcript quantification output directories can be found under - data/Salmon/

The data

You can find an excel file of differential expression analysis for this comparison in the data directory.

  • CSV file of differential expression results for activated versus resting T-cells - data/Group_Activated_minus_Resting.csv.

What we will cover

In our last session we will looked at how we can identify changes in gene expression from two separate methods to gene expression estimates and looked a little at the output from comparing differential expression levels using DESeq2.

In this session we will explore a few ways we can evaluate any enrichment for functionally related genes from our differential expression analysis. This helps us address common questions like:

Are genes related to “immune response” enriched in my set of significantly upregulated genes?

Do “cell cycle” genes change more between conditions then other genes?

Gene Sets


What we test and how we test?

There are many options available to us for both functions/pathways/categories (Gene set) we will test and the methods we can use to test these gene sets for enrichment in our analysis (Gene set Enrichment Analysis).

  • Gene set - A named collection of genes.
  • Gene Set enrichment Analysis - GSA - Broad term for correlating a set of genes with a condition/phenotype.
  • Gene Set Enrichment Analysis - GSEA - Broad’s term for correlating a set of genes with a condition/phenotype.

Gene set testing

A frequent step in RNAseq analysis is to test whether any functionally related sets of genes are enriched within our differential expressed genes.

Sources of well curated gene sets include GO consortium (gene’s function, biological process and cellular localization), REACTOME (Biological Pathways) and MsigDB (Computationally and Experimentally derived).

Gene Ontology

The Gene Ontology consortium aims to provide a comprehensive resource of all the currently available knowledge regarding the functions of genes and gene products.

Functional categories of genes are broadly split into three main groups.

  • Molecular functions. - Activity of a gene’s protein product.
  • Biological processes. - Role of gene’s protein product.
  • Cellular components. - Where in cell molecular function of protein product is performed.

Gene Ontology

The three sub categories of gene ontology are arranged in nested, structured graph with gene sets at the top of graph representing more general terms and those at the bottom more specific terms.

Reactome and KEGG

The Reactome and KEGG (Kyoto Encyclopedia of genes and genomes) contains information on genes’ membership and roles in molecular pathways.

These databases focus largely on metabolic and disease pathways, and allow us to investigate our genes in the context of not only functional roles but relative positions within pathways.

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MsigDB

The molecular signatures database (MsigDB) is available from the Broad institute and provides a set of curated gene sets derived from sources such as GO, pathway databases, motif scans and even other experimental sets.

MsigDB databases are widely used in gene set enrichments analysis and are available as plain text, in formats used with the popular Java based gene set enrichment software GSEA. ]

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Gene sets in Bioconductor

In R we can access information on these gene sets through database libraries (such as the Org.db.eg we have reviewed) such as GO.db, KEGG.db, reactome.db or by making use of libraries which allows us to our gene sets from parse plain text formats, GSEABase.

library(GO.db)
library(KEGG.db)
library(reactome.db)
library(GSEABase)

Gene sets

We have already reviewed how we can get information on genes using the Org.db packages in our previous sessions.

We can also have access to information on the gene sets themselves using some of the bioconductor resources including GO.db, KEGG.db, reactome.db packages.

Another rich source of gene sets can be found at the Molecular Signature DataBase (MSigDB) database.

MSigDB and Gene Set Collections


GSEA and MSigDB

The GSEA software and MSigDB gene set collections can be found at the Broad’s site

MSigDB

We have access to Human gene sets containing information on:

  • H - hallmark gene sets
  • C1 - positional gene sets
  • C2 - curated gene sets
  • C3 - motif gene sets
  • C4 - computational gene sets
  • C5 - GO gene sets
  • C6 - oncogenic gene sets
  • C7 - immunologic gene sets

MSigDB

The gmt (gene matrix transposed) is a GSEA specific format which is easy to edit and spreadsheet programs.

It contains tab separated space with lines containing gene sets of differing sizes.

GSEAbase

We can read in gene sets in the gmt format using the GSEABase package.

library(GSEABase)

Reading gmt

The GSEABase function getGmt allows us to import our gmt formatted gene set collection into a GeneSetCollection object. In this case we are reading in the Hallmarks gene set with gene symbols which we downloaded from the Broad website.

hallMarks <- getGmt(con = "data/h.all.v7.1.symbols.gmt")
hallMarks
## GeneSetCollection
##   names: HALLMARK_TNFA_SIGNALING_VIA_NFKB, HALLMARK_HYPOXIA, ..., HALLMARK_PANCREAS_BETA_CELLS (50 total)
##   unique identifiers: JUNB, CXCL2, ..., SRP14 (4383 total)
##   types in collection:
##     geneIdType: NullIdentifier (1 total)
##     collectionType: NullCollection (1 total)

GeneSetCollection

The GeneSetCollection object can be subset as a list.

hallMarks[1]
## GeneSetCollection
##   names: HALLMARK_TNFA_SIGNALING_VIA_NFKB (1 total)
##   unique identifiers: JUNB, CXCL2, ..., MXD1 (200 total)
##   types in collection:
##     geneIdType: NullIdentifier (1 total)
##     collectionType: NullCollection (1 total)
hallMarks[[1]]
## setName: HALLMARK_TNFA_SIGNALING_VIA_NFKB 
## geneIds: JUNB, CXCL2, ..., MXD1 (total: 200)
## geneIdType: Null
## collectionType: Null 
## details: use 'details(object)'

GeneSetCollection

We can access the names of gene sets using the names() accessor

names(hallMarks)
##  [1] "HALLMARK_TNFA_SIGNALING_VIA_NFKB"          
##  [2] "HALLMARK_HYPOXIA"                          
##  [3] "HALLMARK_CHOLESTEROL_HOMEOSTASIS"          
##  [4] "HALLMARK_MITOTIC_SPINDLE"                  
##  [5] "HALLMARK_WNT_BETA_CATENIN_SIGNALING"       
##  [6] "HALLMARK_TGF_BETA_SIGNALING"               
##  [7] "HALLMARK_IL6_JAK_STAT3_SIGNALING"          
##  [8] "HALLMARK_DNA_REPAIR"                       
##  [9] "HALLMARK_G2M_CHECKPOINT"                   
## [10] "HALLMARK_APOPTOSIS"                        
## [11] "HALLMARK_NOTCH_SIGNALING"                  
## [12] "HALLMARK_ADIPOGENESIS"                     
## [13] "HALLMARK_ESTROGEN_RESPONSE_EARLY"          
## [14] "HALLMARK_ESTROGEN_RESPONSE_LATE"           
## [15] "HALLMARK_ANDROGEN_RESPONSE"                
## [16] "HALLMARK_MYOGENESIS"                       
## [17] "HALLMARK_PROTEIN_SECRETION"                
## [18] "HALLMARK_INTERFERON_ALPHA_RESPONSE"        
## [19] "HALLMARK_INTERFERON_GAMMA_RESPONSE"        
## [20] "HALLMARK_APICAL_JUNCTION"                  
## [21] "HALLMARK_APICAL_SURFACE"                   
## [22] "HALLMARK_HEDGEHOG_SIGNALING"               
## [23] "HALLMARK_COMPLEMENT"                       
## [24] "HALLMARK_UNFOLDED_PROTEIN_RESPONSE"        
## [25] "HALLMARK_PI3K_AKT_MTOR_SIGNALING"          
## [26] "HALLMARK_MTORC1_SIGNALING"                 
## [27] "HALLMARK_E2F_TARGETS"                      
## [28] "HALLMARK_MYC_TARGETS_V1"                   
## [29] "HALLMARK_MYC_TARGETS_V2"                   
## [30] "HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION"
## [31] "HALLMARK_INFLAMMATORY_RESPONSE"            
## [32] "HALLMARK_XENOBIOTIC_METABOLISM"            
## [33] "HALLMARK_FATTY_ACID_METABOLISM"            
## [34] "HALLMARK_OXIDATIVE_PHOSPHORYLATION"        
## [35] "HALLMARK_GLYCOLYSIS"                       
## [36] "HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY"  
## [37] "HALLMARK_P53_PATHWAY"                      
## [38] "HALLMARK_UV_RESPONSE_UP"                   
## [39] "HALLMARK_UV_RESPONSE_DN"                   
## [40] "HALLMARK_ANGIOGENESIS"                     
## [41] "HALLMARK_HEME_METABOLISM"                  
## [42] "HALLMARK_COAGULATION"                      
## [43] "HALLMARK_IL2_STAT5_SIGNALING"              
## [44] "HALLMARK_BILE_ACID_METABOLISM"             
## [45] "HALLMARK_PEROXISOME"                       
## [46] "HALLMARK_ALLOGRAFT_REJECTION"              
## [47] "HALLMARK_SPERMATOGENESIS"                  
## [48] "HALLMARK_KRAS_SIGNALING_UP"                
## [49] "HALLMARK_KRAS_SIGNALING_DN"                
## [50] "HALLMARK_PANCREAS_BETA_CELLS"

GeneSetCollection

The geneIDs() function returns a list named by gene set with each named element containing the genes (their IDS) contained within that set.

geneIds(hallMarks)[1:3]
## $HALLMARK_TNFA_SIGNALING_VIA_NFKB
##   [1] "JUNB"     "CXCL2"    "ATF3"     "NFKBIA"   "TNFAIP3"  "PTGS2"   
##   [7] "CXCL1"    "IER3"     "CD83"     "CCL20"    "CXCL3"    "MAFF"    
##  [13] "NFKB2"    "TNFAIP2"  "HBEGF"    "KLF6"     "BIRC3"    "PLAUR"   
##  [19] "ZFP36"    "ICAM1"    "JUN"      "EGR3"     "IL1B"     "BCL2A1"  
##  [25] "PPP1R15A" "ZC3H12A"  "SOD2"     "NR4A2"    "IL1A"     "RELB"    
##  [31] "TRAF1"    "BTG2"     "DUSP1"    "MAP3K8"   "ETS2"     "F3"      
##  [37] "SDC4"     "EGR1"     "IL6"      "TNF"      "KDM6B"    "NFKB1"   
##  [43] "LIF"      "PTX3"     "FOSL1"    "NR4A1"    "JAG1"     "CCL4"    
##  [49] "GCH1"     "CCL2"     "RCAN1"    "DUSP2"    "EHD1"     "IER2"    
##  [55] "REL"      "CFLAR"    "RIPK2"    "NFKBIE"   "NR4A3"    "PHLDA1"  
##  [61] "IER5"     "TNFSF9"   "GEM"      "GADD45A"  "CXCL10"   "PLK2"    
##  [67] "BHLHE40"  "EGR2"     "SOCS3"    "SLC2A6"   "PTGER4"   "DUSP5"   
##  [73] "SERPINB2" "NFIL3"    "SERPINE1" "TRIB1"    "TIPARP"   "RELA"    
##  [79] "BIRC2"    "CXCL6"    "LITAF"    "TNFAIP6"  "CD44"     "INHBA"   
##  [85] "PLAU"     "MYC"      "TNFRSF9"  "SGK1"     "TNIP1"    "NAMPT"   
##  [91] "FOSL2"    "PNRC1"    "ID2"      "CD69"     "IL7R"     "EFNA1"   
##  [97] "PHLDA2"   "PFKFB3"   "CCL5"     "YRDC"     "IFNGR2"   "SQSTM1"  
## [103] "BTG3"     "GADD45B"  "KYNU"     "G0S2"     "BTG1"     "MCL1"    
## [109] "VEGFA"    "MAP2K3"   "CDKN1A"   "CCN1"     "TANK"     "IFIT2"   
## [115] "IL18"     "TUBB2A"   "IRF1"     "FOS"      "OLR1"     "RHOB"    
## [121] "AREG"     "NINJ1"    "ZBTB10"   "PLPP3"    "KLF4"     "CXCL11"  
## [127] "SAT1"     "CSF1"     "GPR183"   "PMEPA1"   "PTPRE"    "TLR2"    
## [133] "ACKR3"    "KLF10"    "MARCKS"   "LAMB3"    "CEBPB"    "TRIP10"  
## [139] "F2RL1"    "KLF9"     "LDLR"     "TGIF1"    "RNF19B"   "DRAM1"   
## [145] "B4GALT1"  "DNAJB4"   "CSF2"     "PDE4B"    "SNN"      "PLEK"    
## [151] "STAT5A"   "DENND5A"  "CCND1"    "DDX58"    "SPHK1"    "CD80"    
## [157] "TNFAIP8"  "CCNL1"    "FUT4"     "CCRL2"    "SPSB1"    "TSC22D1" 
## [163] "B4GALT5"  "SIK1"     "CLCF1"    "NFE2L2"   "FOSB"     "PER1"    
## [169] "NFAT5"    "ATP2B1"   "IL12B"    "IL6ST"    "SLC16A6"  "ABCA1"   
## [175] "HES1"     "BCL6"     "IRS2"     "SLC2A3"   "CEBPD"    "IL23A"   
## [181] "SMAD3"    "TAP1"     "MSC"      "IFIH1"    "IL15RA"   "TNIP2"   
## [187] "BCL3"     "PANX1"    "FJX1"     "EDN1"     "EIF1"     "BMP2"    
## [193] "DUSP4"    "PDLIM5"   "ICOSLG"   "GFPT2"    "KLF2"     "TNC"     
## [199] "SERPINB8" "MXD1"    
## 
## $HALLMARK_HYPOXIA
##   [1] "PGK1"     "PDK1"     "GBE1"     "PFKL"     "ALDOA"    "ENO2"    
##   [7] "PGM1"     "NDRG1"    "HK2"      "ALDOC"    "GPI"      "MXI1"    
##  [13] "SLC2A1"   "P4HA1"    "ADM"      "P4HA2"    "ENO1"     "PFKP"    
##  [19] "AK4"      "FAM162A"  "PFKFB3"   "VEGFA"    "BNIP3L"   "TPI1"    
##  [25] "ERO1A"    "KDM3A"    "CCNG2"    "LDHA"     "GYS1"     "GAPDH"   
##  [31] "BHLHE40"  "ANGPTL4"  "JUN"      "SERPINE1" "LOX"      "GCK"     
##  [37] "PPFIA4"   "MAFF"     "DDIT4"    "SLC2A3"   "IGFBP3"   "NFIL3"   
##  [43] "FOS"      "RBPJ"     "HK1"      "CITED2"   "ISG20"    "GALK1"   
##  [49] "WSB1"     "PYGM"     "STC1"     "ZNF292"   "BTG1"     "PLIN2"   
##  [55] "CSRP2"    "VLDLR"    "JMJD6"    "EXT1"     "F3"       "PDK3"    
##  [61] "ANKZF1"   "UGP2"     "ALDOB"    "STC2"     "ERRFI1"   "ENO3"    
##  [67] "PNRC1"    "HMOX1"    "PGF"      "GAPDHS"   "CHST2"    "TMEM45A" 
##  [73] "BCAN"     "ATF3"     "CAV1"     "AMPD3"    "GPC3"     "NDST1"   
##  [79] "IRS2"     "SAP30"    "GAA"      "SDC4"     "STBD1"    "IER3"    
##  [85] "PKLR"     "IGFBP1"   "PLAUR"    "CAVIN3"   "CCN5"     "LARGE1"  
##  [91] "NOCT"     "S100A4"   "RRAGD"    "ZFP36"    "EGFR"     "EDN2"    
##  [97] "IDS"      "CDKN1A"   "RORA"     "DUSP1"    "MIF"      "PPP1R3C" 
## [103] "DPYSL4"   "KDELR3"   "DTNA"     "ADORA2B"  "HS3ST1"   "CAVIN1"  
## [109] "NR3C1"    "KLF6"     "GPC4"     "CCN1"     "TNFAIP3"  "CA12"    
## [115] "HEXA"     "BGN"      "PPP1R15A" "PGM2"     "PIM1"     "PRDX5"   
## [121] "NAGK"     "CDKN1B"   "BRS3"     "TKTL1"    "MT1E"     "ATP7A"   
## [127] "MT2A"     "SDC3"     "TIPARP"   "PKP1"     "ANXA2"    "PGAM2"   
## [133] "DDIT3"    "PRKCA"    "SLC37A4"  "CXCR4"    "EFNA3"    "CP"      
## [139] "KLF7"     "CCN2"     "CHST3"    "TPD52"    "LXN"      "B4GALNT2"
## [145] "PPARGC1A" "BCL2"     "GCNT2"    "HAS1"     "KLHL24"   "SCARB1"  
## [151] "SLC25A1"  "SDC2"     "CASP6"    "VHL"      "FOXO3"    "PDGFB"   
## [157] "B3GALT6"  "SLC2A5"   "SRPX"     "EFNA1"    "GLRX"     "ACKR3"   
## [163] "PAM"      "TGFBI"    "DCN"      "SIAH2"    "PLAC8"    "FBP1"    
## [169] "TPST2"    "PHKG1"    "MYH9"     "CDKN1C"   "GRHPR"    "PCK1"    
## [175] "INHA"     "HSPA5"    "NDST2"    "NEDD4L"   "TPBG"     "XPNPEP1" 
## [181] "IL6"      "SLC6A6"   "MAP3K1"   "LDHC"     "AKAP12"   "TES"     
## [187] "KIF5A"    "LALBA"    "COL5A1"   "GPC1"     "HDLBP"    "ILVBL"   
## [193] "NCAN"     "TGM2"     "ETS1"     "HOXB9"    "SELENBP1" "FOSL2"   
## [199] "SULT2B1"  "TGFB3"   
## 
## $HALLMARK_CHOLESTEROL_HOMEOSTASIS
##  [1] "FDPS"      "CYP51A1"   "IDI1"      "FDFT1"     "DHCR7"     "SQLE"     
##  [7] "HMGCS1"    "NSDHL"     "LSS"       "MVD"       "LDLR"      "TM7SF2"   
## [13] "ALDOC"     "EBP"       "SCD"       "PMVK"      "MVK"       "LPL"      
## [19] "SC5D"      "FADS2"     "HMGCR"     "HSD17B7"   "ANXA13"    "SREBF2"   
## [25] "PCYT2"     "ACSS2"     "ATF3"      "ADH4"      "ETHE1"     "ECH1"     
## [31] "CBS"       "GUSB"      "FASN"      "LGALS3"    "ATF5"      "ANXA5"    
## [37] "TP53INP1"  "CHKA"      "GSTM2"     "ACAT2"     "AVPR1A"    "PLSCR1"   
## [43] "CLU"       "ERRFI1"    "TRIB3"     "CXCL16"    "TNFRSF12A" "ACTG1"    
## [49] "JAG1"      "LGMN"      "FBXO6"     "GPX8"      "PNRC1"     "ANTXR2"   
## [55] "MAL2"      "CD9"       "PPARG"     "GLDC"      "STX5"      "STARD4"   
## [61] "CTNNB1"    "TMEM97"    "NIBAN1"    "PDK3"      "PLAUR"     "SEMA3B"   
## [67] "GNAI1"     "ABCA2"     "ATXN2"     "NFIL3"     "ALCAM"     "FABP5"    
## [73] "S100A11"   "CPEB2"

Human to mouse gene sets

To make use of human gene sets in mouse we can either

  • Use an alternative mouse specific set.
  • Translate relevant set to mouse ortholog names.

gskb

The gskb package holds many pathways and gene sets for mouse genome equivalent to MSigDB.

First we can load the package.

library(gskb)

gskb datasets

The gskb package contains 7 collections of genes.

  • mm_GO - gene sets from Gene Ontology for mouse (Mus musculus).
  • mm_location - Gene sets based on chromosomal location.
  • mm_metabolic - metabolic pathways.
  • mm_miRNA - Target genes of microRNAs, predicted or experimentally verified.
  • mm_pathway - Curated pathways.
  • mm_TF - Transcription factor target genes.
  • mm_other - Everything else.

Accessing gskb data

We access gskb datasets by using the data() function to load into memory the gene set collection of interest.

data(mm_miRNA)
names(mm_miRNA)[1:2]
## [1] "MIRNA_MM_BETEL_MMU-LET-7A" "MIRNA_MM_BETEL_MMU-LET-7B"
mm_miRNA[1]
## $`MIRNA_MM_BETEL_MMU-LET-7A`
##    [1] "MIRNA_MM_BETEL_MMU-LET-7A"                                                                        
##    [2] "BETEL_MMU-LET-7A; Good mirSVR score Conserved; The microRNA.org resource: targets and expression."
##    [3] "NSUN4"                                                                                            
##    [4] "DCX"                                                                                              
##    [5] "KCNK6"                                                                                            
##    [6] "PBX1"                                                                                             
##    [7] "PHF8"                                                                                             
##    [8] "RACGAP1"                                                                                          
##    [9] "EFHD2"                                                                                            
##   [10] "DCBLD2"                                                                                           
##   [11] "CCDC88A"                                                                                          
##   [12] "CEP68"                                                                                            
##   [13] "SLITRK4"                                                                                          
##   [14] "NAA40"                                                                                            
##   [15] "DSCAML1"                                                                                          
##   [16] "ESYT2"                                                                                            
##   [17] "DNAJC21"                                                                                          
##   [18] "CDC27"                                                                                            
##   [19] "CHRAC1"                                                                                           
##   [20] "MYL6"                                                                                             
##   [21] "PRLR"                                                                                             
##   [22] "GUF1"                                                                                             
##   [23] "LCK"                                                                                              
##   [24] "GSDMC"                                                                                            
##   [25] "PTGER1"                                                                                           
##   [26] "CADM1"                                                                                            
##   [27] "DGCR2"                                                                                            
##   [28] "CREM"                                                                                             
##   [29] "PPHLN1"                                                                                           
##   [30] "VWA1"                                                                                             
##   [31] "IPMK"                                                                                             
##   [32] "PTPRO"                                                                                            
##   [33] "MPZL1"                                                                                            
##   [34] "CREB1"                                                                                            
##   [35] "RAVER2"                                                                                           
##   [36] "MED24"                                                                                            
##   [37] "TM9SF3"                                                                                           
##   [38] "BTLA"                                                                                             
##   [39] "TMEM72"                                                                                           
##   [40] "TCEANC"                                                                                           
##   [41] "SLAMF7"                                                                                           
##   [42] "MTM1"                                                                                             
##   [43] "ASB8"                                                                                             
##   [44] "USP4"                                                                                             
##   [45] "LRRFIP1"                                                                                          
##   [46] "E330016L19RIK"                                                                                    
##   [47] "GJC2"                                                                                             
##   [48] "GALNT7"                                                                                           
##   [49] "PDGFC"                                                                                            
##   [50] "GPD2"                                                                                             
##   [51] "EDDM3B"                                                                                           
##   [52] "KLHL4"                                                                                            
##   [53] "C2CD2L"                                                                                           
##   [54] "MKS1"                                                                                             
##   [55] "SBNO1"                                                                                            
##   [56] "RTN3"                                                                                             
##   [57] "EIF4E1B"                                                                                          
##   [58] "ZNFX1"                                                                                            
##   [59] "TMEM164"                                                                                          
##   [60] "PADI3"                                                                                            
##   [61] "PLB1"                                                                                             
##   [62] "SEMA5A"                                                                                           
##   [63] "DNMT3A"                                                                                           
##   [64] "AP1G1"                                                                                            
##   [65] "APH1B"                                                                                            
##   [66] "CSPRS"                                                                                            
##   [67] "PISD-PS3"                                                                                         
##   [68] "2310003H01RIK"                                                                                    
##   [69] "FBXO21"                                                                                           
##   [70] "EYA3"                                                                                             
##   [71] "2810011L19RIK"                                                                                    
##   [72] "MSRA"                                                                                             
##   [73] "SPINK5"                                                                                           
##   [74] "PARVA"                                                                                            
##   [75] "CHAC1"                                                                                            
##   [76] "P4HA2"                                                                                            
##   [77] "LRTM2"                                                                                            
##   [78] "ELOVL7"                                                                                           
##   [79] "ZFP568"                                                                                           
##   [80] "AI504432"                                                                                         
##   [81] "AGK"                                                                                              
##   [82] "SLCO2A1"                                                                                          
##   [83] "SH3PXD2A"                                                                                         
##   [84] "MYBL2"                                                                                            
##   [85] "ANKRD10"                                                                                          
##   [86] "1700052N19RIK"                                                                                    
##   [87] "LIN28B"                                                                                           
##   [88] "RNF24"                                                                                            
##   [89] "ESRRB"                                                                                            
##   [90] "PIGS"                                                                                             
##   [91] "TM6SF2"                                                                                           
##   [92] "SNAP91"                                                                                           
##   [93] "VAT1"                                                                                             
##   [94] "4930480K23RIK"                                                                                    
##   [95] "PQLC1"                                                                                            
##   [96] "ZFP473"                                                                                           
##   [97] "EHMT1"                                                                                            
##   [98] "4632428N05RIK"                                                                                    
##   [99] "1700012B07RIK"                                                                                    
##  [100] "FKBP1A"                                                                                           
##  [101] "SARNP"                                                                                            
##  [102] "ERCC6"                                                                                            
##  [103] "PATZ1"                                                                                            
##  [104] "NCOR1"                                                                                            
##  [105] "LBP"                                                                                              
##  [106] "STON2"                                                                                            
##  [107] "GNS"                                                                                              
##  [108] "DHX57"                                                                                            
##  [109] "5031439G07RIK"                                                                                    
##  [110] "CLVS1"                                                                                            
##  [111] "HECW1"                                                                                            
##  [112] "ZFP12"                                                                                            
##  [113] "GEMIN5"                                                                                           
##  [114] "FKRP"                                                                                             
##  [115] "RABGEF1"                                                                                          
##  [116] "UIMC1"                                                                                            
##  [117] "CPEB3"                                                                                            
##  [118] "VILL"                                                                                             
##  [119] "RRAGD"                                                                                            
##  [120] "GNPDA1"                                                                                           
##  [121] "DNLZ"                                                                                             
##  [122] "COPS8"                                                                                            
##  [123] "VGLL3"                                                                                            
##  [124] "CWF19L2"                                                                                          
##  [125] "CD200R1"                                                                                          
##  [126] "OCRL"                                                                                             
##  [127] "SLC16A6"                                                                                          
##  [128] "GRIN1"                                                                                            
##  [129] "COL23A1"                                                                                          
##  [130] "CEP120"                                                                                           
##  [131] "DZIP1"                                                                                            
##  [132] "4930453N24RIK"                                                                                    
##  [133] "B930041F14RIK"                                                                                    
##  [134] "JUND"                                                                                             
##  [135] "GP5"                                                                                              
##  [136] "B230378P21RIK"                                                                                    
##  [137] "YLPM1"                                                                                            
##  [138] "STXBP5"                                                                                           
##  [139] "LOXL3"                                                                                            
##  [140] "ITGA1"                                                                                            
##  [141] "ZSCAN10"                                                                                          
##  [142] "TSPAN18"                                                                                          
##  [143] "CECR5"                                                                                            
##  [144] "SEC24C"                                                                                           
##  [145] "NOS1AP"                                                                                           
##  [146] "9330162012RIK"                                                                                    
##  [147] "GLRX2"                                                                                            
##  [148] "DYNC1I2"                                                                                          
##  [149] "D130017N08RIK"                                                                                    
##  [150] "TTC9C"                                                                                            
##  [151] "GM5922"                                                                                           
##  [152] "AEN"                                                                                              
##  [153] "PDCD1"                                                                                            
##  [154] "ICMT"                                                                                             
##  [155] "SLC23A2"                                                                                          
##  [156] "EXOG"                                                                                             
##  [157] "DDX19B"                                                                                           
##  [158] "SPTY2D1"                                                                                          
##  [159] "BC017643"                                                                                         
##  [160] "LRRC41"                                                                                           
##  [161] "LRRN3"                                                                                            
##  [162] "AFAP1L2"                                                                                          
##  [163] "ZFP446"                                                                                           
##  [164] "ISCA2"                                                                                            
##  [165] "FUCA2"                                                                                            
##  [166] "SMPD1"                                                                                            
##  [167] "ARMC10"                                                                                           
##  [168] "RCN1"                                                                                             
##  [169] "ANKRD6"                                                                                           
##  [170] "ZFP444"                                                                                           
##  [171] "CYB561D1"                                                                                         
##  [172] "ZFP207"                                                                                           
##  [173] "GPRASP1"                                                                                          
##  [174] "SERTAD2"                                                                                          
##  [175] "PKNOX1"                                                                                           
##  [176] "FNDC3A"                                                                                           
##  [177] "GRIA3"                                                                                            
##  [178] "TTC19"                                                                                            
##  [179] "TRIM11"                                                                                           
##  [180] "DNMT3B"                                                                                           
##  [181] "WIPI1"                                                                                            
##  [182] "GLO1"                                                                                             
##  [183] "DLD"                                                                                              
##  [184] "ZFP282"                                                                                           
##  [185] "ATP2B2"                                                                                           
##  [186] "CASP7"                                                                                            
##  [187] "RAB5B"                                                                                            
##  [188] "SH2B1"                                                                                            
##  [189] "TAS1R3"                                                                                           
##  [190] "DLGAP1"                                                                                           
##  [191] "ZBTB16"                                                                                           
##  [192] "TSPAN32"                                                                                          
##  [193] "PUS1"                                                                                             
##  [194] "TNRC6A"                                                                                           
##  [195] "ACPP"                                                                                             
##  [196] "IDO2"                                                                                             
##  [197] "NPTXR"                                                                                            
##  [198] "AP1B1"                                                                                            
##  [199] "PRKRIP1"                                                                                          
##  [200] "TMPO"                                                                                             
##  [201] "EDA"                                                                                              
##  [202] "TRPM6"                                                                                            
##  [203] "NIPAL3"                                                                                           
##  [204] "FPGS"                                                                                             
##  [205] "VPS18"                                                                                            
##  [206] "TRIM33"                                                                                           
##  [207] "WDHD1"                                                                                            
##  [208] "CEP55"                                                                                            
##  [209] "GMIP"                                                                                             
##  [210] "PPP1R16B"                                                                                         
##  [211] "GSDMC3"                                                                                           
##  [212] "MAPKBP1"                                                                                          
##  [213] "LDB3"                                                                                             
##  [214] "GM2897"                                                                                           
##  [215] "NDOR1"                                                                                            
##  [216] "C030039L03RIK"                                                                                    
##  [217] "DIP2A"                                                                                            
##  [218] "BCL7A"                                                                                            
##  [219] "GM5468"                                                                                           
##  [220] "6030443J06RIK"                                                                                    
##  [221] "D930016D06RIK"                                                                                    
##  [222] "GABPB2"                                                                                           
##  [223] "ARHGEF6"                                                                                          
##  [224] "RALGDS"                                                                                           
##  [225] "ZFP92"                                                                                            
##  [226] "MED1"                                                                                             
##  [227] "A330050B17RIK"                                                                                    
##  [228] "CD34"                                                                                             
##  [229] "GRIK5"                                                                                            
##  [230] "MELA"                                                                                             
##  [231] "YBX2"                                                                                             
##  [232] "PNPLA1"                                                                                           
##  [233] "SLC12A6"                                                                                          
##  [234] "TRIM7"                                                                                            
##  [235] "FAM135A"                                                                                          
##  [236] "BCHE"                                                                                             
##  [237] "NTF5"                                                                                             
##  [238] "WWP1"                                                                                             
##  [239] "NEU4"                                                                                             
##  [240] "ELMO1"                                                                                            
##  [241] "DMTF1"                                                                                            
##  [242] "CDK12"                                                                                            
##  [243] "TULP4"                                                                                            
##  [244] "OIT3"                                                                                             
##  [245] "E130218I03RIK"                                                                                    
##  [246] "GUCY1A2"                                                                                          
##  [247] "1300002E11RIK"                                                                                    
##  [248] "POGK"                                                                                             
##  [249] "TEX21"                                                                                            
##  [250] "USP29"                                                                                            
##  [251] "4833424O15RIK"                                                                                    
##  [252] "TTBK2"                                                                                            
##  [253] "POLQ"                                                                                             
##  [254] "CDC123"                                                                                           
##  [255] "4930417H01RIK"                                                                                    
##  [256] "NCOA7"                                                                                            
##  [257] "STAT3"                                                                                            
##  [258] "MLLT1"                                                                                            
##  [259] "4933411K20RIK"                                                                                    
##  [260] "ELK1"                                                                                             
##  [261] "HORMAD1"                                                                                          
##  [262] "ABCB9"                                                                                            
##  [263] "KLHL23"                                                                                           
##  [264] "SENP7"                                                                                            
##  [265] "SULF1"                                                                                            
##  [266] "TREM1"                                                                                            
##  [267] "MTSS1"                                                                                            
##  [268] "AHCYL2"                                                                                           
##  [269] "TRIM39"                                                                                           
##  [270] "HNRNPD"                                                                                           
##  [271] "SLC34A1"                                                                                          
##  [272] "MAPK8IP3"                                                                                         
##  [273] "GJB5"                                                                                             
##  [274] "RREB1"                                                                                            
##  [275] "ENTPD5"                                                                                           
##  [276] "SLC6A8"                                                                                           
##  [277] "CCDC114"                                                                                          
##  [278] "SLC22A23"                                                                                         
##  [279] "GM9"                                                                                              
##  [280] "SHISA5"                                                                                           
##  [281] "RALB"                                                                                             
##  [282] "L3MBTL4"                                                                                          
##  [283] "FNDC3B"                                                                                           
##  [284] "FGD4"                                                                                             
##  [285] "LIMK2"                                                                                            
##  [286] "PPP1R3B"                                                                                          
##  [287] "DOK3"                                                                                             
##  [288] "MBD1"                                                                                             
##  [289] "AFG3L1"                                                                                           
##  [290] "RARG"                                                                                             
##  [291] "SYNM"                                                                                             
##  [292] "TRHDE"                                                                                            
##  [293] "ASB7"                                                                                             
##  [294] "CRYBG3"                                                                                           
##  [295] "STARD9"                                                                                           
##  [296] "VPS37C"                                                                                           
##  [297] "MAN1A2"                                                                                           
##  [298] "SCARA3"                                                                                           
##  [299] "EPM2AIP1"                                                                                         
##  [300] "SKP2"                                                                                             
##  [301] "DIP2C"                                                                                            
##  [302] "AHR"                                                                                              
##  [303] "KLHL30"                                                                                           
##  [304] "NAA10"                                                                                            
##  [305] "GABPA"                                                                                            
##  [306] "TNKS2"                                                                                            
##  [307] "NUDT13"                                                                                           
##  [308] "2010109I03RIK"                                                                                    
##  [309] "RAMP1"                                                                                            
##  [310] "XKR4"                                                                                             
##  [311] "CLEC16A"                                                                                          
##  [312] "CPN2"                                                                                             
##  [313] "SRR"                                                                                              
##  [314] "AGTR1B"                                                                                           
##  [315] "TLE4"                                                                                             
##  [316] "ZFP655"                                                                                           
##  [317] "MIRG"                                                                                             
##  [318] "ANKRD16"                                                                                          
##  [319] "RDH13"                                                                                            
##  [320] "DPY19L2"                                                                                          
##  [321] "AKT1S1"                                                                                           
##  [322] "CAP1"                                                                                             
##  [323] "A630009H07RIK"                                                                                    
##  [324] "KIF16B"                                                                                           
##  [325] "CHST10"                                                                                           
##  [326] "IGF1"                                                                                             
##  [327] "ADAMTS9"                                                                                          
##  [328] "KIF1B"                                                                                            
##  [329] "NSMCE2"                                                                                           
##  [330] "1700006A11RIK"                                                                                    
##  [331] "HES2"                                                                                             
##  [332] "KIF7"                                                                                             
##  [333] "IL15"                                                                                             
##  [334] "FAM102B"                                                                                          
##  [335] "SOD2"                                                                                             
##  [336] "ZFP763"                                                                                           
##  [337] "TFB2M"                                                                                            
##  [338] "USP47"                                                                                            
##  [339] "ZFP644"                                                                                           
##  [340] "TMEM163"                                                                                          
##  [341] "PTRH2"                                                                                            
##  [342] "CTSB"                                                                                             
##  [343] "TTPAL"                                                                                            
##  [344] "MIR155"                                                                                           
##  [345] "ADRA1B"                                                                                           
##  [346] "CDKN2AIPNL"                                                                                       
##  [347] "NEDD8"                                                                                            
##  [348] "GAD1"                                                                                             
##  [349] "SFPQ"                                                                                             
##  [350] "DNAJC27"                                                                                          
##  [351] "JMJD4"                                                                                            
##  [352] "NEIL3"                                                                                            
##  [353] "UBN2"                                                                                             
##  [354] "ABCC9"                                                                                            
##  [355] "KLHDC8A"                                                                                          
##  [356] "MCTP1"                                                                                            
##  [357] "KLRK1"                                                                                            
##  [358] "COL9A3"                                                                                           
##  [359] "ARMC9"                                                                                            
##  [360] "NCS1"                                                                                             
##  [361] "SERPINA3I"                                                                                        
##  [362] "HARS2"                                                                                            
##  [363] "A830018L16RIK"                                                                                    
##  [364] "OXNAD1"                                                                                           
##  [365] "POM121"                                                                                           
##  [366] "SV2A"                                                                                             
##  [367] "TRIM16"                                                                                           
##  [368] "PTPN14"                                                                                           
##  [369] "TRP63"                                                                                            
##  [370] "NT5M"                                                                                             
##  [371] "AMOT"                                                                                             
##  [372] "NFATC1"                                                                                           
##  [373] "KCNC3"                                                                                            
##  [374] "PHLDB1"                                                                                           
##  [375] "RHOT1"                                                                                            
##  [376] "MYT1"                                                                                             
##  [377] "AW549877"                                                                                         
##  [378] "CLN3"                                                                                             
##  [379] "INTS2"                                                                                            
##  [380] "ZFP422"                                                                                           
##  [381] "CBX5"                                                                                             
##  [382] "BAHCC1"                                                                                           
##  [383] "GSDMC4"                                                                                           
##  [384] "ARID3A"                                                                                           
##  [385] "CAR7"                                                                                             
##  [386] "TAF1D"                                                                                            
##  [387] "CTDSP2"                                                                                           
##  [388] "CACNA1D"                                                                                          
##  [389] "SLAMF6"                                                                                           
##  [390] "IQSEC3"                                                                                           
##  [391] "RASGEF1B"                                                                                         
##  [392] "TMPRSS2"                                                                                          
##  [393] "MAGI2"                                                                                            
##  [394] "KIFC2"                                                                                            
##  [395] "ARHGEF5"                                                                                          
##  [396] "STX17"                                                                                            
##  [397] "SLC10A7"                                                                                          
##  [398] "MEST"                                                                                             
##  [399] "EN1"                                                                                              
##  [400] "6330416G13RIK"                                                                                    
##  [401] "SMAD5"                                                                                            
##  [402] "TXN2"                                                                                             
##  [403] "PDGFRL"                                                                                           
##  [404] "F730016J06RIK"                                                                                    
##  [405] "PGM2L1"                                                                                           
##  [406] "SLC25A28"                                                                                         
##  [407] "TBKBP1"                                                                                           
##  [408] "WDR77"                                                                                            
##  [409] "MCTS2"                                                                                            
##  [410] "1700030J22RIK"                                                                                    
##  [411] "FAM78B"                                                                                           
##  [412] "TMEM231"                                                                                          
##  [413] "OGFOD1"                                                                                           
##  [414] "STK36"                                                                                            
##  [415] "CDYL"                                                                                             
##  [416] "TMEM106C"                                                                                         
##  [417] "UBE2O"                                                                                            
##  [418] "FKBP5"                                                                                            
##  [419] "NXT2"                                                                                             
##  [420] "SART1"                                                                                            
##  [421] "PLXNA2"                                                                                           
##  [422] "HDAC6"                                                                                            
##  [423] "SFT2D2"                                                                                           
##  [424] "SSR1"                                                                                             
##  [425] "STAT5B"                                                                                           
##  [426] "SLA"                                                                                              
##  [427] "RHBDD2"                                                                                           
##  [428] "GYK"                                                                                              
##  [429] "SHC4"                                                                                             
##  [430] "TM6SF1"                                                                                           
##  [431] "HECTD2"                                                                                           
##  [432] "NFYA"                                                                                             
##  [433] "SPTLC2"                                                                                           
##  [434] "TGFBR1"                                                                                           
##  [435] "MCTP2"                                                                                            
##  [436] "COPS7A"                                                                                           
##  [437] "NFAM1"                                                                                            
##  [438] "CPSF4"                                                                                            
##  [439] "DDX20"                                                                                            
##  [440] "B3GNT7"                                                                                           
##  [441] "MTPN"                                                                                             
##  [442] "MED7"                                                                                             
##  [443] "CD2AP"                                                                                            
##  [444] "SH2D2A"                                                                                           
##  [445] "GPAA1"                                                                                            
##  [446] "ARL5A"                                                                                            
##  [447] "CDC34"                                                                                            
##  [448] "SYTL4"                                                                                            
##  [449] "4930579C12RIK"                                                                                    
##  [450] "SLC43A2"                                                                                          
##  [451] "MMD"                                                                                              
##  [452] "PRKRIR"                                                                                           
##  [453] "PA2G4"                                                                                            
##  [454] "LAPTM5"                                                                                           
##  [455] "2700081O15RIK"                                                                                    
##  [456] "E2F6"                                                                                             
##  [457] "TIMP4"                                                                                            
##  [458] "KLHL15"                                                                                           
##  [459] "SHISA9"                                                                                           
##  [460] "PDE12"                                                                                            
##  [461] "ARFRP1"                                                                                           
##  [462] "SPOCK1"                                                                                           
##  [463] "H2AFX"                                                                                            
##  [464] "NPAS3"                                                                                            
##  [465] "1600012H06RIK"                                                                                    
##  [466] "GOLGA7"                                                                                           
##  [467] "KCNC2"                                                                                            
##  [468] "KIF14"                                                                                            
##  [469] "PYGO2"                                                                                            
##  [470] "P2RX4"                                                                                            
##  [471] "HPS3"                                                                                             
##  [472] "CYBA"                                                                                             
##  [473] "UBE2J2"                                                                                           
##  [474] "KCNS2"                                                                                            
##  [475] "9530059O14RIK"                                                                                    
##  [476] "HDX"                                                                                              
##  [477] "NRF1"                                                                                             
##  [478] "NEK9"                                                                                             
##  [479] "EIF2S2"                                                                                           
##  [480] "SECTM1B"                                                                                          
##  [481] "SLC24A6"                                                                                          
##  [482] "SNX27"                                                                                            
##  [483] "IMP4"                                                                                             
##  [484] "DBC1"                                                                                             
##  [485] "COL27A1"                                                                                          
##  [486] "SHANK2"                                                                                           
##  [487] "TRP53BP1"                                                                                         
##  [488] "TMEM143"                                                                                          
##  [489] "ANO2"                                                                                             
##  [490] "FN3K"                                                                                             
##  [491] "UBE2E3"                                                                                           
##  [492] "MPP2"                                                                                             
##  [493] "GTPBP2"                                                                                           
##  [494] "MBNL3"                                                                                            
##  [495] "GM15246"                                                                                          
##  [496] "FBXW11"                                                                                           
##  [497] "HIATL1"                                                                                           
##  [498] "E330032C10RIK"                                                                                    
##  [499] "MBTPS2"                                                                                           
##  [500] "TIMM22"                                                                                           
##  [501] "NPSR1"                                                                                            
##  [502] "B430306N03RIK"                                                                                    
##  [503] "CD93"                                                                                             
##  [504] "ZFP36L1"                                                                                          
##  [505] "VASH2"                                                                                            
##  [506] "2610301B20RIK"                                                                                    
##  [507] "SCYL3"                                                                                            
##  [508] "LRRC58"                                                                                           
##  [509] "HMBOX1"                                                                                           
##  [510] "SYS1"                                                                                             
##  [511] "TNFRSF22"                                                                                         
##  [512] "KCNB2"                                                                                            
##  [513] "CABP2"                                                                                            
##  [514] "KLHL32"                                                                                           
##  [515] "MYADM"                                                                                            
##  [516] "B230206H07RIK"                                                                                    
##  [517] "SYT2"                                                                                             
##  [518] "3110002H16RIK"                                                                                    
##  [519] "ZFP248"                                                                                           
##  [520] "SLC25A3"                                                                                          
##  [521] "SMOC2"                                                                                            
##  [522] "ARHGAP8"                                                                                          
##  [523] "SLC7A14"                                                                                          
##  [524] "MTERFD3"                                                                                          
##  [525] "TTC3"                                                                                             
##  [526] "IKBKG"                                                                                            
##  [527] "JPH4"                                                                                             
##  [528] "MAGT1"                                                                                            
##  [529] "PRR18"                                                                                            
##  [530] "HNRPDL"                                                                                           
##  [531] "MTMR6"                                                                                            
##  [532] "ENY2"                                                                                             
##  [533] "EPB4.1L1"                                                                                         
##  [534] "PDZD3"                                                                                            
##  [535] "SENP2"                                                                                            
##  [536] "RFFL"                                                                                             
##  [537] "FAF2"                                                                                             
##  [538] "RNF13"                                                                                            
##  [539] "MICAL3"                                                                                           
##  [540] "PANX2"                                                                                            
##  [541] "NLRP4C"                                                                                           
##  [542] "GSPT2"                                                                                            
##  [543] "ANKRD54"                                                                                          
##  [544] "TTLL9"                                                                                            
##  [545] "LMBRD1"                                                                                           
##  [546] "DBPHT2"                                                                                           
##  [547] "CLN8"                                                                                             
##  [548] "ZDHHC21"                                                                                          
##  [549] "FAM60A"                                                                                           
##  [550] "PFN2"                                                                                             
##  [551] "AGBL2"                                                                                            
##  [552] "1700112E06RIK"                                                                                    
##  [553] "ZDHHC24"                                                                                          
##  [554] "TEF"                                                                                              
##  [555] "8030462N17RIK"                                                                                    
##  [556] "PPP2R1A"                                                                                          
##  [557] "LPHN3"                                                                                            
##  [558] "LIN7C"                                                                                            
##  [559] "DSC3"                                                                                             
##  [560] "NDST1"                                                                                            
##  [561] "1700047M11RIK"                                                                                    
##  [562] "GRID2IP"                                                                                          
##  [563] "CGGBP1"                                                                                           
##  [564] "WARS"                                                                                             
##  [565] "TXNL4B"                                                                                           
##  [566] "UBE2H"                                                                                            
##  [567] "FRS2"                                                                                             
##  [568] "USP45"                                                                                            
##  [569] "ACSM5"                                                                                            
##  [570] "RUNDC1"                                                                                           
##  [571] "TC2N"                                                                                             
##  [572] "CDADC1"                                                                                           
##  [573] "CCNH"                                                                                             
##  [574] "RPGRIP1"                                                                                          
##  [575] "AU015836"                                                                                         
##  [576] "CXCL12"                                                                                           
##  [577] "ZFP111"                                                                                           
##  [578] "IPCEF1"                                                                                           
##  [579] "ANXA8"                                                                                            
##  [580] "ST3GAL1"                                                                                          
##  [581] "GNA15"                                                                                            
##  [582] "TIFAB"                                                                                            
##  [583] "IGF1R"                                                                                            
##  [584] "MIER2"                                                                                            
##  [585] "GNAL"                                                                                             
##  [586] "VTI1A"                                                                                            
##  [587] "1700026D11RIK"                                                                                    
##  [588] "NF2"                                                                                              
##  [589] "TMEM229B"                                                                                         
##  [590] "HGF"                                                                                              
##  [591] "DHRS13"                                                                                           
##  [592] "ARMC8"                                                                                            
##  [593] "GRAMD3"                                                                                           
##  [594] "DNASE2A"                                                                                          
##  [595] "TECPR2"                                                                                           
##  [596] "SYN3"                                                                                             
##  [597] "EBF4"                                                                                             
##  [598] "B3GAT1"                                                                                           
##  [599] "COL10A1"                                                                                          
##  [600] "PRRT2"                                                                                            
##  [601] "TMEM71"                                                                                           
##  [602] "KLF17"                                                                                            
##  [603] "1500026H17RIK"                                                                                    
##  [604] "RBM33"                                                                                            
##  [605] "CACNB2"                                                                                           
##  [606] "MYL9"                                                                                             
##  [607] "SOX2OT"                                                                                           
##  [608] "ISY1"                                                                                             
##  [609] "AGAP1"                                                                                            
##  [610] "RHBDD1"                                                                                           
##  [611] "USP7"                                                                                             
##  [612] "AOC3"                                                                                             
##  [613] "MCPT2"                                                                                            
##  [614] "SKIL"                                                                                             
##  [615] "SRRM4"                                                                                            
##  [616] "C920008G01RIK"                                                                                    
##  [617] "AA987161"                                                                                         
##  [618] "MOBP"                                                                                             
##  [619] "CWC25"                                                                                            
##  [620] "RUNX3"                                                                                            
##  [621] "ZFP300"                                                                                           
##  [622] "IKZF2"                                                                                            
##  [623] "SLC4A7"                                                                                           
##  [624] "PTBP2"                                                                                            
##  [625] "PDZD7"                                                                                            
##  [626] "MLLT10"                                                                                           
##  [627] "4933437N03RIK"                                                                                    
##  [628] "ZBTB37"                                                                                           
##  [629] "CTTNBP2"                                                                                          
##  [630] "SMAP1"                                                                                            
##  [631] "2810429I04RIK"                                                                                    
##  [632] "PSD2"                                                                                             
##  [633] "AP2B1"                                                                                            
##  [634] "UBE2K"                                                                                            
##  [635] "NTRK2"                                                                                            
##  [636] "USP16"                                                                                            
##  [637] "KRT6A"                                                                                            
##  [638] "2900079G21RIK"                                                                                    
##  [639] "TMOD2"                                                                                            
##  [640] "LBH"                                                                                              
##  [641] "ADAMTS14"                                                                                         
##  [642] "LPAR1"                                                                                            
##  [643] "PIM1"                                                                                             
##  [644] "OSBP2"                                                                                            
##  [645] "NIN"                                                                                              
##  [646] "RHOBTB1"                                                                                          
##  [647] "EPSTI1"                                                                                           
##  [648] "PDZRN3"                                                                                           
##  [649] "1810014B01RIK"                                                                                    
##  [650] "STK35"                                                                                            
##  [651] "AI464131"                                                                                         
##  [652] "A1CF"                                                                                             
##  [653] "KLHDC3"                                                                                           
##  [654] "EIF4EBP2"                                                                                         
##  [655] "WDR92"                                                                                            
##  [656] "SLC2A6"                                                                                           
##  [657] "CSNK1G1"                                                                                          
##  [658] "ZFP512"                                                                                           
##  [659] "FRMD5"                                                                                            
##  [660] "AIG1"                                                                                             
##  [661] "NSD1"                                                                                             
##  [662] "AI854517"                                                                                         
##  [663] "MEF2C"                                                                                            
##  [664] "ACTR2"                                                                                            
##  [665] "COL2A1"                                                                                           
##  [666] "TRIM66"                                                                                           
##  [667] "AP3B2"                                                                                            
##  [668] "ANXA3"                                                                                            
##  [669] "NOSIP"                                                                                            
##  [670] "PGLS"                                                                                             
##  [671] "PDGFRB"                                                                                           
##  [672] "SFMBT2"                                                                                           
##  [673] "GM9054"                                                                                           
##  [674] "LPP"                                                                                              
##  [675] "ZFP668"                                                                                           
##  [676] "HSPBAP1"                                                                                          
##  [677] "NAA30"                                                                                            
##  [678] "D030028A08RIK"                                                                                    
##  [679] "SRGAP2"                                                                                           
##  [680] "2500002B13RIK"                                                                                    
##  [681] "KIRREL3"                                                                                          
##  [682] "WDR37"                                                                                            
##  [683] "TMEM91"                                                                                           
##  [684] "MLST8"                                                                                            
##  [685] "MGLL"                                                                                             
##  [686] "DFFA"                                                                                             
##  [687] "PCYT1B"                                                                                           
##  [688] "IL21"                                                                                             
##  [689] "3110052M02RIK"                                                                                    
##  [690] "RBM14"                                                                                            
##  [691] "MAPK10"                                                                                           
##  [692] "CBX7"                                                                                             
##  [693] "4930555G01RIK"                                                                                    
##  [694] "PSG17"                                                                                            
##  [695] "FUT9"                                                                                             
##  [696] "YME1L1"                                                                                           
##  [697] "BC049352"                                                                                         
##  [698] "ZBTB7B"                                                                                           
##  [699] "METTL4"                                                                                           
##  [700] "ATE1"                                                                                             
##  [701] "ANO5"                                                                                             
##  [702] "FBXW4"                                                                                            
##  [703] "B4GALT6"                                                                                          
##  [704] "ZFP653"                                                                                           
##  [705] "ARRDC3"                                                                                           
##  [706] "PELI1"                                                                                            
##  [707] "VPS13D"                                                                                           
##  [708] "A830012C17RIK"                                                                                    
##  [709] "ARNT2"                                                                                            
##  [710] "TPRN"                                                                                             
##  [711] "HOXD3"                                                                                            
##  [712] "4833417C18RIK"                                                                                    
##  [713] "GK5"                                                                                              
##  [714] "SNHG1"                                                                                            
##  [715] "SERPINB8"                                                                                         
##  [716] "EME2"                                                                                             
##  [717] "DEGS1"                                                                                            
##  [718] "4930422G04RIK"                                                                                    
##  [719] "SPIN1"                                                                                            
##  [720] "ESRRG"                                                                                            
##  [721] "ITCH"                                                                                             
##  [722] "RANBP10"                                                                                          
##  [723] "TRAM1L1"                                                                                          
##  [724] "TSC22D2"                                                                                          
##  [725] "RB1"                                                                                              
##  [726] "SDC3"                                                                                             
##  [727] "ACVR1B"                                                                                           
##  [728] "BATF"                                                                                             
##  [729] "BC046251"                                                                                         
##  [730] "PAQR3"                                                                                            
##  [731] "MAST4"                                                                                            
##  [732] "ELL2"                                                                                             
##  [733] "CCDC116"                                                                                          
##  [734] "MGAT1"                                                                                            
##  [735] "TMEM8B"                                                                                           
##  [736] "B530045E10RIK"                                                                                    
##  [737] "DDX58"                                                                                            
##  [738] "4930533N22RIK"                                                                                    
##  [739] "EZH1"                                                                                             
##  [740] "PIN1"                                                                                             
##  [741] "SYNJ1"                                                                                            
##  [742] "PXK"                                                                                              
##  [743] "FBXL22"                                                                                           
##  [744] "NR1D2"                                                                                            
##  [745] "RHEB"                                                                                             
##  [746] "PARD3B"                                                                                           
##  [747] "RNF167"                                                                                           
##  [748] "RBM11"                                                                                            
##  [749] "GPR174"                                                                                           
##  [750] "KIF3A"                                                                                            
##  [751] "ARMC2"                                                                                            
##  [752] "FKBP6"                                                                                            
##  [753] "TSPAN5"                                                                                           
##  [754] "ZFP710"                                                                                           
##  [755] "SPIN4"                                                                                            
##  [756] "CTTN"                                                                                             
##  [757] "SLC2A8"                                                                                           
##  [758] "ARHGEF12"                                                                                         
##  [759] "PPP2R1B"                                                                                          
##  [760] "C030017K20RIK"                                                                                    
##  [761] "NRP2"                                                                                             
##  [762] "RAB11FIP5"                                                                                        
##  [763] "CCBL2"                                                                                            
##  [764] "DENND5B"                                                                                          
##  [765] "LCOR"                                                                                             
##  [766] "SLC6A1"                                                                                           
##  [767] "4930434J06RIK"                                                                                    
##  [768] "AIRN"                                                                                             
##  [769] "SSH2"                                                                                             
##  [770] "TFAM"                                                                                             
##  [771] "DUSP16"                                                                                           
##  [772] "NOL7"                                                                                             
##  [773] "SCN3B"                                                                                            
##  [774] "GATM"                                                                                             
##  [775] "D430042O09RIK"                                                                                    
##  [776] "DOK4"                                                                                             
##  [777] "CCR9"                                                                                             
##  [778] "SUMF2"                                                                                            
##  [779] "NRBP2"                                                                                            
##  [780] "SH3KBP1"                                                                                          
##  [781] "HIST2H2BE"                                                                                        
##  [782] "UBAP1"                                                                                            
##  [783] "LILRB4"                                                                                           
##  [784] "PIKFYVE"                                                                                          
##  [785] "GM4776"                                                                                           
##  [786] "SGSM2"                                                                                            
##  [787] "PROM2"                                                                                            
##  [788] "ABHD12B"                                                                                          
##  [789] "PPP1R1C"                                                                                          
##  [790] "TSPAN7"                                                                                           
##  [791] "TCF25"                                                                                            
##  [792] "HBA-A2"                                                                                           
##  [793] "FADS1"                                                                                            
##  [794] "CHST1"                                                                                            
##  [795] "AIDA"                                                                                             
##  [796] "FOXP2"                                                                                            
##  [797] "NAIP6"                                                                                            
##  [798] "HMGN3"                                                                                            
##  [799] "CLEC5A"                                                                                           
##  [800] "BC048943"                                                                                         
##  [801] "UFM1"                                                                                             
##  [802] "KCNV1"                                                                                            
##  [803] "STK16"                                                                                            
##  [804] "NOD2"                                                                                             
##  [805] "SUPT7L"                                                                                           
##  [806] "TRMT11"                                                                                           
##  [807] "CAP2"                                                                                             
##  [808] "SYT5"                                                                                             
##  [809] "TPRGL"                                                                                            
##  [810] "SLC37A4"                                                                                          
##  [811] "LPL"                                                                                              
##  [812] "UBOX5"                                                                                            
##  [813] "HAND1"                                                                                            
##  [814] "CHD5"                                                                                             
##  [815] "SYT11"                                                                                            
##  [816] "CEP164"                                                                                           
##  [817] "NPR3"                                                                                             
##  [818] "ACN9"                                                                                             
##  [819] "CCDC127"                                                                                          
##  [820] "OPHN1"                                                                                            
##  [821] "MAN2A1"                                                                                           
##  [822] "SCARB1"                                                                                           
##  [823] "ZFP707"                                                                                           
##  [824] "PSMB5"                                                                                            
##  [825] "NKIRAS2"                                                                                          
##  [826] "HAP1"                                                                                             
##  [827] "PDE1C"                                                                                            
##  [828] "VWCE"                                                                                             
##  [829] "DSC1"                                                                                             
##  [830] "MEA1"                                                                                             
##  [831] "ITSN2"                                                                                            
##  [832] "PPP1R3C"                                                                                          
##  [833] "BNC2"                                                                                             
##  [834] "ABCC10"                                                                                           
##  [835] "LYZL4"                                                                                            
##  [836] "INTS9"                                                                                            
##  [837] "DKK3"                                                                                             
##  [838] "CORO2A"                                                                                           
##  [839] "RHBDL3"                                                                                           
##  [840] "MYRIP"                                                                                            
##  [841] "ZC3H11A"                                                                                          
##  [842] "PRMT6"                                                                                            
##  [843] "SLC7A8"                                                                                           
##  [844] "GM6787"                                                                                           
##  [845] "GM410"                                                                                            
##  [846] "EIF3I"                                                                                            
##  [847] "EBAG9"                                                                                            
##  [848] "TMEM62"                                                                                           
##  [849] "GTPBP1"                                                                                           
##  [850] "CCDC53"                                                                                           
##  [851] "B230110G15RIK"                                                                                    
##  [852] "TPPP"                                                                                             
##  [853] "A930024E05RIK"                                                                                    
##  [854] "KLHL26"                                                                                           
##  [855] "MNT"                                                                                              
##  [856] "PTPRH"                                                                                            
##  [857] "SNPH"                                                                                             
##  [858] "LTB"                                                                                              
##  [859] "TRP53RK"                                                                                          
##  [860] "SKINT3"                                                                                           
##  [861] "ANKS1B"                                                                                           
##  [862] "MAN1A"                                                                                            
##  [863] "ZFP9"                                                                                             
##  [864] "ALX3"                                                                                             
##  [865] "ZFP263"                                                                                           
##  [866] "3010003L21RIK"                                                                                    
##  [867] "ACOX1"                                                                                            
##  [868] "CASP9"                                                                                            
##  [869] "IARS"                                                                                             
##  [870] "CHSY3"                                                                                            
##  [871] "FGF1"                                                                                             
##  [872] "FAM196B"                                                                                          
##  [873] "SBK1"                                                                                             
##  [874] "MALT1"                                                                                            
##  [875] "SMYD5"                                                                                            
##  [876] "LRRTM1"                                                                                           
##  [877] "RAPGEF6"                                                                                          
##  [878] "GM15623"                                                                                          
##  [879] "KLHL20"                                                                                           
##  [880] "MAPRE1"                                                                                           
##  [881] "ZFP329"                                                                                           
##  [882] "STARD3NL"                                                                                         
##  [883] "HTR2C"                                                                                            
##  [884] "CD160"                                                                                            
##  [885] "GNAI3"                                                                                            
##  [886] "BCL2L13"                                                                                          
##  [887] "NT5DC1"                                                                                           
##  [888] "KDM4D"                                                                                            
##  [889] "NCTC1"                                                                                            
##  [890] "ARHGEF16"                                                                                         
##  [891] "ZDHHC3"                                                                                           
##  [892] "ADAM23"                                                                                           
##  [893] "MAVS"                                                                                             
##  [894] "PDE4B"                                                                                            
##  [895] "STIM1"                                                                                            
##  [896] "NVL"                                                                                              
##  [897] "COPS7B"                                                                                           
##  [898] "IGF2AS"                                                                                           
##  [899] "EDNRA"                                                                                            
##  [900] "ZC3H7B"                                                                                           
##  [901] "STAB2"                                                                                            
##  [902] "SMCR7"                                                                                            
##  [903] "NCALD"                                                                                            
##  [904] "CDR2L"                                                                                            
##  [905] "PNPT1"                                                                                            
##  [906] "HIC2"                                                                                             
##  [907] "ARRDC4"                                                                                           
##  [908] "WDR82"                                                                                            
##  [909] "BAIAP2"                                                                                           
##  [910] "ST13"                                                                                             
##  [911] "CNTN2"                                                                                            
##  [912] "SLC6A17"                                                                                          
##  [913] "CWC22"                                                                                            
##  [914] "FAM133B"                                                                                          
##  [915] "CELA1"                                                                                            
##  [916] "TRIM2"                                                                                            
##  [917] "CAMK2D"                                                                                           
##  [918] "UNC5C"                                                                                            
##  [919] "NUDT4"                                                                                            
##  [920] "LCORL"                                                                                            
##  [921] "SLC35A4"                                                                                          
##  [922] "STARD13"                                                                                          
##  [923] "BCAP29"                                                                                           
##  [924] "4930403D09RIK"                                                                                    
##  [925] "IL1F5"                                                                                            
##  [926] "MYOZ2"                                                                                            
##  [927] "ATXN7L3"                                                                                          
##  [928] "HSD3B3"                                                                                           
##  [929] "CCND1"                                                                                            
##  [930] "WDTC1"                                                                                            
##  [931] "TAF9B"                                                                                            
##  [932] "FAM132B"                                                                                          
##  [933] "TAC4"                                                                                             
##  [934] "RPRD2"                                                                                            
##  [935] "SPHKAP"                                                                                           
##  [936] "ZBTB33"                                                                                           
##  [937] "AKT1"                                                                                             
##  [938] "ARID3B"                                                                                           
##  [939] "GPR31C"                                                                                           
##  [940] "NEUROD2"                                                                                          
##  [941] "OGFR"                                                                                             
##  [942] "C230072F16RIK"                                                                                    
##  [943] "EEF1D"                                                                                            
##  [944] "ANKRD40"                                                                                          
##  [945] "6330403A02RIK"                                                                                    
##  [946] "MKL1"                                                                                             
##  [947] "CEP57"                                                                                            
##  [948] "SLC25A22"                                                                                         
##  [949] "OSBPL6"                                                                                           
##  [950] "MED28"                                                                                            
##  [951] "PRKD3"                                                                                            
##  [952] "SRPK2"                                                                                            
##  [953] "NDST3"                                                                                            
##  [954] "ASNSD1"                                                                                           
##  [955] "AHI1"                                                                                             
##  [956] "PTP4A3"                                                                                           
##  [957] "SYNJ2BP"                                                                                          
##  [958] "PKNOX2"                                                                                           
##  [959] "DDO"                                                                                              
##  [960] "ADAM11"                                                                                           
##  [961] "SH3PXD2B"                                                                                         
##  [962] "ADAM12"                                                                                           
##  [963] "MCFD2"                                                                                            
##  [964] "SUV39H1"                                                                                          
##  [965] "CDK18"                                                                                            
##  [966] "GRIA2"                                                                                            
##  [967] "AHRR"                                                                                             
##  [968] "KRTAP5-2"                                                                                         
##  [969] "A430105I19RIK"                                                                                    
##  [970] "RNF32"                                                                                            
##  [971] "SNX30"                                                                                            
##  [972] "D630045J12RIK"                                                                                    
##  [973] "KIF9"                                                                                             
##  [974] "4933407E24RIK"                                                                                    
##  [975] "ABHD14B"                                                                                          
##  [976] "HIF1AN"                                                                                           
##  [977] "ISL1"                                                                                             
##  [978] "SLC29A2"                                                                                          
##  [979] "NOTCH2"                                                                                           
##  [980] "CHRNB4"                                                                                           
##  [981] "LRRIQ3"                                                                                           
##  [982] "RHOH"                                                                                             
##  [983] "ZBTB10"                                                                                           
##  [984] "PLXNB1"                                                                                           
##  [985] "KLHL18"                                                                                           
##  [986] "IL6ST"                                                                                            
##  [987] "TDRD1"                                                                                            
##  [988] "4930428N03RIK"                                                                                    
##  [989] "SLC18A1"                                                                                          
##  [990] "ARNT"                                                                                             
##  [991] "1600014C10RIK"                                                                                    
##  [992] "GCNT3"                                                                                            
##  [993] "ARHGEF15"                                                                                         
##  [994] "LY86"                                                                                             
##  [995] "THOC2"                                                                                            
##  [996] "PYGB"                                                                                             
##  [997] "PTPRN2"                                                                                           
##  [998] "TARBP2"                                                                                           
##  [999] "SFXN3"                                                                                            
## [1000] "TBC1D14"                                                                                          
## [1001] "GM16515"                                                                                          
## [1002] "CLCN3"                                                                                            
## [1003] "TTLL1"                                                                                            
## [1004] "RGS9BP"                                                                                           
## [1005] "ITFG2"                                                                                            
## [1006] "ESYT1"                                                                                            
## [1007] "CTDSPL2"                                                                                          
## [1008] "ATXN1L"                                                                                           
## [1009] "BMF"                                                                                              
## [1010] "ABL1"                                                                                             
## [1011] "SLC2A3"                                                                                           
## [1012] "TRCG1"                                                                                            
## [1013] "MPDZ"                                                                                             
## [1014] "TMEM139"                                                                                          
## [1015] "COL19A1"                                                                                          
## [1016] "UPK1A"                                                                                            
## [1017] "MYCL1"                                                                                            
## [1018] "AAK1"                                                                                             
## [1019] "LNP"                                                                                              
## [1020] "SPAG9"                                                                                            
## [1021] "2700099C18RIK"                                                                                    
## [1022] "RAB11FIP2"                                                                                        
## [1023] "OTUD7B"                                                                                           
## [1024] "POLR3G"                                                                                           
## [1025] "TLN2"                                                                                             
## [1026] "PGAM1"                                                                                            
## [1027] "TSR2"                                                                                             
## [1028] "FABP12"                                                                                           
## [1029] "IRF4"                                                                                             
## [1030] "RFX2"                                                                                             
## [1031] "UHRF2"                                                                                            
## [1032] "ITGA8"                                                                                            
## [1033] "TTPA"                                                                                             
## [1034] "ZFP532"                                                                                           
## [1035] "DOHH"                                                                                             
## [1036] "ART1"                                                                                             
## [1037] "PGS1"                                                                                             
## [1038] "SMCR8"                                                                                            
## [1039] "4933406F09RIK"                                                                                    
## [1040] "ZFP174"                                                                                           
## [1041] "VAV3"                                                                                             
## [1042] "SLC8A1"                                                                                           
## [1043] "IFT80"                                                                                            
## [1044] "ZEB2"                                                                                             
## [1045] "SPEG"                                                                                             
## [1046] "1110051M20RIK"                                                                                    
## [1047] "TGFBRAP1"                                                                                         
## [1048] "SEMA4B"                                                                                           
## [1049] "TMED10"                                                                                           
## [1050] "GM13547"                                                                                          
## [1051] "CRB1"                                                                                             
## [1052] "CRTAP"                                                                                            
## [1053] "ABI1"                                                                                             
## [1054] "AGBL5"                                                                                            
## [1055] "GAS1"                                                                                             
## [1056] "1700095A21RIK"                                                                                    
## [1057] "VRK1"                                                                                             
## [1058] "TMEM129"                                                                                          
## [1059] "MGAT4C"                                                                                           
## [1060] "KCTD10"                                                                                           
## [1061] "DENND4C"                                                                                          
## [1062] "CD83"                                                                                             
## [1063] "RAB6B"                                                                                            
## [1064] "MNAT1"                                                                                            
## [1065] "CLDN19"                                                                                           
## [1066] "1110008L16RIK"                                                                                    
## [1067] "4933427E13RIK"                                                                                    
## [1068] "MEIS2"                                                                                            
## [1069] "RNF169"                                                                                           
## [1070] "FMN1"                                                                                             
## [1071] "ARHGAP25"                                                                                         
## [1072] "TNRC6B"                                                                                           
## [1073] "TMIE"                                                                                             
## [1074] "HRASLS"                                                                                           
## [1075] "PLCD4"                                                                                            
## [1076] "VPS25"                                                                                            
## [1077] "SLC39A14"                                                                                         
## [1078] "ZKSCAN2"                                                                                          
## [1079] "GJC3"                                                                                             
## [1080] "DGKI"                                                                                             
## [1081] "MAPT"                                                                                             
## [1082] "PRPF18"                                                                                           
## [1083] "ZFP618"                                                                                           
## [1084] "IL23R"                                                                                            
## [1085] "AKNAD1"                                                                                           
## [1086] "DST"                                                                                              
## [1087] "UTP23"                                                                                            
## [1088] "CD47"                                                                                             
## [1089] "GIT2"                                                                                             
## [1090] "PLEKHB2"                                                                                          
## [1091] "GM5766"                                                                                           
## [1092] "IGSF9"                                                                                            
## [1093] "CDK19"                                                                                            
## [1094] "SEBOX"                                                                                            
## [1095] "ALX4"                                                                                             
## [1096] "CLCF1"                                                                                            
## [1097] "ENOX1"                                                                                            
## [1098] "PTPN7"                                                                                            
## [1099] "DPAGT1"                                                                                           
## [1100] "HN1L"                                                                                             
## [1101] "ZFP781"                                                                                           
## [1102] "MLEC"                                                                                             
## [1103] "NRAS"                                                                                             
## [1104] "NCAM1"                                                                                            
## [1105] "PROX2"                                                                                            
## [1106] "THSD4"                                                                                            
## [1107] "IMP3"                                                                                             
## [1108] "ALDH6A1"                                                                                          
## [1109] "RNPS1"                                                                                            
## [1110] "BCL2L14"                                                                                          
## [1111] "PLOD1"                                                                                            
## [1112] "HOMER3"                                                                                           
## [1113] "FXYD5"                                                                                            
## [1114] "ZBTB39"                                                                                           
## [1115] "PIK3R4"                                                                                           
## [1116] "EPHB3"                                                                                            
## [1117] "TOM1"                                                                                             
## [1118] "TMEM191C"                                                                                         
## [1119] "DDIT4L"                                                                                           
## [1120] "RBMS3"                                                                                            
## [1121] "UNC13B"                                                                                           
## [1122] "DCAF8"                                                                                            
## [1123] "ZFP275"                                                                                           
## [1124] "DDX5"                                                                                             
## [1125] "GRM6"                                                                                             
## [1126] "ZFP777"                                                                                           
## [1127] "SLC16A1"                                                                                          
## [1128] "NUP50"                                                                                            
## [1129] "OLFR701"                                                                                          
## [1130] "ACER3"                                                                                            
## [1131] "AI846148"                                                                                         
## [1132] "E430024P14RIK"                                                                                    
## [1133] "LARP4B"                                                                                           
## [1134] "DOK6"                                                                                             
## [1135] "SF3B3"                                                                                            
## [1136] "LIG3"                                                                                             
## [1137] "TTC14"                                                                                            
## [1138] "STIL"                                                                                             
## [1139] "TRIB1"                                                                                            
## [1140] "OTUD4"                                                                                            
## [1141] "MED13"                                                                                            
## [1142] "TBL2"                                                                                             
## [1143] "ANGEL2"                                                                                           
## [1144] "POFUT1"                                                                                           
## [1145] "HMGXB3"                                                                                           
## [1146] "GNL3L"                                                                                            
## [1147] "IFNAR1"                                                                                           
## [1148] "MIDN"                                                                                             
## [1149] "1110018G07RIK"                                                                                    
## [1150] "INSR"                                                                                             
## [1151] "CSDE1"                                                                                            
## [1152] "GIGYF1"                                                                                           
## [1153] "CELF1"                                                                                            
## [1154] "1700054K19RIK"                                                                                    
## [1155] "HMGA2"                                                                                            
## [1156] "CCDC155"                                                                                          
## [1157] "HLCS"                                                                                             
## [1158] "TWSG1"                                                                                            
## [1159] "MYD88"                                                                                            
## [1160] "FDX1"                                                                                             
## [1161] "PRKACB"                                                                                           
## [1162] "DAB1"                                                                                             
## [1163] "B4GALT4"                                                                                          
## [1164] "GALP"                                                                                             
## [1165] "TUB"                                                                                              
## [1166] "C1QTNF1"                                                                                          
## [1167] "CYP2C65"                                                                                          
## [1168] "SPATA7"                                                                                           
## [1169] "ZFYVE20"                                                                                          
## [1170] "LYZL6"                                                                                            
## [1171] "JRK"                                                                                              
## [1172] "NRL"                                                                                              
## [1173] "GCNT1"                                                                                            
## [1174] "PRRC1"                                                                                            
## [1175] "A830049A06"                                                                                       
## [1176] "PIGW"                                                                                             
## [1177] "PRKAA2"                                                                                           
## [1178] "FAM174A"                                                                                          
## [1179] "D430020J02RIK"                                                                                    
## [1180] "TTC21B"                                                                                           
## [1181] "CAB39L"                                                                                           
## [1182] "VWA3B"                                                                                            
## [1183] "GOLPH3L"                                                                                          
## [1184] "STX6"                                                                                             
## [1185] "FAHD1"                                                                                            
## [1186] "PLAT"                                                                                             
## [1187] "RASSF3"                                                                                           
## [1188] "ZFP783"                                                                                           
## [1189] "DCAF7"                                                                                            
## [1190] "SLC45A3"                                                                                          
## [1191] "PPP1R3A"                                                                                          
## [1192] "LIMK1"                                                                                            
## [1193] "FGFBP1"                                                                                           
## [1194] "JAGN1"                                                                                            
## [1195] "CD5"                                                                                              
## [1196] "ASPA"                                                                                             
## [1197] "COL16A1"                                                                                          
## [1198] "GLYCTK"                                                                                           
## [1199] "CDH11"                                                                                            
## [1200] "CFLAR"                                                                                            
## [1201] "GM14296"                                                                                          
## [1202] "EPB4.1L5"                                                                                         
## [1203] "PLA2G10"                                                                                          
## [1204] "SLCO3A1"                                                                                          
## [1205] "KRBA1"                                                                                            
## [1206] "NAV2"                                                                                             
## [1207] "UTP18"                                                                                            
## [1208] "TIA1"                                                                                             
## [1209] "APTX"                                                                                             
## [1210] "MAN2A2"                                                                                           
## [1211] "STT3B"                                                                                            
## [1212] "EPS8L3"                                                                                           
## [1213] "NR1I3"                                                                                            
## [1214] "COL9A1"                                                                                           
## [1215] "KCNA4"                                                                                            
## [1216] "GRB10"                                                                                            
## [1217] "RABEPK"                                                                                           
## [1218] "A330050F15RIK"                                                                                    
## [1219] "ANK3"                                                                                             
## [1220] "HVCN1"                                                                                            
## [1221] "UBXN2A"                                                                                           
## [1222] "ZFP146"                                                                                           
## [1223] "HN1"                                                                                              
## [1224] "CSF2RB2"                                                                                          
## [1225] "DTWD2"                                                                                            
## [1226] "4933412E12RIK"                                                                                    
## [1227] "ABAT"                                                                                             
## [1228] "RNF38"                                                                                            
## [1229] "GM807"                                                                                            
## [1230] "GM5524"                                                                                           
## [1231] "PLEKHA2"                                                                                          
## [1232] "SSPN"                                                                                             
## [1233] "BCL2L11"                                                                                          
## [1234] "RPL22"                                                                                            
## [1235] "DNM3"                                                                                             
## [1236] "NUP133"                                                                                           
## [1237] "FAM26E"                                                                                           
## [1238] "ZFP322A"                                                                                          
## [1239] "EFR3A"                                                                                            
## [1240] "ADIPOR2"                                                                                          
## [1241] "RGR"                                                                                              
## [1242] "BRSK2"                                                                                            
## [1243] "MYO3A"                                                                                            
## [1244] "ATP11A"                                                                                           
## [1245] "ARHGAP6"                                                                                          
## [1246] "RNF165"                                                                                           
## [1247] "RRP7A"                                                                                            
## [1248] "RNF216"                                                                                           
## [1249] "FAM149B"                                                                                          
## [1250] "PEX26"                                                                                            
## [1251] "GLCE"                                                                                             
## [1252] "A230108P19RIK"                                                                                    
## [1253] "MAP2K7"                                                                                           
## [1254] "SGPP2"                                                                                            
## [1255] "TOR1AIP2"                                                                                         
## [1256] "CGN"                                                                                              
## [1257] "SGK3"                                                                                             
## [1258] "CNTLN"                                                                                            
## [1259] "SLC25A35"                                                                                         
## [1260] "TMED8"                                                                                            
## [1261] "GPR35"                                                                                            
## [1262] "THOC1"                                                                                            
## [1263] "RSAD2"                                                                                            
## [1264] "ATAD2"                                                                                            
## [1265] "EDEM1"                                                                                            
## [1266] "CELF5"                                                                                            
## [1267] "PITPNC1"                                                                                          
## [1268] "SETD5"                                                                                            
## [1269] "DCP1A"                                                                                            
## [1270] "ARSG"                                                                                             
## [1271] "SCOC"                                                                                             
## [1272] "RFX1"                                                                                             
## [1273] "NUMBL"                                                                                            
## [1274] "KBTBD8"                                                                                           
## [1275] "B4GALNT2"                                                                                         
## [1276] "NF1"                                                                                              
## [1277] "CCDC115"                                                                                          
## [1278] "RASSF7"                                                                                           
## [1279] "CNOT3"                                                                                            
## [1280] "CHRNA3"                                                                                           
## [1281] "4930513N10RIK"                                                                                    
## [1282] "NIPAL1"                                                                                           
## [1283] "GINS1"                                                                                            
## [1284] "HCFC1"                                                                                            
## [1285] "COMMD9"                                                                                           
## [1286] "MPZ"                                                                                              
## [1287] "HSPH1"                                                                                            
## [1288] "LMLN"                                                                                             
## [1289] "ZER1"                                                                                             
## [1290] "KCNAB1"                                                                                           
## [1291] "KPTN"                                                                                             
## [1292] "MYOM1"                                                                                            
## [1293] "CYB561"                                                                                           
## [1294] "4930478P22RIK"                                                                                    
## [1295] "TAT"                                                                                              
## [1296] "PGPEP1"                                                                                           
## [1297] "PER3"                                                                                             
## [1298] "ZCCHC11"                                                                                          
## [1299] "ZMYM5"                                                                                            
## [1300] "1700072I22RIK"                                                                                    
## [1301] "CD200"                                                                                            
## [1302] "ZKSCAN14"                                                                                         
## [1303] "RNF222"                                                                                           
## [1304] "4930435E12RIK"                                                                                    
## [1305] "ACAT1"                                                                                            
## [1306] "SLC35D1"                                                                                          
## [1307] "DSTYK"                                                                                            
## [1308] "CYYR1"                                                                                            
## [1309] "B130046B21RIK"                                                                                    
## [1310] "BLVRA"                                                                                            
## [1311] "RAB11FIP4"                                                                                        
## [1312] "CCNG1"                                                                                            
## [1313] "ZZZ3"                                                                                             
## [1314] "PRICKLE1"                                                                                         
## [1315] "CYP2C39"                                                                                          
## [1316] "RNF144A"                                                                                          
## [1317] "GM4858"                                                                                           
## [1318] "PVT1"                                                                                             
## [1319] "IFT122"                                                                                           
## [1320] "RNF170"                                                                                           
## [1321] "METTL8"                                                                                           
## [1322] "GM597"                                                                                            
## [1323] "ZFP563"                                                                                           
## [1324] "ZCCHC4"                                                                                           
## [1325] "RFTN2"                                                                                            
## [1326] "PRPF39"                                                                                           
## [1327] "1700037H04RIK"                                                                                    
## [1328] "KCNIP3"                                                                                           
## [1329] "PPP1R16A"                                                                                         
## [1330] "WDR13"                                                                                            
## [1331] "PPM1E"                                                                                            
## [1332] "STX11"                                                                                            
## [1333] "PDXK"                                                                                             
## [1334] "ASTE1"                                                                                            
## [1335] "GM10419"                                                                                          
## [1336] "CD276"                                                                                            
## [1337] "CDKL2"                                                                                            
## [1338] "RAPGEFL1"                                                                                         
## [1339] "TJP1"                                                                                             
## [1340] "GM13111"                                                                                          
## [1341] "LRP11"                                                                                            
## [1342] "4930447F24RIK"                                                                                    
## [1343] "PHC2"                                                                                             
## [1344] "EIF2AK3"                                                                                          
## [1345] "SF3A1"                                                                                            
## [1346] "TRIM45"                                                                                           
## [1347] "KCTD1"                                                                                            
## [1348] "DCBLD1"                                                                                           
## [1349] "CHORDC1"                                                                                          
## [1350] "YEATS4"                                                                                           
## [1351] "HERC1"                                                                                            
## [1352] "ERLIN2"                                                                                           
## [1353] "ADRA2A"                                                                                           
## [1354] "BC034902"                                                                                         
## [1355] "SEPP1"                                                                                            
## [1356] "TMPRSS11F"                                                                                        
## [1357] "2810474O19RIK"                                                                                    
## [1358] "COQ3"                                                                                             
## [1359] "CCDC34"                                                                                           
## [1360] "2810006K23RIK"                                                                                    
## [1361] "HSD11B1"                                                                                          
## [1362] "SAMD4B"                                                                                           
## [1363] "BSN"                                                                                              
## [1364] "PKIB"                                                                                             
## [1365] "RECQL"                                                                                            
## [1366] "G630016G05RIK"                                                                                    
## [1367] "ATP6V1G3"                                                                                         
## [1368] "EXOC6B"                                                                                           
## [1369] "ZFYVE26"                                                                                          
## [1370] "SLC8A2"                                                                                           
## [1371] "MMAB"                                                                                             
## [1372] "UBXN4"                                                                                            
## [1373] "METTL14"                                                                                          
## [1374] "HS2ST1"                                                                                           
## [1375] "TMX4"                                                                                             
## [1376] "PPFIBP2"                                                                                          
## [1377] "LRRC16A"                                                                                          
## [1378] "SLC7A13"                                                                                          
## [1379] "GOLPH3"                                                                                           
## [1380] "ARSJ"                                                                                             
## [1381] "GJA5"                                                                                             
## [1382] "ARHGAP19"                                                                                         
## [1383] "RILPL1"                                                                                           
## [1384] "TBXA2R"                                                                                           
## [1385] "BIRC5"                                                                                            
## [1386] "NCKAP1L"                                                                                          
## [1387] "4930451C15RIK"                                                                                    
## [1388] "PSKH1"                                                                                            
## [1389] "SLC25A45"                                                                                         
## [1390] "ZFP398"                                                                                           
## [1391] "PPP2R5C"                                                                                          
## [1392] "FBXW2"                                                                                            
## [1393] "NDUFS1"                                                                                           
## [1394] "SUMF1"                                                                                            
## [1395] "GPATCH2"                                                                                          
## [1396] "PALLD"                                                                                            
## [1397] "HRH3"                                                                                             
## [1398] "ADH6B"                                                                                            
## [1399] "GTF2IRD1"                                                                                         
## [1400] "GM12185"                                                                                          
## [1401] "EME1"                                                                                             
## [1402] "C430049E01RIK"                                                                                    
## [1403] "ATG16L1"                                                                                          
## [1404] "NLRP5"                                                                                            
## [1405] "RBM41"                                                                                            
## [1406] "ANGPTL2"                                                                                          
## [1407] "1810062O18RIK"                                                                                    
## [1408] "SEMA3C"                                                                                           
## [1409] "PCSK2"                                                                                            
## [1410] "CDK1"                                                                                             
## [1411] "KIF21B"                                                                                           
## [1412] "PDLIM7"                                                                                           
## [1413] "WBSCR22"                                                                                          
## [1414] "A330023F24RIK"                                                                                    
## [1415] "BCAT1"                                                                                            
## [1416] "PRPF4"                                                                                            
## [1417] "UMPS"                                                                                             
## [1418] "MYO1H"                                                                                            
## [1419] "GRIN2B"                                                                                           
## [1420] "FIBCD1"                                                                                           
## [1421] "PKD1"                                                                                             
## [1422] "MTMR4"                                                                                            
## [1423] "FNBP1"                                                                                            
## [1424] "9530077C05RIK"                                                                                    
## [1425] "CYB5B"                                                                                            
## [1426] "GM9903"                                                                                           
## [1427] "ERGIC1"                                                                                           
## [1428] "4833420G17RIK"                                                                                    
## [1429] "CDK5R2"                                                                                           
## [1430] "GM5878"                                                                                           
## [1431] "ATP2A3"                                                                                           
## [1432] "SEMA7A"                                                                                           
## [1433] "SCNN1G"                                                                                           
## [1434] "SIK1"                                                                                             
## [1435] "MICAL1"                                                                                           
## [1436] "RGS12"                                                                                            
## [1437] "GM4798"                                                                                           
## [1438] "SCFD1"                                                                                            
## [1439] "ATF7IP2"                                                                                          
## [1440] "PDE10A"                                                                                           
## [1441] "ANKFY1"                                                                                           
## [1442] "SH3D19"                                                                                           
## [1443] "SYN2"                                                                                             
## [1444] "AKNA"                                                                                             
## [1445] "EIF4EBP1"                                                                                         
## [1446] "MED13L"                                                                                           
## [1447] "TOMM70A"                                                                                          
## [1448] "9530026P05RIK"                                                                                    
## [1449] "VWC2L"                                                                                            
## [1450] "RGS11"                                                                                            
## [1451] "NIPSNAP3A"                                                                                        
## [1452] "CEP110"                                                                                           
## [1453] "ZFP407"                                                                                           
## [1454] "SLC9A3R2"                                                                                         
## [1455] "LY6G6E"                                                                                           
## [1456] "AQP6"                                                                                             
## [1457] "D630037F22RIK"                                                                                    
## [1458] "GYS1"                                                                                             
## [1459] "CFH"                                                                                              
## [1460] "MTDH"                                                                                             
## [1461] "FAM115C"                                                                                          
## [1462] "GNG2"                                                                                             
## [1463] "ETOHD2"                                                                                           
## [1464] "TTC28"                                                                                            
## [1465] "SLC24A3"                                                                                          
## [1466] "IGHMBP2"                                                                                          
## [1467] "PLA1A"                                                                                            
## [1468] "PROKR1"                                                                                           
## [1469] "BLK"                                                                                              
## [1470] "KL"                                                                                               
## [1471] "PSD3"                                                                                             
## [1472] "NKX1-2"                                                                                           
## [1473] "DCUN1D4"                                                                                          
## [1474] "SEC14L1"                                                                                          
## [1475] "SBNO2"                                                                                            
## [1476] "STAMBP"                                                                                           
## [1477] "SPATS2L"                                                                                          
## [1478] "NRP1"                                                                                             
## [1479] "H2-OB"                                                                                            
## [1480] "PRR3"                                                                                             
## [1481] "MMP11"                                                                                            
## [1482] "FBXO41"                                                                                           
## [1483] "POMT2"                                                                                            
## [1484] "HMGCS1"                                                                                           
## [1485] "OBFC1"                                                                                            
## [1486] "LARP4"                                                                                            
## [1487] "RIMKLA"                                                                                           
## [1488] "SLAIN2"                                                                                           
## [1489] "IMPACT"                                                                                           
## [1490] "VPS26A"                                                                                           
## [1491] "WDR73"                                                                                            
## [1492] "TMEM57"                                                                                           
## [1493] "FGF5"                                                                                             
## [1494] "GLS"                                                                                              
## [1495] "ARL13B"                                                                                           
## [1496] "KLHDC7A"                                                                                          
## [1497] "SERPINA12"                                                                                        
## [1498] "LFNG"                                                                                             
## [1499] "LRRC4"                                                                                            
## [1500] "ANKRD34A"                                                                                         
## [1501] "GM5134"                                                                                           
## [1502] "TECPR1"                                                                                           
## [1503] "PLP1"                                                                                             
## [1504] "6330408A02RIK"                                                                                    
## [1505] "WASF2"                                                                                            
## [1506] "RPH3A"                                                                                            
## [1507] "PRR9"                                                                                             
## [1508] "TSPAN31"                                                                                          
## [1509] "FOXK1"                                                                                            
## [1510] "IL1RN"                                                                                            
## [1511] "NCOA2"                                                                                            
## [1512] "9430065F17RIK"                                                                                    
## [1513] "ZXDA"                                                                                             
## [1514] "DHRS9"                                                                                            
## [1515] "PRKCB"                                                                                            
## [1516] "N6AMT1"                                                                                           
## [1517] "KCNAB2"                                                                                           
## [1518] "FLAD1"                                                                                            
## [1519] "MTUS2"                                                                                            
## [1520] "FUNDC2"                                                                                           
## [1521] "ZDHHC8"                                                                                           
## [1522] "IPO5"                                                                                             
## [1523] "GGT5"                                                                                             
## [1524] "ATP1A3"                                                                                           
## [1525] "RGS16"                                                                                            
## [1526] "ANO6"                                                                                             
## [1527] "PBX3"                                                                                             
## [1528] "TMEM18"                                                                                           
## [1529] "MAP3K4"                                                                                           
## [1530] "RNFT2"                                                                                            
## [1531] "FADD"                                                                                             
## [1532] "LOX"                                                                                              
## [1533] "SLC2A4"                                                                                           
## [1534] "GALK2"                                                                                            
## [1535] "9330188P03RIK"                                                                                    
## [1536] "DUSP19"                                                                                           
## [1537] "GM14085"                                                                                          
## [1538] "GM10634"                                                                                          
## [1539] "IL4RA"                                                                                            
## [1540] "NEK7"                                                                                             
## [1541] "PAPOLA"                                                                                           
## [1542] "ATG4C"                                                                                            
## [1543] "FICD"                                                                                             
## [1544] "TSPAN2"                                                                                           
## [1545] "0610009O20RIK"                                                                                    
## [1546] "A930011O12RIK"                                                                                    
## [1547] "EIF5A2"                                                                                           
## [1548] "ZNF512B"                                                                                          
## [1549] "GRIK1"                                                                                            
## [1550] "CYTH4"                                                                                            
## [1551] "CACNB4"                                                                                           
## [1552] "2410080I02RIK"                                                                                    
## [1553] "PCDH15"                                                                                           
## [1554] "MSI2"                                                                                             
## [1555] "GRM2"                                                                                             
## [1556] "UBE2B"                                                                                            
## [1557] "KIF5C"                                                                                            
## [1558] "2010002M12RIK"                                                                                    
## [1559] "NRD1"                                                                                             
## [1560] "SCN5A"                                                                                            
## [1561] "MAPK9"                                                                                            
## [1562] "RBM26"                                                                                            
## [1563] "TDGF1"                                                                                            
## [1564] "LMNB2"                                                                                            
## [1565] "BRMS1"                                                                                            
## [1566] "GDNF"                                                                                             
## [1567] "ANAPC5"                                                                                           
## [1568] "ZPBP2"                                                                                            
## [1569] "KCNJ16"                                                                                           
## [1570] "TAB2"                                                                                             
## [1571] "ZFP709"                                                                                           
## [1572] "MSI1"                                                                                             
## [1573] "RBM7"                                                                                             
## [1574] "BMPR1A"                                                                                           
## [1575] "LMBR1"                                                                                            
## [1576] "B3GALT5"                                                                                          
## [1577] "BCL2L1"                                                                                           
## [1578] "KCNK16"                                                                                           
## [1579] "TRAPPC9"                                                                                          
## [1580] "TTLL7"                                                                                            
## [1581] "DOCK5"                                                                                            
## [1582] "WARS2"                                                                                            
## [1583] "ALDH1A3"                                                                                          
## [1584] "ME3"                                                                                              
## [1585] "XIRP1"                                                                                            
## [1586] "YARS2"                                                                                            
## [1587] "PLEKHA6"                                                                                          
## [1588] "NUDCD3"                                                                                           
## [1589] "ETL4"                                                                                             
## [1590] "VDR"                                                                                              
## [1591] "GIMAP8"                                                                                           
## [1592] "RASA2"                                                                                            
## [1593] "PARP14"                                                                                           
## [1594] "SSBP3"                                                                                            
## [1595] "SLC38A1"                                                                                          
## [1596] "4930407I19RIK"                                                                                    
## [1597] "OGDH"                                                                                             
## [1598] "ABR"                                                                                              
## [1599] "MERTK"                                                                                            
## [1600] "TRP53INP1"                                                                                        
## [1601] "PRX"                                                                                              
## [1602] "A430057M04RIK"                                                                                    
## [1603] "TYR"                                                                                              
## [1604] "GOLM1"                                                                                            
## [1605] "KIFAP3"                                                                                           
## [1606] "CCBE1"                                                                                            
## [1607] "FAM163A"                                                                                          
## [1608] "A930015D03RIK"                                                                                    
## [1609] "KDM5D"                                                                                            
## [1610] "EID1"                                                                                             
## [1611] "ARHGEF9"                                                                                          
## [1612] "BC037034"                                                                                         
## [1613] "MMP15"                                                                                            
## [1614] "CLDN23"                                                                                           
## [1615] "CDAN1"                                                                                            
## [1616] "DENND4A"                                                                                          
## [1617] "GM3002"                                                                                           
## [1618] "DNAJB12"                                                                                          
## [1619] "TANC2"                                                                                            
## [1620] "GTF2A1"                                                                                           
## [1621] "GLRX3"                                                                                            
## [1622] "CTLA4"                                                                                            
## [1623] "APAF1"                                                                                            
## [1624] "IGFBP5"                                                                                           
## [1625] "HIC1"                                                                                             
## [1626] "TMEM201"                                                                                          
## [1627] "ILKAP"                                                                                            
## [1628] "LRRCC1"                                                                                           
## [1629] "MESDC2"                                                                                           
## [1630] "CGNL1"                                                                                            
## [1631] "AUH"                                                                                              
## [1632] "APBA1"                                                                                            
## [1633] "SAA2"                                                                                             
## [1634] "ETNK1"                                                                                            
## [1635] "NNT"                                                                                              
## [1636] "6030458C11RIK"                                                                                    
## [1637] "BC039771"                                                                                         
## [1638] "SON"                                                                                              
## [1639] "HSF2BP"                                                                                           
## [1640] "FAM167A"                                                                                          
## [1641] "GRHL2"                                                                                            
## [1642] "BC043934"                                                                                         
## [1643] "ECHS1"                                                                                            
## [1644] "TNFSF18"                                                                                          
## [1645] "ILTIFB"                                                                                           
## [1646] "PLEKHJ1"                                                                                          
## [1647] "KIF18A"                                                                                           
## [1648] "RPS6KB1"                                                                                          
## [1649] "GSDMA2"                                                                                           
## [1650] "BSG"                                                                                              
## [1651] "DUSP9"                                                                                            
## [1652] "1700028D13RIK"                                                                                    
## [1653] "KCTD12B"                                                                                          
## [1654] "UEVLD"                                                                                            
## [1655] "PDPK1"                                                                                            
## [1656] "9330155M09RIK"                                                                                    
## [1657] "LAMP2"                                                                                            
## [1658] "TRPS1"                                                                                            
## [1659] "SFRS18"                                                                                           
## [1660] "EPHB1"                                                                                            
## [1661] "JAK3"                                                                                             
## [1662] "MBTD1"                                                                                            
## [1663] "GATA5"                                                                                            
## [1664] "OLFR1502"                                                                                         
## [1665] "SEC24A"                                                                                           
## [1666] "ZSCAN12"                                                                                          
## [1667] "ABHD13"                                                                                           
## [1668] "UNC5D"                                                                                            
## [1669] "REEP5"                                                                                            
## [1670] "FGF23"                                                                                            
## [1671] "EIF1AD"                                                                                           
## [1672] "CYP4F15"                                                                                          
## [1673] "NEO1"                                                                                             
## [1674] "GPR157"                                                                                           
## [1675] "ASB12"                                                                                            
## [1676] "RALGAPB"                                                                                          
## [1677] "HEY2"                                                                                             
## [1678] "RNF39"                                                                                            
## [1679] "CLDN2"                                                                                            
## [1680] "TET2"                                                                                             
## [1681] "C530047H08RIK"                                                                                    
## [1682] "PTPN22"                                                                                           
## [1683] "PLD2"                                                                                             
## [1684] "TPSAB1"                                                                                           
## [1685] "FAM96A"                                                                                           
## [1686] "ADAMTSL3"                                                                                         
## [1687] "EXOC2"                                                                                            
## [1688] "CALM1"                                                                                            
## [1689] "NUDT8"                                                                                            
## [1690] "SPCS3"                                                                                            
## [1691] "RUFY2"                                                                                            
## [1692] "TPP1"                                                                                             
## [1693] "ZFHX4"                                                                                            
## [1694] "CHST3"                                                                                            
## [1695] "BRWD1"                                                                                            
## [1696] "DONSON"                                                                                           
## [1697] "CD3E"                                                                                             
## [1698] "ARHGEF18"                                                                                         
## [1699] "SHC1"                                                                                             
## [1700] "AF366264"                                                                                         
## [1701] "GPRC5A"                                                                                           
## [1702] "RAPGEF1"                                                                                          
## [1703] "ZFP740"                                                                                           
## [1704] "ZFP759"                                                                                           
## [1705] "PXDN"                                                                                             
## [1706] "TES"                                                                                              
## [1707] "TCERG1"                                                                                           
## [1708] "SLCO5A1"                                                                                          
## [1709] "RORA"                                                                                             
## [1710] "CAPN6"                                                                                            
## [1711] "SMARCC1"                                                                                          
## [1712] "WDR76"                                                                                            
## [1713] "ABCC5"                                                                                            
## [1714] "NTN3"                                                                                             
## [1715] "ZFP7"                                                                                             
## [1716] "5430435G22RIK"                                                                                    
## [1717] "ZFP719"                                                                                           
## [1718] "SMYD4"                                                                                            
## [1719] "I730028E13RIK"                                                                                    
## [1720] "PTPRG"                                                                                            
## [1721] "STRA13"                                                                                           
## [1722] "YAP1"                                                                                             
## [1723] "SCML2"                                                                                            
## [1724] "VPS37B"                                                                                           
## [1725] "MICALL1"                                                                                          
## [1726] "AARS2"                                                                                            
## [1727] "TXK"                                                                                              
## [1728] "ZFP608"                                                                                           
## [1729] "GAA"                                                                                              
## [1730] "NECAP2"                                                                                           
## [1731] "TNFRSF1B"                                                                                         
## [1732] "SH2D7"                                                                                            
## [1733] "CCDC25"                                                                                           
## [1734] "IP6K2"                                                                                            
## [1735] "A930012L18RIK"                                                                                    
## [1736] "LRRC15"                                                                                           
## [1737] "LRCH1"                                                                                            
## [1738] "GPR63"                                                                                            
## [1739] "CDH26"                                                                                            
## [1740] "NACC2"                                                                                            
## [1741] "UGGT1"                                                                                            
## [1742] "CLPB"                                                                                             
## [1743] "SEMA3G"                                                                                           
## [1744] "CYTH3"                                                                                            
## [1745] "TMED7"                                                                                            
## [1746] "INPP4A"                                                                                           
## [1747] "PLCG1"                                                                                            
## [1748] "EXOC8"                                                                                            
## [1749] "HYAL1"                                                                                            
## [1750] "TMEM194"                                                                                          
## [1751] "RAB3D"                                                                                            
## [1752] "1600020E01RIK"                                                                                    
## [1753] "C130074G19RIK"                                                                                    
## [1754] "RND3"                                                                                             
## [1755] "2810459M11RIK"                                                                                    
## [1756] "PRKCQ"                                                                                            
## [1757] "GP49A"                                                                                            
## [1758] "PFKFB2"                                                                                           
## [1759] "FAM131B"                                                                                          
## [1760] "NRARP"                                                                                            
## [1761] "GM7457"                                                                                           
## [1762] "NRCAM"                                                                                            
## [1763] "GSDMCL-PS"                                                                                        
## [1764] "PRDX6"                                                                                            
## [1765] "GM10389"                                                                                          
## [1766] "POLDIP3"                                                                                          
## [1767] "STK11IP"                                                                                          
## [1768] "ATAD5"                                                                                            
## [1769] "ACVR2A"                                                                                           
## [1770] "ITIH5"                                                                                            
## [1771] "IL17RD"                                                                                           
## [1772] "AMBRA1"                                                                                           
## [1773] "NECAP1"                                                                                           
## [1774] "ZFP276"                                                                                           
## [1775] "FUT10"                                                                                            
## [1776] "GRAMD1B"                                                                                          
## [1777] "NR6A1"                                                                                            
## [1778] "LRP2BP"                                                                                           
## [1779] "TRIM21"                                                                                           
## [1780] "ZFP516"                                                                                           
## [1781] "C330008G21RIK"                                                                                    
## [1782] "MLLT6"                                                                                            
## [1783] "BC021767"                                                                                         
## [1784] "ANKIB1"                                                                                           
## [1785] "PGR15L"                                                                                           
## [1786] "A430078G23RIK"                                                                                    
## [1787] "DAAM2"                                                                                            
## [1788] "STX3"                                                                                             
## [1789] "TMEM161B"                                                                                         
## [1790] "C3AR1"                                                                                            
## [1791] "ATP6V1A"                                                                                          
## [1792] "MRPS15"                                                                                           
## [1793] "PKIG"                                                                                             
## [1794] "FES"                                                                                              
## [1795] "RAP1GAP2"                                                                                         
## [1796] "MARVELD3"                                                                                         
## [1797] "HSDL1"                                                                                            
## [1798] "IFFO2"                                                                                            
## [1799] "SEC16A"                                                                                           
## [1800] "FMO9"                                                                                             
## [1801] "MRPL17"                                                                                           
## [1802] "CHD3"                                                                                             
## [1803] "ZSWIM4"                                                                                           
## [1804] "SLC11A1"                                                                                          
## [1805] "HNRNPA1"                                                                                          
## [1806] "NUP210"                                                                                           
## [1807] "DPP3"                                                                                             
## [1808] "ADRBK2"                                                                                           
## [1809] "9430021M05RIK"                                                                                    
## [1810] "LGI1"                                                                                             
## [1811] "D930048N14RIK"                                                                                    
## [1812] "CTSO"                                                                                             
## [1813] "CALU"                                                                                             
## [1814] "NIPBL"                                                                                            
## [1815] "CASKIN1"                                                                                          
## [1816] "BTRC"                                                                                             
## [1817] "SLMAP"                                                                                            
## [1818] "D830032E09RIK"                                                                                    
## [1819] "JAM3"                                                                                             
## [1820] "RGS19"                                                                                            
## [1821] "FBXO27"                                                                                           
## [1822] "VAMP1"                                                                                            
## [1823] "CER1"                                                                                             
## [1824] "2410003L11RIK"                                                                                    
## [1825] "TMC7"                                                                                             
## [1826] "DOLPP1"                                                                                           
## [1827] "MIER3"                                                                                            
## [1828] "IL1R1"                                                                                            
## [1829] "SLC25A4"                                                                                          
## [1830] "TRIB2"                                                                                            
## [1831] "ARHGAP4"                                                                                          
## [1832] "PPP1R12C"                                                                                         
## [1833] "SAA4"                                                                                             
## [1834] "ITGA9"                                                                                            
## [1835] "BRAF"                                                                                             
## [1836] "MZF1"                                                                                             
## [1837] "C2"                                                                                               
## [1838] "PIGQ"                                                                                             
## [1839] "AP1M2"                                                                                            
## [1840] "BMP3"                                                                                             
## [1841] "ZFP593"                                                                                           
## [1842] "EHHADH"                                                                                           
## [1843] "ANO10"                                                                                            
## [1844] "ABL2"                                                                                             
## [1845] "ASCL1"                                                                                            
## [1846] "DBX2"                                                                                             
## [1847] "NUAK1"                                                                                            
## [1848] "GUCY1A3"                                                                                          
## [1849] "NOVA1"                                                                                            
## [1850] "4930544L04RIK"                                                                                    
## [1851] "MECP2"                                                                                            
## [1852] "HEATR5A"                                                                                          
## [1853] "MTX2"                                                                                             
## [1854] "APOL6"                                                                                            
## [1855] "RNF220"                                                                                           
## [1856] "EXOSC9"                                                                                           
## [1857] "B930082K07RIK"                                                                                    
## [1858] "GRPEL2"                                                                                           
## [1859] "SRCAP"                                                                                            
## [1860] "CPA4"                                                                                             
## [1861] "TMEM115"                                                                                          
## [1862] "GM4876"                                                                                           
## [1863] "MOV10"                                                                                            
## [1864] "CEP192"                                                                                           
## [1865] "ATG2B"                                                                                            
## [1866] "FAM102A"                                                                                          
## [1867] "1700099I09RIK"                                                                                    
## [1868] "CEP170"                                                                                           
## [1869] "GM3896"                                                                                           
## [1870] "EXOC5"                                                                                            
## [1871] "INTU"                                                                                             
## [1872] "ZFP862"                                                                                           
## [1873] "TMEM167"                                                                                          
## [1874] "DMD"                                                                                              
## [1875] "RRAS"                                                                                             
## [1876] "GM867"                                                                                            
## [1877] "DSCAM"                                                                                            
## [1878] "IGF2BP1"                                                                                          
## [1879] "ZFP652"                                                                                           
## [1880] "NEUROG3"                                                                                          
## [1881] "GXYLT1"                                                                                           
## [1882] "2610042L04RIK"                                                                                    
## [1883] "TRAK1"                                                                                            
## [1884] "AI854703"                                                                                         
## [1885] "LRRC18"                                                                                           
## [1886] "L3MBTL2"                                                                                          
## [1887] "ZFP71-RS1"                                                                                        
## [1888] "4632433K11RIK"                                                                                    
## [1889] "GGTA1"                                                                                            
## [1890] "LMOD1"                                                                                            
## [1891] "SLFN1"                                                                                            
## [1892] "HMGCLL1"                                                                                          
## [1893] "ZFP28"                                                                                            
## [1894] "CSNK1E"                                                                                           
## [1895] "3010001F23RIK"                                                                                    
## [1896] "FNDC5"                                                                                            
## [1897] "NECAB1"                                                                                           
## [1898] "RBM22"                                                                                            
## [1899] "LACTB2"                                                                                           
## [1900] "KPNA1"                                                                                            
## [1901] "C8A"                                                                                              
## [1902] "ZFP622"                                                                                           
## [1903] "ATIC"                                                                                             
## [1904] "PRRX1"                                                                                            
## [1905] "SUSD1"                                                                                            
## [1906] "LRRC2"                                                                                            
## [1907] "4931408C20RIK"                                                                                    
## [1908] "MAP4K5"                                                                                           
## [1909] "MYH8"                                                                                             
## [1910] "9330111N05RIK"                                                                                    
## [1911] "CNOT1"                                                                                            
## [1912] "ARPP19"                                                                                           
## [1913] "NHSL1"                                                                                            
## [1914] "FOXN2"                                                                                            
## [1915] "D2HGDH"                                                                                           
## [1916] "2810407C02RIK"                                                                                    
## [1917] "WHSC1L1"                                                                                          
## [1918] "RSRC1"                                                                                            
## [1919] "ADARB2"                                                                                           
## [1920] "CASC4"                                                                                            
## [1921] "IGFBP4"                                                                                           
## [1922] "LDOC1L"                                                                                           
## [1923] "GPR56"                                                                                            
## [1924] "HAS3"                                                                                             
## [1925] "FAM120B"                                                                                          
## [1926] "ACTR1B"                                                                                           
## [1927] "HOMER2"                                                                                           
## [1928] "SLC36A1"                                                                                          
## [1929] "AP3S2"                                                                                            
## [1930] "B630005N14RIK"                                                                                    
## [1931] "TMC1"                                                                                             
## [1932] "EPB4.1"                                                                                           
## [1933] "FAM19A1"                                                                                          
## [1934] "PDIK1L"                                                                                           
## [1935] "SUSD2"                                                                                            
## [1936] "DCAF10"                                                                                           
## [1937] "MED6"                                                                                             
## [1938] "E030013I19RIK"                                                                                    
## [1939] "EGR3"                                                                                             
## [1940] "SURF4"                                                                                            
## [1941] "BICD1"                                                                                            
## [1942] "REPIN1"                                                                                           
## [1943] "PATL1"                                                                                            
## [1944] "D14ABB1E"                                                                                         
## [1945] "MAT2B"                                                                                            
## [1946] "ADRA2B"                                                                                           
## [1947] "TTC24"                                                                                            
## [1948] "ATF7IP"                                                                                           
## [1949] "LASP1"                                                                                            
## [1950] "ASTN2"                                                                                            
## [1951] "RBM20"                                                                                            
## [1952] "CTNS"                                                                                             
## [1953] "FAM175B"                                                                                          
## [1954] "UBE2D3"                                                                                           
## [1955] "CAR1"                                                                                             
## [1956] "TRAF6"                                                                                            
## [1957] "G630025P09RIK"                                                                                    
## [1958] "LTA4H"                                                                                            
## [1959] "PTK2"                                                                                             
## [1960] "POLD3"                                                                                            
## [1961] "PHACTR4"                                                                                          
## [1962] "SCD1"                                                                                             
## [1963] "B3GAT2"                                                                                           
## [1964] "MS4A8A"                                                                                           
## [1965] "LYVE1"                                                                                            
## [1966] "CCDC148"                                                                                          
## [1967] "NR2C2"                                                                                            
## [1968] "MPL"                                                                                              
## [1969] "SYNPO2L"                                                                                          
## [1970] "GNB4"                                                                                             
## [1971] "ZF12"                                                                                             
## [1972] "TRIM26"                                                                                           
## [1973] "ASAH2"                                                                                            
## [1974] "GSR"                                                                                              
## [1975] "ST7"                                                                                              
## [1976] "D630033O11RIK"                                                                                    
## [1977] "SP100"                                                                                            
## [1978] "TET3"                                                                                             
## [1979] "CNR2"                                                                                             
## [1980] "TM4SF5"                                                                                           
## [1981] "DTX4"                                                                                             
## [1982] "KCNK5"                                                                                            
## [1983] "ETV5"                                                                                             
## [1984] "PKHD1"                                                                                            
## [1985] "AP2A1"                                                                                            
## [1986] "KLF3"                                                                                             
## [1987] "SMS"                                                                                              
## [1988] "RAB27B"                                                                                           
## [1989] "AA536875"                                                                                         
## [1990] "MIPEP"                                                                                            
## [1991] "ZFP488"                                                                                           
## [1992] "PRKAB2"                                                                                           
## [1993] "CDC6"                                                                                             
## [1994] "CSMD1"                                                                                            
## [1995] "AW011738"                                                                                         
## [1996] "NLGN1"                                                                                            
## [1997] "PRDM1"                                                                                            
## [1998] "SHPRH"                                                                                            
## [1999] "MEIS3"                                                                                            
## [2000] "BC052688"                                                                                         
## [2001] "POLE4"                                                                                            
## [2002] "MYH10"                                                                                            
## [2003] "BTBD7"                                                                                            
## [2004] "CSF3R"                                                                                            
## [2005] "SLC39A2"                                                                                          
## [2006] "OLFR536"                                                                                          
## [2007] "USP3"                                                                                             
## [2008] "LMF1"                                                                                             
## [2009] "TRAF4"                                                                                            
## [2010] "ABCB10"                                                                                           
## [2011] "LARS2"                                                                                            
## [2012] "ZFP871"                                                                                           
## [2013] "ACOT11"                                                                                           
## [2014] "STAM"                                                                                             
## [2015] "2310022A10RIK"                                                                                    
## [2016] "SMARCD1"                                                                                          
## [2017] "IL2"                                                                                              
## [2018] "GM15800"                                                                                          
## [2019] "SNF8"                                                                                             
## [2020] "LMX1A"                                                                                            
## [2021] "DYM"                                                                                              
## [2022] "SCD2"                                                                                             
## [2023] "MYCBP2"                                                                                           
## [2024] "4930581F22RIK"                                                                                    
## [2025] "RAB11B"                                                                                           
## [2026] "GPS1"                                                                                             
## [2027] "SLC35F4"                                                                                          
## [2028] "ASPH"                                                                                             
## [2029] "SPRN"                                                                                             
## [2030] "ONECUT1"                                                                                          
## [2031] "SLC38A8"                                                                                          
## [2032] "FATE1"                                                                                            
## [2033] "EHD1"                                                                                             
## [2034] "MYO5A"                                                                                            
## [2035] "SLC15A2"                                                                                          
## [2036] "CASK"                                                                                             
## [2037] "TNRC6C"                                                                                           
## [2038] "DHRS7C"                                                                                           
## [2039] "TMEM215"                                                                                          
## [2040] "ADAMTS19"                                                                                         
## [2041] "DDX10"                                                                                            
## [2042] "FRK"                                                                                              
## [2043] "PMP22"                                                                                            
## [2044] "1200014J11RIK"                                                                                    
## [2045] "RUSC2"                                                                                            
## [2046] "KLF12"                                                                                            
## [2047] "AMZ2"                                                                                             
## [2048] "PGAM5"                                                                                            
## [2049] "KCNJ15"                                                                                           
## [2050] "EFR3B"                                                                                            
## [2051] "FMN2"                                                                                             
## [2052] "NARS2"                                                                                            
## [2053] "AFF4"                                                                                             
## [2054] "WSB2"                                                                                             
## [2055] "NPHP4"                                                                                            
## [2056] "IL4I1"                                                                                            
## [2057] "HMGXB4"                                                                                           
## [2058] "NPLOC4"                                                                                           
## [2059] "SLC38A7"                                                                                          
## [2060] "ZFP185"                                                                                           
## [2061] "NLK"                                                                                              
## [2062] "CNP"                                                                                              
## [2063] "CPLX3"                                                                                            
## [2064] "GM6583"                                                                                           
## [2065] "DNM3OS"                                                                                           
## [2066] "SGCG"                                                                                             
## [2067] "CLEC4A1"                                                                                          
## [2068] "A630020A06"                                                                                       
## [2069] "MTMR7"                                                                                            
## [2070] "TMEM161A"                                                                                         
## [2071] "ACP1"                                                                                             
## [2072] "SLC4A8"                                                                                           
## [2073] "SPSB4"                                                                                            
## [2074] "CKLF"                                                                                             
## [2075] "TEAD3"                                                                                            
## [2076] "RIMS3"                                                                                            
## [2077] "PTK7"                                                                                             
## [2078] "APC2"                                                                                             
## [2079] "SLC28A2"                                                                                          
## [2080] "NUCB1"                                                                                            
## [2081] "VMN2R10"                                                                                          
## [2082] "4732465J04RIK"                                                                                    
## [2083] "ATAD1"                                                                                            
## [2084] "PEX5"                                                                                             
## [2085] "C230081A13RIK"                                                                                    
## [2086] "ZBTB20"                                                                                           
## [2087] "GORASP1"                                                                                          
## [2088] "MTOR"                                                                                             
## [2089] "FAM43A"                                                                                           
## [2090] "AP3M2"                                                                                            
## [2091] "TKTL2"                                                                                            
## [2092] "ST8SIA6"                                                                                          
## [2093] "ANKRD52"                                                                                          
## [2094] "LMAN1"                                                                                            
## [2095] "KEG1"                                                                                             
## [2096] "CLCN6"                                                                                            
## [2097] "LRRC8D"                                                                                           
## [2098] "LRFN4"                                                                                            
## [2099] "NHLRC2"                                                                                           
## [2100] "INADL"                                                                                            
## [2101] "DLC1"                                                                                             
## [2102] "UVRAG"                                                                                            
## [2103] "OVGP1"                                                                                            
## [2104] "DDOST"                                                                                            
## [2105] "SLC38A6"                                                                                          
## [2106] "AGTR2"                                                                                            
## [2107] "EPHA1"                                                                                            
## [2108] "HEG1"                                                                                             
## [2109] "MTCH2"                                                                                            
## [2110] "MPI"                                                                                              
## [2111] "NAT10"                                                                                            
## [2112] "PHF3"                                                                                             
## [2113] "AR"                                                                                               
## [2114] "ZFAND2A"                                                                                          
## [2115] "SLC13A4"                                                                                          
## [2116] "LRP1B"                                                                                            
## [2117] "NSG2"                                                                                             
## [2118] "E030003E18RIK"                                                                                    
## [2119] "PRTG"                                                                                             
## [2120] "GKAP1"                                                                                            
## [2121] "SDR42E1"                                                                                          
## [2122] "EPHA8"                                                                                            
## [2123] "GM16499"                                                                                          
## [2124] "TRPM1"                                                                                            
## [2125] "USP20"                                                                                            
## [2126] "CMAH"                                                                                             
## [2127] "CAMK4"                                                                                            
## [2128] "ITGA4"                                                                                            
## [2129] "CD200R3"                                                                                          
## [2130] "TNFSF10"                                                                                          
## [2131] "ORMDL1"                                                                                           
## [2132] "LOC627891"                                                                                        
## [2133] "FBXW17"                                                                                           
## [2134] "PRRG3"                                                                                            
## [2135] "PRDM5"                                                                                            
## [2136] "PALM2"                                                                                            
## [2137] "TAOK1"                                                                                            
## [2138] "BTF3L4"                                                                                           
## [2139] "EPX"                                                                                              
## [2140] "PPP1R2"                                                                                           
## [2141] "HS6ST2"                                                                                           
## [2142] "HSPA14"                                                                                           
## [2143] "SERINC4"                                                                                          
## [2144] "WIPF2"                                                                                            
## [2145] "ZKSCAN17"                                                                                         
## [2146] "ZFP68"                                                                                            
## [2147] "PTGS2"                                                                                            
## [2148] "GM4793"                                                                                           
## [2149] "PTK6"                                                                                             
## [2150] "BAHD1"                                                                                            
## [2151] "ATR"                                                                                              
## [2152] "NPC2"                                                                                             
## [2153] "OBSCN"                                                                                            
## [2154] "GPR155"                                                                                           
## [2155] "SMUG1"                                                                                            
## [2156] "CAPNS1"                                                                                           
## [2157] "FBXL5"                                                                                            
## [2158] "EPHB2"                                                                                            
## [2159] "ROBO2"                                                                                            
## [2160] "PARP9"                                                                                            
## [2161] "1700016L04RIK"                                                                                    
## [2162] "CHM"                                                                                              
## [2163] "INTS4"                                                                                            
## [2164] "2210408F21RIK"                                                                                    
## [2165] "C920021L13RIK"                                                                                    
## [2166] "ARID1B"                                                                                           
## [2167] "ELOVL1"                                                                                           
## [2168] "HDAC11"                                                                                           
## [2169] "PARD6G"                                                                                           
## [2170] "SLC2A13"                                                                                          
## [2171] "GPR137B"                                                                                          
## [2172] "GSDMC2"                                                                                           
## [2173] "FTSJ1"                                                                                            
## [2174] "MACROD2"                                                                                          
## [2175] "CREG1"                                                                                            
## [2176] "ADAM28"                                                                                           
## [2177] "TLN1"                                                                                             
## [2178] "2310014L17RIK"                                                                                    
## [2179] "NAP1L1"                                                                                           
## [2180] "PIGN"                                                                                             
## [2181] "CSPG5"                                                                                            
## [2182] "PPP2R3A"                                                                                          
## [2183] "VWA5A"                                                                                            
## [2184] "TTLL12"                                                                                           
## [2185] "CLDN1"                                                                                            
## [2186] "KLHL24"                                                                                           
## [2187] "ADAM22"                                                                                           
## [2188] "NEU3"                                                                                             
## [2189] "PLD6"                                                                                             
## [2190] "NIPAL4"                                                                                           
## [2191] "RNF130"                                                                                           
## [2192] "RASSF4"                                                                                           
## [2193] "PCNXL2"                                                                                           
## [2194] "FANCC"                                                                                            
## [2195] "GAD2"                                                                                             
## [2196] "ACER2"                                                                                            
## [2197] "9230117E06RIK"                                                                                    
## [2198] "PLA2G4D"                                                                                          
## [2199] "CRB2"                                                                                             
## [2200] "UBE2E1"                                                                                           
## [2201] "TMEM104"                                                                                          
## [2202] "CX3CR1"                                                                                           
## [2203] "GUCA1B"                                                                                           
## [2204] "NRXN2"                                                                                            
## [2205] "ATG9A"                                                                                            
## [2206] "MGA"                                                                                              
## [2207] "LGR5"                                                                                             
## [2208] "RGS2"                                                                                             
## [2209] "ATF6B"                                                                                            
## [2210] "BTG2"                                                                                             
## [2211] "ZCCHC6"                                                                                           
## [2212] "PNMA2"                                                                                            
## [2213] "TMEM79"                                                                                           
## [2214] "DVL3"                                                                                             
## [2215] "ADH6-PS1"                                                                                         
## [2216] "1700020I14RIK"                                                                                    
## [2217] "NUP214"                                                                                           
## [2218] "1700001C19RIK"                                                                                    
## [2219] "GFM2"                                                                                             
## [2220] "SH3YL1"                                                                                           
## [2221] "PI4KA"                                                                                            
## [2222] "DDB1"                                                                                             
## [2223] "FAM178A"                                                                                          
## [2224] "ZBTB46"                                                                                           
## [2225] "TNNI3K"                                                                                           
## [2226] "MEG3"                                                                                             
## [2227] "FAR2"                                                                                             
## [2228] "FCHSD2"                                                                                           
## [2229] "PIAS4"                                                                                            
## [2230] "TCTE2"                                                                                            
## [2231] "PEX6"                                                                                             
## [2232] "FOXO1"                                                                                            
## [2233] "4930425L21RIK"                                                                                    
## [2234] "KCNA1"                                                                                            
## [2235] "PTCD3"                                                                                            
## [2236] "4930529M08RIK"                                                                                    
## [2237] "TRPM5"                                                                                            
## [2238] "CPLX4"                                                                                            
## [2239] "CD28"                                                                                             
## [2240] "PEG10"                                                                                            
## [2241] "LYNX1"                                                                                            
## [2242] "HOXB4"                                                                                            
## [2243] "NPEPL1"                                                                                           
## [2244] "E130309D14RIK"                                                                                    
## [2245] "DENND3"                                                                                           
## [2246] "GRIP2"                                                                                            
## [2247] "AGPAT5"                                                                                           
## [2248] "PTPRM"                                                                                            
## [2249] "TXNDC5"                                                                                           
## [2250] "ZFP456"                                                                                           
## [2251] "TNFSF13B"                                                                                         
## [2252] "EXOC3"                                                                                            
## [2253] "DUSP28"                                                                                           
## [2254] "GPRC5C"                                                                                           
## [2255] "RICTOR"                                                                                           
## [2256] "PIF1"                                                                                             
## [2257] "IFT57"                                                                                            
## [2258] "STEAP2"                                                                                           
## [2259] "DNAJC18"                                                                                          
## [2260] "CAMK1D"                                                                                           
## [2261] "PPM1A"                                                                                            
## [2262] "BC037704"                                                                                         
## [2263] "BYSL"                                                                                             
## [2264] "NAA15"                                                                                            
## [2265] "PLEKHA4"                                                                                          
## [2266] "SCAI"                                                                                             
## [2267] "GM13139"                                                                                          
## [2268] "ZFP597"                                                                                           
## [2269] "HMCN1"                                                                                            
## [2270] "ZFP160"                                                                                           
## [2271] "ARHGAP29"                                                                                         
## [2272] "DNAJC12"                                                                                          
## [2273] "TXNDC11"                                                                                          
## [2274] "ATP10B"                                                                                           
## [2275] "FRY"                                                                                              
## [2276] "TUBA1B"                                                                                           
## [2277] "2010111I01RIK"                                                                                    
## [2278] "LOXL4"                                                                                            
## [2279] "ERC2"                                                                                             
## [2280] "4932438A13RIK"                                                                                    
## [2281] "1110057K04RIK"                                                                                    
## [2282] "PGAP3"                                                                                            
## [2283] "PLEK2"                                                                                            
## [2284] "NARG2"                                                                                            
## [2285] "GPX7"                                                                                             
## [2286] "AFF1"                                                                                             
## [2287] "ZBP1"                                                                                             
## [2288] "SMOK4A"                                                                                           
## [2289] "ZFP11"                                                                                            
## [2290] "MANEAL"                                                                                           
## [2291] "COL4A1"                                                                                           
## [2292] "CCDC78"                                                                                           
## [2293] "ACSS1"                                                                                            
## [2294] "LSM14A"                                                                                           
## [2295] "ZFP280B"                                                                                          
## [2296] "SLC19A2"                                                                                          
## [2297] "COL4A2"                                                                                           
## [2298] "NYNRIN"                                                                                           
## [2299] "BRCC3"                                                                                            
## [2300] "EP300"                                                                                            
## [2301] "CPNE7"                                                                                            
## [2302] "DENND1A"                                                                                          
## [2303] "ASCL3"                                                                                            
## [2304] "LIFR"                                                                                             
## [2305] "TRAPPC5"                                                                                          
## [2306] "UHRF1BP1"                                                                                         
## [2307] "FMR1"                                                                                             
## [2308] "STK40"                                                                                            
## [2309] "SLC41A2"                                                                                          
## [2310] "ZBTB43"                                                                                           
## [2311] "RAB11FIP1"                                                                                        
## [2312] "ADAMTS20"                                                                                         
## [2313] "RNMT"                                                                                             
## [2314] "MTMR2"                                                                                            
## [2315] "ENC1"                                                                                             
## [2316] "VMN1R58"                                                                                          
## [2317] "ASAH1"                                                                                            
## [2318] "KLHL12"                                                                                           
## [2319] "COL6A2"                                                                                           
## [2320] "CD209E"                                                                                           
## [2321] "MAGI1"                                                                                            
## [2322] "GNAO1"                                                                                            
## [2323] "TRPM3"                                                                                            
## [2324] "GOLGA7B"                                                                                          
## [2325] "DPY19L1"                                                                                          
## [2326] "GM5108"                                                                                           
## [2327] "CALD1"                                                                                            
## [2328] "IER3IP1"                                                                                          
## [2329] "UGP2"                                                                                             
## [2330] "GML"                                                                                              
## [2331] "SYT1"                                                                                             
## [2332] "CWF19L1"                                                                                          
## [2333] "DICER1"                                                                                           
## [2334] "LIMD1"                                                                                            
## [2335] "SLC7A1"                                                                                           
## [2336] "SOX11"                                                                                            
## [2337] "ST8SIA2"                                                                                          
## [2338] "DNAJB11"                                                                                          
## [2339] "SNAP29"                                                                                           
## [2340] "4930532M18RIK"                                                                                    
## [2341] "A530054K11RIK"                                                                                    
## [2342] "CADM3"                                                                                            
## [2343] "IDS"                                                                                              
## [2344] "ISLR2"                                                                                            
## [2345] "MAP3K3"                                                                                           
## [2346] "BRCA1"                                                                                            
## [2347] "NID1"                                                                                             
## [2348] "PRODH"                                                                                            
## [2349] "AGPAT1"                                                                                           
## [2350] "RINL"                                                                                             
## [2351] "MAPK1"                                                                                            
## [2352] "FUBP1"                                                                                            
## [2353] "SYPL2"                                                                                            
## [2354] "PID1"                                                                                             
## [2355] "GM13476"                                                                                          
## [2356] "9930013L23RIK"                                                                                    
## [2357] "BCL7C"                                                                                            
## [2358] "UHRF1BP1L"                                                                                        
## [2359] "9530051G07RIK"                                                                                    
## [2360] "CEBPD"                                                                                            
## [2361] "IGF2BP2"                                                                                          
## [2362] "HIST1H2AC"                                                                                        
## [2363] "MPG"                                                                                              
## [2364] "LYST"                                                                                             
## [2365] "APBB1IP"                                                                                          
## [2366] "MED20"                                                                                            
## [2367] "4931406H21RIK"                                                                                    
## [2368] "MELK"                                                                                             
## [2369] "SUCLG2"                                                                                           
## [2370] "FAM84B"                                                                                           
## [2371] "ZFP462"                                                                                           
## [2372] "PSME3"                                                                                            
## [2373] "BC068157"                                                                                         
## [2374] "4931406C07RIK"                                                                                    
## [2375] "SMCR7L"                                                                                           
## [2376] "CRP"                                                                                              
## [2377] "AQP2"                                                                                             
## [2378] "RPGRIP1L"                                                                                         
## [2379] "CELF2"                                                                                            
## [2380] "SLC24A2"                                                                                          
## [2381] "FAM117A"                                                                                          
## [2382] "GM16432"                                                                                          
## [2383] "5730588L14RIK"                                                                                    
## [2384] "LOC545966"                                                                                        
## [2385] "MAN2B1"                                                                                           
## [2386] "N28178"                                                                                           
## [2387] "RFNG"                                                                                             
## [2388] "PTPRD"                                                                                            
## [2389] "ZC3HAV1"                                                                                          
## [2390] "KHK"                                                                                              
## [2391] "LSM11"                                                                                            
## [2392] "SNRNP48"                                                                                          
## [2393] "FEV"                                                                                              
## [2394] "KLF6"                                                                                             
## [2395] "PITPNM3"                                                                                          
## [2396] "RPRML"                                                                                            
## [2397] "B230325K18RIK"                                                                                    
## [2398] "SLC9A1"                                                                                           
## [2399] "AKAP8"                                                                                            
## [2400] "ATXN3"                                                                                            
## [2401] "COMMD2"                                                                                           
## [2402] "PLA2G15"                                                                                          
## [2403] "CDK6"                                                                                             
## [2404] "FIGNL1"                                                                                           
## [2405] "GRK1"                                                                                             
## [2406] "SULT4A1"                                                                                          
## [2407] "GM6999"                                                                                           
## [2408] "NKAIN2"                                                                                           
## [2409] "DIO2"                                                                                             
## [2410] "CSRNP2"                                                                                           
## [2411] "ZIK1"                                                                                             
## [2412] "SDHAF2"                                                                                           
## [2413] "GCK"                                                                                              
## [2414] "PPAPDC2"                                                                                          
## [2415] "IPO9"                                                                                             
## [2416] "KCNK18"                                                                                           
## [2417] "PPIL2"                                                                                            
## [2418] "LSAMP"                                                                                            
## [2419] "VPS13A"                                                                                           
## [2420] "UCHL3"                                                                                            
## [2421] "GM6086"                                                                                           
## [2422] "VPS13C"                                                                                           
## [2423] "FGF15"                                                                                            
## [2424] "HCN1"                                                                                             
## [2425] "IQCK"                                                                                             
## [2426] "ZFP30"                                                                                            
## [2427] "RPAP1"                                                                                            
## [2428] "NME1"                                                                                             
## [2429] "RCL1"                                                                                             
## [2430] "FBLN5"                                                                                            
## [2431] "PPM1D"                                                                                            
## [2432] "BTBD3"                                                                                            
## [2433] "SCN8A"                                                                                            
## [2434] "4930523C07RIK"                                                                                    
## [2435] "GDAP1L1"                                                                                          
## [2436] "ALKBH1"                                                                                           
## [2437] "CYP3A41A"                                                                                         
## [2438] "PSG29"                                                                                            
## [2439] "CXCR2"                                                                                            
## [2440] "SLC26A9"                                                                                          
## [2441] "TMEM177"                                                                                          
## [2442] "PIBF1"                                                                                            
## [2443] "MED15"                                                                                            
## [2444] "PRPS2"                                                                                            
## [2445] "PPP1R9A"                                                                                          
## [2446] "HSD3B2"                                                                                           
## [2447] "SLC11A2"                                                                                          
## [2448] "CORO1C"                                                                                           
## [2449] "CSNK1D"                                                                                           
## [2450] "POT1B"                                                                                            
## [2451] "2700089E24RIK"                                                                                    
## [2452] "GABRA4"                                                                                           
## [2453] "DVL2"                                                                                             
## [2454] "COPZ1"                                                                                            
## [2455] "RSF1"                                                                                             
## [2456] "TAF5"                                                                                             
## [2457] "PHYHIP"                                                                                           
## [2458] "CD164"                                                                                            
## [2459] "CCDC97"                                                                                           
## [2460] "ENTPD6"                                                                                           
## [2461] "RXFP3"                                                                                            
## [2462] "UBE2J1"                                                                                           
## [2463] "CALCR"                                                                                            
## [2464] "PLCXD3"                                                                                           
## [2465] "CASP12"                                                                                           
## [2466] "PHF20L1"                                                                                          
## [2467] "ZFP831"                                                                                           
## [2468] "KCNK3"                                                                                            
## [2469] "PMM2"                                                                                             
## [2470] "PCCB"                                                                                             
## [2471] "NDRG1"                                                                                            
## [2472] "PTPRJ"                                                                                            
## [2473] "RPF2"                                                                                             
## [2474] "D730039F16RIK"                                                                                    
## [2475] "BB287469"                                                                                         
## [2476] "BRPF3"                                                                                            
## [2477] "BRD8"                                                                                             
## [2478] "DUSP6"                                                                                            
## [2479] "CASC3"                                                                                            
## [2480] "C330018A13RIK"                                                                                    
## [2481] "DUSP7"                                                                                            
## [2482] "SIK2"                                                                                             
## [2483] "NGP"                                                                                              
## [2484] "TAF8"                                                                                             
## [2485] "CLINT1"                                                                                           
## [2486] "TBATA"                                                                                            
## [2487] "PLA2G4C"                                                                                          
## [2488] "TMEM125"                                                                                          
## [2489] "4930417O13RIK"                                                                                    
## [2490] "CYLD"                                                                                             
## [2491] "CD96"                                                                                             
## [2492] "STYX"                                                                                             
## [2493] "NAPG"                                                                                             
## [2494] "OPCML"                                                                                            
## [2495] "USP8"                                                                                             
## [2496] "TAF4B"                                                                                            
## [2497] "CYTH1"                                                                                            
## [2498] "AJAP1"                                                                                            
## [2499] "CDC23"                                                                                            
## [2500] "ORAI1"                                                                                            
## [2501] "SEL1L3"                                                                                           
## [2502] "TRIM71"                                                                                           
## [2503] "HNRNPM"                                                                                           
## [2504] "PMAIP1"                                                                                           
## [2505] "SSTR3"                                                                                            
## [2506] "CLCC1"                                                                                            
## [2507] "SORT1"                                                                                            
## [2508] "GM3696"                                                                                           
## [2509] "SRRM1"                                                                                            
## [2510] "COL3A1"                                                                                           
## [2511] "GABRB3"                                                                                           
## [2512] "ZFP433"                                                                                           
## [2513] "ZFP712"                                                                                           
## [2514] "STXBP4"                                                                                           
## [2515] "XK"                                                                                               
## [2516] "SIT1"                                                                                             
## [2517] "KDELR3"                                                                                           
## [2518] "4933404I11RIK"                                                                                    
## [2519] "CD99L2"                                                                                           
## [2520] "PDGFB"                                                                                            
## [2521] "CCDC39"                                                                                           
## [2522] "AOX1"                                                                                             
## [2523] "PLA2G2F"                                                                                          
## [2524] "FUZ"                                                                                              
## [2525] "CPN1"                                                                                             
## [2526] "ANGPTL3"                                                                                          
## [2527] "KCNQ2"                                                                                            
## [2528] "OSTM1"                                                                                            
## [2529] "IPO8"                                                                                             
## [2530] "KCNC1"                                                                                            
## [2531] "DNAHC5"                                                                                           
## [2532] "5430400D12RIK"                                                                                    
## [2533] "SEH1L"                                                                                            
## [2534] "SPON2"                                                                                            
## [2535] "RFX5"                                                                                             
## [2536] "PRR5L"                                                                                            
## [2537] "RRAGC"                                                                                            
## [2538] "PPTC7"                                                                                            
## [2539] "LAIR1"                                                                                            
## [2540] "RP1"                                                                                              
## [2541] "IARS2"                                                                                            
## [2542] "MRPL34"                                                                                           
## [2543] "XPO7"                                                                                             
## [2544] "IL22"                                                                                             
## [2545] "AP3D1"                                                                                            
## [2546] "GOLGA2"                                                                                           
## [2547] "IL20RB"                                                                                           
## [2548] "FASTKD1"                                                                                          
## [2549] "SLC39A8"                                                                                          
## [2550] "TBC1D13"                                                                                          
## [2551] "5430425J12RIK"                                                                                    
## [2552] "CDC25B"                                                                                           
## [2553] "FREM2"                                                                                            
## [2554] "MAMDC2"                                                                                           
## [2555] "GM10516"                                                                                          
## [2556] "SOX9"                                                                                             
## [2557] "LANCL2"                                                                                           
## [2558] "HTR5A"                                                                                            
## [2559] "B130024G19RIK"                                                                                    
## [2560] "ZFP526"                                                                                           
## [2561] "A330009N23RIK"                                                                                    
## [2562] "BCL7B"                                                                                            
## [2563] "SALL3"                                                                                            
## [2564] "KBTBD11"                                                                                          
## [2565] "SEC63"                                                                                            
## [2566] "CIAPIN1"                                                                                          
## [2567] "GM11194"                                                                                          
## [2568] "AKAP10"                                                                                           
## [2569] "MLLT3"                                                                                            
## [2570] "GPR165"                                                                                           
## [2571] "CYP2J6"                                                                                           
## [2572] "PCSK7"                                                                                            
## [2573] "CNR1"                                                                                             
## [2574] "SLC6A6"                                                                                           
## [2575] "FOXR1"                                                                                            
## [2576] "CPNE5"                                                                                            
## [2577] "RAB33B"                                                                                           
## [2578] "S100A1"                                                                                           
## [2579] "VAMP3"                                                                                            
## [2580] "1700066B19RIK"                                                                                    
## [2581] "SGCB"                                                                                             
## [2582] "YPEL2"                                                                                            
## [2583] "C2CD2"                                                                                            
## [2584] "GRM7"                                                                                             
## [2585] "GABRG2"                                                                                           
## [2586] "E2F2"                                                                                             
## [2587] "TGIF2"                                                                                            
## [2588] "SMG1"                                                                                             
## [2589] "FOXK2"                                                                                            
## [2590] "WNT9B"                                                                                            
## [2591] "TTC23L"                                                                                           
## [2592] "A530072M11RIK"                                                                                    
## [2593] "SEMA4F"                                                                                           
## [2594] "REEP1"                                                                                            
## [2595] "RELN"                                                                                             
## [2596] "RAD54L2"                                                                                          
## [2597] "WFDC5"                                                                                            
## [2598] "AWAT2"                                                                                            
## [2599] "CLN5"                                                                                             
## [2600] "FAT4"                                                                                             
## [2601] "SHISA6"                                                                                           
## [2602] "HK2"                                                                                              
## [2603] "RAG1"                                                                                             
## [2604] "ANAPC1"                                                                                           
## [2605] "PSTK"                                                                                             
## [2606] "KCNJ10"                                                                                           
## [2607] "TNFRSF23"                                                                                         
## [2608] "MTF1"                                                                                             
## [2609] "4930506M07RIK"                                                                                    
## [2610] "NIPSNAP1"                                                                                         
## [2611] "ZFP697"                                                                                           
## [2612] "RRM2"                                                                                             
## [2613] "TRIM42"                                                                                           
## [2614] "1700029F12RIK"                                                                                    
## [2615] "RTP1"                                                                                             
## [2616] "ADAMTS6"                                                                                          
## [2617] "P4HTM"                                                                                            
## [2618] "PSMD2"                                                                                            
## [2619] "LMAN2"                                                                                            
## [2620] "CHKA"                                                                                             
## [2621] "CCND2"                                                                                            
## [2622] "ERO1L"                                                                                            
## [2623] "SLC15A1"                                                                                          
## [2624] "CACNA1E"                                                                                          
## [2625] "CHAF1B"                                                                                           
## [2626] "RAB37"                                                                                            
## [2627] "ZMYM6"                                                                                            
## [2628] "NTM"                                                                                              
## [2629] "4930402D18RIK"                                                                                    
## [2630] "KLRC2"                                                                                            
## [2631] "XCR1"                                                                                             
## [2632] "B230354K17RIK"                                                                                    
## [2633] "SDK1"                                                                                             
## [2634] "REEP4"                                                                                            
## [2635] "CPT1C"                                                                                            
## [2636] "NFKB2"                                                                                            
## [2637] "LMTK2"                                                                                            
## [2638] "DOT1L"                                                                                            
## [2639] "HIST1H2BE"                                                                                        
## [2640] "KCTD7"                                                                                            
## [2641] "4921513I03RIK"                                                                                    
## [2642] "TOB2"                                                                                             
## [2643] "TMED4"                                                                                            
## [2644] "INTS12"                                                                                           
## [2645] "KCND3"                                                                                            
## [2646] "UGGT2"                                                                                            
## [2647] "SHPK"                                                                                             
## [2648] "MRPL19"                                                                                           
## [2649] "OLFR121"                                                                                          
## [2650] "TEAD1"                                                                                            
## [2651] "PDCD7"                                                                                            
## [2652] "TSEN34"                                                                                           
## [2653] "RHOBTB2"                                                                                          
## [2654] "DGCR14"                                                                                           
## [2655] "BC058420"                                                                                         
## [2656] "DTNB"                                                                                             
## [2657] "LEPROTL1"                                                                                         
## [2658] "SPRYD4"                                                                                           
## [2659] "SPRY4"                                                                                            
## [2660] "AFAP1"                                                                                            
## [2661] "GABPB1"                                                                                           
## [2662] "TMEM214"                                                                                          
## [2663] "LEP"                                                                                              
## [2664] "BFSP2"                                                                                            
## [2665] "TBX19"                                                                                            
## [2666] "GLB1"                                                                                             
## [2667] "HDGFRP3"                                                                                          
## [2668] "PNP"                                                                                              
## [2669] "BHLHA15"                                                                                          
## [2670] "BOD1L"                                                                                            
## [2671] "E2F7"                                                                                             
## [2672] "GYPC"                                                                                             
## [2673] "D230017M19RIK"                                                                                    
## [2674] "CRLF3"                                                                                            
## [2675] "PYCR1"                                                                                            
## [2676] "DOCK2"                                                                                            
## [2677] "RABGAP1L"                                                                                         
## [2678] "ZFAND3"                                                                                           
## [2679] "ZRANB2"                                                                                           
## [2680] "LAMC3"                                                                                            
## [2681] "BIK"                                                                                              
## [2682] "CRK"                                                                                              
## [2683] "EPHA4"                                                                                            
## [2684] "NXNL1"                                                                                            
## [2685] "PIGV"                                                                                             
## [2686] "ARFGEF2"                                                                                          
## [2687] "SH3BGRL2"                                                                                         
## [2688] "TDO2"                                                                                             
## [2689] "ZCCHC5"                                                                                           
## [2690] "4933413J09RIK"                                                                                    
## [2691] "GM6498"                                                                                           
## [2692] "A230051N06RIK"                                                                                    
## [2693] "3110082I17RIK"                                                                                    
## [2694] "KLHL5"                                                                                            
## [2695] "9530052C20RIK"                                                                                    
## [2696] "SDK2"                                                                                             
## [2697] "MAOA"                                                                                             
## [2698] "UGT3A1"                                                                                           
## [2699] "CHD7"                                                                                             
## [2700] "WNT9A"                                                                                            
## [2701] "CAT"                                                                                              
## [2702] "GABRA3"                                                                                           
## [2703] "FAM110B"                                                                                          
## [2704] "3110006O06RIK"                                                                                    
## [2705] "TRIM67"                                                                                           
## [2706] "4933415F23RIK"                                                                                    
## [2707] "CYP2C38"                                                                                          
## [2708] "SLC30A4"                                                                                          
## [2709] "KHDRBS2"                                                                                          
## [2710] "ZFP120"                                                                                           
## [2711] "2810047C21RIK1"                                                                                   
## [2712] "NSUN2"                                                                                            
## [2713] "ABCB7"                                                                                            
## [2714] "FAM57A"                                                                                           
## [2715] "BCKDK"                                                                                            
## [2716] "HSD3B6"                                                                                           
## [2717] "4921536K21RIK"                                                                                    
## [2718] "FOXN4"                                                                                            
## [2719] "GPCPD1"                                                                                           
## [2720] "4930524L23RIK"                                                                                    
## [2721] "MS4A18"                                                                                           
## [2722] "FGR"                                                                                              
## [2723] "HIST3H2BA"                                                                                        
## [2724] "CHD9"                                                                                             
## [2725] "1700029H14RIK"                                                                                    
## [2726] "RAI14"                                                                                            
## [2727] "ELAC1"                                                                                            
## [2728] "FAM194A"                                                                                          
## [2729] "DPP6"                                                                                             
## [2730] "EIF5B"                                                                                            
## [2731] "CALM4"                                                                                            
## [2732] "PIGU"                                                                                             
## [2733] "ING5"                                                                                             
## [2734] "A330008L17RIK"                                                                                    
## [2735] "FAM13B"                                                                                           
## [2736] "COPA"                                                                                             
## [2737] "PLAA"                                                                                             
## [2738] "IL10"                                                                                             
## [2739] "F13A1"                                                                                            
## [2740] "A930009E05RIK"                                                                                    
## [2741] "SAMD8"                                                                                            
## [2742] "ARCN1"                                                                                            
## [2743] "TMEFF2"                                                                                           
## [2744] "KPNA7"                                                                                            
## [2745] "SLC43A1"                                                                                          
## [2746] "RAD23B"                                                                                           
## [2747] "WDR33"                                                                                            
## [2748] "USP49"                                                                                            
## [2749] "CSTF3"                                                                                            
## [2750] "CENPL"                                                                                            
## [2751] "1810013L24RIK"                                                                                    
## [2752] "GABRB2"                                                                                           
## [2753] "PTGDS"                                                                                            
## [2754] "DNAHC7B"                                                                                          
## [2755] "FREM1"                                                                                            
## [2756] "DOCK9"                                                                                            
## [2757] "RMND1"                                                                                            
## [2758] "TMEM29"                                                                                           
## [2759] "FOXJ3"                                                                                            
## [2760] "ZKSCAN1"                                                                                          
## [2761] "FAM160B2"                                                                                         
## [2762] "ITPKC"                                                                                            
## [2763] "ABCB11"                                                                                           
## [2764] "4933417D19RIK"                                                                                    
## [2765] "GPR137B-PS"                                                                                       
## [2766] "CCNL2"                                                                                            
## [2767] "GNB3"                                                                                             
## [2768] "SFXN5"                                                                                            
## [2769] "APH1C"                                                                                            
## [2770] "CYB5R4"                                                                                           
## [2771] "GM5101"                                                                                           
## [2772] "CC2D1A"                                                                                           
## [2773] "LIN52"                                                                                            
## [2774] "RASGRP4"                                                                                          
## [2775] "C820005J03RIK"                                                                                    
## [2776] "GALNT1"                                                                                           
## [2777] "2310035C23RIK"                                                                                    
## [2778] "RIAN"                                                                                             
## [2779] "IKZF4"                                                                                            
## [2780] "FADS3"                                                                                            
## [2781] "PROSC"                                                                                            
## [2782] "FLYWCH1"                                                                                          
## [2783] "RGS9"                                                                                             
## [2784] "OCIAD1"                                                                                           
## [2785] "EPS8L1"                                                                                           
## [2786] "SDC2"                                                                                             
## [2787] "ZFP113"                                                                                           
## [2788] "SLC16A14"                                                                                         
## [2789] "COL5A3"                                                                                           
## [2790] "MAP2K5"                                                                                           
## [2791] "STAT2"                                                                                            
## [2792] "ZFP553"                                                                                           
## [2793] "METTL6"                                                                                           
## [2794] "SENP1"                                                                                            
## [2795] "BPHL"                                                                                             
## [2796] "TMEM47"                                                                                           
## [2797] "CENPC1"                                                                                           
## [2798] "STARD5"                                                                                           
## [2799] "9430020K01RIK"                                                                                    
## [2800] "NKAIN3"                                                                                           
## [2801] "TCAM1"                                                                                            
## [2802] "CCL22"                                                                                            
## [2803] "GM7729"                                                                                           
## [2804] "ERMAP"                                                                                            
## [2805] "DPP9"                                                                                             
## [2806] "TERF2IP"                                                                                          
## [2807] "GJE1"                                                                                             
## [2808] "VRK2"                                                                                             
## [2809] "HELQ"                                                                                             
## [2810] "MMGT1"                                                                                            
## [2811] "PACS2"                                                                                            
## [2812] "SERINC1"                                                                                          
## [2813] "USP9X"                                                                                            
## [2814] "GPR123"                                                                                           
## [2815] "N4BP2L2"                                                                                          
## [2816] "CDS1"                                                                                             
## [2817] "2210016L21RIK"                                                                                    
## [2818] "GGA3"                                                                                             
## [2819] "BC016579"                                                                                         
## [2820] "COG8"                                                                                             
## [2821] "VPS13B"                                                                                           
## [2822] "RLIM"                                                                                             
## [2823] "CNIH"                                                                                             
## [2824] "NUP188"                                                                                           
## [2825] "ABCE1"                                                                                            
## [2826] "DAD1"                                                                                             
## [2827] "GNAQ"                                                                                             
## [2828] "TMEM130"                                                                                          
## [2829] "GDF6"                                                                                             
## [2830] "CASP4"                                                                                            
## [2831] "RELL1"                                                                                            
## [2832] "SLC19A1"                                                                                          
## [2833] "CCDC163"                                                                                          
## [2834] "ANKRD44"                                                                                          
## [2835] "NSA2"                                                                                             
## [2836] "CAR2"                                                                                             
## [2837] "SLC29A3"                                                                                          
## [2838] "HBEGF"                                                                                            
## [2839] "SLC7A11"                                                                                          
## [2840] "ACSS2"                                                                                            
## [2841] "MRPS25"                                                                                           
## [2842] "PGM3"                                                                                             
## [2843] "MEGF10"                                                                                           
## [2844] "SMURF1"                                                                                           
## [2845] "ZFP362"                                                                                           
## [2846] "TERT"                                                                                             
## [2847] "SLC34A2"                                                                                          
## [2848] "SLC20A1"                                                                                          
## [2849] "FAM13C"                                                                                           
## [2850] "DSCR3"                                                                                            
## [2851] "CREG2"                                                                                            
## [2852] "TAB1"                                                                                             
## [2853] "PHLPP2"                                                                                           
## [2854] "GALNT2"                                                                                           
## [2855] "ROCK2"                                                                                            
## [2856] "ORAOV1"                                                                                           
## [2857] "AP3M1"                                                                                            
## [2858] "OSGIN2"                                                                                           
## [2859] "WNT1"                                                                                             
## [2860] "APOBEC2"                                                                                          
## [2861] "L3MBTL3"                                                                                          
## [2862] "ONECUT2"                                                                                          
## [2863] "RSBN1L"                                                                                           
## [2864] "IGSF11"                                                                                           
## [2865] "MURC"                                                                                             
## [2866] "B230120H23RIK"                                                                                    
## [2867] "NFIA"                                                                                             
## [2868] "SIPA1L1"                                                                                          
## [2869] "D930028M14RIK"                                                                                    
## [2870] "MUC3"                                                                                             
## [2871] "LPAR2"                                                                                            
## [2872] "PKP1"                                                                                             
## [2873] "RGS8"                                                                                             
## [2874] "1700016G14RIK"                                                                                    
## [2875] "4930543N07RIK"                                                                                    
## [2876] "IGF2"                                                                                             
## [2877] "SRPX2"                                                                                            
## [2878] "NFRKB"                                                                                            
## [2879] "NQO1"                                                                                             
## [2880] "PASK"                                                                                             
## [2881] "TSC1"                                                                                             
## [2882] "SIRT7"                                                                                            
## [2883] "1700018B24RIK"                                                                                    
## [2884] "B230307C23RIK"                                                                                    
## [2885] "CBLN4"                                                                                            
## [2886] "CAMK2A"                                                                                           
## [2887] "1700055N04RIK"                                                                                    
## [2888] "MTHFR"                                                                                            
## [2889] "FBXW10"                                                                                           
## [2890] "ZFP748"                                                                                           
## [2891] "KYNU"                                                                                             
## [2892] "PAPPA"                                                                                            
## [2893] "RPS24"                                                                                            
## [2894] "CRAMP1L"                                                                                          
## [2895] "DDX21"                                                                                            
## [2896] "CSMD2"                                                                                            
## [2897] "ZFP523"                                                                                           
## [2898] "ITGAV"                                                                                            
## [2899] "4921529L05RIK"                                                                                    
## [2900] "UBXN1"                                                                                            
## [2901] "GAS8"                                                                                             
## [2902] "TPBPA"                                                                                            
## [2903] "EPPK1"                                                                                            
## [2904] "GM1070"                                                                                           
## [2905] "NTN1"                                                                                             
## [2906] "TROVE2"                                                                                           
## [2907] "COL22A1"                                                                                          
## [2908] "TNFAIP3"                                                                                          
## [2909] "RFC3"                                                                                             
## [2910] "ROBO1"                                                                                            
## [2911] "HRAS1"                                                                                            
## [2912] "CNN1"                                                                                             
## [2913] "GRIP1"                                                                                            
## [2914] "GABRD"                                                                                            
## [2915] "DOCK4"                                                                                            
## [2916] "GFOD1"                                                                                            
## [2917] "HAT1"                                                                                             
## [2918] "PFKFB4"                                                                                           
## [2919] "PIP4K2B"                                                                                          
## [2920] "RAB8B"                                                                                            
## [2921] "HAS2"                                                                                             
## [2922] "C920009B18RIK"                                                                                    
## [2923] "FNTB"                                                                                             
## [2924] "BC048559"                                                                                         
## [2925] "PLCE1"                                                                                            
## [2926] "DOPEY2"                                                                                           
## [2927] "NPHP3"                                                                                            
## [2928] "ELAVL1"                                                                                           
## [2929] "MRPL50"                                                                                           
## [2930] "2010012O05RIK"                                                                                    
## [2931] "MED9"                                                                                             
## [2932] "4933431K23RIK"                                                                                    
## [2933] "FAM126A"                                                                                          
## [2934] "ELF5"                                                                                             
## [2935] "MED25"                                                                                            
## [2936] "CAMK2B"                                                                                           
## [2937] "BRDT"                                                                                             
## [2938] "ZFR2"                                                                                             
## [2939] "MEX3A"                                                                                            
## [2940] "KDM4C"                                                                                            
## [2941] "ADARB1"                                                                                           
## [2942] "PMPCA"                                                                                            
## [2943] "ARPP21"                                                                                           
## [2944] "BNIP1"                                                                                            
## [2945] "EFCAB8"                                                                                           
## [2946] "ATAD3A"                                                                                           
## [2947] "RASSF8"                                                                                           
## [2948] "SLC31A2"                                                                                          
## [2949] "GM15053"                                                                                          
## [2950] "A830011K09RIK"                                                                                    
## [2951] "IDI2"                                                                                             
## [2952] "TYW1"                                                                                             
## [2953] "ABHD10"                                                                                           
## [2954] "PRAMEL1"                                                                                          
## [2955] "TMEM30A"                                                                                          
## [2956] "MMP12"                                                                                            
## [2957] "FGF16"                                                                                            
## [2958] "CHD4"                                                                                             
## [2959] "PARVG"                                                                                            
## [2960] "ARHGAP11A"                                                                                        
## [2961] "ONECUT3"                                                                                          
## [2962] "SSBP2"                                                                                            
## [2963] "MLL3"                                                                                             
## [2964] "DCLK1"                                                                                            
## [2965] "STX8"                                                                                             
## [2966] "BC049265"                                                                                         
## [2967] "VOPP1"                                                                                            
## [2968] "HK1"                                                                                              
## [2969] "RNF111"                                                                                           
## [2970] "SOCS7"                                                                                            
## [2971] "PLXNC1"                                                                                           
## [2972] "TMED5"                                                                                            
## [2973] "FBXO42"                                                                                           
## [2974] "CAR12"                                                                                            
## [2975] "WDR35"                                                                                            
## [2976] "LARGE"                                                                                            
## [2977] "ZBTB22"                                                                                           
## [2978] "RDH1"                                                                                             
## [2979] "ZBTB49"                                                                                           
## [2980] "ITSN1"                                                                                            
## [2981] "AI197445"                                                                                         
## [2982] "MFRP"                                                                                             
## [2983] "GM904"                                                                                            
## [2984] "ATL2"                                                                                             
## [2985] "MKRN2"                                                                                            
## [2986] "MSRB3"                                                                                            
## [2987] "PIR"                                                                                              
## [2988] "ELP2"                                                                                             
## [2989] "ZFP91"                                                                                            
## [2990] "KRT26"                                                                                            
## [2991] "CPD"                                                                                              
## [2992] "TMEM116"                                                                                          
## [2993] "TMEM170"                                                                                          
## [2994] "TLK1"                                                                                             
## [2995] "SH2D4A"                                                                                           
## [2996] "NUP98"                                                                                            
## [2997] "CXX1C"                                                                                            
## [2998] "IDH2"                                                                                             
## [2999] "SERPINA4-PS1"                                                                                     
## [3000] "CNPY1"                                                                                            
## [3001] "F730048M01RIK"                                                                                    
## [3002] "GTF3C2"                                                                                           
## [3003] "5430416O09RIK"                                                                                    
## [3004] "AQP1"                                                                                             
## [3005] "PTCD1"                                                                                            
## [3006] "NPC1"                                                                                             
## [3007] "GM5784"                                                                                           
## [3008] "PSG26"                                                                                            
## [3009] "GM13262"                                                                                          
## [3010] "CD274"                                                                                            
## [3011] "OSBPL8"                                                                                           
## [3012] "RBMX"                                                                                             
## [3013] "MCPH1"                                                                                            
## [3014] "LRRC59"                                                                                           
## [3015] "EXT2"                                                                                             
## [3016] "PSG25"                                                                                            
## [3017] "DMRTA1"                                                                                           
## [3018] "GM1653"                                                                                           
## [3019] "GDPD4"                                                                                            
## [3020] "GM5166"                                                                                           
## [3021] "ADCY10"                                                                                           
## [3022] "F730311O21RIK"                                                                                    
## [3023] "1810009N23RIK"                                                                                    
## [3024] "TTC39B"                                                                                           
## [3025] "FAM101B"                                                                                          
## [3026] "1110059G10RIK"                                                                                    
## [3027] "POP5"                                                                                             
## [3028] "PAX1"                                                                                             
## [3029] "MBNL1"                                                                                            
## [3030] "EFTUD1"                                                                                           
## [3031] "STMN2"                                                                                            
## [3032] "ZFP664"                                                                                           
## [3033] "AKAP6"                                                                                            
## [3034] "ZBTB40"                                                                                           
## [3035] "ZFP106"                                                                                           
## [3036] "CAPZA2"                                                                                           
## [3037] "FAM73A"                                                                                           
## [3038] "RASL12"                                                                                           
## [3039] "EFNB3"                                                                                            
## [3040] "ELOVL3"                                                                                           
## [3041] "GGPS1"                                                                                            
## [3042] "GM5643"                                                                                           
## [3043] "FAM115A"                                                                                          
## [3044] "ARC"                                                                                              
## [3045] "LYSMD3"                                                                                           
## [3046] "GLTPD1"                                                                                           
## [3047] "TMEM180"                                                                                          
## [3048] "AI593442"                                                                                         
## [3049] "SLCO1A4"                                                                                          
## [3050] "CHFR"                                                                                             
## [3051] "UBFD1"                                                                                            
## [3052] "KPNA6"                                                                                            
## [3053] "GRID2"                                                                                            
## [3054] "DMP1"                                                                                             
## [3055] "MYO1B"                                                                                            
## [3056] "EGLN2"                                                                                            
## [3057] "SRGAP3"                                                                                           
## [3058] "E230001N04RIK"                                                                                    
## [3059] "2310069G16RIK"                                                                                    
## [3060] "9530053A07RIK"                                                                                    
## [3061] "TMX3"                                                                                             
## [3062] "CCDC15"                                                                                           
## [3063] "TSPAN3"                                                                                           
## [3064] "MUM1L1"                                                                                           
## [3065] "LRRC9"                                                                                            
## [3066] "FOXL1"                                                                                            
## [3067] "USP22"                                                                                            
## [3068] "MED10"                                                                                            
## [3069] "PRPH2"                                                                                            
## [3070] "ZFP334"                                                                                           
## [3071] "P2RY4"                                                                                            
## [3072] "CDH12"                                                                                            
## [3073] "4933424M12RIK"                                                                                    
## [3074] "DUSP11"                                                                                           
## [3075] "UBXN2B"                                                                                           
## [3076] "1200011I18RIK"                                                                                    
## [3077] "RNGTT"                                                                                            
## [3078] "OPN1MW"                                                                                           
## [3079] "PCGF3"                                                                                            
## [3080] "CSNK2A2"                                                                                          
## [3081] "DYNLT3"                                                                                           
## [3082] "SLC10A5"                                                                                          
## [3083] "ATPAF1"                                                                                           
## [3084] "TCF23"                                                                                            
## [3085] "C330005M16RIK"                                                                                    
## [3086] "KCNH1"                                                                                            
## [3087] "CHD6"                                                                                             
## [3088] "CAR10"                                                                                            
## [3089] "NT5E"                                                                                             
## [3090] "CCDC42"                                                                                           
## [3091] "VAMP7"                                                                                            
## [3092] "TRAF3IP2"                                                                                         
## [3093] "9430016H08RIK"                                                                                    
## [3094] "CCDC3"                                                                                            
## [3095] "SLC9A3"                                                                                           
## [3096] "D930020B18RIK"                                                                                    
## [3097] "VPS26B"                                                                                           
## [3098] "IQSEC2"                                                                                           
## [3099] "COMMD7"                                                                                           
## [3100] "CCDC158"                                                                                          
## [3101] "THBD"                                                                                             
## [3102] "OMP"                                                                                              
## [3103] "DDX24"                                                                                            
## [3104] "PLN"                                                                                              
## [3105] "G730013B05RIK"                                                                                    
## [3106] "MPP7"                                                                                             
## [3107] "FNBP1L"                                                                                           
## [3108] "SMAP2"                                                                                            
## [3109] "SH2D1B1"                                                                                          
## [3110] "TMEM98"                                                                                           
## [3111] "GM5478"                                                                                           
## [3112] "NAT8L"                                                                                            
## [3113] "POMP"                                                                                             
## [3114] "SHC2"                                                                                             
## [3115] "HMG20A"                                                                                           
## [3116] "WNT3A"                                                                                            
## [3117] "SECTM1A"                                                                                          
## [3118] "LRP8"                                                                                             
## [3119] "ZC3H10"                                                                                           
## [3120] "ZFP397"                                                                                           
## [3121] "ST5"                                                                                              
## [3122] "ADC"                                                                                              
## [3123] "ESR2"                                                                                             
## [3124] "MESDC1"                                                                                           
## [3125] "RHOJ"                                                                                             
## [3126] "NACC1"                                                                                            
## [3127] "MAN1B1"                                                                                           
## [3128] "SCLT1"                                                                                            
## [3129] "IMPAD1"                                                                                           
## [3130] "QARS"                                                                                             
## [3131] "ZFP689"                                                                                           
## [3132] "COG2"                                                                                             
## [3133] "BCAM"                                                                                             
## [3134] "BRIP1"                                                                                            
## [3135] "SACM1L"                                                                                           
## [3136] "TTF1"                                                                                             
## [3137] "GM4890"                                                                                           
## [3138] "ATP1A2"                                                                                           
## [3139] "CXXC4"                                                                                            
## [3140] "STK24"                                                                                            
## [3141] "ERF"                                                                                              
## [3142] "KLHL2"                                                                                            
## [3143] "PLEKHG5"                                                                                          
## [3144] "WBSCR17"                                                                                          
## [3145] "QSOX1"                                                                                            
## [3146] "LRRC55"                                                                                           
## [3147] "UBA2"                                                                                             
## [3148] "E330009J07RIK"                                                                                    
## [3149] "TCRB-J"                                                                                           
## [3150] "PRKX"                                                                                             
## [3151] "BRI3"                                                                                             
## [3152] "ST8SIA1"                                                                                          
## [3153] "2010110K18RIK"                                                                                    
## [3154] "CD226"                                                                                            
## [3155] "MED29"                                                                                            
## [3156] "TYROBP"                                                                                           
## [3157] "GM15401"                                                                                          
## [3158] "MRGPRA3"                                                                                          
## [3159] "GPR55"                                                                                            
## [3160] "1700073E17RIK"                                                                                    
## [3161] "MSR1"                                                                                             
## [3162] "4930547E14RIK"                                                                                    
## [3163] "RGP1"                                                                                             
## [3164] "C330004P14RIK"                                                                                    
## [3165] "COL4A5"                                                                                           
## [3166] "LPCAT2"                                                                                           
## [3167] "CYP2J9"                                                                                           
## [3168] "CHST2"                                                                                            
## [3169] "D930048G16RIK"                                                                                    
## [3170] "SVIP"                                                                                             
## [3171] "D11WSU47E"                                                                                        
## [3172] "FAM20B"                                                                                           
## [3173] "LNX1"                                                                                             
## [3174] "PTRF"                                                                                             
## [3175] "WNT10A"                                                                                           
## [3176] "SLC27A4"                                                                                          
## [3177] "PPARGC1A"

Translating to human

An alternative is that we translate our human MSigDB collection to mouse gene set, and throw away terms specific to human (such as chromosome location).

Thankfully someone already did just this for us (and they also do regular updates).

We can find mouse translations from human here and we can load the RDS object directly into our session.

Mm.H <- readRDS("Mm.h.all.v7.1.entrez.rds")
class(Mm.H)
## [1] "list"

Translating to human

This contains a named list gene sets converted to mouse Entrez IDs.

Mm.H
## $HALLMARK_TNFA_SIGNALING_VIA_NFKB
##   [1] "11303"  "11304"  "27403"  "268379" "74591"  "11305"  "12778"  "11839" 
##   [9] "11910"  "67972"  "11941"  "320707" "381290" "14595"  "56336"  "12044" 
##  [17] "12047"  "12045"  "12046"  "12051"  "12053"  "20893"  "11797"  "11796" 
##  [25] "17951"  "17952"  "17940"  "17948"  "12156"  "12226"  "194735" "436199"
##  [33] "12227"  "12228"  "20293"  "20296"  "20292"  "20306"  "20297"  "20303" 
##  [41] "20304"  "16007"  "14219"  "12443"  "12444"  "12445"  "56706"  "56036" 
##  [49] "54199"  "12505"  "12515"  "12519"  "12522"  "12575"  "12608"  "12609" 
##  [57] "12633"  "56708"  "12977"  "12981"  "14825"  "20310"  "330122" "20309" 
##  [65] "15945"  "56066"  "20311"  "230073" "19347"  "320560" "67035"  "71712" 
##  [73] "19252"  "319520" "13537"  "240672" "13614"  "13636"  "13653"  "13654" 
##  [81] "13655"  "13660"  "57440"  "98878"  "259300" "20918"  "68969"  "23872" 
##  [89] "14063"  "14066"  "14221"  "14281"  "14282"  "14283"  "14284"  "14345" 
##  [97] "14373"  "13197"  "23882"  "17873"  "14528"  "14579"  "14584"  "321019"
## [105] "15200"  "15205"  "15894"  "15898"  "50723"  "230623" "230613" "329918"
## [113] "15902"  "15936"  "15937"  "15939"  "71586"  "15958"  "15959"  "667370"
## [121] "15980"  "16160"  "16169"  "16173"  "16175"  "16176"  "83430"  "16193" 
## [129] "16195"  "16197"  "16323"  "16324"  "16362"  "384783" "16369"  "16367" 
## [137] "16449"  "16450"  "16476"  "16477"  "16478"  "216850" "22290"  "21847" 
## [145] "16598"  "16600"  "16596"  "236537" "23849"  "16601"  "70789"  "16780" 
## [153] "16835"  "22359"  "16878"  "56722"  "17133"  "26397"  "26399"  "26410" 
## [161] "17118"  "17210"  "17681"  "17119"  "17869"  "107771" "59027"  "54446" 
## [169] "18024"  "18030"  "18033"  "18034"  "18035"  "18037"  "18081"  "15370" 
## [177] "18227"  "18124"  "108078" "381816" "55991"  "208098" "18578"  "238871"
## [185] "110385" "18577"  "56376"  "67399"  "18626"  "18627"  "170768" "18640" 
## [193] "18639"  "270198" "21664"  "22113"  "18792"  "18793"  "56193"  "20620" 
## [201] "67916"  "65112"  "108767" "17872"  "19219"  "19225"  "19224"  "19267" 
## [209] "19262"  "19288"  "54720"  "19696"  "19697"  "19698"  "11852"  "192656"
## [217] "75234"  "30945"  "20229"  "20971"  "18788"  "20725"  "18787"  "20393" 
## [225] "17691"  "235344" "104681" "20527"  "20525"  "227659" "17127"  "17126" 
## [233] "20621"  "12702"  "20656"  "20698"  "74646"  "211949" "18412"  "20850" 
## [241] "20851"  "21353"  "21354"  "21815"  "99929"  "24088"  "21923"  "21926" 
## [249] "21928"  "21929"  "21930"  "106869" "21942"  "21950"  "57783"  "231130"
## [257] "22029"  "211770" "106628" "21807"  "22151"  "227613" "73710"  "22154" 
## [265] "22153"  "22152"  "545486" "67951"  "22339"  "230734" "229055" "230738"
## [273] "22695" 
## 
## $HALLMARK_HYPOXIA
##   [1] "12778"     "11535"     "11541"     "11540"     "11639"     "56248"    
##   [7] "83397"     "11674"     "79459"     "353204"    "230163"    "11676"    
##  [13] "11717"     "57875"     "52231"     "12306"     "11910"     "11977"    
##  [19] "11979"     "117592"    "14422"     "12032"     "12043"     "12111"    
##  [25] "20893"     "12177"     "100043324" "12209"     "12226"     "194735"   
##  [31] "436199"    "12227"     "76459"     "12368"     "12389"     "19285"    
##  [37] "109042"    "20324"     "16007"     "14219"     "22403"     "12452"    
##  [43] "12575"     "12576"     "12577"     "54371"     "60322"     "53374"    
##  [49] "17684"     "12831"     "12829"     "12828"     "107581"    "53867"    
##  [55] "71355"     "94216"     "373864"    "12824"     "12825"     "12826"    
##  [61] "12827"     "12830"     "12832"     "12836"     "12842"     "12843"    
##  [67] "12870"     "15203"     "13008"     "12767"     "13179"     "13198"    
##  [73] "74747"     "26757"     "12933"     "22240"     "12934"     "13527"    
##  [79] "13528"     "19252"     "319520"    "13615"     "13636"     "13638"    
##  [85] "13649"     "13869"     "13866"     "13867"     "13806"     "433182"   
##  [91] "13807"     "13808"     "50527"     "74155"     "23871"     "14042"    
##  [97] "14066"     "70186"     "14121"     "14120"     "14281"     "14284"    
## [103] "56484"     "14387"     "69983"     "14635"     "14433"     "100039229"
## [109] "100042427" "100042025" "622339"    "14447"     "74185"     "103988"   
## [115] "14538"     "93692"     "14733"     "14734"     "14735"     "23888"    
## [121] "14751"     "76238"     "14936"     "232493"    "15116"     "110611"   
## [127] "211208"    "245598"    "15211"     "15212"     "15275"     "15277"    
## [133] "216019"    "212032"    "15368"     "15417"     "15427"     "15476"    
## [139] "14828"     "15481"     "15482"     "15512"     "193740"    "15931"    
## [145] "15937"     "16006"     "16009"     "16011"     "16193"     "216136"   
## [151] "16322"     "384783"    "16369"     "16367"     "57444"     "68048"    
## [157] "229504"    "107817"    "16476"     "16477"     "16478"     "105785"   
## [163] "66913"     "68137"     "104263"    "108829"    "277250"    "16572"    
## [169] "16573"     "16574"     "23849"     "93691"     "75785"     "16770"    
## [175] "16795"     "228366"    "16828"     "16833"     "16948"     "17035"    
## [181] "17133"     "26401"     "17319"     "17748"     "17750"     "17859"    
## [187] "17886"     "17880"     "17883"     "17882"     "17879"     "17885"    
## [193] "17884"     "544791"    "71960"     "77579"     "140781"    "668940"   
## [199] "17888"     "56174"     "13004"     "17988"     "15531"     "83398"    
## [205] "17423"     "83814"     "18030"     "12457"     "14815"     "18451"    
## [211] "18452"     "18484"     "18534"     "74551"     "18591"     "228026"   
## [217] "236900"    "170768"    "18640"     "18639"     "270198"    "18641"    
## [223] "56421"     "18642"     "56012"     "18648"     "18654"     "18655"    
## [229] "18663"     "72157"     "226041"    "66681"     "70974"     "18682"    
## [235] "18712"     "223775"    "18770"     "18772"     "231507"    "18793"    
## [241] "11520"     "108767"    "19017"     "68507"     "327814"    "233977"   
## [247] "17872"     "53412"     "54683"     "18750"     "18751"     "18752"    
## [253] "19309"     "110078"    "110095"    "19664"     "19883"     "52187"    
## [259] "54170"     "20198"     "268686"    "60406"     "50724"     "20778"    
## [265] "12492"     "15529"     "20970"     "20971"     "20342"     "20341"    
## [271] "18787"     "20439"     "13358"     "20525"     "20528"     "20527"    
## [277] "56485"     "435818"    "14385"     "21366"     "51795"     "52331"    
## [283] "20855"     "20856"     "54200"     "100043194" "76971"     "638251"   
## [289] "434121"    "629203"    "434264"    "629219"    "20859"     "21753"    
## [295] "236749"    "245376"    "21809"     "21810"     "21817"     "331046"   
## [301] "99929"     "83553"     "74419"     "21881"     "56277"     "69457"    
## [307] "21929"     "21983"     "21985"     "21991"     "22022"     "216558"   
## [313] "22339"     "22346"     "22359"     "16835"     "78889"     "170750"   
## [319] "22695"     "30046"     "109263"   
## 
## $HALLMARK_CHOLESTEROL_HOMEOSTASIS
##   [1] "11305"     "224530"    "110460"    "60525"     "11465"     "11461"    
##   [7] "26876"     "69117"     "100417514" "11522"     "11529"     "11532"    
##  [13] "11658"     "11676"     "71914"     "69787"     "11747"     "11910"    
##  [19] "107503"    "20239"     "54140"     "12411"     "12527"     "12660"    
##  [25] "12759"     "231207"    "12387"     "16480"     "66102"     "13121"    
##  [31] "13360"     "13595"     "51798"     "74155"     "66071"     "16592"    
##  [37] "56473"     "76267"     "60527"     "228151"    "14104"     "50762"    
##  [43] "230903"    "14137"     "110196"    "104174"    "14677"     "14678"    
##  [49] "14679"     "69590"     "68312"     "14862"     "14863"     "14864"    
##  [55] "14867"     "14866"     "14865"     "110006"    "15357"     "208715"   
##  [61] "15360"     "15490"     "319554"    "16449"     "16450"     "16835"    
##  [67] "22359"     "16854"     "19141"     "16956"     "16987"     "105853"   
##  [73] "192156"    "17855"     "18030"     "63913"     "18194"     "68671"    
##  [79] "236900"    "18793"     "22038"     "18828"     "78459"     "68603"    
##  [85] "108767"    "19016"     "20195"     "277089"    "235293"    "20250"    
##  [91] "20249"     "30049"     "329065"    "20347"     "20775"     "20788"    
##  [97] "20787"     "170459"    "56389"     "73166"     "69071"     "27279"    
## [103] "60599"     "228775"   
## 
## $HALLMARK_MITOTIC_SPINDLE
##   [1] "11308"     "329165"    "11350"     "11352"     "109934"    "110279"   
##   [7] "60595"     "11472"     "109711"    "11474"     "75547"     "236266"   
##  [13] "74018"     "68743"     "11789"     "106952"    "212285"    "11845"    
##  [19] "211673"    "99371"     "76932"     "78514"     "71544"     "71302"    
##  [25] "544817"    "214137"    "171207"    "117600"    "259302"    "11855"    
##  [31] "232906"    "192662"    "213498"    "69632"     "16800"     "71704"    
##  [37] "54126"     "73341"     "68724"     "67166"     "66615"     "20878"    
##  [43] "12927"     "12125"     "30948"     "11799"     "12190"     "12235"    
##  [49] "12345"     "108686"    "68339"     "12442"     "12488"     "217232"   
##  [55] "12540"     "226751"    "217866"    "240505"    "104445"    "104252"   
##  [61] "56699"     "12534"     "214444"    "229841"    "108000"    "219103"   
##  [67] "21461"     "21462"     "100041352" "12009"     "17120"     "70799"    
##  [73] "16328"     "74360"     "74470"     "75786"     "76707"     "76499"    
##  [79] "56430"     "269713"    "81910"     "26920"     "216846"    "54141"    
##  [85] "104318"    "27373"     "13043"     "19158"     "19157"     "19159"    
##  [91] "13383"     "23859"     "13385"     "53310"     "218977"    "94176"    
##  [97] "330662"    "68813"     "238130"    "208869"    "13518"     "13424"    
## [103] "110082"    "110084"    "327954"    "110350"    "330355"    "13411"    
## [109] "237806"    "69926"     "627872"    "68097"     "13605"     "269587"   
## [115] "13822"     "105988"    "22350"     "17698"     "19684"     "223254"   
## [121] "227377"    "67141"     "224014"    "14163"     "13998"     "26382"    
## [127] "30938"     "192176"    "286940"    "68794"     "14086"     "238021"   
## [133] "276919"    "227753"    "20259"     "11567"     "22349"     "15185"    
## [139] "56233"     "320191"    "16151"     "77963"     "170833"    "16319"    
## [145] "16443"     "20403"     "23924"     "231912"    "74187"     "16551"    
## [151] "209737"    "207607"    "16561"     "16560"     "240641"    "110033"   
## [157] "71819"     "73804"     "16563"     "16569"     "16568"     "16570"    
## [163] "383592"    "16571"     "16573"     "16582"     "16572"     "16574"    
## [169] "16579"     "16593"     "16594"     "74764"     "208628"    "268958"   
## [175] "73647"     "170725"    "12333"     "12334"     "70394"     "16798"    
## [181] "50523"     "16897"     "217325"    "16906"     "16907"     "16905"    
## [187] "72416"     "270058"    "26403"     "269881"    "234878"    "338372"   
## [193] "13589"     "17118"     "232944"    "226778"    "100043566" "100043665"
## [199] "620736"    "628475"    "381937"    "545926"    "100043638" "13728"    
## [205] "17318"     "23947"     "68041"     "77579"     "71960"     "17880"    
## [211] "17886"     "17883"     "17882"     "17879"     "17885"     "17884"    
## [217] "544791"    "140781"    "668940"    "17888"     "71602"     "17916"    
## [223] "17925"     "17973"     "17974"     "67052"     "18003"     "18005"    
## [229] "56349"     "18015"     "18080"     "18129"     "18128"     "18132"    
## [235] "18131"     "101706"    "108907"    "94190"     "18472"     "72333"    
## [241] "76073"     "18536"     "18541"     "56376"     "67399"     "208084"   
## [247] "18764"     "329064"    "101497"    "18817"     "232314"    "233406"   
## [253] "277360"    "109294"    "19303"     "226407"    "227800"    "29809"    
## [259] "338346"    "26934"     "19765"     "56705"     "74334"     "217944"   
## [265] "192786"    "76089"     "218397"    "114713"    "19414"     "226525"   
## [271] "69601"     "240057"    "19687"     "23912"     "214952"    "59040"    
## [277] "78757"     "19877"     "19878"     "66406"     "72776"     "53860"    
## [283] "71774"     "110380"    "24061"     "140557"    "13006"     "70099"    
## [289] "234214"    "20662"     "20740"     "20739"     "20742"     "20743"    
## [295] "80297"     "20741"     "237860"    "231637"    "20853"     "232533"   
## [301] "106504"    "223697"    "104027"    "381921"    "216965"    "330177"   
## [307] "108903"    "21844"     "24001"     "228012"    "24086"     "21973"    
## [313] "72119"     "223435"    "545156"    "64930"     "22137"     "22145"    
## [319] "22143"     "22144"     "22147"     "22146"     "22142"     "53857"    
## [325] "238463"    "56427"     "74237"     "259279"    "233276"    "328580"   
## [331] "22294"     "22330"     "83767"     "242687"    "73178"     "22376"    
## [337] "22627"    
## 
## $HALLMARK_WNT_BETA_CATENIN_SIGNALING
##  [1] "11491"  "12005"  "12006"  "12444"  "12443"  "12445"  "27373"  "104318"
##  [9] "12387"  "16480"  "26965"  "13380"  "234130" "13388"  "54485"  "13543" 
## [17] "13544"  "13542"  "27412"  "14296"  "212398" "14362"  "57265"  "14369" 
## [25] "14370"  "14367"  "14677"  "14678"  "14679"  "232232" "15182"  "15184" 
## [33] "56233"  "208727" "15213"  "15214"  "16449"  "16450"  "14534"  "18519" 
## [41] "16842"  "103806" "433586" "17869"  "107771" "20602"  "20185"  "59287" 
## [49] "93960"  "18128"  "18129"  "18132"  "18131"  "18222"  "19015"  "19165" 
## [57] "19206"  "19207"  "19664"  "27401"  "21414"  "22059"  "22408"  "22419" 
## [65] "22418"  "22420" 
## 
## $HALLMARK_TGF_BETA_SIGNALING
##   [1] "11477"  "11789"  "94246"  "29815"  "12156"  "12166"  "12168"  "12550" 
##   [9] "12560"  "12561"  "107951" "12577"  "12387"  "16480"  "13805"  "14225" 
##  [17] "14226"  "14272"  "18550"  "18553"  "18551"  "18552"  "433759" "15182" 
##  [25] "15181"  "15258"  "15257"  "15259"  "15901"  "15902"  "15903"  "15980" 
##  [33] "16477"  "16476"  "16478"  "21847"  "320202" "13590"  "16997"  "268977"
##  [41] "108075" "26409"  "20602"  "20185"  "18121"  "65112"  "19042"  "232941"
##  [49] "19045"  "19047"  "434233" "17872"  "106572" "19334"  "11848"  "67653" 
##  [57] "11853"  "18787"  "20481"  "20482"  "20515"  "20516"  "17125"  "17129" 
##  [65] "55994"  "17127"  "17126"  "17130"  "17131"  "75788"  "66313"  "20742" 
##  [73] "20743"  "80297"  "20740"  "20741"  "21803"  "21812"  "11479"  "269275"
##  [81] "21815"  "21825"  "21828"  "12845"  "21827"  "21872"  "21873"  "27375" 
##  [89] "94093"  "21848"  "66105"  "73318"  "56550"  "381534" "97064"  "11798" 
##  [97] "17951"  "17952"  "17940"  "17948" 
## 
## $HALLMARK_IL6_JAK_STAT3_SIGNALING
##   [1] "232345" "17837"  "17836"  "104681" "232400" "11287"  "11479"  "269275"
##   [9] "21812"  "11482"  "12018"  "12402"  "20306"  "20292"  "20293"  "20296" 
##  [17] "12768"  "12770"  "12475"  "12491"  "12494"  "12182"  "12505"  "12527" 
##  [25] "12804"  "57914"  "12977"  "12981"  "12982"  "16188"  "12984"  "12983" 
##  [33] "16190"  "12986"  "14825"  "20310"  "330122" "20309"  "15945"  "56066" 
##  [41] "55985"  "17329"  "21673"  "50498"  "14102"  "79201"  "14784"  "71520" 
##  [49] "23897"  "15368"  "15975"  "15979"  "15980"  "16155"  "16161"  "16164" 
##  [57] "16169"  "16172"  "50905"  "16182"  "16176"  "16177"  "16178"  "16184" 
##  [65] "16186"  "16193"  "16195"  "16196"  "16199"  "16326"  "16362"  "16391" 
##  [73] "16401"  "104099" "16416"  "16476"  "16477"  "16478"  "16847"  "16994" 
##  [81] "17000"  "26410"  "17874"  "18414"  "16880"  "54635"  "56744"  "320207"
##  [89] "18712"  "223775" "18780"  "19246"  "19247"  "19255"  "19692"  "19693" 
##  [97] "12703"  "12702"  "56324"  "20846"  "20848"  "20849"  "20847"  "21803" 
## [105] "24088"  "21926"  "27279"  "21937"  "21938"  "94185"  "54721"  "16451" 
## [113] "16452" 
## 
## $HALLMARK_DNA_REPAIR
##   [1] "223921"    "11486"     "11512"     "11513"     "11514"     "224129"   
##   [7] "104110"    "210044"    "432530"    "56436"     "100043022" "76850"    
##  [13] "236511"    "239528"    "214150"    "11636"     "56248"     "11639"    
##  [19] "21681"     "56009"     "100043227" "100043231" "100043239" "100043292"
##  [25] "100861880" "70988"     "435615"    "100043224" "100043235" "100043247"
##  [31] "637578"    "100861901" "627488"    "667692"    "100861891" "11821"    
##  [37] "54208"     "57278"     "84004"     "27061"     "66162"     "66653"    
##  [43] "76025"     "218630"    "72269"     "26370"     "98985"     "22169"    
##  [49] "12856"     "228410"    "13135"     "67665"     "13194"     "107986"   
##  [55] "94223"     "27369"     "110074"    "59022"     "68969"     "20918"    
##  [61] "13716"     "27224"     "13870"     "70333"     "13871"     "13872"    
##  [67] "50505"     "22592"     "71991"     "14156"     "105446"    "23918"    
##  [73] "625249"    "54722"     "235459"    "229906"    "98053"     "14884"    
##  [79] "209357"    "66467"     "70239"     "14923"     "15163"     "15452"    
##  [85] "23917"     "100042069" "16434"     "16881"     "70456"     "268395"   
##  [91] "18100"     "68092"     "58202"     "57314"     "27632"     "74164"    
##  [97] "18102"     "79059"     "56520"     "230103"    "18160"     "50773"    
## [103] "103850"    "107569"    "68106"     "68219"     "74167"     "18538"    
## [109] "18540"     "18578"     "238871"    "110385"    "18577"     "18588"    
## [115] "78600"     "667034"    "18950"     "18968"     "18969"     "18970"    
## [121] "18971"     "67967"     "69745"     "105948585" "66979"     "80905"    
## [127] "56626"     "20016"     "20018"     "66136"     "20020"     "20021"    
## [133] "69241"     "66420"     "69833"     "67710"     "245841"    "69920"    
## [139] "20022"     "17749"     "74414"     "69870"     "107939"    "19075"    
## [145] "19361"     "19365"     "66679"     "56044"     "56438"     "100043674"
## [151] "19823"     "19714"     "19718"     "69263"     "106344"    "72151"    
## [157] "67897"     "19891"     "68240"     "382985"    "20135"     "66406"    
## [163] "53378"     "53421"     "57743"     "75062"     "17129"     "55994"    
## [169] "227644"    "330959"    "67996"     "57317"     "20833"     "20908"    
## [175] "20922"     "100041294" "20924"     "20930"     "24075"     "216185"   
## [181] "66464"     "99730"     "21341"     "21343"     "108143"    "102216272"
## [187] "21357"     "57813"     "56334"     "100862175" "22059"     "22088"    
## [193] "22171"     "22247"     "68134"     "236733"    "14479"     "22258"    
## [199] "66914"     "72749"     "330192"    "194309"    "22591"     "69020"    
## [205] "52696"    
## 
## $HALLMARK_G2M_CHECKPOINT
##   [1] "11350"     "11352"     "11702"     "100041585" "238247"    "94246"    
##   [7] "107503"    "22589"     "20878"     "20877"     "20871"     "12021"    
##  [13] "12051"     "11799"     "12190"     "12235"     "12237"     "26885"    
##  [19] "12412"     "12428"     "12442"     "12443"     "12444"     "12445"    
##  [25] "12449"     "12455"     "107995"    "12530"     "12531"     "217232"   
##  [31] "12544"     "23834"     "12545"     "12534"     "12567"     "12576"    
##  [37] "12580"     "72391"     "12615"     "229841"    "108000"    "27221"    
##  [43] "12649"     "234852"    "54124"     "624855"    "66197"     "13018"    
##  [49] "26965"     "26554"     "99375"     "72584"     "75717"     "27214"    
##  [55] "68278"     "53817"     "245474"    "13405"     "22288"     "13497"    
##  [61] "13486"     "21915"     "13555"     "242705"    "13557"     "104394"   
##  [67] "13559"     "13640"     "13645"     "105988"    "14030"     "26909"    
##  [73] "14056"     "14055"     "14088"     "67141"     "71375"     "27041"    
##  [79] "272551"    "14852"     "14853"     "15270"     "319173"    "621893"   
##  [85] "319176"    "319191"    "319162"    "232440"    "319171"    "15267"    
##  [91] "319192"    "319163"    "319164"    "319165"    "319166"    "319167"   
##  [97] "319168"    "319169"    "319170"    "665433"    "319172"    "51788"    
## [103] "77605"     "319184"    "68024"     "319179"    "319180"    "319181"   
## [109] "319183"    "319185"    "319186"    "319187"    "319188"    "319189"   
## [115] "78303"     "319182"    "319190"    "665596"    "665622"    "15251"    
## [121] "13819"     "15260"     "15361"     "111241"    "15364"     "15354"    
## [127] "619829"    "15331"     "100042405" "625514"    "115488195" "15366"    
## [133] "71653"     "11991"     "51810"     "209448"    "15481"     "15482"    
## [139] "193740"    "14828"     "15512"     "15511"     "15574"     "210554"   
## [145] "16201"     "20744"     "16319"     "15374"     "23924"     "231912"   
## [151] "16551"     "209737"    "207607"    "240641"    "110033"    "71819"    
## [157] "73804"     "16563"     "16571"     "16573"     "16582"     "16572"    
## [163] "16574"     "67956"     "76464"     "16647"     "100043906" "16211"    
## [169] "98386"     "16882"     "16906"     "16907"     "16905"     "56150"    
## [175] "65964"     "26416"     "19094"     "17118"     "17216"     "17215"    
## [181] "17218"     "17219"     "17268"     "17536"     "17345"     "17420"    
## [187] "17750"     "17748"     "17765"     "17865"     "17864"     "17869"    
## [193] "107771"    "50927"     "17975"     "67052"     "18005"     "70769"    
## [199] "18129"     "18128"     "18132"     "18131"     "107823"    "18193"    
## [205] "234135"    "101706"    "18141"     "78482"     "269966"    "108907"   
## [211] "18263"     "18286"     "26429"     "56452"     "18472"     "52033"    
## [217] "100710"    "71521"     "18817"     "20873"     "18854"     "18969"    
## [223] "18973"     "77782"     "233406"    "19076"     "27374"     "19134"    
## [229] "30939"     "19290"     "19291"     "26934"     "19357"     "19359"    
## [235] "19366"     "226525"    "69601"     "240057"    "19650"     "19651"    
## [241] "56275"     "102902673" "19891"     "73086"     "56613"     "60406"    
## [247] "50724"     "71514"     "20496"     "20495"     "20497"     "105727"   
## [253] "11987"     "11989"     "11988"     "20539"     "17127"     "17126"    
## [259] "20588"     "68094"     "24061"     "140557"    "14211"     "70099"    
## [265] "20641"     "20775"     "110809"    "14105"     "20382"     "245492"   
## [271] "268996"    "20842"     "20843"     "50878"     "20460"     "16765"    
## [277] "20937"     "56403"     "74326"     "21335"     "210106"    "21781"    
## [283] "21803"     "21887"     "21888"     "21885"     "21917"     "212999"   
## [289] "238799"    "21969"     "72960"     "21973"     "72119"     "20462"    
## [295] "22036"     "78733"     "22137"     "68612"     "77891"     "80914"    
## [301] "22245"     "19704"     "22427"     "103573"    "231386"   
## 
## $HALLMARK_APOPTOSIS
##   [1] "11518"     "27360"     "11519"     "72168"     "11732"     "16952"    
##   [7] "11820"     "11910"     "54140"     "12028"     "27061"     "12042"    
##  [13] "12048"     "12049"     "12125"     "12050"     "12111"     "12122"    
##  [19] "12124"     "11796"     "11797"     "17951"     "17952"     "17940"    
##  [25] "17948"     "171543"    "12156"     "12177"     "100043324" "12189"    
##  [31] "12227"     "436199"    "194735"    "12226"     "12228"     "12362"    
##  [37] "12366"     "12367"     "12363"     "12368"     "12369"     "12370"    
##  [43] "12371"     "12389"     "12427"     "12443"     "12444"     "12445"    
##  [49] "12475"     "12481"     "12494"     "12182"     "12505"     "12515"    
##  [55] "12531"     "12566"     "12575"     "12576"     "12633"     "12759"    
##  [61] "12914"     "328572"    "107869"    "12387"     "16480"     "74256"    
##  [67] "223453"    "65111"     "13179"     "13198"     "13347"     "66593"    
##  [73] "15502"     "100037258" "74006"     "99586"     "13595"     "13655"    
##  [79] "13730"     "13807"     "433182"    "13806"     "13808"     "13866"    
##  [85] "13869"     "13649"     "13867"     "13874"     "225363"    "14061"    
##  [91] "14062"     "14102"     "79201"     "14103"     "14149"     "235180"   
##  [97] "13197"     "23882"     "17873"     "14528"     "14676"     "14775"    
## [103] "14778"     "75512"     "14780"     "625249"    "227753"    "20259"    
## [109] "11567"     "22349"     "14782"     "14863"     "14864"     "14867"    
## [115] "14862"     "14865"     "14866"     "68312"     "14919"     "245650"   
## [121] "14958"     "15234"     "97165"     "15368"     "15507"     "15937"    
## [127] "66141"     "68713"     "80876"     "74482"     "213002"    "69147"    
## [133] "73835"     "15977"     "15979"     "16004"     "16012"     "16173"    
## [139] "16175"     "16176"     "16193"     "16362"     "57444"     "68048"    
## [145] "229504"    "16476"     "16477"     "16478"     "16668"     "16842"    
## [151] "16854"     "16905"     "16906"     "16907"     "17022"     "228355"   
## [157] "17210"     "17314"     "17390"     "18003"     "380684"    "18040"    
## [163] "18479"     "18481"     "224105"    "18569"     "18596"     "18595"    
## [169] "18611"     "18791"     "18796"     "18797"     "18798"     "18795"    
## [175] "229791"    "58801"     "225849"    "26932"     "19058"     "19059"    
## [181] "19063"     "18646"     "19164"     "19165"     "14083"     "19401"    
## [187] "218772"    "19411"     "19697"     "67442"     "11852"     "214952"   
## [193] "59040"     "24014"     "19877"     "19878"     "20229"     "20230"    
## [199] "235293"    "20515"     "20516"     "17131"     "17130"     "20655"    
## [205] "20656"     "20740"     "20739"     "18412"     "21354"     "21808"    
## [211] "21814"     "21857"     "21858"     "21859"     "21926"     "27279"    
## [217] "22035"     "21973"     "12257"     "56338"     "22334"     "22390"    
## [223] "11798"    
## 
## $HALLMARK_NOTCH_SIGNALING
##  [1] "226548"    "109689"    "216869"    "12443"     "12444"     "12445"    
##  [7] "26965"     "13388"     "54485"     "14357"     "207521"    "74198"    
## [13] "103583"    "12234"     "14362"     "57265"     "14369"     "14367"    
## [19] "14370"     "15205"     "56198"     "15214"     "16449"     "16450"    
## [25] "14534"     "18519"     "16848"     "17305"     "19719"     "270118"   
## [31] "18128"     "18129"     "18132"     "18131"     "19015"     "18750"    
## [37] "18751"     "18752"     "19165"     "66340"     "56438"     "100043674"
## [43] "19823"     "60406"     "50724"     "21402"     "54613"     "21416"    
## [49] "21415"     "22413"     "22418"     "22419"    
## 
## $HALLMARK_ADIPOGENESIS
##   [1] "11303"     "11304"     "27403"     "268379"    "74591"     "11305"    
##   [7] "74610"     "52538"     "11363"     "11364"     "11409"     "104112"   
##  [13] "11429"     "11430"     "11512"     "11513"     "11514"     "224129"   
##  [19] "104110"    "210044"    "432530"    "246747"    "11450"     "68465"    
##  [25] "28169"     "68262"     "26926"     "11637"     "11669"     "72535"    
##  [31] "19378"     "26358"     "11668"     "56847"     "11674"     "79459"    
##  [37] "353204"    "11600"     "57875"     "11804"     "11816"     "11836"    
##  [43] "109880"    "110157"    "11861"     "56298"     "73991"     "109168"   
##  [49] "11933"     "28080"     "116848"    "12039"     "94044"     "12053"    
##  [55] "12266"     "12268"     "15139"     "12359"     "19285"     "20324"    
##  [61] "109042"    "12452"     "12476"     "68498"     "66205"     "12491"    
##  [67] "12580"     "103172"    "12675"     "16150"     "12683"     "14311"    
##  [73] "69574"     "66588"     "12819"     "12822"     "12826"     "12829"    
##  [79] "12828"     "107581"    "53867"     "71355"     "94216"     "373864"   
##  [85] "12824"     "12825"     "12827"     "12830"     "12831"     "12832"    
##  [91] "12836"     "12842"     "12843"     "230027"    "52064"     "67914"    
##  [97] "12861"     "66142"     "78174"     "12868"     "12896"     "12908"    
## [103] "12647"     "12974"     "71832"     "66445"     "13120"     "13119"    
## [109] "81906"     "666168"    "13118"     "230639"    "435802"    "100040843"
## [115] "13117"     "277753"    "13171"     "13202"     "67460"     "13350"    
## [121] "13360"     "66375"     "209183"    "216820"    "235339"    "13382"    
## [127] "27362"     "66148"     "67171"     "51798"     "93747"     "232089"   
## [133] "170439"    "18606"     "209558"    "18605"     "13850"     "26379"    
## [139] "23943"     "110826"    "11770"     "18857"     "21884"     "14085"    
## [145] "14366"     "23881"     "13197"     "23882"     "74185"     "66092"    
## [151] "14732"     "102247"    "231510"    "14571"     "268566"    "14778"    
## [157] "75512"     "14780"     "625249"    "17713"     "15107"     "227095"   
## [163] "80888"     "15926"     "269951"    "67834"     "15929"     "243996"   
## [169] "15979"     "76614"     "16404"     "16400"     "209378"    "16443"    
## [175] "20403"     "67767"     "16775"     "16776"     "16774"     "16846"    
## [181] "16880"     "18414"     "16890"     "14792"     "16956"     "17001"    
## [187] "225028"    "26412"     "26411"     "399510"    "72039"     "17448"    
## [193] "17436"     "109264"    "107029"    "23945"     "66447"     "108958"   
## [199] "77037"     "27395"     "67247"     "66112"     "56428"     "107589"   
## [205] "109019"    "69917"     "68202"     "70316"     "102634451" "66916"    
## [211] "68349"     "69721"     "18107"     "18108"     "27047"     "18405"    
## [217] "18406"     "18407"     "18569"     "18618"     "56273"     "170768"   
## [223] "18640"     "18639"     "270198"    "18641"     "72157"     "226041"   
## [229] "102693"    "16922"     "223775"    "18712"     "11520"     "18984"    
## [235] "19016"     "19043"     "232941"    "108954"    "11757"     "50907"    
## [241] "69956"     "19218"     "110391"    "19376"     "13476"     "70335"    
## [247] "57264"     "57263"     "67442"     "66878"     "67809"     "29864"    
## [253] "68750"     "20168"     "68653"     "20778"     "12492"     "20280"    
## [259] "67680"     "66052"     "20509"     "116914"    "20514"     "13358"    
## [265] "27376"     "26457"     "26569"     "330064"    "217430"    "20618"    
## [271] "20655"     "20411"     "268301"    "13602"     "59010"     "16651"    
## [277] "20850"     "20851"     "13830"     "229277"    "56451"     "20887"    
## [283] "53315"     "57429"     "57430"     "215895"    "21351"     "21353"    
## [289] "21881"     "74419"     "83553"     "22057"     "22117"     "246221"   
## [295] "22190"     "22187"     "56085"     "54609"     "94232"     "22245"    
## [301] "80914"     "22228"     "66152"     "66594"     "22273"     "22272"    
## [307] "22340"     "22628"     "22629"    
## 
## $HALLMARK_ESTROGEN_RESPONSE_EARLY
##   [1] "268860"    "27410"     "381072"    "268379"    "67928"     "320631"   
##   [7] "233810"    "54608"     "226251"    "231148"    "319713"    "432530"   
##  [13] "11514"     "11512"     "11515"     "27360"     "11518"     "11519"    
##  [19] "17355"     "93736"     "11640"     "67689"     "73458"     "621603"   
##  [25] "23802"     "71790"     "11828"     "11835"     "11839"     "56350"    
##  [31] "142688"    "14595"     "12017"     "58208"     "14025"     "12043"    
##  [37] "20893"     "233016"    "76459"     "12308"     "12311"     "54598"    
##  [43] "76025"     "12398"     "12395"     "12396"     "22403"     "12443"    
##  [49] "12444"     "12445"     "12505"     "12614"     "53883"     "107934"   
##  [55] "212862"    "99712"     "12700"     "53624"     "69454"     "20315"    
##  [61] "232174"    "546726"    "97998"     "13360"     "71412"     "28200"    
##  [67] "20148"     "50768"     "243362"    "236920"    "67117"     "13655"    
##  [73] "13709"     "13710"     "54326"     "68801"     "71946"     "77411"    
##  [79] "207920"    "98952"     "223254"    "227377"    "14104"     "69169"    
##  [85] "14137"     "14200"     "14228"     "14229"     "286940"    "192176"   
##  [91] "68794"     "14281"     "17300"     "14234"     "14302"     "14389"    
##  [97] "14585"     "14609"     "414089"    "11605"     "268527"    "381157"   
## [103] "15205"     "15460"     "80888"     "16001"     "16010"     "50905"    
## [109] "16195"     "16324"     "16323"     "101490"    "229504"    "68048"    
## [115] "57444"     "217837"    "16452"     "54721"     "16451"     "71529"    
## [121] "241769"    "16529"     "193796"    "76804"     "230674"    "21847"    
## [127] "16600"     "16598"     "69540"     "16663"     "16665"     "16668"    
## [133] "16669"     "16691"     "16763"     "16206"     "269473"    "320398"   
## [139] "17762"     "328329"    "56527"     "17776"     "76199"     "327987"   
## [145] "23989"     "243864"    "266815"    "75007"     "171531"    "77015"    
## [151] "223726"    "381269"    "17695"     "17829"     "17863"     "18432"    
## [157] "17864"     "17865"     "17869"     "107771"    "226101"    "26903"    
## [163] "83762"     "78914"     "78286"     "260315"    "215690"    "17965"    
## [169] "20602"     "20185"     "18166"     "268903"    "56488"     "237082"   
## [175] "56177"     "229759"    "99543"     "13603"     "107586"    "18426"    
## [181] "18442"     "57385"     "23972"     "23971"     "53318"     "59020"    
## [187] "18631"     "18667"     "225845"    "58801"     "27205"     "105675"   
## [193] "76453"     "64292"     "19329"     "106572"    "19334"     "268480"   
## [199] "19401"     "218772"    "19411"     "19419"     "240168"    "225182"   
## [205] "52250"     "225362"    "19713"     "66270"     "73296"     "11854"    
## [211] "20112"     "110651"    "20111"     "67071"     "107094"    "20778"    
## [217] "12492"     "20276"     "67815"     "103655"    "380683"    "20347"    
## [223] "55948"     "24056"     "20439"     "20501"     "116914"    "20509"    
## [229] "20510"     "55963"     "20520"     "56517"     "30805"     "94249"    
## [235] "238384"    "13521"     "231583"    "26458"     "225579"    "20525"    
## [241] "20528"     "20527"     "224674"    "56857"     "106957"    "11988"    
## [247] "11989"     "11987"     "20539"     "26941"     "65962"     "69226"    
## [253] "20675"     "20681"     "20682"     "20856"     "54200"     "100043194"
## [259] "76971"     "638251"    "434121"    "629203"    "434264"    "629219"   
## [265] "20859"     "225115"    "319613"    "20972"     "171180"    "74694"    
## [271] "21420"     "21784"     "21786"     "228839"    "21817"     "331046"   
## [277] "207596"    "229595"    "21844"     "24001"     "99929"     "27375"    
## [283] "209497"    "140765"    "50528"     "22057"     "21983"     "21987"    
## [289] "244152"    "230603"    "73710"     "22151"     "22154"     "22153"    
## [295] "227613"    "22152"     "545486"    "67951"     "22234"     "22248"    
## [301] "106840"    "22393"     "211652"    "52357"     "22433"     "22673"    
## 
## $HALLMARK_ESTROGEN_RESPONSE_LATE
##   [1] "27410"     "381072"    "268379"    "67928"     "320631"    "233810"   
##   [7] "54608"     "93732"     "27360"     "11518"     "11519"     "17355"    
##  [13] "93736"     "23795"     "403205"    "11671"     "67689"     "73458"    
##  [19] "621603"    "23802"     "71790"     "11839"     "56350"     "17172"    
##  [25] "11898"     "381290"    "67972"     "11941"     "320707"    "12017"    
##  [31] "53314"     "12043"     "233016"    "12228"     "76459"     "12349"    
##  [37] "56808"     "12293"     "12311"     "54598"     "12389"     "22403"    
##  [43] "12427"     "12443"     "12444"     "12445"     "12505"     "12527"    
##  [49] "107995"    "23834"     "12550"     "12560"     "12561"     "53883"    
##  [55] "12614"     "107934"    "212862"    "99712"     "68947"     "71367"    
##  [61] "12700"     "12709"     "12715"     "69454"     "12864"     "102640946"
##  [67] "12876"     "20315"     "57266"     "232174"    "546726"    "64385"    
##  [73] "106648"    "631304"    "72054"     "70101"     "170716"    "677156"   
##  [79] "320997"    "666168"    "208285"    "435802"    "100040843" "13117"    
##  [85] "67880"     "12409"     "13360"     "71412"     "28200"     "71228"    
##  [91] "13418"     "30045"     "13537"     "67117"     "13655"     "68801"    
##  [97] "54326"     "13731"     "110826"    "16592"     "98952"     "223254"   
## [103] "227377"    "14137"     "14184"     "14228"     "14229"     "286940"   
## [109] "192176"    "68794"     "14281"     "17300"     "14234"     "14302"    
## [115] "14419"     "74246"     "22122"     "272551"    "14620"     "11605"    
## [121] "76854"     "15360"     "26557"     "15452"     "15460"     "18415"    
## [127] "80888"     "15902"     "269951"    "15926"     "16010"     "209268"   
## [133] "50905"     "16195"     "114663"    "57444"     "68048"     "229504"   
## [139] "217837"    "16451"     "54721"     "16452"     "16529"     "19348"    
## [145] "16600"     "16598"     "69540"     "56538"     "16663"     "16665"    
## [151] "16669"     "16782"     "226519"    "16795"     "228366"    "217325"   
## [157] "16897"     "54135"     "17002"     "71775"     "22041"     "26415"    
## [163] "29857"     "17762"     "17242"     "17294"     "56335"     "74407"    
## [169] "243864"    "266815"    "17434"     "17863"     "226101"    "26903"    
## [175] "83762"     "17937"     "17965"     "20602"     "20185"     "56183"    
## [181] "18166"     "268903"    "56488"     "237082"    "56177"     "229759"   
## [187] "13603"     "107586"    "18426"     "23972"     "23971"     "18546"    
## [193] "18569"     "53318"     "59020"     "64058"     "18667"     "56460"    
## [199] "225845"    "56096"     "20873"     "235611"    "140571"    "18846"    
## [205] "18845"     "18844"     "140570"    "67784"     "243743"    "105675"   
## [211] "19088"     "19087"     "19116"     "76453"     "19218"     "64292"    
## [217] "15170"     "106572"    "19334"     "54189"     "268480"    "225182"   
## [223] "19713"     "69724"     "20112"     "110651"    "20111"     "67071"    
## [229] "20202"     "545541"    "20778"     "12492"     "20276"     "56788"    
## [235] "18690"     "20347"     "20704"     "20703"     "20701"     "20700"    
## [241] "20702"     "68348"     "194604"    "16625"     "20716"     "271047"   
## [247] "20717"     "238393"    "20714"     "20715"     "74069"     "628900"   
## [253] "238395"    "268591"    "55948"     "20393"     "20439"     "20501"    
## [259] "55963"     "20520"     "56517"     "30805"     "94249"     "238384"   
## [265] "13521"     "231583"    "26458"     "225579"    "63959"     "56017"    
## [271] "20539"     "26941"     "65962"     "71982"     "20322"     "20675"    
## [277] "20681"     "20682"     "19143"     "20446"     "20460"     "54200"    
## [283] "100043194" "76971"     "638251"    "434121"    "629203"    "434264"   
## [289] "629219"    "20859"     "21420"     "21784"     "21786"     "21789"    
## [295] "21823"     "21844"     "24001"     "27375"     "140765"    "50528"    
## [301] "21924"     "22057"     "21973"     "21983"     "21987"     "17229"    
## [307] "100503895" "72169"     "66109"     "22117"     "246221"    "22235"    
## [313] "22249"     "208898"    "22393"     "22433"     "74335"     "22695"    
## 
## $HALLMARK_ANDROGEN_RESPONSE
##   [1] "239273"    "54608"     "74205"     "50790"     "109711"    "60595"    
##   [7] "11474"     "11472"     "11504"     "23794"     "30806"     "101401"   
##  [13] "235130"    "223838"    "56436"     "100043022" "83397"     "11651"    
##  [19] "11652"     "23797"     "56847"     "19378"     "26358"     "11668"    
##  [25] "72535"     "11669"     "11732"     "66884"     "71371"     "12007"    
##  [31] "12010"     "14595"     "12167"     "12166"     "207565"    "55984"    
##  [37] "12443"     "12444"     "12445"     "218294"    "12571"     "72155"    
##  [43] "13167"     "74754"     "27362"     "13714"     "192657"    "68801"    
##  [49] "54326"     "76267"     "60527"     "56473"     "228151"    "14229"    
##  [55] "14679"     "14677"     "14678"     "333433"    "14555"     "14782"    
##  [61] "60596"     "14958"     "73998"     "15357"     "208715"    "15360"    
##  [67] "26557"     "15446"     "66065"     "319554"    "234515"    "269180"   
##  [73] "231070"    "544963"    "404710"    "16410"     "241226"    "16402"    
##  [79] "16612"     "16619"     "16615"     "16624"     "16623"     "16622"    
##  [85] "16617"     "16616"     "16613"     "13646"     "13648"     "18048"    
##  [91] "18050"     "16618"     "13647"     "16669"     "16691"     "16880"    
##  [97] "18414"     "70361"     "235416"    "17132"     "16658"     "17152"    
## [103] "56542"     "17761"     "17289"     "26362"     "67268"     "67938"    
## [109] "27057"     "17988"     "59007"     "18095"     "18813"     "56376"    
## [115] "67399"     "109785"    "56469"     "17344"     "229615"    "19012"    
## [121] "65112"     "19229"     "24000"     "19250"     "19341"     "19342"    
## [127] "110651"    "20111"     "67071"     "20112"     "107094"    "20229"    
## [133] "20250"     "20249"     "30049"     "329065"    "69608"     "218811"   
## [139] "20363"     "20393"     "13521"     "231583"    "67760"     "20603"    
## [145] "671878"    "20322"     "76687"     "76219"     "76976"     "30051"    
## [151] "20807"     "66384"     "22184"     "22183"     "117167"    "53416"    
## [157] "108737"    "71817"     "77975"     "50528"     "140765"    "106869"   
## [163] "21985"     "21807"     "107652"    "22196"     "56228"     "30960"    
## [169] "22596"     "14375"     "229055"    "328365"    "52915"    
## 
## $HALLMARK_MYOGENESIS
##   [1] "226251"    "231148"    "319713"    "11423"     "14081"     "433256"   
##   [7] "216739"    "11459"     "11468"     "11464"     "11475"     "238880"   
##  [13] "11461"     "11472"     "60595"     "109711"    "11474"     "11489"    
##  [19] "11492"     "11515"     "11568"     "55987"     "56264"     "77559"    
##  [25] "11603"     "11636"     "11652"     "23797"     "56642"     "107765"   
##  [31] "78321"     "23796"     "11815"     "11820"     "11937"     "11938"    
##  [37] "53313"     "54411"     "12017"     "12062"     "20893"     "30948"    
##  [43] "58226"     "12291"     "239556"    "12299"     "12323"     "108058"   
##  [49] "12325"     "12322"     "12372"     "12373"     "12391"     "12491"    
##  [55] "12554"     "12575"     "11537"     "11435"     "11443"     "11449"    
##  [61] "12709"     "12715"     "76722"     "12716"     "12759"     "71994"    
##  [67] "12797"     "12819"     "12822"     "12842"     "12829"     "12828"    
##  [73] "107581"    "53867"     "71355"     "94216"     "373864"    "12824"    
##  [79] "12825"     "12826"     "12827"     "12830"     "12831"     "12832"    
##  [85] "12836"     "12843"     "74320"     "12834"     "12833"     "12835"    
##  [91] "68553"     "245026"    "12862"     "12865"     "12908"     "12647"    
##  [97] "12955"     "13009"     "13019"     "13143"     "13144"     "76954"    
## [103] "209773"    "13346"     "19132"     "22352"     "13405"     "22288"    
## [109] "13497"     "13400"     "13527"     "13528"     "13644"     "13682"    
## [115] "13681"     "53975"     "13808"     "13845"     "270190"    "13844"    
## [121] "13846"     "13835"     "13840"     "13842"     "13848"     "13841"    
## [127] "13836"     "13838"     "13837"     "13839"     "13867"     "13869"    
## [133] "13649"     "13866"     "14077"     "12140"     "14074"     "110196"   
## [139] "14173"     "14199"     "14202"     "14226"     "14248"     "54601"    
## [145] "14313"     "56188"     "14387"     "69983"     "93739"     "17873"    
## [151] "14613"     "14681"     "14778"     "75512"     "14780"     "227753"   
## [157] "20259"     "11567"     "22349"     "15200"     "15184"     "56233"    
## [163] "208727"    "15464"     "69253"     "80888"     "15982"     "15983"    
## [169] "16000"     "16009"     "16011"     "29817"     "16404"     "16400"    
## [175] "16412"     "192897"    "16419"     "16416"     "16420"     "16510"    
## [181] "238271"    "16511"     "170738"    "192775"    "16582"     "16581"    
## [187] "12224"     "16773"     "16795"     "228366"    "24131"     "14245"    
## [193] "64899"     "16985"     "29857"     "26415"     "100732"    "17189"    
## [199] "17258"     "17260"     "17261"     "17259"     "17532"     "17868"    
## [205] "233199"    "109272"    "53311"     "68753"     "17878"     "17879"    
## [211] "17884"     "17880"     "17886"     "17883"     "17882"     "17885"    
## [217] "544791"    "71960"     "77579"     "140781"    "668940"    "17888"    
## [223] "17901"     "17906"     "17907"     "17897"     "17896"     "216459"   
## [229] "17904"     "17898"     "107589"    "17913"     "17928"     "17929"    
## [235] "17930"     "242702"    "59011"     "78286"     "260315"    "215690"   
## [241] "17967"     "17968"     "18125"     "18126"     "18127"     "18128"    
## [247] "18129"     "18104"     "18105"     "77090"     "18563"     "83679"    
## [253] "75216"     "67399"     "18642"     "56421"     "18641"     "56012"    
## [259] "18648"     "18693"     "18767"     "140570"    "18846"     "18845"    
## [265] "18844"     "235611"    "140571"    "67784"     "243743"    "68507"    
## [271] "327814"    "233977"    "53412"     "19122"     "19165"     "19223"    
## [277] "19245"     "19293"     "19309"     "110078"    "110095"    "19645"    
## [283] "52250"     "225362"    "19769"     "19762"     "20190"     "20192"    
## [289] "20191"     "20250"     "20249"     "30049"     "329065"    "30953"    
## [295] "100505386" "20391"     "24052"     "24053"     "244431"    "20399"    
## [301] "50795"     "212531"    "56726"     "64383"     "102857"    "66402"    
## [307] "29856"     "276829"    "20657"     "20411"     "20410"     "20692"    
## [313] "30051"     "11790"     "20698"     "20740"     "20739"     "16651"    
## [319] "20856"     "225115"    "20973"     "21345"     "21393"     "21679"    
## [325] "21676"     "21803"     "21924"     "21925"     "21952"     "21953"    
## [331] "21954"     "21955"     "21956"     "21957"     "21987"     "22004"    
## [337] "59069"     "621054"    "22084"     "22354"     "97064"    
## 
## $HALLMARK_PROTEIN_SECRETION
##   [1] "11303"     "11304"     "27403"     "268379"    "74591"     "11305"    
##   [7] "11487"     "66471"     "68981"     "11765"     "71770"     "11764"    
##  [13] "11773"     "232910"    "11774"     "11775"     "11777"     "213827"   
##  [19] "11840"     "11841"     "66251"     "211673"    "99371"     "99889"    
##  [25] "11928"     "98660"     "232975"    "11944"     "27222"     "192113"   
##  [31] "110935"    "11966"     "108664"    "11977"     "11979"     "12068"    
##  [37] "12176"     "12390"     "12512"     "12725"     "12727"     "211286"   
##  [43] "12757"     "74325"     "67300"     "76332"     "70349"     "50797"    
##  [49] "59042"     "13032"     "74006"     "320615"    "70028"     "13518"    
##  [55] "13649"     "13869"     "13866"     "13867"     "66366"     "14420"    
##  [61] "107338"    "11605"     "14683"     "14680"     "54214"     "56494"    
##  [67] "15893"     "16004"     "16561"     "16560"     "16668"     "16784"    
##  [73] "70361"     "235416"    "17113"     "26413"     "26417"     "67074"    
##  [79] "108124"    "17957"     "108123"    "320634"    "16330"     "18484"    
##  [85] "19063"     "68365"     "19334"     "106572"    "59021"     "76338"    
##  [91] "271457"    "56382"     "67830"     "110651"    "20111"     "67071"    
##  [97] "20112"     "107767"    "24045"     "69938"     "20333"     "69608"    
## [103] "218811"    "69162"     "208449"    "20404"     "20405"     "20408"    
## [109] "20619"     "67804"     "20655"     "16651"     "20844"     "100226"   
## [115] "228960"    "53331"     "68581"     "100042773" "56334"     "100862175"
## [121] "72736"     "71943"     "21985"     "22088"     "216350"    "56041"    
## [127] "22319"     "53330"     "20955"     "22365"     "20479"     "116733"   
## [133] "77929"     "56418"     "26951"    
## 
## $HALLMARK_INTERFERON_ALPHA_RESPONSE
##   [1] "56417"     "12010"     "74481"     "69550"     "317677"    "50908"    
##   [7] "12362"     "12370"     "54199"     "16423"     "16149"     "22169"    
##  [13] "74157"     "12799"     "12977"     "15945"     "56066"     "234311"   
##  [19] "80861"     "19106"     "13709"     "108670"    "14469"     "14468"    
##  [25] "229900"    "55932"     "236573"    "76074"     "100702"    "634650"   
##  [31] "626578"    "17472"     "66355"     "229003"    "67138"     "73998"    
##  [37] "15013"     "15040"     "14972"     "14990"     "15006"     "14964"    
##  [43] "14991"     "15007"     "15018"     "630294"    "14963"     "14985"    
##  [49] "110696"    "333715"    "224753"    "224754"    "399549"    "667977"   
##  [55] "100529082" "240095"    "15015"     "110557"    "15043"     "15039"    
##  [61] "224761"    "14997"     "224756"    "15024"     "14980"     "15019"    
##  [67] "110558"    "52668"     "217845"    "76933"     "65972"     "70110"    
##  [73] "99899"     "15061"     "71586"     "15958"     "15959"     "667370"   
##  [79] "68713"     "66141"     "74482"     "80876"     "213002"    "69147"    
##  [85] "73835"     "16168"     "16190"     "16196"     "16362"     "16363"    
##  [91] "54123"     "16391"     "100038882" "57444"     "68048"     "229504"   
##  [97] "239739"    "66988"     "19039"     "67168"     "17069"     "17454"    
## [103] "73711"     "17858"     "17857"     "211329"    "170719"    "64685"    
## [109] "53312"     "23960"     "246730"    "243262"    "100535"    "114643"   
## [115] "246729"    "231699"    "23961"     "231655"    "23962"     "72075"    
## [121] "243771"    "547253"    "80285"     "22038"     "18828"     "78459"    
## [127] "71701"     "19124"     "19167"     "16913"     "16912"     "19186"    
## [133] "19188"     "621823"    "192656"    "268749"    "58185"     "67775"    
## [139] "209086"    "20343"     "246696"    "109032"    "434484"    "20684"    
## [145] "624083"    "101056250" "102638047" "102633783" "100041057" "671917"   
## [151] "546061"    "677525"    "20847"     "21354"     "100121"    "212943"   
## [157] "74645"     "68487"     "231712"    "74735"     "20821"     "217069"   
## [163] "67606"     "22670"     "224762"    "667823"    "319236"    "94088"    
## [169] "209387"    "20128"     "76681"     "94094"     "434218"    "434219"   
## [175] "56338"     "74153"     "22201"     "56791"     "24110"     "22375"    
## 
## $HALLMARK_INTERFERON_GAMMA_RESPONSE
##   [1] "56417"     "71939"     "71371"     "11861"     "319974"    "12010"    
##   [7] "242248"    "74481"     "12183"     "69550"     "12226"     "194735"   
##  [13] "436199"    "12227"     "667277"    "50909"     "66686"     "317677"   
##  [19] "50908"     "12362"     "12367"     "12363"     "12369"     "12370"    
##  [25] "20293"     "20296"     "20292"     "20306"     "20304"     "60533"    
##  [31] "12494"     "12182"     "21939"     "12515"     "16149"     "12524"    
##  [37] "12575"     "14962"     "12628"     "214403"    "545366"    "12265"    
##  [43] "14747"     "22169"     "74157"     "12984"     "12983"     "16190"    
##  [49] "15945"     "56066"     "17329"     "230073"    "234311"    "80861"    
##  [55] "19106"     "66892"     "108670"    "14102"     "79201"     "14129"    
##  [61] "14190"     "14293"     "14289"     "14294"     "14291"     "14290"    
##  [67] "321020"    "55932"     "229900"    "236573"    "76074"     "100702"   
##  [73] "634650"    "626578"    "17472"     "14528"     "110168"    "14938"    
##  [79] "229003"    "67138"     "73998"     "15251"     "13819"     "15006"    
##  [85] "15013"     "14972"     "15040"     "14990"     "15007"     "15018"    
##  [91] "14964"     "14991"     "14963"     "15015"     "110557"    "630294"   
##  [97] "667977"    "240095"    "15043"     "14985"     "110696"    "333715"   
## [103] "224753"    "224754"    "399549"    "100529082" "15039"     "224756"   
## [109] "15024"     "224761"    "14997"     "69717"     "14980"     "15019"    
## [115] "110558"    "14998"     "14960"     "381091"    "14969"     "15894"    
## [121] "15898"     "15930"     "52668"     "217845"    "76933"     "65972"    
## [127] "70110"     "99899"     "15061"     "71586"     "667373"    "112419"   
## [133] "15957"     "15958"     "15959"     "667370"    "80876"     "66141"    
## [139] "68713"     "74482"     "213002"    "69147"     "73835"     "15976"    
## [145] "16154"     "16168"     "16169"     "16068"     "16185"     "16193"    
## [151] "16196"     "16362"     "16363"     "16364"     "27056"     "54123"    
## [157] "15900"     "16391"     "100038882" "57444"     "68048"     "229504"   
## [163] "66307"     "16421"     "16412"     "16414"     "16452"     "54721"    
## [169] "16451"     "27007"     "381816"    "66988"     "50523"     "16798"    
## [175] "16822"     "19039"     "17069"     "70082"     "72925"     "71664"    
## [181] "70152"     "380975"    "668178"    "554292"    "17750"     "17748"    
## [187] "17768"     "78388"     "17858"     "17857"     "17874"     "59027"    
## [193] "17979"     "17978"     "18033"     "18034"     "18035"     "434341"   
## [199] "64685"     "107607"    "71805"     "246728"    "246727"    "231655"   
## [205] "23962"     "72075"     "140795"    "243771"    "547253"    "18578"    
## [211] "238871"    "110385"    "18577"     "67245"     "93834"     "56421"    
## [217] "18641"     "18642"     "18712"     "223775"    "18783"     "22038"    
## [223] "18828"     "78459"     "18854"     "667034"    "18950"     "71701"    
## [229] "19166"     "19167"     "19171"     "26445"     "16913"     "16912"    
## [235] "19186"     "19188"     "621823"    "19225"     "19224"     "19246"    
## [241] "19255"     "15170"     "192786"    "76089"     "24105"     "19766"    
## [247] "192656"    "672511"    "268749"    "58185"     "67775"     "209086"   
## [253] "56045"     "209588"    "58210"     "20344"     "12258"     "75345"    
## [259] "246696"    "12703"     "12702"     "20656"     "109032"    "434484"   
## [265] "20684"     "624083"    "101056250" "102638047" "102633783" "100041057"
## [271] "671917"    "546061"    "677525"    "66552"     "237958"    "73218"    
## [277] "109552"    "16651"     "20454"     "20452"     "20846"     "20848"    
## [283] "20849"     "20847"     "21354"     "21356"     "100121"    "21928"    
## [289] "21929"     "21930"     "22035"     "30934"     "30931"     "231712"   
## [295] "74735"     "20821"     "217069"    "67606"     "22670"     "224762"   
## [301] "56338"     "56791"     "22271"     "76654"     "24110"     "53620"    
## [307] "22320"     "22329"     "22375"     "327959"    "16963"     "58203"    
## [313] "98999"    
## 
## $HALLMARK_APICAL_JUNCTION
##   [1] "11459"     "11468"     "11464"     "11475"     "238880"    "11461"    
##   [7] "11465"     "109711"    "60595"     "11474"     "11472"     "11490"    
##  [13] "23792"     "11488"     "11502"     "23794"     "11504"     "30806"    
##  [19] "235130"    "11548"     "11550"     "11652"     "23797"     "11688"    
##  [25] "11686"     "23801"     "11689"     "11705"     "229715"    "105827"   
##  [31] "73341"     "54126"     "76709"     "232975"    "27222"     "192113"   
##  [37] "11928"     "98660"     "11944"     "14595"     "108100"    "12153"    
##  [43] "21892"     "24087"     "239857"    "57278"     "94332"     "12308"    
##  [49] "12331"     "69165"     "170779"    "170780"    "170786"    "170776"   
##  [55] "69142"     "70192"     "60533"     "102657"    "12490"     "12524"    
##  [61] "673094"    "12550"     "12560"     "12561"     "12552"     "12564"    
##  [67] "12565"     "12563"     "320873"    "215654"    "104010"    "23836"    
##  [73] "239096"    "241201"    "12555"     "227485"    "264064"    "78334"    
##  [79] "386463"    "99151"     "234407"    "269132"    "18417"     "56173"    
##  [85] "60363"     "56492"     "242653"    "12740"     "57255"     "12739"    
##  [91] "12741"     "54419"     "53624"     "54420"     "239931"    "56863"    
##  [97] "12798"     "12805"     "21367"     "269784"    "53870"     "244682"   
## [103] "18488"     "107581"    "12829"     "12828"     "53867"     "71355"    
## [109] "94216"     "373864"    "12824"     "12825"     "12826"     "12827"    
## [115] "12830"     "12831"     "12832"     "12836"     "12842"     "12843"    
## [121] "12821"     "12839"     "12840"     "12841"     "12908"     "12647"    
## [127] "224912"    "12385"     "12388"     "20312"     "69192"     "13204"    
## [133] "217207"    "64340"     "13383"     "23859"     "13385"     "53310"    
## [139] "13406"     "13505"     "13507"     "13506"     "13649"     "13869"    
## [145] "13866"     "13867"     "13822"     "269587"    "14026"     "20336"    
## [151] "14118"     "14119"     "68794"     "286940"    "192176"    "14086"    
## [157] "238021"    "23880"     "14431"     "14677"     "14678"     "14679"    
## [163] "14786"     "98053"     "15107"     "15461"     "15894"     "15898"    
## [169] "15896"     "78369"     "16151"     "16332"     "16331"     "231070"   
## [175] "16367"     "384783"    "16369"     "213119"    "319480"    "109700"   
## [181] "16398"     "16400"     "104099"    "16412"     "192897"    "83964"    
## [187] "16480"     "12387"     "16511"     "170738"    "192775"    "16660"    
## [193] "16671"     "71888"     "16672"     "16774"     "16780"     "16782"    
## [199] "226519"    "244864"    "100017"    "65970"     "17123"     "65964"    
## [205] "26412"     "225028"    "26411"     "399510"    "19094"     "26416"    
## [211] "26415"     "29857"     "17242"     "17390"     "17395"     "56217"    
## [217] "68481"     "14012"     "17698"     "19684"     "22350"     "192156"   
## [223] "77579"     "71960"     "17880"     "17886"     "17883"     "17882"    
## [229] "17879"     "17885"     "17884"     "544791"    "140781"    "668940"   
## [235] "17888"     "67938"     "67268"     "98932"     "58235"     "19294"    
## [241] "52118"     "58998"     "71740"     "320840"    "268890"    "68810"    
## [247] "18015"     "18016"     "269116"    "216856"    "192167"    "245537"   
## [253] "18175"     "17996"     "18188"     "18190"     "18191"     "18189"    
## [259] "93737"     "58220"     "57342"     "170736"    "18515"     "18516"    
## [265] "18514"     "75599"     "211712"    "54216"     "245578"    "170761"   
## [271] "18613"     "18643"     "18645"     "74769"     "18707"     "18706"    
## [277] "18710"     "18763"     "18803"     "234779"    "269643"    "52432"    
## [283] "71978"     "72930"     "19211"     "14083"     "19264"     "19354"    
## [289] "170758"    "218397"    "23912"     "20130"     "20163"     "20970"    
## [295] "20392"     "20416"     "110380"    "19261"     "668101"    "100038947"
## [301] "320832"    "381484"    "751864"    "54353"     "22784"     "20563"    
## [307] "20564"     "20562"     "20410"     "11790"     "20779"     "20909"    
## [313] "20963"     "22637"     "68188"     "381921"    "216965"    "330177"   
## [319] "21810"     "21827"     "21828"     "12845"     "21825"     "21838"    
## [325] "21843"     "21841"     "21872"     "21873"     "27375"     "242409"   
## [331] "18383"     "22029"     "56191"     "64930"     "64540"     "109246"   
## [337] "103733"    "103768"    "22323"     "22325"     "57257"     "22324"    
## [343] "22329"     "13003"     "22330"     "22371"     "17833"     "17831"    
## [349] "73178"     "22376"     "69847"     "22629"     "22628"     "22793"    
## 
## $HALLMARK_APICAL_SURFACE
##  [1] "11487"  "68465"  "226250" "432442" "11820"  "140494" "11975"  "21871" 
##  [9] "27060"  "54670"  "67331"  "14595"  "12189"  "54215"  "230872" "16328" 
## [17] "11630"  "20312"  "73379"  "13640"  "13846"  "13835"  "13840"  "13842" 
## [25] "270190" "13848"  "13841"  "13836"  "13838"  "13844"  "13837"  "13839" 
## [33] "13845"  "14252"  "14451"  "14462"  "14461"  "58991"  "14866"  "14864" 
## [41] "14867"  "68312"  "14862"  "14863"  "14865"  "15507"  "16185"  "16186" 
## [49] "17096"  "72434"  "17153"  "74762"  "320772" "56406"  "80883"  "171171"
## [57] "100102" "241035" "192190" "18793"  "56315"  "58176"  "237847" "269295"
## [65] "64706"  "268935" "56788"  "110380" "20521"  "20528"  "20525"  "142681"
## [73] "51795"  "72043"  "21838"  "242409"
## 
## $HALLMARK_HEDGEHOG_SIGNALING
##  [1] "11423"  "14766"  "27494"  "12569"  "12571"  "12614"  "53883"  "12804" 
##  [9] "12933"  "22240"  "12934"  "26757"  "23872"  "14632"  "15213"  "15214" 
## [17] "16728"  "269116" "12661"  "16825"  "17886"  "17880"  "17883"  "17882" 
## [25] "17879"  "17885"  "17884"  "544791" "71960"  "77579"  "140781" "668940"
## [33] "17888"  "18015"  "18096"  "14912"  "74561"  "319504" "18186"  "18187" 
## [41] "94190"  "18815"  "18854"  "19206"  "19207"  "218397" "104001" "20254" 
## [49] "20423"  "13363"  "16147"  "20562"  "20563"  "20564"  "21838"  "21885" 
## [57] "21888"  "21887"  "22253"  "107448" "107449" "22339"  "22359"  "16835" 
## 
## $HALLMARK_COMPLEMENT
##   [1] "11472"     "60595"     "109711"    "11474"     "11502"     "11552"    
##   [7] "56697"     "11727"     "11731"     "219033"    "503844"    "630952"   
##  [13] "11730"     "11747"     "11808"     "66809"     "80287"     "11812"    
##  [19] "11927"     "268936"    "223770"    "78783"     "12259"     "12262"    
##  [25] "667277"    "50909"     "66686"     "317677"    "50908"     "12263"    
##  [31] "12266"     "12268"     "15139"     "12279"     "230558"    "12274"    
##  [37] "109828"    "110382"    "12349"     "12313"     "12315"     "12314"    
##  [43] "12362"     "12367"     "12363"     "12369"     "12371"     "208650"   
##  [49] "20304"     "12491"     "21947"     "17221"     "13136"     "13137"    
##  [55] "333883"    "12509"     "72269"     "12554"     "12569"     "12608"    
##  [61] "14962"     "12628"     "214403"    "545366"    "12759"     "12827"    
##  [67] "107581"    "53867"     "71355"     "94216"     "373864"    "12824"    
##  [73] "12825"     "12826"     "12830"     "12831"     "12832"     "12836"    
##  [79] "12842"     "12843"     "12829"     "12828"     "12870"     "15203"    
##  [85] "70574"     "54381"     "12946"     "64817"     "12902"     "13007"    
##  [91] "13030"     "13032"     "13033"     "13036"     "13039"     "26898"    
##  [97] "56092"     "56094"     "56835"     "58518"     "70202"     "214639"   
## [103] "64139"     "104002"    "117066"    "218275"    "229445"    "13040"    
## [109] "13038"     "14825"     "20310"     "330122"    "20309"     "110197"   
## [115] "13139"     "380921"    "227333"    "210293"    "75974"     "238130"   
## [121] "208869"    "105445"    "13482"     "14089"     "240672"    "67603"    
## [127] "235584"    "69181"     "226419"    "13660"     "57440"     "98878"    
## [133] "259300"    "14058"     "14071"     "14061"     "14066"     "14067"    
## [139] "14068"     "14069"     "14127"     "14134"     "14133"     "14148"    
## [145] "14268"     "14360"     "22612"     "14191"     "20779"     "14462"    
## [151] "14461"     "227960"    "63985"     "63986"     "14678"     "14677"    
## [157] "14679"     "14693"     "14696"     "14688"     "14702"     "14710"    
## [163] "14723"     "54368"     "14571"     "14784"     "71520"     "14938"    
## [169] "14939"     "14940"     "14942"     "14944"     "14943"     "14941"    
## [175] "245839"    "17231"     "14945"     "15378"     "170638"    "26950"    
## [181] "193740"    "15511"     "15481"     "15482"     "14828"     "15512"    
## [187] "16193"     "16362"     "16363"     "54123"     "16409"     "381924"   
## [193] "16411"     "16424"     "16426"     "16452"     "54721"     "16451"    
## [199] "80906"     "56461"     "16563"     "73470"     "73804"     "16612"    
## [205] "16624"     "16619"     "16615"     "16623"     "16622"     "16617"    
## [211] "16616"     "16613"     "13646"     "13648"     "18048"     "18050"    
## [217] "16618"     "13647"     "16621"     "109821"    "70789"     "320858"   
## [223] "16784"     "66988"     "16818"     "17096"     "15162"     "16822"    
## [229] "16854"     "19141"     "16889"     "16971"     "16973"     "16974"    
## [235] "94217"     "228357"    "14725"     "16993"     "17002"     "71775"    
## [241] "22041"     "17133"     "17436"     "109264"    "107029"    "17381"    
## [247] "17386"     "17387"     "17388"     "17389"     "17391"     "17394"    
## [253] "83995"     "83996"     "27361"     "17751"     "18132"     "18128"    
## [259] "18129"     "18131"     "108078"    "381816"    "26875"     "100102"   
## [265] "18591"     "381511"    "18643"     "18645"     "18675"     "18706"    
## [271] "18707"     "74769"     "30955"     "320207"    "18712"     "223775"   
## [277] "18783"     "27226"     "18791"     "18793"     "56193"     "18815"    
## [283] "22038"     "18828"     "78459"     "19053"     "19052"     "56420"    
## [289] "67857"     "72461"     "72843"     "19072"     "18753"     "18761"    
## [295] "22074"     "114228"    "103964"    "22073"     "22072"     "100040233"
## [301] "436523"    "436522"    "67373"     "386551"    "77613"     "214531"   
## [307] "19164"     "16912"     "98710"     "110157"    "11836"     "109880"   
## [313] "19419"     "240168"    "78287"     "19671"     "56212"     "19822"    
## [319] "20196"     "20202"     "545541"    "20255"     "20704"     "20703"    
## [325] "20701"     "20700"     "20702"     "68348"     "194604"    "18788"    
## [331] "11905"     "18787"     "12258"     "16923"     "50721"     "94214"    
## [337] "20909"     "21789"     "21857"     "21858"     "71753"     "21929"    
## [343] "59025"     "14479"     "236733"    "22258"     "74112"     "84092"    
## [349] "70675"     "22376"     "73178"     "170750"    "21417"     "24136"    
## [355] "22762"    
## 
## $HALLMARK_UNFOLDED_PROTEIN_RESPONSE
##   [1] "56454"     "228998"    "27053"     "11910"     "11911"     "226641"   
##   [7] "11972"     "29810"     "23825"     "12317"     "20293"     "20296"    
##  [13] "20292"     "20306"     "12608"     "12611"     "69065"     "54124"    
##  [19] "624855"    "72068"     "53621"     "104625"    "231464"    "211948"   
##  [25] "74322"     "75901"     "70640"     "13191"     "74747"     "77591"    
##  [31] "245474"    "58233"     "27362"     "100037258" "234699"    "192193"   
##  [37] "13629"     "20624"     "13666"     "13665"     "13681"     "13682"    
##  [43] "53975"     "192170"    "668137"    "434080"    "13684"     "218268"   
##  [49] "13685"     "13688"     "208643"    "78943"     "26918"     "50527"    
##  [55] "66482"     "66583"     "50912"     "227715"    "109075"    "27998"    
##  [61] "50911"     "231997"    "233908"    "276919"    "56494"     "15270"    
##  [67] "319173"    "621893"    "319176"    "319191"    "319162"    "232440"   
##  [73] "319171"    "15267"     "319192"    "319163"    "319164"    "319165"   
##  [79] "319166"    "319167"    "319168"    "319169"    "319170"    "665433"   
##  [85] "319172"    "64209"     "22027"     "15516"     "15519"     "14828"    
##  [91] "15481"     "15482"     "15512"     "193740"    "15526"     "12282"    
##  [97] "105148"    "667373"    "112419"    "15957"     "16006"     "102462"   
## [103] "105785"    "66913"     "68137"     "16549"     "16573"     "16582"    
## [109] "16572"     "16574"     "67207"     "50783"     "17768"     "72198"    
## [115] "109019"    "69917"     "18044"     "18045"     "52530"     "70769"    
## [121] "75416"     "67134"     "18148"     "218693"    "74108"     "72599"    
## [127] "71853"     "66161"     "50907"     "107272"    "20044"     "27966"    
## [133] "231452"    "56529"     "66286"     "69162"     "28146"     "72661"    
## [139] "20416"     "55963"     "69048"     "20539"     "69019"     "76687"    
## [145] "76219"     "76976"     "67398"     "20818"     "107513"    "20856"    
## [151] "110960"    "272396"    "71807"     "381801"    "52808"     "218343"   
## [157] "22151"     "227613"    "73710"     "22154"     "22153"     "22152"    
## [163] "545486"    "67951"     "22339"     "22393"     "52639"     "74781"    
## [169] "22433"     "73192"     "68090"     "77254"     "22631"     "22642"    
## 
## $HALLMARK_PI3K_AKT_MTOR_SIGNALING
##   [1] "107476"    "100705"    "66713"     "74117"     "242894"    "210044"   
##   [7] "104110"    "11513"     "11514"     "11512"     "11651"     "11652"    
##  [13] "23797"     "67605"     "11773"     "11840"     "11841"     "192662"   
##  [19] "56378"     "11908"     "100040260" "12912"     "12283"     "69008"    
##  [25] "12317"     "12326"     "12534"     "12566"     "12567"     "12575"    
##  [31] "12576"     "12631"     "12632"     "67300"     "13001"     "12767"    
##  [37] "26377"     "13198"     "72349"     "13555"     "26940"     "13649"    
##  [43] "13869"     "13866"     "13867"     "13684"     "218268"    "14103"    
##  [49] "14171"     "14172"     "14179"     "67112"     "14177"     "14675"    
##  [55] "14672"     "14682"     "14699"     "66066"     "14784"     "71520"    
##  [61] "110355"    "320129"    "56637"     "15461"     "22027"     "15516"    
##  [67] "15519"     "16186"     "16189"     "266632"    "16439"     "16438"    
##  [73] "16440"     "16818"     "17096"     "15162"     "26397"     "26399"    
##  [79] "26409"     "26413"     "26417"     "26414"     "26419"     "26420"    
##  [85] "227743"    "17346"     "17347"     "17874"     "17973"     "18036"    
##  [91] "18049"     "107607"    "70584"     "228026"    "18643"     "18645"    
##  [97] "18710"     "18711"     "23988"     "241593"    "18741"     "66350"    
## [103] "18795"     "18797"     "18798"     "18796"     "18803"     "234779"   
## [109] "19045"     "19047"     "434233"    "73699"     "51792"     "108079"   
## [115] "105787"    "19082"     "19087"     "19088"     "18751"     "18750"    
## [121] "18752"     "19211"     "19247"     "19353"     "110157"    "11836"    
## [127] "109880"    "64143"     "19766"     "19769"     "19762"     "20111"    
## [133] "20112"     "110651"    "67071"     "74370"     "55948"     "20491"    
## [139] "20525"     "20528"     "20527"     "17126"     "17127"     "18412"    
## [145] "20847"     "56480"     "56489"     "75778"     "21844"     "24001"    
## [151] "21937"     "22030"     "228775"    "22084"     "66105"     "73318"    
## [157] "56550"     "381534"    "93765"     "57257"     "22324"     "22325"    
## [163] "54401"    
## 
## $HALLMARK_MTORC1_SIGNALING
##   [1] "27407"     "107476"    "100705"    "104112"    "74205"     "50790"    
##   [7] "66713"     "74117"     "242894"    "27360"     "11518"     "11519"    
##  [13] "68465"     "11639"     "56248"     "11674"     "79459"     "353204"   
##  [19] "74192"     "27053"     "11938"     "11937"     "11951"     "228033"   
##  [25] "73834"     "20878"     "12035"     "20893"     "12227"     "436199"   
##  [31] "194735"    "12226"     "12235"     "12301"     "12317"     "12330"    
##  [37] "12745"     "12449"     "12450"     "12466"     "12467"     "12527"    
##  [43] "12530"     "12575"     "18636"     "26754"     "12721"     "23789"    
##  [49] "23790"     "107869"    "13032"     "12767"     "66427"     "13121"    
##  [55] "26377"     "13198"     "74747"     "68278"     "53817"     "74754"    
##  [61] "13360"     "13361"     "13595"     "192193"    "66143"     "112407"   
##  [67] "67204"     "100040220" "68801"     "54326"     "170439"    "13806"    
##  [73] "433182"    "13807"     "13808"     "107508"    "50527"     "225363"   
##  [79] "76267"     "60527"     "56473"     "228151"    "14149"     "14190"    
##  [85] "14227"     "14381"     "14380"     "14433"     "100039229" "100042427"
##  [91] "100042025" "622339"    "74185"     "14629"     "74105"     "11605"    
##  [97] "93692"     "229363"    "14718"     "14751"     "56637"     "14782"    
## [103] "14884"     "15277"     "216019"    "212032"    "15275"     "15288"    
## [109] "15357"     "208715"    "15360"     "15452"     "22027"     "15516"    
## [115] "15519"     "15525"     "14828"     "15481"     "15482"     "15512"    
## [121] "193740"    "15526"     "15510"     "15528"     "628438"    "15926"    
## [127] "269951"    "319554"    "65972"     "15982"     "15983"     "16011"    
## [133] "16009"     "76614"     "231070"    "16414"     "16415"     "16412"    
## [139] "16421"     "16828"     "16835"     "22359"     "19141"     "16993"    
## [145] "17113"     "26397"     "26399"     "17216"     "17217"     "17436"    
## [151] "109264"    "107029"    "56772"     "17768"     "665563"    "59027"    
## [157] "18030"     "18036"     "18046"     "63913"     "18107"     "18108"    
## [163] "27275"     "70699"     "56312"     "18451"     "18452"     "231887"   
## [169] "228026"    "18641"     "18655"     "18663"     "72157"     "226041"   
## [175] "236539"    "18710"     "56305"     "18738"     "18817"     "26432"    
## [181] "26433"     "18822"     "66249"     "667034"    "18950"     "67486"    
## [187] "67895"     "268373"    "269569"    "17872"     "18477"     "21672"    
## [193] "107272"    "19167"     "26441"     "19173"     "19181"     "23996"    
## [199] "67089"     "66997"     "23997"     "59029"     "19192"     "56088"    
## [205] "100678"    "110391"    "19324"     "17252"     "19769"     "19762"    
## [211] "68275"     "103963"    "20135"     "382985"    "27966"     "235293"   
## [217] "20250"     "20249"     "30049"     "329065"    "64136"     "56529"    
## [223] "66286"     "28146"     "72661"     "12406"     "108037"    "20425"    
## [229] "54353"     "20491"     "55963"     "20514"     "20525"     "20528"    
## [235] "20527"     "14385"     "21366"     "26570"     "20539"     "26941"    
## [241] "65962"     "20322"     "20775"     "18412"     "78925"     "94224"    
## [247] "107513"    "170459"    "20855"     "20867"     "83671"     "56480"    
## [253] "56489"     "21399"     "21400"     "21753"     "236749"    "245376"   
## [259] "22042"     "73166"     "69071"     "53333"     "21991"     "228775"   
## [265] "22145"     "22143"     "22144"     "22147"     "22146"     "22142"    
## [271] "53857"     "238463"    "103733"    "103768"    "50493"     "232223"   
## [277] "66105"     "73318"     "56550"     "381534"    "56207"     "67890"    
## [283] "22256"     "56041"     "22375"     "22433"     "56418"    
## 
## $HALLMARK_E2F_TARGETS
##   [1] "11637"     "66471"     "68981"     "66403"     "66929"     "70472"    
##   [7] "20878"     "20877"     "20871"     "12021"     "11799"     "12189"    
##  [13] "12190"     "52592"     "12236"     "12419"     "12442"     "12447"    
##  [19] "101565"    "107995"    "12530"     "12531"     "14793"     "52276"    
##  [25] "12534"     "12567"     "12575"     "12576"     "12578"     "12579"    
##  [31] "12580"     "72391"     "229841"    "66570"     "12649"     "50883"    
##  [37] "12704"     "329977"    "54124"     "624855"    "66197"     "58184"    
##  [43] "110750"    "13018"     "51797"     "55936"     "13178"     "140917"   
##  [49] "66422"     "68278"     "53817"     "110052"    "76131"     "56419"    
##  [55] "54004"     "218977"    "13433"     "60364"     "28080"     "72107"    
##  [61] "110074"    "108961"    "13626"     "13665"     "105988"    "69639"    
##  [67] "14056"     "14055"     "69270"     "78833"     "109145"    "14852"    
##  [73] "14853"     "15270"     "319173"    "621893"    "319176"    "319191"   
##  [79] "319162"    "232440"    "319171"    "15267"     "319192"    "319163"   
##  [85] "319164"    "319165"    "319166"    "319167"    "319168"    "319169"   
##  [91] "319170"    "665433"    "319172"    "51788"     "77605"     "15201"    
##  [97] "15361"     "111241"    "15364"     "97165"     "15354"     "619829"   
## [103] "15366"     "71653"     "11991"     "15574"     "210554"    "16201"    
## [109] "20744"     "71777"     "233726"    "320727"    "15374"     "70218"    
## [115] "110033"    "73804"     "16563"     "16571"     "16647"     "100043906"
## [121] "98386"     "16881"     "16906"     "16907"     "16905"     "67684"    
## [127] "17089"     "56150"     "17216"     "17215"     "17217"     "17218"    
## [133] "17219"     "17220"     "17279"     "17345"     "17350"     "212377"   
## [139] "17535"     "17685"     "17768"     "17121"     "17865"     "17864"    
## [145] "17869"     "107771"    "78304"     "53605"     "50927"     "27354"    
## [151] "68298"     "18102"     "70769"     "67134"     "68219"     "103468"   
## [157] "218210"    "70699"     "18393"     "56452"     "18813"     "67054"    
## [163] "103135"    "18538"     "18540"     "100710"    "71521"     "68479"    
## [169] "18817"     "20873"     "18861"     "18949"     "18969"     "18971"    
## [175] "18972"     "67967"     "18973"     "66979"     "74097"     "53892"    
## [181] "100336"    "53381"     "19076"     "19090"     "19139"     "328099"   
## [187] "75456"     "110639"    "101739"    "19183"     "30939"     "26934"    
## [193] "19355"     "19357"     "19360"     "19362"     "114714"    "19384"    
## [199] "19428"     "75471"     "19385"     "245688"    "19646"     "19687"    
## [205] "19718"     "69263"     "69724"     "68275"     "19891"     "68240"    
## [211] "20135"     "382985"    "20425"     "108037"    "20492"     "24061"    
## [217] "140557"    "13006"     "70099"     "67241"     "20638"     "20646"    
## [223] "54141"     "67629"     "66442"     "110809"    "20382"     "245492"   
## [229] "20833"     "20842"     "20843"     "50878"     "16765"     "20937"    
## [235] "56403"     "74326"     "21335"     "21379"     "106795"    "22042"    
## [241] "21853"     "66131"     "21877"     "21917"     "21973"     "22059"    
## [247] "20462"     "69716"     "22154"     "22152"     "545486"    "22153"    
## [253] "22151"     "67951"     "227613"    "73710"     "103733"    "103768"   
## [259] "77891"     "67196"     "66622"     "22256"     "230484"    "106618"   
## [265] "22390"     "103573"    "14375"     "26951"    
## 
## $HALLMARK_MYC_TARGETS_V1
##   [1] "24015"     "11431"     "231872"    "11777"     "11792"     "12237"    
##   [7] "12261"     "69719"     "227231"    "12330"     "12745"     "12417"    
##  [13] "12428"     "12461"     "12462"     "12464"     "12465"     "12468"    
##  [19] "107995"    "12544"     "12566"     "12567"     "12729"     "12785"    
##  [25] "75064"     "26754"     "12858"     "108062"    "83410"     "51797"    
##  [31] "55936"     "26965"     "66445"     "66942"     "56200"     "94213"    
##  [37] "110052"    "13204"     "217207"    "69192"     "110074"    "55949"    
##  [43] "66235"     "13664"     "666806"    "544881"    "435337"    "100861908"
##  [49] "266459"    "627873"    "100039042" "100039076" "100039129" "100039162"
##  [55] "666862"    "100503047" "100039226" "544883"    "100039052" "100042776"
##  [61] "100861898" "13665"     "67204"     "100040220" "27979"     "55944"    
##  [67] "78655"     "100042807" "13681"     "13682"     "53975"     "13684"    
##  [73] "218268"    "13690"     "22384"     "107508"    "13877"     "100042777"
##  [79] "225363"    "66446"     "218236"    "14113"     "237730"    "27041"    
##  [85] "109801"    "30877"     "14719"     "14852"     "14853"     "51788"    
##  [91] "77605"     "15182"     "69692"     "15191"     "15192"     "15382"    
##  [97] "229279"    "545091"    "53379"     "627828"    "668559"    "15381"    
## [103] "11991"     "74326"     "51810"     "15452"     "15516"     "15519"    
## [109] "22027"     "15510"     "15528"     "628438"    "105148"    "15982"    
## [115] "15983"     "67781"     "23918"     "23917"     "100042069" "85305"    
## [121] "16647"     "100043906" "16211"     "16828"     "27756"     "66094"    
## [127] "56150"     "17216"     "17217"     "17218"     "17219"     "17220"    
## [133] "19935"     "78523"     "66973"     "17869"     "107771"    "53605"    
## [139] "433702"    "68092"     "70316"     "102634451" "52530"     "18102"    
## [145] "70769"     "28126"     "67134"     "18148"     "18263"     "18393"    
## [151] "18813"     "18458"     "18459"     "67543"     "381404"    "230721"   
## [157] "23983"     "18538"     "18540"     "18655"     "18663"     "18673"    
## [163] "237880"    "12034"     "18972"     "59001"     "268373"    "269569"   
## [169] "14208"     "11757"     "53381"     "68988"     "110639"    "75456"    
## [175] "328099"    "19139"     "26440"     "19166"     "26441"     "26443"    
## [181] "26444"     "73677"     "26445"     "26446"     "240289"    "23996"    
## [187] "67089"     "70247"     "59029"     "22123"     "17463"     "57296"    
## [193] "56351"     "100043508" "103136"    "14694"     "19359"     "19384"    
## [199] "19428"     "75471"     "19385"     "106344"    "19826"     "67115"    
## [205] "19899"     "19934"     "68436"     "623174"    "619547"    "100043876"
## [211] "19988"     "432502"    "11837"     "667618"    "67097"     "16898"    
## [217] "27050"     "20103"     "20104"     "105244208" "20133"     "27966"    
## [223] "66409"     "20174"     "66870"     "56086"     "67465"     "101943"   
## [229] "18674"     "20588"     "68094"     "53607"     "20639"     "68981"    
## [235] "20641"     "107686"    "67332"     "68011"     "666609"    "20810"    
## [241] "20815"     "20817"     "110809"    "20382"     "245492"    "20383"    
## [247] "100502754" "225027"    "20823"     "381760"    "99138"     "56403"    
## [253] "230908"    "21454"     "21781"     "28185"     "20462"     "21849"    
## [259] "233870"    "100041265" "27366"     "22171"     "108121"    "233073"   
## [265] "50995"     "22194"     "218793"    "22195"     "100042355" "230484"   
## [271] "22327"     "22333"     "22335"     "103573"    "73192"     "14375"    
## [277] "22627"     "22630"     "102634437"
## 
## $HALLMARK_MYC_TARGETS_V2
##  [1] "231872" "53414"  "12417"  "12567"  "66422"  "66942"  "13537"  "27998" 
##  [9] "66590"  "30877"  "101612" "15277"  "216019" "212032" "15275"  "15510" 
## [17] "15528"  "628438" "27993"  "75751"  "76130"  "53608"  "17217"  "17218" 
## [25] "67973"  "69902"  "668455" "434693" "18432"  "17869"  "107771" "68493" 
## [33] "66164"  "100608" "70769"  "28126"  "110109" "67134"  "18148"  "18813" 
## [41] "64934"  "18673"  "237880" "18817"  "20873"  "235036" "226169" "71974" 
## [49] "56361"  "227746" "59028"  "107094" "27966"  "20509"  "116914" "13340" 
## [57] "20322"  "20810"  "338359" "21379"  "21453"  "15278"  "69071"  "22256" 
## [65] "70683"  "72515"  "107071"
## 
## $HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION
##   [1] "320712"    "11475"     "11468"     "11459"     "11464"     "238880"   
##   [7] "11461"     "11489"     "11492"     "16790"     "11803"     "11839"    
##  [13] "70350"     "12064"     "12111"     "12153"     "21892"     "24087"    
##  [19] "54725"     "109624"    "12321"     "67252"     "12332"     "16007"    
##  [25] "14219"     "12505"     "333883"    "12509"     "12552"     "12564"    
##  [31] "12565"     "12563"     "320873"    "215654"    "104010"    "23836"    
##  [37] "239096"    "241201"    "12558"     "12550"     "12560"     "12561"    
##  [43] "227485"    "12814"     "12829"     "12828"     "107581"    "53867"    
##  [49] "71355"     "94216"     "373864"    "12824"     "12825"     "12826"    
##  [55] "12827"     "12830"     "12831"     "12832"     "12836"     "12842"    
##  [61] "12843"     "12816"     "12818"     "74320"     "12834"     "12833"    
##  [67] "12835"     "68553"     "245026"    "329941"    "12837"     "234407"   
##  [73] "269132"    "99151"     "12845"     "21828"     "21825"     "21827"    
##  [79] "12847"     "50797"     "12931"     "68588"     "14825"     "20310"    
##  [85] "330122"    "20309"     "20315"     "20311"     "13132"     "13179"    
##  [91] "13380"     "22240"     "12934"     "12933"     "26757"     "13518"    
##  [97] "13601"     "407800"    "13612"     "58859"     "23876"     "13717"    
## [103] "13732"     "13807"     "433182"    "13806"     "13808"     "14089"    
## [109] "13482"     "14102"     "79201"     "14114"     "14115"     "14118"    
## [115] "14119"     "218952"    "108101"    "241639"    "14173"     "192176"   
## [121] "286940"    "68794"     "14264"     "14268"     "14234"     "17300"    
## [127] "14314"     "83554"     "71665"     "14370"     "14367"     "13197"    
## [133] "23882"     "17873"     "14451"     "14579"     "14609"     "414089"   
## [139] "73690"     "69286"     "544736"    "14733"     "67305"     "23892"    
## [145] "56213"     "78558"     "15902"     "16008"     "16009"     "16011"    
## [151] "16010"     "16168"     "16193"     "16323"     "16324"     "16398"    
## [157] "213119"    "319480"    "109700"    "16402"     "241226"    "16399"    
## [163] "16410"     "16412"     "16416"     "16419"     "16420"     "16476"    
## [169] "16477"     "16478"     "16772"     "16773"     "16774"     "226519"   
## [175] "18208"     "18209"     "23928"     "16782"     "16852"     "16948"    
## [181] "16949"     "94352"     "16950"     "67573"     "100862072" "16971"    
## [187] "16973"     "16974"     "94217"     "228357"    "14725"     "74488"    
## [193] "17022"     "107528"    "17181"     "17182"     "17220"     "17294"    
## [199] "50530"     "17313"     "83995"     "83996"     "17394"     "17387"    
## [205] "17388"     "17389"     "17391"     "17390"     "17392"     "17384"    
## [211] "17701"     "17702"     "242050"    "98932"     "107589"    "18074"    
## [217] "18113"     "21743"     "18129"     "18128"     "18132"     "18131"    
## [223] "23959"     "235106"    "330908"    "18430"     "56401"     "210530"   
## [229] "18542"     "76477"     "18596"     "18595"     "30794"     "18645"    
## [235] "18643"     "18793"     "18822"     "26432"     "26433"     "65112"    
## [241] "18858"     "50706"     "19035"     "18933"     "20204"     "103964"   
## [247] "22074"     "22073"     "22072"     "100040233" "436523"    "436522"   
## [253] "114228"    "67373"     "386551"    "19227"     "19288"     "52118"    
## [259] "19294"     "104009"    "19736"     "11852"     "20229"     "20254"    
## [265] "20969"     "20971"     "18787"     "20720"     "12406"     "20377"    
## [271] "54612"     "20379"     "24051"     "24052"     "24053"     "244431"   
## [277] "102857"    "20563"     "20564"     "20562"     "20583"     "20649"    
## [283] "20650"     "20692"     "20745"     "72902"     "20750"     "21345"    
## [289] "21789"     "21803"     "21810"     "21814"     "21817"     "331046"   
## [295] "21826"     "21838"     "21857"     "21859"     "21923"     "21929"    
## [301] "18383"     "27279"     "22003"     "22004"     "326618"    "22329"    
## [307] "13003"     "22339"     "22341"     "22352"     "13346"     "19132"    
## [313] "215280"    "22418"     "22419"    
## 
## $HALLMARK_INFLAMMATORY_RESPONSE
##   [1] "11303"     "11304"     "27403"     "268379"    "74591"     "11305"    
##   [7] "11308"     "329165"    "11479"     "269275"    "21812"     "11480"    
##  [13] "11481"     "13733"     "11535"     "11541"     "11540"     "56436"    
##  [19] "100043022" "11622"     "23796"     "64008"     "11938"     "11937"    
##  [25] "67972"     "11941"     "320707"    "381290"    "235574"    "26362"    
##  [31] "17289"     "12061"     "24115"     "69550"     "12227"     "436199"   
##  [37] "194735"    "12226"     "12267"     "12273"     "319430"    "54598"    
##  [43] "12311"     "20295"     "20293"     "20296"     "20292"     "20306"    
##  [49] "20297"     "20299"     "56221"     "20304"     "12775"     "54199"    
##  [55] "12475"     "21939"     "12506"     "13136"     "13137"     "12515"    
##  [61] "21948"     "12521"     "12493"     "12575"     "54371"     "60322"    
##  [67] "23845"     "14747"     "12977"     "12985"     "12986"     "20312"    
##  [73] "15945"     "56066"     "20311"     "20309"     "17329"     "80901"    
##  [79] "13058"     "237038"    "73379"     "50498"     "13614"     "19106"    
##  [85] "13732"     "13874"     "14066"     "233079"    "14293"     "14289"    
##  [91] "14294"     "14291"     "14290"     "321020"    "14367"     "14370"    
##  [97] "54393"     "14528"     "14676"     "14679"     "14677"     "14678"    
## [103] "14723"     "14734"     "56696"     "321019"    "15117"     "15118"    
## [109] "15200"     "15251"     "13819"     "15451"     "15465"     "15894"    
## [115] "15898"     "78369"     "50723"     "230623"    "230613"    "329918"   
## [121] "68713"     "66141"     "74482"     "80876"     "213002"    "69147"    
## [127] "15975"     "15980"     "16153"     "16154"     "16160"     "16168"    
## [133] "16169"     "16173"     "16182"     "16174"     "16175"     "16176"    
## [139] "16177"     "16185"     "16190"     "16193"     "16197"     "16323"    
## [145] "16324"     "108960"    "16362"     "54123"     "16402"     "241226"   
## [151] "16399"     "16410"     "16416"     "320910"    "16491"     "16485"    
## [157] "16490"     "16492"     "16493"     "16494"     "16518"     "72413"    
## [163] "16561"     "16560"     "23849"     "239739"    "16818"     "17096"    
## [169] "15162"     "16822"     "16835"     "22359"     "16878"     "14745"    
## [175] "16992"     "17069"     "17167"     "54483"     "17287"     "17295"    
## [181] "19882"     "17387"     "17388"     "17389"     "17391"     "20288"    
## [187] "17119"     "17869"     "107771"    "59027"     "17986"     "18033"    
## [193] "18034"     "18035"     "216799"    "378425"    "195046"    "637515"   
## [199] "64685"     "14767"     "257632"    "104443"    "108078"    "381816"   
## [205] "18387"     "18413"     "18414"     "16880"     "18438"     "18439"    
## [211] "18442"     "57385"     "54216"     "18578"     "238871"    "110385"   
## [217] "18577"     "14726"     "320207"    "18793"     "50501"     "19164"    
## [223] "19204"     "19217"     "19219"     "19222"     "19267"     "19262"    
## [229] "52118"     "19294"     "110157"    "11836"     "109880"    "19419"    
## [235] "240168"    "19697"     "50778"     "19734"     "56212"     "192656"   
## [241] "218215"    "108089"    "19886"     "67775"     "380713"    "224024"   
## [247] "20266"     "20339"     "109815"    "20343"     "20354"     "18787"    
## [253] "74442"     "27218"     "18174"     "18173"     "20511"     "269346"   
## [259] "381417"    "434203"    "20529"     "20530"     "54403"     "20535"    
## [265] "59033"     "94229"     "232156"    "240215"    "218756"    "11987"    
## [271] "11989"     "11988"     "20698"     "109552"    "192187"    "192188"   
## [277] "21336"     "21338"     "21356"     "21857"     "21897"     "21899"    
## [283] "24088"     "142980"    "279572"    "21930"     "21938"     "21942"    
## [289] "22035"     "326623"    "21950"     "21983"     "22353"    
## 
## $HALLMARK_XENOBIOTIC_METABOLISM
##   [1] "12780"     "76408"     "17250"     "27421"     "20927"     "20928"    
##   [7] "244562"    "239273"    "26874"     "11666"     "66082"     "11429"    
##  [13] "11430"     "93732"     "80911"     "11431"     "11432"     "117147"   
##  [19] "233799"    "272428"    "233801"    "11522"     "26876"     "69117"    
##  [25] "100417514" "11529"     "11532"     "269378"    "11615"     "70861"    
##  [31] "77337"     "83702"     "116852"    "105349"    "105387"    "622402"   
##  [37] "27384"     "432720"    "11655"     "11669"     "72535"     "19378"    
##  [43] "26358"     "11668"     "56847"     "11670"     "56752"     "30924"    
##  [49] "11761"     "71724"     "71872"     "213043"    "22436"     "67489"    
##  [55] "11816"     "64008"     "11846"     "11847"     "59046"     "109900"   
##  [61] "71093"     "11938"     "11937"     "12927"     "12035"     "233016"   
##  [67] "68021"     "12349"     "12368"     "12359"     "12408"     "435489"   
##  [73] "20300"     "12491"     "72269"     "12583"     "104158"    "12623"    
##  [79] "234564"    "382044"    "13884"     "13897"     "75704"     "244595"   
##  [85] "14962"     "66054"     "338403"    "12846"     "791260"    "74114"    
##  [91] "12944"     "66289"     "100504232" "20219"     "246277"    "109672"   
##  [97] "76884"     "20430"     "13074"     "13076"     "13077"     "13082"    
## [103] "104086"    "72082"     "13097"     "13095"     "13096"     "13098"    
## [109] "69888"     "72303"     "107141"    "226105"    "433247"    "545288"   
## [115] "404195"    "13099"     "226143"    "100043108" "13106"     "74519"    
## [121] "13110"     "230459"    "13109"     "242546"    "100066"    "665095"   
## [127] "546837"    "224044"    "74134"     "64385"     "106648"    "631304"   
## [133] "72054"     "70101"     "170716"    "208285"    "677156"    "67880"    
## [139] "12409"     "51793"     "69219"     "13195"     "15186"     "13202"    
## [145] "330817"    "52585"     "66375"     "209183"    "51798"     "68801"    
## [151] "54326"     "13809"     "12499"     "13836"     "13846"     "13845"    
## [157] "13835"     "13840"     "13842"     "270190"    "13848"     "13841"    
## [163] "13838"     "13844"     "13837"     "13839"     "13849"     "13982"    
## [169] "66841"     "23872"     "14058"     "14071"     "109821"    "16621"    
## [175] "14080"     "14085"     "14102"     "79201"     "14114"     "14121"    
## [181] "14120"     "59083"     "14261"     "55990"     "14262"     "226565"   
## [187] "14377"     "14378"     "57436"     "14415"     "14417"     "14450"    
## [193] "14528"     "231103"    "14629"     "14538"     "14711"     "14782"    
## [199] "14854"     "14859"     "14857"     "100042314" "14858"     "100042295"
## [205] "14865"     "14864"     "14866"     "14867"     "68312"     "14862"    
## [211] "14863"     "14873"     "68214"     "14872"     "56794"     "55927"    
## [217] "54426"     "58992"     "15368"     "15378"     "15452"     "94175"    
## [223] "15483"     "15486"     "15902"     "15926"     "269951"    "16000"    
## [229] "16006"     "16010"     "16177"     "15900"     "16424"     "16426"    
## [235] "16427"     "16480"     "12387"     "85305"     "70789"     "16816"    
## [241] "192654"    "259301"    "74142"     "64898"     "14245"     "64899"    
## [247] "17155"     "17156"     "230815"    "17161"     "109731"    "223455"   
## [253] "17195"     "78038"     "50997"     "17750"     "17748"     "108156"   
## [259] "29811"     "18041"     "18081"     "18107"     "18108"     "18145"    
## [265] "237636"    "18104"     "18105"     "23972"     "23971"     "18563"    
## [271] "27273"     "56376"     "67399"     "18618"     "110208"    "53328"    
## [277] "70804"     "68943"     "18815"     "29858"     "18984"     "19015"    
## [283] "19128"     "19171"     "19215"     "64292"     "56351"     "100043508"
## [289] "67103"     "19286"     "209027"    "69051"     "110351"    "380711"   
## [295] "19662"     "19692"     "19693"     "67442"     "66397"     "12401"    
## [301] "18787"     "55942"     "108037"    "20425"     "20498"     "20499"    
## [307] "107723"    "20514"     "20517"     "20518"     "110172"    "108652"   
## [313] "242585"    "70484"     "71706"     "14411"     "14412"     "243616"   
## [319] "102857"    "21366"     "228608"    "20733"     "67437"     "234724"   
## [325] "56720"     "21808"     "225913"    "110213"    "65963"     "69071"    
## [331] "21937"     "22021"     "50500"     "22173"     "22235"     "103149"   
## [337] "22271"     "76654"     "22361"     "26464"     "22370"    
## 
## $HALLMARK_FATTY_ACID_METABOLISM
##   [1] "23923"     "235674"    "113868"    "52538"     "11363"     "11364"    
##   [7] "11409"     "11370"     "224530"    "110460"    "11429"     "171210"   
##  [13] "171281"    "26897"     "217698"    "217700"    "171282"    "170789"   
##  [19] "11430"     "14081"     "433256"    "216739"    "50790"     "20216"    
##  [25] "233799"    "272428"    "233801"    "68738"     "11522"     "26876"    
##  [31] "69117"     "100417514" "11529"     "11532"     "68465"     "11564"    
##  [37] "17025"     "11668"     "26358"     "19378"     "56847"     "72535"    
##  [43] "11669"     "11670"     "11671"     "56752"     "11674"     "79459"    
##  [49] "353204"    "11754"     "237940"    "11792"     "11832"     "11992"    
##  [55] "12040"     "109778"    "12167"     "12166"     "68021"     "12349"    
##  [61] "12351"     "12353"     "12408"     "435489"    "109857"    "381045"   
##  [67] "12479"     "12480"     "12491"     "12613"     "12683"     "14311"    
##  [73] "12892"     "12894"     "12895"     "78070"     "12896"     "12908"    
##  [79] "12647"     "12972"     "13076"     "13077"     "666168"    "100040843"
##  [85] "13117"     "13118"     "13119"     "277753"    "435802"    "230639"   
##  [91] "13120"     "81906"     "98314"     "67460"     "74754"     "13382"    
##  [97] "78920"     "51798"     "93747"     "13177"     "23986"     "69123"    
## [103] "74147"     "68801"     "54326"     "13807"     "433182"    "13806"    
## [109] "13808"     "13849"     "67397"     "66841"     "14080"     "14079"    
## [115] "14104"     "14194"     "14261"     "55990"     "14373"     "57436"    
## [121] "14417"     "14415"     "14447"     "14433"     "270076"    "14645"    
## [127] "14555"     "14571"     "76238"     "14874"     "51788"     "77605"    
## [133] "15107"     "231086"    "56185"     "15159"     "227095"    "15356"    
## [139] "208982"    "208715"    "15360"     "15446"     "15108"     "114664"   
## [145] "243168"    "15488"     "15490"     "72479"     "15519"     "15516"    
## [151] "22027"     "15505"     "15525"     "15926"     "269951"    "170718"   
## [157] "15929"     "243996"    "319554"    "100328588" "14204"     "73988"    
## [163] "100470"    "21743"     "18113"     "67956"     "16828"     "16852"    
## [169] "17001"     "17161"     "109731"    "73724"     "17449"     "17448"    
## [175] "17436"     "109264"    "107029"    "75624"     "23945"     "17319"    
## [181] "56690"     "27354"     "52683"     "18194"     "18207"     "18263"    
## [187] "66357"     "13180"     "72562"     "18597"     "18598"     "68263"    
## [193] "19013"     "11758"     "320769"    "19186"     "19270"     "19283"    
## [199] "19286"     "229877"    "17252"     "107605"    "103142"    "19683"    
## [205] "54150"     "216453"    "216454"    "27400"     "70335"     "13476"    
## [211] "67442"     "20194"     "66945"     "66052"     "66925"     "56442"    
## [217] "26943"     "20520"     "56517"     "30805"     "20603"     "671878"   
## [223] "20916"     "56451"     "20917"     "56720"     "68728"     "56791"    
## [229] "22235"     "22275"     "22276"     "22361"     "26464"     "213742"   
## [235] "22629"     "22628"    
## 
## $HALLMARK_OXIDATIVE_PHOSPHORYLATION
##   [1] "11306"     "235674"    "113868"    "52538"     "11364"     "66885"    
##   [7] "11370"     "110446"    "11429"     "69597"     "114896"    "26926"    
##  [13] "11655"     "104776"    "11931"     "11946"     "11947"     "11949"    
##  [19] "66043"     "67126"     "11951"     "228033"    "67942"     "11958"    
##  [25] "57423"     "27425"     "432491"    "11950"     "71679"     "240853"   
##  [31] "11957"     "28080"     "54411"     "114143"    "11984"     "11974"    
##  [37] "76252"     "66335"     "73834"     "11973"     "66144"     "66290"    
##  [43] "338375"    "108664"    "12028"     "12039"     "69772"     "12369"    
##  [49] "70383"     "69802"     "226139"    "12856"     "12857"     "12858"    
##  [55] "12859"     "100040340" "12861"     "110323"    "12864"     "102640946"
##  [61] "12866"     "20463"     "66142"     "78174"     "12867"     "100504157"
##  [67] "12868"     "12894"     "12895"     "78070"     "12974"     "71832"    
##  [73] "109672"    "109754"    "66445"     "13063"     "672195"    "670717"   
##  [79] "13067"     "67460"     "235339"    "13382"     "78920"     "51798"    
##  [85] "93747"     "13177"     "110842"    "110826"    "66841"     "14148"    
##  [91] "14194"     "14297"     "14661"     "14719"     "14751"     "625249"   
##  [97] "17713"     "97212"     "231086"    "15159"     "15108"     "15526"    
## [103] "64704"     "15926"     "269951"    "67834"     "170718"    "15929"    
## [109] "243996"    "76614"     "69046"     "432732"    "66383"     "16828"    
## [115] "16832"     "72416"     "109731"    "17161"     "17449"     "17448"    
## [121] "170731"    "67414"     "66447"     "55951"     "66419"     "27395"    
## [127] "94065"     "66223"     "67994"     "24030"     "66407"     "64655"    
## [133] "59054"     "211253"    "210009"    "53375"     "54405"     "17991"    
## [139] "66091"     "17992"     "68202"     "67130"     "66416"     "68375"    
## [145] "66108"     "70316"     "102634451" "102631912" "68198"     "66495"    
## [151] "68194"     "100041273" "100042503" "66046"     "230075"    "66916"    
## [157] "67264"     "66377"     "68197"     "227197"    "226646"    "68349"    
## [163] "17993"     "407785"    "623286"    "75406"     "225887"    "17995"    
## [169] "72900"     "18115"     "18105"     "18104"     "18242"     "18293"    
## [175] "239017"    "74143"     "69089"     "18597"     "18598"     "68263"    
## [181] "27402"     "27273"     "381511"    "12034"     "16922"     "66865"    
## [187] "69833"     "18984"     "11757"     "67442"     "59040"     "214952"   
## [193] "66945"     "67680"     "66052"     "66925"     "67863"     "78830"    
## [199] "50799"     "57279"     "18674"     "11739"     "11740"     "20916"    
## [205] "56451"     "338359"    "20930"     "27060"     "11975"     "21871"    
## [211] "140494"    "30059"     "30055"     "21854"     "66525"     "30057"    
## [217] "30056"     "223696"    "28185"     "66152"     "66594"     "67530"    
## [223] "22273"     "67003"     "66694"     "66576"     "100042918" "22272"    
## [229] "22333"     "22334"     "22335"    
## 
## $HALLMARK_GLYCOLYSIS
##   [1] "74104"  "11541"  "11540"  "77559"  "11603"  "56248"  "11639"  "58810" 
##   [9] "110695" "56752"  "11674"  "79459"  "353204" "230163" "208211" "11727" 
##  [17] "11731"  "219033" "503844" "630952" "11730"  "57875"  "52231"  "59046" 
##  [25] "11876"  "20878"  "117592" "76898"  "280645" "72727"  "72297"  "272411"
##  [33] "14595"  "53418"  "56375"  "218271" "12124"  "23827"  "58226"  "12291" 
##  [41] "239556" "12337"  "12368"  "12505"  "12534"  "12615"  "74241"  "100910"
##  [49] "76969"  "59031"  "54371"  "60322"  "26887"  "56773"  "17684"  "12739" 
##  [57] "12740"  "56863"  "76524"  "76332"  "12831"  "12829"  "12828"  "107581"
##  [65] "53867"  "71355"  "94216"  "373864" "12824"  "12825"  "12826"  "12827" 
##  [73] "12830"  "12832"  "12836"  "12842"  "12843"  "50797"  "107869" "12767" 
##  [81] "109672" "13179"  "74747"  "76131"  "13382"  "26757"  "12933"  "22240" 
##  [89] "12934"  "13506"  "13507"  "70601"  "13638"  "13649"  "13869"  "13866" 
##  [97] "13867"  "112407" "13710"  "13806"  "433182" "13807"  "13808"  "50527" 
## [105] "14042"  "14043"  "70186"  "14120"  "14121"  "14228"  "53618"  "14381" 
## [113] "14380"  "53897"  "74246"  "14635"  "69976"  "14447"  "14433"  "14629" 
## [121] "14583"  "14584"  "22122"  "93683"  "93692"  "69080"  "331026" "50798" 
## [129] "26384"  "67980"  "14718"  "14719"  "14733"  "14734"  "14735"  "23888" 
## [137] "84111"  "110006" "14936"  "232493" "23897"  "110611" "211208" "245598"
## [145] "15277"  "216019" "212032" "15275"  "15366"  "71653"  "26556"  "23908" 
## [153] "50786"  "50785"  "50787"  "14828"  "15481"  "15482"  "15512"  "193740"
## [161] "15926"  "269951" "15932"  "15937"  "16009"  "16011"  "16164"  "384783"
## [169] "16369"  "16367"  "57444"  "68048"  "229504" "105785" "66913"  "68137" 
## [177] "19348"  "16563"  "73470"  "73804"  "226413" "16591"  "83379"  "16828" 
## [185] "16833"  "76429"  "76987"  "16876"  "16870"  "17449"  "17448"  "17436" 
## [193] "109264" "107029" "23989"  "17289"  "26362"  "17295"  "19882"  "17319" 
## [201] "56727"  "110119" "17859"  "67311"  "627235" "50927"  "83398"  "64580" 
## [209] "17423"  "78330"  "78688"  "18194"  "23959"  "18451"  "18452"  "18484" 
## [217] "55982"  "18563"  "236900" "18639"  "18640"  "270198" "56421"  "18641" 
## [225] "18642"  "18648"  "56012"  "18655"  "18663"  "66171"  "66681"  "70974" 
## [233] "110094" "18679"  "18746"  "67451"  "18822"  "26432"  "26433"  "54128" 
## [241] "67005"  "68507"  "327814" "233977" "268373" "269569" "19053"  "19052" 
## [249] "19139"  "328099" "75456"  "110639" "23996"  "110078" "19309"  "110095"
## [257] "104009" "104458" "24105"  "66646"  "52187"  "54170"  "60406"  "50724" 
## [265] "20969"  "15529"  "20970"  "66052"  "80879"  "57274"  "27376"  "50799" 
## [273] "229782" "14385"  "20655"  "20682"  "20665"  "20681"  "245865" "57357" 
## [281] "20855"  "20856"  "16765"  "21351"  "21786"  "21802"  "21810"  "83553" 
## [289] "74419"  "21881"  "21983"  "21991"  "22021"  "22166"  "67402"  "216558"
## [297] "13003"  "22339"  "22359"  "16835"  "217119" "233781" "30046"  "109263"
## 
## $HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY
##  [1] "17250"     "76408"     "27421"     "27416"     "12780"     "20927"    
##  [7] "20928"     "224814"    "244562"    "239273"    "11927"     "12359"    
## [13] "12581"     "112406"    "13871"     "14159"     "14158"     "14325"    
## [19] "100862446" "434624"    "14337"     "14381"     "14380"     "14629"    
## [25] "14630"     "93692"     "69367"     "14778"     "75512"     "14780"    
## [31] "625249"    "14782"     "15242"     "15369"     "320495"    "16477"    
## [37] "16476"     "16478"     "68576"     "16985"     "17196"     "56615"    
## [43] "17523"     "13861"     "76113"     "110265"    "67130"     "68194"    
## [49] "100041273" "100042503" "226646"    "18104"     "18105"     "108737"   
## [55] "53416"     "54132"     "56421"     "18641"     "18642"     "18477"    
## [61] "21672"     "53381"     "11758"     "320769"    "19122"     "110854"   
## [67] "216161"    "224432"    "109815"    "20655"     "20656"     "76650"    
## [73] "59041"     "22166"     "67402"     "50493"     "232223"    "26462"    
## 
## $HALLMARK_P53_PATHWAY
##   [1] "268860"    "27416"     "244562"    "17250"     "12780"     "20927"    
##   [7] "20928"     "239273"    "105501"    "11479"     "269275"    "21812"    
##  [13] "11486"     "68048"     "57444"     "229504"    "11636"     "11688"    
##  [19] "11686"     "23801"     "11689"     "68558"     "11783"     "11820"    
##  [25] "11910"     "108100"    "12018"     "12028"     "53619"     "12156"    
##  [31] "12226"     "194735"    "436199"    "12227"     "12362"     "12444"    
##  [37] "12443"     "12445"     "12450"     "12454"     "101565"    "12520"    
##  [43] "12521"     "12493"     "12554"     "12569"     "12575"     "12578"    
##  [49] "12579"     "70925"     "12606"     "68755"     "229933"    "12722"    
##  [55] "23844"     "80797"     "99663"     "99709"     "229927"    "67426"    
##  [61] "207785"    "13033"     "56464"     "76884"     "20430"     "67880"    
##  [67] "12409"     "107986"    "13198"     "74747"     "23853"     "13139"    
##  [73] "110197"    "217480"    "99480"     "71712"     "13663"     "230233"   
##  [79] "13836"     "13846"     "13845"     "13835"     "13840"     "13842"    
##  [85] "270190"    "13848"     "13841"     "13838"     "13844"     "13837"    
##  [91] "13839"     "13849"     "98845"     "22592"     "14062"     "70186"    
##  [97] "14102"     "79201"     "50754"     "14149"     "14168"     "14167"    
## [103] "14169"     "14281"     "56484"     "71665"     "13197"     "23882"    
## [109] "216456"    "14660"     "14667"     "14776"     "50708"     "14957"    
## [115] "56702"     "80838"     "50709"     "232440"    "15267"     "319192"   
## [121] "319163"    "319164"    "319165"    "319166"    "319167"    "319168"   
## [127] "319169"    "319170"    "665433"    "319172"    "319173"    "319176"   
## [133] "319191"    "319162"    "319171"    "15270"     "621893"    "15200"    
## [139] "15183"     "192231"    "15254"     "15368"     "15461"     "18415"    
## [145] "15937"     "15939"     "65972"     "16175"     "16324"     "16323"    
## [151] "76500"     "16970"     "16179"     "66383"     "192897"    "16450"    
## [157] "16449"     "16476"     "16477"     "16478"     "16554"     "16600"    
## [163] "16598"     "259277"    "16667"     "68239"     "16664"     "16666"    
## [169] "16832"     "16878"     "102626"    "17164"     "17246"     "17347"    
## [175] "17346"     "17119"     "17122"     "17988"     "18072"     "18081"    
## [181] "70930"     "18128"     "18129"     "214254"    "433241"    "56312"    
## [187] "71839"     "18538"     "18540"     "18590"     "64058"     "27280"    
## [193] "57913"     "71795"     "20620"     "12795"     "140570"    "18846"    
## [199] "18845"     "18844"     "235611"    "140571"    "67784"     "243743"   
## [205] "29858"     "80905"     "107939"    "53892"     "17872"     "19079"    
## [211] "15468"     "19124"     "19250"     "24000"     "19267"     "19262"    
## [217] "19296"     "224624"    "217371"    "14694"     "114714"    "19367"    
## [223] "19730"     "74012"     "19645"     "68098"     "67442"     "19734"    
## [229] "217344"    "13650"     "75234"     "30945"     "19899"     "54217"    
## [235] "626888"    "100043215" "100043718" "20042"     "100034727" "67941"    
## [241] "57294"     "100043813" "56437"     "101867"    "20181"     "20183"    
## [247] "20194"     "20198"     "268686"    "20229"     "20969"     "53421"    
## [253] "57743"     "20724"     "170742"    "140742"    "55948"     "116914"   
## [259] "20509"     "242585"    "70484"     "17254"     "26570"     "12703"    
## [265] "20683"     "20698"     "19143"     "68428"     "13830"     "229277"   
## [271] "21354"     "76281"     "99681"     "21452"     "21802"     "21803"    
## [277] "17112"     "67623"     "21950"     "21952"     "21953"     "21954"    
## [283] "22057"     "22059"     "22061"     "22062"     "21987"     "69786"    
## [289] "22032"     "231712"    "69076"     "228775"    "21807"     "52808"    
## [295] "56338"     "22271"     "76654"     "22320"     "22337"     "67776"    
## [301] "244810"    "59002"     "107568"    "16396"     "66894"     "22591"    
## [307] "235320"    "12192"     "22401"     "216049"   
## 
## $HALLMARK_UV_RESPONSE_UP
##   [1] "18671"     "18669"     "18670"     "27413"     "235674"    "113868"   
##   [7] "239528"    "236511"    "214150"    "11655"     "11674"     "79459"    
##  [13] "353204"    "11702"     "100041585" "232910"    "55938"     "11828"    
##  [19] "216869"    "109689"    "27053"     "11910"     "66335"     "66144"    
##  [25] "12018"     "12125"     "12122"     "12156"     "12215"     "12226"    
##  [31] "194735"    "436199"    "12227"     "12228"     "12349"     "12367"    
##  [37] "12424"     "12445"     "12443"     "12444"     "12447"     "216150"   
##  [43] "111266"    "67615"     "71702"     "668198"    "668213"    "668216"   
##  [49] "668209"    "102635357" "668205"    "668203"    "102635473" "12566"    
##  [55] "12577"     "12579"     "12583"     "12611"     "12660"     "110835"   
##  [61] "12724"     "12723"     "74325"     "12757"     "12799"     "12824"    
##  [67] "12829"     "12828"     "107581"    "53867"     "71355"     "94216"    
##  [73] "373864"    "12825"     "12826"     "12827"     "12830"     "12831"    
##  [79] "12832"     "12836"     "12842"     "12843"     "433375"    "13039"    
##  [85] "26898"     "56092"     "56094"     "56835"     "58518"     "70202"    
##  [91] "214639"    "64139"     "104002"    "117066"    "218275"    "14825"    
##  [97] "20310"     "330122"    "20309"     "66427"     "72017"     "13076"    
## [103] "13077"     "56200"     "94213"     "13350"     "13385"     "15502"    
## [109] "81489"     "13559"     "104394"    "26905"     "26908"     "217869"   
## [115] "13807"     "433182"    "13806"     "13808"     "17075"     "13849"    
## [121] "14156"     "14172"     "14171"     "14179"     "14228"     "14261"    
## [127] "55990"     "14281"     "14282"     "18550"     "18553"     "18551"    
## [133] "18552"     "14419"     "14528"     "14590"     "14660"     "216456"   
## [139] "14778"     "75512"     "14780"     "66168"     "17713"     "15270"    
## [145] "319173"    "621893"    "319176"    "319191"    "319162"    "232440"   
## [151] "319171"    "15267"     "319192"    "319163"    "319164"    "319165"   
## [157] "319166"    "319167"    "319168"    "319169"    "319170"    "665433"   
## [163] "319172"    "15013"     "15040"     "14972"     "14991"     "15006"    
## [169] "15007"     "15018"     "14964"     "14990"     "15015"     "630294"   
## [175] "110557"    "15039"     "100529082" "14963"     "240095"    "15043"    
## [181] "14985"     "110696"    "333715"    "224753"    "224754"    "399549"   
## [187] "667977"    "224756"    "15024"     "224761"    "14997"     "14980"    
## [193] "15019"     "110558"    "15368"     "51810"     "110920"    "15512"    
## [199] "15481"     "14828"     "15482"     "193740"    "15566"     "15587"    
## [205] "15894"     "15898"     "16008"     "16193"     "16195"     "16362"    
## [211] "16477"     "16476"     "16478"     "16511"     "170738"    "192775"   
## [217] "71765"     "16870"     "16876"     "17096"     "17161"     "109731"   
## [223] "60597"     "13728"     "232944"    "226778"    "17308"     "17387"    
## [229] "17388"     "17389"     "17391"     "19935"     "17701"     "17702"    
## [235] "17961"     "17960"     "17962"     "18035"     "18091"     "53324"    
## [241] "18164"     "73340"     "504193"    "15370"     "18213"     "18212"    
## [247] "18211"     "71844"     "53319"     "83454"     "170722"    "56177"    
## [253] "229759"    "15379"     "225631"    "246086"    "11546"     "11545"    
## [259] "231887"    "53318"     "227120"    "224860"    "59001"     "50776"    
## [265] "245841"    "231327"    "105675"    "66849"     "19063"     "18747"    
## [271] "18749"     "18753"     "18761"     "70767"     "19182"     "19266"    
## [277] "19268"     "19280"     "11891"     "80718"     "19419"     "240168"   
## [283] "19713"     "106344"    "11852"     "103963"    "56437"     "20182"    
## [289] "20364"     "20429"     "18391"     "11739"     "11740"     "14411"    
## [295] "14412"     "243616"    "102857"    "21366"     "20656"     "20751"    
## [301] "18412"     "59045"     "20867"     "59041"     "20887"     "53315"    
## [307] "57429"     "57430"     "215895"    "21338"     "21336"     "21354"    
## [313] "110960"    "272396"    "71807"     "99681"     "22042"     "73122"    
## [319] "110213"    "22117"     "246221"    "22145"     "22143"     "22144"    
## [325] "22147"     "22146"     "22142"     "53857"     "238463"    "22174"    
## [331] "26362"     "17289"     "22275"     "22404"     "56418"    
## 
## $HALLMARK_UV_RESPONSE_DN
##   [1] "17250"     "76408"     "27421"     "27416"     "12780"     "20927"    
##   [7] "20928"     "224814"    "244562"    "239273"    "11480"     "11481"    
##  [13] "27360"     "11518"     "11519"     "99633"     "330814"    "319387"   
##  [19] "11541"     "11540"     "66549"     "23797"     "11652"     "218038"   
##  [25] "12306"     "11746"     "11787"     "236915"    "219140"    "226970"   
##  [31] "67972"     "11941"     "320707"    "381290"    "235574"    "11990"    
##  [37] "226255"    "22589"     "20238"     "12040"     "12064"     "20893"    
##  [43] "12166"     "12286"     "12288"     "12290"     "54652"     "12289"    
##  [49] "12292"     "12287"     "67252"     "12389"     "16007"     "14219"    
##  [55] "226751"    "217866"    "240505"    "69562"     "69131"     "12576"    
##  [61] "57810"     "14007"     "13046"     "17684"     "12814"     "12829"    
##  [67] "12828"     "107581"    "53867"     "71355"     "94216"     "373864"   
##  [73] "12824"     "12825"     "12826"     "12827"     "12830"     "12831"    
##  [79] "12832"     "12836"     "12842"     "12843"     "74320"     "13132"    
##  [85] "13170"     "69219"     "51793"     "50768"     "243362"    "236920"   
##  [91] "13383"     "23859"     "13385"     "53310"     "68055"     "19252"    
##  [97] "319520"    "13548"     "216616"    "13866"     "13869"     "13649"    
## [103] "13867"     "14066"     "23876"     "58859"     "14200"     "14360"    
## [109] "22612"     "14191"     "20779"     "57265"     "14362"     "14369"    
## [115] "14537"     "14609"     "414089"    "14773"     "26385"     "14772"    
## [121] "15117"     "15118"     "15893"     "15901"     "16001"     "16011"    
## [127] "16009"     "234515"    "269180"    "231070"    "16367"     "384783"   
## [133] "16369"     "16416"     "545156"    "223435"    "16531"     "16532"    
## [139] "16590"     "12978"     "226519"    "18208"     "18209"     "23928"    
## [145] "16772"     "16782"     "16835"     "22359"     "14745"     "268977"   
## [151] "16997"     "50791"     "14924"     "17755"     "17754"     "23938"    
## [157] "26416"     "19094"     "17295"     "19882"     "23945"     "17314"    
## [163] "252875"    "17389"     "17387"     "17388"     "17391"     "57312"    
## [169] "17748"     "17750"     "116870"    "23942"     "116871"    "17869"    
## [175] "107771"    "59125"     "18028"     "18027"     "18029"     "18032"    
## [181] "18033"     "18034"     "71175"     "18129"     "18128"     "18132"    
## [187] "18131"     "353187"    "14815"     "18186"     "18187"     "18596"    
## [193] "18595"     "56376"     "67399"     "56273"     "213109"    "229615"   
## [199] "17344"     "56469"     "18707"     "74769"     "18706"     "18710"    
## [205] "18798"     "67916"     "18858"     "19016"     "110593"    "19088"    
## [211] "19087"     "18750"     "18751"     "18752"     "18754"     "18755"    
## [217] "19211"     "19220"     "24000"     "19250"     "19274"     "19281"    
## [223] "19272"     "19273"     "114713"    "19414"     "19663"     "71973"    
## [229] "19736"     "74194"     "12394"     "12399"     "12393"     "20181"    
## [235] "20183"     "106583"    "30953"     "100505386" "20273"     "20272"    
## [241] "20264"     "24046"     "20265"     "110876"    "20269"     "20271"    
## [247] "15529"     "18787"     "54650"     "217692"    "74206"     "244668"   
## [253] "18400"     "11987"     "11989"     "11988"     "17127"     "17126"    
## [259] "17131"     "17130"     "20583"     "20747"     "399676"    "212727"   
## [265] "207213"    "399674"    "399675"    "383977"    "229571"    "668359"   
## [271] "100043188" "399673"    "436563"    "668346"    "100042761" "109552"   
## [277] "64009"     "20975"     "104015"    "210106"    "21788"     "21813"    
## [283] "21814"     "21872"     "21873"     "27375"     "328108"    "22325"    
## [289] "57257"     "22324"     "207615"    "231386"    "328365"    "52915"    
## 
## $HALLMARK_ANGIOGENESIS
##  [1] "11818"  "11820"  "12444"  "12443"  "12445"  "12825"  "12829"  "12828" 
##  [9] "107581" "53867"  "71355"  "74320"  "94216"  "373864" "12824"  "12826" 
## [17] "12827"  "12830"  "12831"  "12832"  "12836"  "12842"  "12843"  "20311" 
## [25] "20309"  "14182"  "14183"  "14184"  "14186"  "14314"  "16410"  "241226"
## [33] "16402"  "16449"  "16450"  "16523"  "16956"  "16976"  "17022"  "17701" 
## [41] "17702"  "18186"  "18187"  "108078" "381816" "18590"  "56744"  "21946" 
## [49] "50706"  "19074"  "53856"  "14083"  "20198"  "268686" "268591" "24059" 
## [57] "20750"  "20855"  "21824"  "21857"  "94185"  "22325"  "57257"  "22324" 
## [65] "13003"  "22339"  "22370" 
## 
## $HALLMARK_HEME_METABOLISM
##   [1] "74104"     "26357"     "27405"     "13349"     "11433"     "216739"   
##   [7] "11518"     "27360"     "11519"     "72674"     "68262"     "28169"    
##  [13] "170812"    "17025"     "11656"     "107747"    "216188"    "104776"   
##  [19] "11733"     "11828"     "69632"     "213498"    "107566"    "27053"    
##  [25] "666468"    "102926"    "11975"     "21871"     "140494"    "27060"    
##  [31] "12013"     "57278"     "84004"     "109778"    "233016"    "140780"   
##  [37] "269774"    "12177"     "100043324" "12183"     "12215"     "12227"    
##  [43] "436199"    "194735"    "12226"     "12234"     "103583"    "12266"    
##  [49] "12268"     "15139"     "12346"     "12349"     "12380"     "12359"    
##  [55] "215814"    "12445"     "12443"     "12444"     "217232"    "12585"    
##  [61] "237988"    "66935"     "12725"     "12727"     "12892"     "83429"    
##  [67] "13030"     "13034"     "208846"    "242418"    "28199"     "114893"   
##  [73] "54339"     "102323"    "13829"     "242705"    "15467"     "192657"   
##  [79] "71946"     "269587"    "13822"     "13828"     "13857"     "27028"    
##  [85] "14055"     "78938"     "69754"     "71538"     "14151"     "63828"    
##  [91] "238024"    "60611"     "56484"     "14317"     "66691"     "14460"    
##  [97] "14629"     "14630"     "56209"     "73046"     "229363"    "14934"    
## [103] "71683"     "14958"     "97122"     "326619"    "319155"    "319159"   
## [109] "326620"    "319156"    "319157"    "69386"     "319158"    "319160"   
## [115] "100041230" "320332"    "319161"    "14651"     "68977"     "101488143"
## [121] "100503605" "436003"    "15135"     "15129"     "15130"     "544763"   
## [127] "216635"    "15122"     "110257"    "15126"     "15191"     "15192"    
## [133] "15199"     "15288"     "53415"     "64704"     "78369"     "78908"    
## [139] "69046"     "432732"    "18519"     "338523"    "23925"     "219094"   
## [145] "16596"     "16599"     "75753"     "16784"     "16909"     "64898"    
## [151] "14245"     "64899"     "65107"     "26397"     "26399"     "224703"   
## [157] "71779"     "17169"     "232944"    "105787"    "226778"    "13728"    
## [163] "67216"     "218121"    "52065"     "66447"     "17330"     "54484"    
## [169] "22652"     "68591"     "70380"     "17524"     "17859"     "17896"    
## [175] "67608"     "67563"     "27057"     "59125"     "18022"     "18023"    
## [181] "18115"     "14815"     "71207"     "58242"     "102954"    "71648"    
## [187] "74309"     "76303"     "18452"     "18451"     "18563"     "67182"    
## [193] "66171"     "233489"    "14755"     "19044"     "225849"    "26932"    
## [199] "21672"     "18477"     "67151"     "19358"     "74334"     "110351"   
## [205] "380711"    "56190"     "666794"    "83486"     "236732"    "59028"    
## [211] "19743"     "19746"     "66878"     "84585"     "30945"     "53378"    
## [217] "74136"     "665119"    "20342"     "20341"     "214597"    "320007"   
## [223] "214601"    "18174"     "18173"     "30805"     "20520"     "56517"    
## [229] "67712"     "208638"    "20525"     "20528"     "20527"     "22782"    
## [235] "226781"    "20533"     "20535"     "66943"     "102857"    "14664"    
## [241] "104245"    "26570"     "228608"    "20617"     "20739"     "20740"    
## [247] "20741"     "104015"    "20975"     "21349"     "21399"     "21400"    
## [253] "74645"     "212943"    "211586"    "22042"     "68875"     "330401"   
## [259] "56786"     "66241"     "213988"    "233833"    "217351"    "21961"    
## [265] "319939"    "21969"     "72960"     "70827"     "67095"     "19824"    
## [271] "69097"     "224762"    "216781"    "56224"     "74257"     "70026"    
## [277] "22173"     "98766"     "22228"     "22275"     "22276"     "14479"    
## [283] "236733"    "22258"     "22344"     "22439"     "65246"     "66011"    
## [289] "383295"   
## 
## $HALLMARK_COAGULATION
##   [1] "232345"    "17837"     "17836"     "104681"    "232400"    "11287"    
##   [7] "93732"     "11502"     "11727"     "11731"     "219033"    "503844"   
##  [13] "630952"    "11730"     "16952"     "11806"     "11812"     "11813"    
##  [19] "105886299" "11814"     "11843"     "11844"     "12153"     "21892"    
##  [25] "24087"     "12259"     "667277"    "50909"     "66686"     "317677"   
##  [31] "50908"     "12263"     "12266"     "12268"     "15139"     "230558"   
##  [37] "12279"     "12274"     "109828"    "110382"    "69379"     "12334"    
##  [43] "170725"    "12333"     "12335"     "268958"    "73647"     "12337"    
##  [49] "12371"     "12527"     "14962"     "11537"     "12628"     "214403"   
##  [55] "545366"    "12630"     "12759"     "12845"     "21828"     "21825"    
##  [61] "21827"     "56373"     "93721"     "54381"     "68337"     "114570"   
##  [67] "13007"     "13030"     "13034"     "13036"     "13038"     "13040"    
##  [73] "229445"    "13039"     "26898"     "56092"     "56094"     "56835"    
##  [79] "58518"     "70202"     "214639"    "64139"     "104002"    "117066"   
##  [85] "218275"    "13190"     "13482"     "14089"     "56405"     "67603"    
##  [91] "235584"    "14058"     "14071"     "109821"    "16621"     "58992"    
##  [97] "54426"     "14060"     "14061"     "14064"     "14066"     "14069"    
## [103] "14118"     "14119"     "14161"     "99571"     "14268"     "18550"    
## [109] "18553"     "18551"     "18552"     "14360"     "22612"     "14191"    
## [115] "20779"     "14544"     "14693"     "14696"     "14688"     "14701"    
## [121] "14723"     "54368"     "227753"    "20259"     "11567"     "22349"    
## [127] "15360"     "15378"     "15451"     "94175"     "56213"     "78558"    
## [133] "66383"     "16398"     "213119"    "319480"    "109700"    "16416"    
## [139] "16424"     "16426"     "93691"     "259277"    "16784"     "320202"   
## [145] "13590"     "19141"     "16971"     "16973"     "16974"     "94217"    
## [151] "228357"    "14725"     "16993"     "17133"     "17175"     "230908"   
## [157] "17195"     "17287"     "83995"     "83996"     "17394"     "17384"    
## [163] "17392"     "17385"     "17387"     "17388"     "17389"     "17391"    
## [169] "17390"     "17393"     "17395"     "76467"     "15235"     "108078"   
## [175] "381816"    "18441"     "18591"     "18613"     "67898"     "56744"    
## [181] "20309"     "18791"     "18792"     "56193"     "18815"     "19072"    
## [187] "19123"     "19128"     "66901"     "76453"     "98710"     "19353"    
## [193] "223864"    "56508"     "19733"     "20193"     "20196"     "20704"    
## [199] "20703"     "20701"     "20700"     "20702"     "68348"     "194604"   
## [205] "18788"     "11905"     "18787"     "12258"     "23921"     "64383"    
## [211] "20692"     "22041"     "71775"     "17002"     "21789"     "21824"    
## [217] "21857"     "21859"     "71753"     "236733"    "14479"     "22258"    
## [223] "22371"     "17833"     "17831"     "22388"    
## 
## $HALLMARK_IL2_STAT5_SIGNALING
##   [1] "18671"     "18669"     "18670"     "27413"     "11492"     "11596"    
##   [7] "269378"    "11615"     "66395"     "100041194" "11622"     "11658"    
##  [13] "17117"     "11746"     "11803"     "11861"     "53314"     "381319"   
##  [19] "12043"     "12048"     "20893"     "12156"     "12168"     "12349"    
##  [25] "12332"     "12335"     "268958"    "73647"     "170725"    "12333"    
##  [31] "12334"     "12367"     "12444"     "12443"     "12445"     "12447"    
##  [37] "12773"     "12505"     "12506"     "15985"     "12520"     "12522"    
##  [43] "12524"     "72729"     "57912"     "23834"     "109332"    "12577"    
##  [49] "12700"     "216197"    "12810"     "12833"     "12834"     "12977"    
##  [55] "12981"     "13011"     "12477"     "64138"     "15945"     "20430"    
##  [61] "76884"     "69305"     "19347"     "320560"    "20148"     "381738"   
##  [67] "13601"     "68043"     "13730"     "13808"     "18605"     "209558"   
##  [73] "13813"     "320204"    "18612"     "14064"     "14085"     "213056"   
##  [79] "14190"     "14256"     "18550"     "18553"     "18551"     "18552"    
##  [85] "57436"     "17873"     "319625"    "14460"     "55932"     "229900"   
##  [91] "236573"    "76074"     "100702"    "634650"    "626578"    "17472"    
##  [97] "384009"    "14744"     "14608"     "76206"     "245526"    "625249"   
## [103] "14873"     "68214"     "54195"     "15258"     "15257"     "15259"    
## [109] "15277"     "216019"    "212032"    "15275"     "74318"     "59026"    
## [115] "54167"     "66141"     "68713"     "80876"     "74482"     "213002"   
## [121] "69147"     "73835"     "15979"     "16001"     "16004"     "22779"    
## [127] "22781"     "16153"     "16154"     "16163"     "16182"     "16178"    
## [133] "17082"     "16184"     "16185"     "16188"     "12982"     "16190"    
## [139] "16364"     "54139"     "15900"     "16403"     "16407"     "16410"    
## [145] "241226"    "16402"     "209378"    "23849"     "225010"    "16878"    
## [151] "16206"     "269473"    "320398"    "100604"    "72267"     "231549"   
## [157] "433926"    "241296"    "16994"     "17133"     "26410"     "17760"    
## [163] "17164"     "102626"    "17829"     "17119"     "17869"     "107771"   
## [169] "17913"     "71602"     "17916"     "17979"     "17978"     "14299"    
## [175] "17988"     "18030"     "80859"     "110109"    "18186"     "18187"    
## [181] "23959"     "18263"     "18438"     "18439"     "18451"     "18452"    
## [187] "68079"     "18619"     "21664"     "68770"     "18712"     "223775"   
## [193] "22634"     "18810"     "13518"     "11426"     "11520"     "19012"    
## [199] "22038"     "18828"     "78459"     "667034"    "18950"     "18986"    
## [205] "54637"     "18755"     "18754"     "19122"     "19206"     "19207"    
## [211] "19217"     "19228"     "213527"    "217057"    "56361"     "29809"    
## [217] "227800"    "19734"     "11852"     "74734"     "107702"    "102635744"
## [223] "19883"     "52187"     "54170"     "20193"     "20274"     "110876"   
## [229] "20269"     "20271"     "20272"     "20273"     "20264"     "24046"    
## [235] "20265"     "20343"     "20344"     "20719"     "97848"     "20708"    
## [241] "238568"    "435350"    "11905"     "212531"    "50795"     "56726"    
## [247] "214547"    "20514"     "13340"     "20527"     "20525"     "67547"    
## [253] "57319"     "244962"    "66616"     "12703"     "216233"    "100043256"
## [259] "20750"     "114716"    "24066"     "20443"     "20947"     "20973"    
## [265] "229521"    "21817"     "331046"    "21844"     "24001"     "170743"   
## [271] "170744"    "279572"    "21936"     "21938"     "94185"     "22163"    
## [277] "21941"     "21942"     "22035"     "21943"     "22029"     "69863"    
## [283] "65960"     "80914"     "22245"     "22247"     "68151"     "22433"    
## 
## $HALLMARK_BILE_ACID_METABOLISM
##   [1] "11303"     "11304"     "27403"     "268379"    "74591"     "11305"    
##   [7] "27410"     "381072"    "67928"     "320631"    "233810"    "217265"   
##  [13] "76184"     "27404"     "217262"    "217258"    "11666"     "26874"    
##  [19] "19299"     "192663"    "67470"     "14081"     "433256"    "216739"   
##  [25] "11611"     "208665"    "11668"     "26358"     "19378"     "56847"    
##  [31] "72535"     "11669"     "237320"    "56752"     "17117"     "11806"    
##  [37] "64008"     "11835"     "20238"     "170442"    "29815"     "12161"    
##  [43] "12359"     "12642"     "74114"     "104086"    "56050"     "13116"    
##  [49] "13122"     "13123"     "13124"     "74754"     "13370"     "107585"   
##  [55] "13371"     "71877"     "13850"     "76267"     "60527"     "56473"    
##  [61] "228151"    "14149"     "14473"     "14630"     "14711"     "14712"    
##  [67] "76263"     "56794"     "15112"     "114664"    "243168"    "15488"    
##  [73] "27400"     "107605"    "19683"     "54150"     "103142"    "216453"   
##  [79] "216454"    "15494"     "15496"     "15497"     "15492"     "15493"    
##  [85] "15495"     "100043456" "100043461" "101502"    "15926"     "269951"   
##  [91] "319554"    "66307"     "16596"     "16818"     "17096"     "15162"    
##  [97] "16890"     "66887"     "56690"     "17999"     "18145"     "237636"   
## [103] "23957"     "20186"     "18171"     "110784"    "67993"     "71648"    
## [109] "212503"    "111175"    "71382"     "18631"     "69129"     "103737"   
## [115] "72129"     "18633"     "19298"     "74043"     "224824"    "18634"    
## [121] "18642"     "56421"     "18641"     "16922"     "19193"     "67452"    
## [127] "54683"     "19301"     "19659"     "67442"     "20181"     "20183"    
## [133] "20280"     "12401"     "18400"     "20522"     "54338"     "26458"    
## [139] "225579"    "26459"     "63959"     "73836"     "28250"     "28248"    
## [145] "28254"     "108096"    "625716"    "435927"    "28253"     "58807"    
## [151] "223920"    "20655"     "56362"     "54200"     "100043194" "76971"    
## [157] "638251"    "434121"    "629203"    "434264"    "629219"    "20859"    
## [163] "81879"     "22221"     "22139"    
## 
## $HALLMARK_PEROXISOME
##   [1] "18671"     "18669"     "18670"     "27413"     "56325"     "21355"    
##   [7] "27416"     "244562"    "17250"     "12780"     "20927"     "20928"    
##  [13] "239273"    "11666"     "26874"     "19299"     "235674"    "113868"   
##  [19] "170789"    "11430"     "14081"     "433256"    "216739"    "50790"    
##  [25] "11657"     "11668"     "26358"     "19378"     "56847"     "72535"    
##  [31] "11669"     "56752"     "20238"     "12042"     "12287"     "12286"    
##  [37] "12288"     "12290"     "54652"     "12289"     "12292"     "54725"    
##  [43] "12359"     "12572"     "12613"     "76524"     "26889"     "12785"    
##  [49] "75064"     "12903"     "12904"     "12908"     "12647"     "13016"    
##  [55] "13017"     "51797"     "55936"     "74754"     "20148"     "13370"    
##  [61] "107585"    "13385"     "51798"     "23986"     "69123"     "74147"    
##  [67] "68801"     "54326"     "13850"     "13870"     "70333"     "13872"    
##  [73] "13983"     "16204"     "76267"     "60527"     "56473"     "228151"   
##  [79] "110196"    "66437"     "14712"     "76263"     "56185"     "15356"    
##  [85] "208982"    "15461"     "15484"     "114664"    "243168"    "15488"    
##  [91] "101502"    "15492"     "15925"     "15926"     "269951"    "319554"   
##  [97] "66307"     "16413"     "66887"     "56690"     "17685"     "78388"    
## [103] "18171"     "110959"    "18458"     "18459"     "67543"     "381404"   
## [109] "230721"    "18631"     "18632"     "72129"     "56273"     "19302"    
## [115] "19305"     "224824"    "18477"     "21672"     "54683"     "17252"    
## [121] "67442"     "20183"     "20181"     "22287"     "20280"     "20348"    
## [127] "20346"     "20347"     "20349"     "108151"    "12401"     "20437"    
## [133] "20438"     "54338"     "20524"     "67283"     "11739"     "11740"    
## [139] "26458"     "225579"    "73836"     "20588"     "68094"     "20655"    
## [145] "20656"     "20905"     "54200"     "100043194" "76971"     "638251"   
## [151] "434121"    "629203"    "434264"    "629219"    "20859"     "21973"    
## [157] "12257"     "22139"     "71773"     "100559"    "100727"    "112417"   
## [163] "243085"    "231396"    "22238"     "72094"     "552899"    "20479"    
## [169] "116733"    "22629"     "22628"    
## 
## $HALLMARK_ALLOGRAFT_REJECTION
##   [1] "234734"    "24015"     "11308"     "329165"    "11423"     "11480"    
##   [7] "11481"     "11651"     "11652"     "23797"     "11785"     "12010"    
##  [13] "12035"     "12042"     "12051"     "12189"     "12263"     "12332"    
##  [19] "27220"     "20292"     "20306"     "20293"     "20296"     "24047"    
##  [25] "100040035" "100861618" "100039789" "100861647" "100039848" "100039053"
##  [31] "100043918" "100043921" "100039973" "20299"     "20303"     "20304"    
##  [37] "12444"     "12443"     "12445"     "12768"     "12770"     "12772"    
##  [43] "12774"     "12479"     "12480"     "12481"     "12503"     "12487"    
##  [49] "12500"     "12501"     "12502"     "12504"     "21939"     "21947"    
##  [55] "16423"     "12516"     "16149"     "12518"     "12519"     "12524"    
##  [61] "12525"     "12526"     "84544"     "12578"     "12579"     "18636"    
##  [67] "54698"     "12977"     "12988"     "13040"     "13038"     "55985"    
##  [73] "17329"     "12766"     "226414"    "13244"     "619326"    "70059"    
##  [79] "226419"    "69181"     "13649"     "13869"     "13866"     "13867"    
##  [85] "13669"     "55944"     "78655"     "100042807" "230861"    "208643"   
##  [91] "276770"    "50701"     "19152"     "56501"     "13874"     "23871"    
##  [97] "14061"     "14062"     "14102"     "79201"     "14103"     "14130"    
## [103] "14131"     "677296"    "14191"     "14360"     "20779"     "22612"    
## [109] "192176"    "286940"    "68794"     "23880"     "14423"     "271786"   
## [115] "14469"     "14468"     "229900"    "14537"     "170823"    "14744"    
## [121] "14938"     "14939"     "14940"     "14942"     "14944"     "14943"    
## [127] "14941"     "245839"    "17231"     "15163"     "79221"     "15184"    
## [133] "56233"     "208727"    "15251"     "13819"     "15006"     "15013"    
## [139] "14972"     "15040"     "14990"     "15007"     "15018"     "14964"    
## [145] "14991"     "14963"     "15015"     "110557"    "630294"    "667977"   
## [151] "240095"    "15043"     "14985"     "110696"    "333715"    "224753"   
## [157] "224754"    "399549"    "100529082" "15039"     "224756"    "15024"    
## [163] "224761"    "14997"     "69717"     "14980"     "15019"     "110558"   
## [169] "14998"     "15000"     "14999"     "15001"     "15002"     "14961"    
## [175] "14960"     "100504404" "667803"    "15894"     "15898"     "50723"    
## [181] "230623"    "230613"    "329918"    "15976"     "15978"     "15979"    
## [187] "15980"     "80719"     "16150"     "12675"     "16153"     "16156"    
## [193] "16159"     "16160"     "16161"     "16163"     "16168"     "16170"    
## [199] "16173"     "16174"     "16176"     "16183"     "50931"     "16184"    
## [205] "16185"     "16186"     "16189"     "16190"     "16193"     "16196"    
## [211] "16198"     "16323"     "16324"     "16364"     "54123"     "15900"    
## [217] "16408"     "16414"     "16415"     "16412"     "16421"     "16428"    
## [223] "21682"     "12229"     "16452"     "54721"     "16451"     "16643"    
## [229] "16678"     "16681"     "16687"     "16688"     "406220"    "110308"   
## [235] "16818"     "17096"     "15162"     "16822"     "16878"     "16994"    
## [241] "17076"     "17084"     "26409"     "26411"     "17195"     "17395"    
## [247] "94062"     "76784"     "17972"     "17973"     "17086"     "216799"   
## [253] "378425"    "195046"    "637515"    "18102"     "18126"     "18127"    
## [259] "18125"     "18148"     "56744"     "20309"     "18646"     "18751"    
## [265] "18750"     "18752"     "19171"     "15170"     "19264"     "104458"   
## [271] "192656"    "67248"     "68172"     "66211"     "27367"     "20005"    
## [277] "100042823" "194905"    "20085"     "20091"     "100043780" "76846"    
## [283] "54390"     "12703"     "56468"     "20375"     "19073"     "20452"    
## [289] "192187"    "192188"    "20846"     "20848"     "20849"     "21354"    
## [295] "21355"     "56325"     "21356"     "21803"     "21808"     "21838"    
## [301] "21857"     "21897"     "21899"     "24088"     "142980"    "279572"   
## [307] "21926"     "21985"     "22030"     "77647"     "216080"    "75097"    
## [313] "237009"    "93765"     "22375"     "22376"     "73178"     "22637"    
## [319] "20963"    
## 
## $HALLMARK_SPERMATOGENESIS
##   [1] "11421"     "54137"     "11451"     "11471"     "11470"     "21744"    
##   [7] "11495"     "11516"     "15463"     "11643"     "11642"     "11687"    
##  [13] "11685"     "11684"     "11861"     "109979"    "11872"     "20878"    
##  [19] "109880"    "11836"     "110157"    "12235"     "12326"     "12427"    
##  [25] "12442"     "12467"     "12466"     "12534"     "72391"     "12638"    
##  [31] "231600"    "12672"     "12745"     "12330"     "20480"     "74438"    
##  [37] "215890"    "12794"     "72978"     "12812"     "22024"     "11572"    
##  [43] "11571"     "13000"     "12995"     "13012"     "69294"     "27214"    
##  [49] "13176"     "18007"     "30959"     "13206"     "13404"     "50796"    
##  [55] "56691"     "71854"     "319446"    "13479"     "12686"     "14056"    
##  [61] "14055"     "14415"     "14417"     "14447"     "14433"     "14581"    
##  [67] "14582"     "23885"     "627264"    "434725"    "668964"    "668963"   
##  [73] "668960"    "668958"    "630022"    "100040482" "100040533" "100040606"
##  [79] "100040722" "100040732" "100040781" "100042168" "100042254" "100042275"
##  [85] "100861971" "100862067" "100862329" "11536"     "14823"     "268934"   
##  [91] "108073"    "14816"     "108069"    "108071"    "108072"    "14840"    
##  [97] "14866"     "14864"     "14867"     "68312"     "14862"     "14863"    
## [103] "14865"     "107970"    "15126"     "216635"    "544763"    "15122"    
## [109] "110257"    "15407"     "15429"     "15482"     "15481"     "193740"   
## [115] "14828"     "15512"     "15511"     "18415"     "15563"     "15564"    
## [121] "15925"     "21821"     "16162"     "16165"     "27399"     "83964"    
## [127] "73804"     "16563"     "16833"     "14245"     "64899"     "17761"    
## [133] "17776"     "56527"     "328329"    "17288"     "17349"     "17354"    
## [139] "246198"    "17773"     "244701"    "56717"     "97243"     "56292"    
## [145] "117903916" "215387"    "380684"    "18040"     "18005"     "18016"    
## [151] "18125"     "18126"     "18127"     "53885"     "18168"     "53814"    
## [157] "18285"     "69310"     "56522"     "18789"     "216578"    "11546"    
## [163] "11545"     "30052"     "18551"     "18550"     "18598"     "18597"    
## [169] "23980"     "76400"     "18663"     "18655"     "74451"     "71838"    
## [175] "68961"     "17344"     "18976"     "19087"     "19088"     "19119"    
## [181] "56088"     "19356"     "106344"    "68172"     "67248"     "20255"    
## [187] "20394"     "18952"     "214547"    "93759"     "20496"     "20495"    
## [193] "20497"     "56485"     "435818"    "20616"     "67946"     "56324"    
## [199] "20744"     "16201"     "20957"     "21351"     "21463"     "71841"    
## [205] "24084"     "21830"     "71868"     "83553"     "74419"     "21881"    
## [211] "21888"     "21887"     "21885"     "21954"     "21953"     "21952"    
## [217] "21958"     "21959"     "235559"    "22099"     "22115"     "22137"    
## [223] "22144"     "22147"     "22143"     "22146"     "22145"     "22142"    
## [229] "53857"     "238463"    "56734"     "22335"     "53422"     "72350"    
## [235] "75553"     "20834"     "53604"    
## 
## $HALLMARK_KRAS_SIGNALING_UP
##   [1] "18671"     "18669"     "18670"     "27413"     "11421"     "11491"    
##   [7] "11501"     "58860"     "13522"     "78560"     "70693"     "170757"   
##  [13] "83397"     "11652"     "23797"     "19378"     "26358"     "11668"    
##  [19] "56847"     "72535"     "11669"     "56068"     "225339"    "57875"    
##  [25] "11732"     "101772"    "243634"    "228432"    "26359"     "11815"    
##  [31] "11846"     "66795"     "78937"     "11796"     "11797"     "17951"    
##  [37] "17952"     "17940"     "17948"     "12156"     "12183"     "228662"   
##  [43] "12223"     "12267"     "12349"     "69008"     "12402"     "234309"   
##  [49] "30951"     "20297"     "12444"     "12443"     "12445"     "72972"    
##  [55] "12493"     "12521"     "71891"     "14962"     "12628"     "214403"   
##  [61] "545366"    "50702"     "12683"     "14311"     "73149"     "269799"   
##  [67] "26888"     "474145"    "69810"     "381809"    "17474"     "56620"    
##  [73] "14747"     "12876"     "74114"     "12981"     "12982"     "16188"    
##  [79] "13040"     "13038"     "15945"     "12767"     "73379"     "71972"    
##  [85] "94176"     "330662"    "68813"     "67603"     "235584"    "13730"    
##  [91] "13805"     "13823"     "13844"     "13845"     "270190"    "13846"    
##  [97] "13835"     "13840"     "13842"     "13848"     "13841"     "13836"    
## [103] "13838"     "13837"     "13839"     "13874"     "50527"     "23871"    
## [109] "14009"     "18612"     "104156"    "14020"     "213027"    "74145"    
## [115] "331046"    "14063"     "106052"    "14127"     "14180"     "80857"    
## [121] "80903"     "14257"     "14254"     "71665"     "14373"     "14396"    
## [127] "14394"     "14395"     "110886"    "23882"     "13197"     "14425"    
## [133] "207839"    "14584"     "93692"     "66066"     "14699"     "93695"    
## [139] "64297"     "70355"     "60596"     "71683"     "319178"    "319184"   
## [145] "319185"    "319186"    "319187"    "319188"    "319189"    "68024"    
## [151] "69389"     "78303"     "319179"    "319180"    "319181"    "319183"   
## [157] "15200"     "79221"     "15184"     "56233"     "208727"    "216019"   
## [163] "15277"     "212032"    "15275"     "15431"     "15483"     "15902"    
## [169] "16002"     "16009"     "16011"     "22778"     "16154"     "16176"    
## [175] "107527"    "16186"     "77125"     "16197"     "16323"     "16324"    
## [181] "15900"     "16398"     "213119"    "319480"    "109700"    "16414"    
## [187] "16415"     "16412"     "16421"     "223272"    "16480"     "12387"    
## [193] "16534"     "16574"     "16572"     "16573"     "16600"     "16598"    
## [199] "16792"     "56743"     "18826"     "102866"    "102502"    "16878"    
## [205] "17087"     "16658"     "17132"     "228576"    "26401"     "26411"    
## [211] "17761"     "67468"     "75104"     "17384"     "17392"     "17385"    
## [217] "17395"     "14012"     "233315"    "18109"     "17870"     "17954"    
## [223] "18049"     "18080"     "23957"     "20186"     "18186"     "18187"    
## [229] "18546"     "30052"     "58205"     "18613"     "18616"     "18703"    
## [235] "18791"     "18792"     "18793"     "27260"     "84094"     "57349"    
## [241] "20309"     "17872"     "12142"     "66390"     "225655"    "19092"    
## [247] "19091"     "18933"     "20204"     "16913"     "56195"     "68927"    
## [253] "19225"     "19224"     "19279"     "320139"    "29809"     "227800"   
## [259] "19653"     "66704"     "102902673" "19662"     "19699"     "57264"    
## [265] "57263"     "19734"     "20230"     "20255"     "20394"     "20266"    
## [271] "76816"     "20347"     "16625"     "20716"     "271047"    "20717"    
## [277] "238393"    "20714"     "20715"     "74069"     "628900"    "238395"   
## [283] "194604"    "20568"     "20614"     "20616"     "20682"     "20665"    
## [289] "20681"     "13602"     "233744"    "20750"     "24064"     "20440"    
## [295] "268980"    "94186"     "97387"     "21788"     "170744"    "170743"   
## [301] "67888"     "72309"     "66058"     "65963"     "21929"     "21938"    
## [307] "21956"     "21957"     "21955"     "240832"    "21990"     "22029"    
## [313] "211770"    "217410"    "66805"     "66109"     "21912"     "56496"    
## [319] "72088"     "22217"     "69727"     "67776"     "244810"    "74320"    
## [325] "22421"     "22422"     "230734"    "246196"    "67778"    
## 
## $HALLMARK_KRAS_SIGNALING_DN
##   [1] "27413"  "192663" "11464"  "11468"  "11459"  "11475"  "238880" "11461" 
##   [9] "11553"  "14187"  "67861"  "11997"  "11686"  "11688"  "23801"  "11689" 
##  [17] "11698"  "14570"  "74100"  "117589" "11944"  "27222"  "192113" "11928" 
##  [25] "98660"  "232975" "110935" "11966"  "12021"  "12167"  "12166"  "114642"
##  [33] "12227"  "436199" "194735" "12226"  "15139"  "12266"  "54652"  "12288" 
##  [41] "12290"  "12286"  "12289"  "12292"  "12299"  "116903" "12310"  "80796" 
##  [49] "494124" "227541" "52163"  "73647"  "12335"  "170725" "12333"  "12334" 
##  [57] "232821" "12427"  "12776"  "246278" "21947"  "12519"  "12556"  "68916" 
##  [65] "53883"  "12614"  "107934" "11449"  "54371"  "60322"  "12715"  "12709" 
##  [73] "114141" "54420"  "57255"  "239931" "109791" "232370" "64085"  "12804" 
##  [81] "12824"  "12829"  "12828"  "107581" "53867"  "71355"  "94216"  "373864"
##  [89] "12825"  "12826"  "12827"  "12830"  "12831"  "12832"  "12836"  "12842" 
##  [97] "12843"  "56358"  "56447"  "67426"  "232680" "71791"  "76703"  "208922"
## [105] "67579"  "231207" "110115" "13072"  "56050"  "13176"  "18007"  "106565"
## [113] "13528"  "13527"  "13608"  "13614"  "13615"  "98363"  "27984"  "13645" 
## [121] "93685"  "67464"  "13839"  "13837"  "13846"  "13845"  "13835"  "13840" 
## [129] "13842"  "270190" "13848"  "13841"  "13836"  "13838"  "13844"  "80903" 
## [137] "14180"  "80857"  "67112"  "14184"  "75578"  "14308"  "14431"  "14573" 
## [145] "14723"  "67133"  "22242"  "665186" "14760"  "14748"  "70355"  "64297" 
## [153] "14804"  "14803"  "70239"  "21405"  "15484"  "15551"  "15552"  "15932" 
## [161] "15061"  "99899"  "15978"  "16008"  "16160"  "16191"  "23919"  "16370" 
## [169] "16369"  "26549"  "16426"  "16424"  "16427"  "16425"  "16506"  "16508" 
## [177] "56543"  "246133" "16533"  "84036"  "140492" "140493" "16536"  "110862"
## [185] "213417" "23993"  "259277" "381022" "231051" "16678"  "16681"  "16687" 
## [193] "16688"  "406220" "110308" "16663"  "16665"  "16682"  "239673" "109052"
## [201] "77055"  "406223" "16848"  "17305"  "19719"  "16858"  "72434"  "404634"
## [209] "26914"  "54634"  "546071" "56527"  "328329" "17776"  "54483"  "98682" 
## [217] "17687"  "17769"  "17858"  "17857"  "140781" "17888"  "17910"  "58916" 
## [225] "72333"  "64242"  "18125"  "18126"  "18127"  "54631"  "19065"  "18227" 
## [233] "18124"  "14536"  "60345"  "18205"  "102954" "58242"  "71207"  "18429" 
## [241] "11998"  "18440"  "57385"  "18442"  "18505"  "18509"  "18506"  "93872" 
## [249] "93873"  "93874"  "93875"  "93876"  "93877"  "93878"  "93879"  "93880" 
## [257] "93881"  "93882"  "93883"  "93884"  "93885"  "93886"  "93887"  "93888" 
## [265] "93889"  "93890"  "93892"  "93893"  "18566"  "18587"  "110855" "225600"
## [273] "18604"  "18772"  "56711"  "18948"  "50873"  "19125"  "19127"  "19220" 
## [281] "19271"  "50782"  "67747"  "66611"  "58185"  "20190"  "20192"  "20191" 
## [289] "22287"  "20264"  "20272"  "20273"  "24046"  "20265"  "110876" "20269" 
## [297] "20271"  "20363"  "217847" "18788"  "20393"  "20429"  "320007" "214597"
## [305] "20482"  "20497"  "20496"  "20495"  "20503"  "66972"  "71279"  "22784" 
## [313] "76257"  "114479" "56774"  "13162"  "20538"  "66106"  "104069" "20621" 
## [321] "20665"  "20681"  "20682"  "56632"  "20766"  "20754"  "20753"  "20743" 
## [329] "20742"  "80297"  "20741"  "20608"  "50878"  "20843"  "20842"  "104027"
## [337] "57253"  "21415"  "21416"  "21432"  "23964"  "23965"  "23966"  "74645" 
## [345] "212943" "104271" "21419"  "21418"  "81879"  "22221"  "21785"  "21819" 
## [353] "21808"  "21816"  "331046" "232078" "21834"  "21908"  "21954"  "21953" 
## [361] "21952"  "22094"  "71773"  "100559" "100727" "112417" "243085" "231396"
## [369] "22238"  "72094"  "552899" "100647" "22363"  "22362"  "73288"  "93735" 
## [377] "53422"  "106369" "77864"  "235320" "72350"  "57745"  "22756"  "56525" 
## 
## $HALLMARK_PANCREAS_BETA_CELLS
##  [1] "20927"  "20928"  "17250"  "27416"  "244562" "239273" "23797"  "11652" 
##  [9] "12652"  "13193"  "13482"  "14089"  "77766"  "15376"  "56458"  "14378" 
## [17] "14377"  "14526"  "103988" "21405"  "15874"  "16334"  "16333"  "53626" 
## [25] "56856"  "16392"  "104360" "16909"  "16658"  "17132"  "18012"  "11925" 
## [33] "18088"  "18096"  "14912"  "74561"  "18481"  "18479"  "224105" "18506" 
## [41] "18508"  "18548"  "18549"  "18609"  "18770"  "214189" "56529"  "66286" 
## [49] "20526"  "69019"  "20813"  "27058"  "20818"  "20604"  "20910"  "20911" 
## [57] "80976"  "22337"

List to GeneSetCollection

We can convert the list to a GeneSetCollection to take advantage of GSEABase functionality.

We must first create a list of GeneSet objects using GeneSet() constructor and then create GeneSetCollection from list usin GeneSetCollection constructor.

myGeneSetList <- list()
for (i in 1:length(Mm.H)) {
    myGeneSetList[[i]] <- GeneSet(Mm.H[[i]], setName = names(Mm.H)[i])
}
myGeneSetCollection <- GeneSetCollection(myGeneSetList)
myGeneSetCollection
## GeneSetCollection
##   names: HALLMARK_TNFA_SIGNALING_VIA_NFKB, HALLMARK_HYPOXIA, ..., HALLMARK_PANCREAS_BETA_CELLS (50 total)
##   unique identifiers: 11303, 11304, ..., 80976 (5897 total)
##   types in collection:
##     geneIdType: NullIdentifier (1 total)
##     collectionType: NullCollection (1 total)

GeneSetCollection to gmt

We can now use the toGmt function to export our GeneSetCollection to gmt formated file for use in other software.

toGmt(myGeneSetCollection, con = "mouse_Hallmarks.gmt")

Testing gene set enrichment


Testing gene sets

We will review two different methods to identify functional groups associated with our condition of interest.

  • The first method will test for any association of our gene set with our a group of interesting genes (differentially expressed genes).
  • The second method will test for any association of our gene set with the ranking of all our genes (ranked by measure of differential expression).

DE results from DESeq2

First lets read in our differential expression results from DESeq2 analysis of activated vs resting T-cells.

Activated_minus_Resting <- read.delim(file = "data/Group_Activated_minus_Resting.csv", 
    sep = ",")
Activated_minus_Resting[1:3, ]
##    ENTREZID  SYMBOL baseMean log2FoldChange    lfcSE      stat   pvalue padj
## 1 100009600   Zglp1 3.685411      0.2755725 1.855514 0.1485154 0.881936   NA
## 2 100009609 Vmn2r65 0.000000             NA       NA        NA       NA   NA
## 3 100009614 Gm10024 0.000000             NA       NA        NA       NA   NA
##   newPadj
## 1       1
## 2      NA
## 3      NA

Background

All GSA methods will require us to filter to genes to those tested for differential expression.

We will therefore filter to all genes which pass our independent filtering step from DESeq2. These will be our genes with no NA in the DESeq2 padj column

Activated_minus_Resting <- Activated_minus_Resting[!is.na(Activated_minus_Resting$padj), 
    ]
Activated_minus_Resting[1:3, ]
##    ENTREZID  SYMBOL baseMean log2FoldChange      lfcSE        stat       pvalue
## 6    100017 Ldlrap1 2752.367    -0.04815446 0.08880811  -0.5422305 5.876598e-01
## 7    100019    Mdn1 2281.866    -1.09612289 0.09214164 -11.8960650 1.240603e-32
## 8 100033459  Ifi208 3282.679    -0.02774770 0.09029354  -0.3073055 7.586109e-01
##           padj      newPadj
## 6 7.416249e-01 1.000000e+00
## 7 7.038705e-31 2.424386e-28
## 8 8.601547e-01 1.000000e+00

goseq package

We can use the goseq package to identify any functional enrichment in a set of interesting genes (i.e. differentially expressed). The goseq package requires a named vector of 1s or 0s indicating whether a gene is upregulated/downregulated.

Here we define a set of genes significantly upregulated in Activated vs Naive T-reg cells (padj <0 05 and log2FC > 0).

UpInAct <- Activated_minus_Resting$padj < 0.05 & Activated_minus_Resting$log2FoldChange > 
    0
UpInAct <- as.integer(UpInAct)
names(UpInAct) <- Activated_minus_Resting$ENTREZID
UpInAct[1:4]
##    100017    100019 100033459 100034251 
##         0         0         0         0
table(UpInAct)
## UpInAct
##     0     1 
## 10883  2450

Gene ontology and functional testing.

We can see which genomes are supported using the supportedGenomes() function.

supGenomes <- supportedGenomes()
supGenomes[1:2, ]
##     db species      date                               name
## 2 hg19   Human Feb. 2009 Genome Reference Consortium GRCh37
## 3 hg18   Human Mar. 2006                    NCBI Build 36.1
##                                                                                                                  AvailableGeneIDs
## 2                                                    ccdsGene,ensGene,exoniphy,geneSymbol,knownGene,nscanGene,refGene,xenoRefGene
## 3 acembly,acescan,ccdsGene,ensGene,exoniphy,geneid,geneSymbol,genscan,knownGene,knownGeneOld3,refGene,sgpGene,sibGene,xenoRefGene

Gene length bias

The goseq package is specifically designed to account for potential length biases in differential expression analysis and so can remove any artefactual enrichment for long and short genes.

The nullp function assess any biases by evaluating the relationship between differential expression and length.

library(goseq)
pwf = nullp(UpInAct, "mm10", "knownGene", plot.fit = TRUE)

igv

Functional Enrichment analysis

Having corrected for any bias we can now use the goseq function to for enrichment of GO or KEGG terms.

We must specify the genome build and ID we are using (here matching our TxDb.UCSC.mm10.knownGene.db) and the categories we wish to test (GO:BP, GO:MF, GO:CC, KEGG).

Here we identify the top enriched functional terms in GO biological processes.

GO_UpInAct <- goseq(pwf, "mm10", "knownGene", test.cats = c("GO:BP"))
GO_UpInAct[1:3, ]
##        category over_represented_pvalue under_represented_pvalue numDEInCat
## 614  GO:0002376            7.149167e-40                        1        532
## 8129 GO:0050896            1.485855e-36                        1       1236
## 1787 GO:0006955            3.913461e-33                        1        330
##      numInCat                  term ontology
## 614      1706 immune system process       BP
## 8129     5113  response to stimulus       BP
## 1787      951       immune response       BP

Retrieving function groups

We can retrieve the genes in the immune response (GO:0006955) functional group using the select and the org.Mm.eg.db object.

library(org.Mm.eg.db)
ImmuneResponseGenes <- select(org.Mm.eg.db, keytype = "GOALL", keys = "GO:0006955", 
    columns = "ENTREZID")
ImmuneResponseGenes
##           GOALL EVIDENCEALL ONTOLOGYALL  ENTREZID
## 1    GO:0006955         IDA          BP     11350
## 2    GO:0006955         IGI          BP     11350
## 3    GO:0006955         IMP          BP     11350
## 4    GO:0006955         IDA          BP     11465
## 5    GO:0006955         IMP          BP     11486
## 6    GO:0006955         ISO          BP     11490
## 7    GO:0006955         IMP          BP     11491
## 8    GO:0006955         IDA          BP     11501
## 9    GO:0006955         IMP          BP     11513
## 10   GO:0006955         ISO          BP     11516
## 11   GO:0006955         IEA          BP     11537
## 12   GO:0006955         IMP          BP     11541
## 13   GO:0006955         IDA          BP     11542
## 14   GO:0006955         IMP          BP     11542
## 15   GO:0006955         ISO          BP     11596
## 16   GO:0006955         IDA          BP     11600
## 17   GO:0006955         IMP          BP     11628
## 18   GO:0006955         IBA          BP     11634
## 19   GO:0006955         IDA          BP     11634
## 20   GO:0006955         IMP          BP     11634
## 21   GO:0006955         IEA          BP     11658
## 22   GO:0006955         IMP          BP     11687
## 23   GO:0006955         ISO          BP     11692
## 24   GO:0006955         ISO          BP     11745
## 25   GO:0006955         ISO          BP     11765
## 26   GO:0006955         IMP          BP     11793
## 27   GO:0006955         IMP          BP     11801
## 28   GO:0006955         ISO          BP     11806
## 29   GO:0006955         ISO          BP     11807
## 30   GO:0006955         IMP          BP     11808
## 31   GO:0006955         ISO          BP     11808
## 32   GO:0006955         IMP          BP     11816
## 33   GO:0006955         ISO          BP     11820
## 34   GO:0006955         ISO          BP     11829
## 35   GO:0006955         IEA          BP     11846
## 36   GO:0006955         IMP          BP     11846
## 37   GO:0006955         ISO          BP     11846
## 38   GO:0006955         IEA          BP     11847
## 39   GO:0006955         IMP          BP     11847
## 40   GO:0006955         IMP          BP     11891
## 41   GO:0006955         IMP          BP     11977
## 42   GO:0006955         IBA          BP     12007
## 43   GO:0006955         IEA          BP     12010
## 44   GO:0006955         IMP          BP     12010
## 45   GO:0006955         ISO          BP     12010
## 46   GO:0006955         ISO          BP     12028
## 47   GO:0006955         IBA          BP     12042
## 48   GO:0006955         IMP          BP     12042
## 49   GO:0006955         ISO          BP     12042
## 50   GO:0006955         ISO          BP     12043
## 51   GO:0006955         IDA          BP     12047
## 52   GO:0006955         IMP          BP     12051
## 53   GO:0006955         IBA          BP     12053
## 54   GO:0006955         IGI          BP     12053
## 55   GO:0006955         IMP          BP     12053
## 56   GO:0006955         ISO          BP     12062
## 57   GO:0006955         IEA          BP     12142
## 58   GO:0006955         ISO          BP     12143
## 59   GO:0006955         IBA          BP     12145
## 60   GO:0006955         IMP          BP     12151
## 61   GO:0006955         ISO          BP     12161
## 62   GO:0006955         ISO          BP     12166
## 63   GO:0006955         IBA          BP     12169
## 64   GO:0006955         IBA          BP     12229
## 65   GO:0006955         IEA          BP     12229
## 66   GO:0006955         IMP          BP     12229
## 67   GO:0006955         ISO          BP     12229
## 68   GO:0006955         IBA          BP     12231
## 69   GO:0006955         IEA          BP     12258
## 70   GO:0006955         ISO          BP     12258
## 71   GO:0006955         IEA          BP     12259
## 72   GO:0006955         IMP          BP     12259
## 73   GO:0006955         IEA          BP     12260
## 74   GO:0006955         IBA          BP     12261
## 75   GO:0006955         IEA          BP     12261
## 76   GO:0006955         ISO          BP     12261
## 77   GO:0006955         IEA          BP     12262
## 78   GO:0006955         IEA          BP     12263
## 79   GO:0006955         ISO          BP     12263
## 80   GO:0006955         IDA          BP     12265
## 81   GO:0006955         ISO          BP     12265
## 82   GO:0006955         IBA          BP     12266
## 83   GO:0006955         IDA          BP     12266
## 84   GO:0006955         IEA          BP     12266
## 85   GO:0006955         IMP          BP     12266
## 86   GO:0006955         ISO          BP     12266
## 87   GO:0006955         IBA          BP     12267
## 88   GO:0006955         ISO          BP     12267
## 89   GO:0006955         IBA          BP     12268
## 90   GO:0006955         IMP          BP     12268
## 91   GO:0006955         IEA          BP     12269
## 92   GO:0006955         IBA          BP     12273
## 93   GO:0006955         ISO          BP     12273
## 94   GO:0006955         IMP          BP     12274
## 95   GO:0006955         IEA          BP     12279
## 96   GO:0006955         IMP          BP     12297
## 97   GO:0006955         IMP          BP     12298
## 98   GO:0006955         IEA          BP     12326
## 99   GO:0006955         IDA          BP     12332
## 100  GO:0006955         ISO          BP     12362
## 101  GO:0006955         IEA          BP     12363
## 102  GO:0006955         IBA          BP     12458
## 103  GO:0006955         IMP          BP     12458
## 104  GO:0006955         IEA          BP     12475
## 105  GO:0006955         IBA          BP     12477
## 106  GO:0006955         IEA          BP     12477
## 107  GO:0006955         ISO          BP     12477
## 108  GO:0006955         IBA          BP     12478
## 109  GO:0006955         IDA          BP     12478
## 110  GO:0006955         IEA          BP     12478
## 111  GO:0006955         IMP          BP     12478
## 112  GO:0006955         ISO          BP     12478
## 113  GO:0006955         IBA          BP     12479
## 114  GO:0006955         IDA          BP     12479
## 115  GO:0006955         IEA          BP     12479
## 116  GO:0006955         IMP          BP     12479
## 117  GO:0006955         IBA          BP     12480
## 118  GO:0006955         ISO          BP     12482
## 119  GO:0006955         IGI          BP     12483
## 120  GO:0006955         ISO          BP     12483
## 121  GO:0006955         IDA          BP     12484
## 122  GO:0006955         IEA          BP     12484
## 123  GO:0006955         IMP          BP     12484
## 124  GO:0006955         IBA          BP     12487
## 125  GO:0006955         IEA          BP     12487
## 126  GO:0006955         IMP          BP     12487
## 127  GO:0006955         IEA          BP     12491
## 128  GO:0006955         IMP          BP     12491
## 129  GO:0006955         IMP          BP     12493
## 130  GO:0006955         ISO          BP     12494
## 131  GO:0006955         IEA          BP     12500
## 132  GO:0006955         IDA          BP     12501
## 133  GO:0006955         IEA          BP     12501
## 134  GO:0006955         IEA          BP     12502
## 135  GO:0006955         IBA          BP     12503
## 136  GO:0006955         IDA          BP     12503
## 137  GO:0006955         IEA          BP     12503
## 138  GO:0006955         IEA          BP     12504
## 139  GO:0006955         IMP          BP     12504
## 140  GO:0006955         NAS          BP     12505
## 141  GO:0006955         IEA          BP     12506
## 142  GO:0006955         IBA          BP     12509
## 143  GO:0006955         IDA          BP     12509
## 144  GO:0006955         IMP          BP     12509
## 145  GO:0006955         ISO          BP     12509
## 146  GO:0006955         ISO          BP     12511
## 147  GO:0006955         IDA          BP     12514
## 148  GO:0006955         IEA          BP     12516
## 149  GO:0006955         IBA          BP     12518
## 150  GO:0006955         IDA          BP     12518
## 151  GO:0006955         IEA          BP     12518
## 152  GO:0006955         IBA          BP     12519
## 153  GO:0006955         IEA          BP     12520
## 154  GO:0006955         IMP          BP     12520
## 155  GO:0006955         ISO          BP     12520
## 156  GO:0006955         IEA          BP     12523
## 157  GO:0006955         ISO          BP     12523
## 158  GO:0006955         IBA          BP     12524
## 159  GO:0006955         IEA          BP     12524
## 160  GO:0006955         IBA          BP     12525
## 161  GO:0006955         IEA          BP     12525
## 162  GO:0006955         IMP          BP     12525
## 163  GO:0006955         IEA          BP     12526
## 164  GO:0006955         ISO          BP     12539
## 165  GO:0006955         IDA          BP     12540
## 166  GO:0006955         IMP          BP     12557
## 167  GO:0006955         IDA          BP     12611
## 168  GO:0006955         IMP          BP     12611
## 169  GO:0006955         IEA          BP     12628
## 170  GO:0006955         IMP          BP     12628
## 171  GO:0006955         ISO          BP     12628
## 172  GO:0006955         IEA          BP     12630
## 173  GO:0006955         ISO          BP     12652
## 174  GO:0006955         IEA          BP     12703
## 175  GO:0006955         IDA          BP     12705
## 176  GO:0006955         ISO          BP     12721
## 177  GO:0006955         IBA          BP     12765
## 178  GO:0006955         ISO          BP     12765
## 179  GO:0006955         IBA          BP     12766
## 180  GO:0006955         IBA          BP     12767
## 181  GO:0006955         IBA          BP     12768
## 182  GO:0006955         IMP          BP     12768
## 183  GO:0006955         ISO          BP     12768
## 184  GO:0006955         IBA          BP     12769
## 185  GO:0006955         IBA          BP     12770
## 186  GO:0006955         IBA          BP     12771
## 187  GO:0006955         IBA          BP     12772
## 188  GO:0006955          IC          BP     12772
## 189  GO:0006955         IMP          BP     12772
## 190  GO:0006955         IBA          BP     12773
## 191  GO:0006955         IBA          BP     12774
## 192  GO:0006955         IBA          BP     12775
## 193  GO:0006955          IC          BP     12775
## 194  GO:0006955         IMP          BP     12775
## 195  GO:0006955         IBA          BP     12776
## 196  GO:0006955         IBA          BP     12777
## 197  GO:0006955         IBA          BP     12778
## 198  GO:0006955         IBA          BP     12796
## 199  GO:0006955         IMP          BP     12796
## 200  GO:0006955         ISO          BP     12796
## 201  GO:0006955         ISO          BP     12801
## 202  GO:0006955         IMP          BP     12810
## 203  GO:0006955         ISO          BP     12825
## 204  GO:0006955         IEA          BP     12890
## 205  GO:0006955         IEA          BP     12902
## 206  GO:0006955         IEA          BP     12909
## 207  GO:0006955         ISO          BP     12921
## 208  GO:0006955         ISO          BP     12927
## 209  GO:0006955         ISO          BP     12928
## 210  GO:0006955         IDA          BP     12929
## 211  GO:0006955         IBA          BP     12944
## 212  GO:0006955         ISO          BP     12944
## 213  GO:0006955         IEA          BP     12946
## 214  GO:0006955         IMP          BP     12946
## 215  GO:0006955         ISO          BP     12946
## 216  GO:0006955         TAS          BP     12946
## 217  GO:0006955         IEA          BP     12977
## 218  GO:0006955         IEA          BP     12978
## 219  GO:0006955         IEA          BP     12981
## 220  GO:0006955         IEA          BP     12985
## 221  GO:0006955         IBA          BP     12988
## 222  GO:0006955         IEA          BP     12988
## 223  GO:0006955         ISO          BP     12988
## 224  GO:0006955         IDA          BP     13013
## 225  GO:0006955         IGI          BP     13032
## 226  GO:0006955         IGI          BP     13035
## 227  GO:0006955         IMP          BP     13035
## 228  GO:0006955         ISO          BP     13035
## 229  GO:0006955         IGI          BP     13036
## 230  GO:0006955         ISO          BP     13036
## 231  GO:0006955         IBA          BP     13051
## 232  GO:0006955          IC          BP     13051
## 233  GO:0006955         IMP          BP     13051
## 234  GO:0006955         IMP          BP     13057
## 235  GO:0006955         ISO          BP     13057
## 236  GO:0006955         IMP          BP     13058
## 237  GO:0006955         ISO          BP     13058
## 238  GO:0006955         ISO          BP     13115
## 239  GO:0006955         IEA          BP     13136
## 240  GO:0006955         IMP          BP     13136
## 241  GO:0006955         ISO          BP     13136
## 242  GO:0006955         IEA          BP     13137
## 243  GO:0006955         IMP          BP     13144
## 244  GO:0006955         ISO          BP     13144
## 245  GO:0006955         IEA          BP     13169
## 246  GO:0006955         ISO          BP     13205
## 247  GO:0006955         IEA          BP     13211
## 248  GO:0006955         IMP          BP     13211
## 249  GO:0006955         IMP          BP     13214
## 250  GO:0006955         IBA          BP     13216
## 251  GO:0006955         IBA          BP     13218
## 252  GO:0006955         IBA          BP     13219
## 253  GO:0006955         IBA          BP     13221
## 254  GO:0006955         IBA          BP     13222
## 255  GO:0006955         IBA          BP     13226
## 256  GO:0006955         IBA          BP     13229
## 257  GO:0006955         IBA          BP     13230
## 258  GO:0006955         IBA          BP     13232
## 259  GO:0006955         IBA          BP     13233
## 260  GO:0006955         IBA          BP     13234
## 261  GO:0006955         IBA          BP     13235
## 262  GO:0006955         IBA          BP     13236
## 263  GO:0006955         IBA          BP     13237
## 264  GO:0006955         IBA          BP     13238
## 265  GO:0006955         IDA          BP     13238
## 266  GO:0006955         IBA          BP     13239
## 267  GO:0006955         IBA          BP     13240
## 268  GO:0006955         IBA          BP     13241
## 269  GO:0006955         IBA          BP     13242
## 270  GO:0006955         IBA          BP     13243
## 271  GO:0006955         IMP          BP     13383
## 272  GO:0006955         IMP          BP     13388
## 273  GO:0006955         IDA          BP     13419
## 274  GO:0006955         IDA          BP     13421
## 275  GO:0006955         IGI          BP     13423
## 276  GO:0006955         ISO          BP     13482
## 277  GO:0006955         IMP          BP     13489
## 278  GO:0006955         IMP          BP     13601
## 279  GO:0006955         IEA          BP     13607
## 280  GO:0006955         ISO          BP     13667
## 281  GO:0006955         IGI          BP     13709
## 282  GO:0006955         IDA          BP     13731
## 283  GO:0006955         IEA          BP     13733
## 284  GO:0006955         IBA          BP     13813
## 285  GO:0006955         IDA          BP     13813
## 286  GO:0006955         IEA          BP     13813
## 287  GO:0006955         ISO          BP     13813
## 288  GO:0006955         IMP          BP     13848
## 289  GO:0006955         IMP          BP     13870
## 290  GO:0006955         IMP          BP     13874
## 291  GO:0006955         IDA          BP     14026
## 292  GO:0006955         ISO          BP     14061
## 293  GO:0006955         IDA          BP     14063
## 294  GO:0006955         IEA          BP     14063
## 295  GO:0006955         ISO          BP     14063
## 296  GO:0006955         IMP          BP     14082
## 297  GO:0006955         ISO          BP     14082
## 298  GO:0006955         TAS          BP     14082
## 299  GO:0006955         IEA          BP     14102
## 300  GO:0006955         IMP          BP     14102
## 301  GO:0006955         IEA          BP     14103
## 302  GO:0006955         IDA          BP     14109
## 303  GO:0006955         ISO          BP     14109
## 304  GO:0006955         IDA          BP     14125
## 305  GO:0006955         IMP          BP     14125
## 306  GO:0006955         IEA          BP     14126
## 307  GO:0006955         ISO          BP     14126
## 308  GO:0006955         IBA          BP     14127
## 309  GO:0006955         IDA          BP     14127
## 310  GO:0006955         IMP          BP     14127
## 311  GO:0006955         ISO          BP     14127
## 312  GO:0006955         IMP          BP     14128
## 313  GO:0006955         IEA          BP     14129
## 314  GO:0006955         IMP          BP     14129
## 315  GO:0006955         IMP          BP     14130
## 316  GO:0006955         ISO          BP     14130
## 317  GO:0006955         IDA          BP     14131
## 318  GO:0006955         IMP          BP     14131
## 319  GO:0006955         IBA          BP     14132
## 320  GO:0006955         IDA          BP     14133
## 321  GO:0006955         IEA          BP     14133
## 322  GO:0006955         IEA          BP     14134
## 323  GO:0006955         ISO          BP     14134
## 324  GO:0006955         IBA          BP     14158
## 325  GO:0006955         IMP          BP     14158
## 326  GO:0006955         IBA          BP     14159
## 327  GO:0006955         ISO          BP     14159
## 328  GO:0006955         IEA          BP     14161
## 329  GO:0006955         ISO          BP     14161
## 330  GO:0006955         IMP          BP     14190
## 331  GO:0006955         IDA          BP     14191
## 332  GO:0006955         IEA          BP     14191
## 333  GO:0006955         IMP          BP     14191
## 334  GO:0006955         ISO          BP     14225
## 335  GO:0006955         IMP          BP     14245
## 336  GO:0006955         IBA          BP     14289
## 337  GO:0006955         ISO          BP     14289
## 338  GO:0006955         IBA          BP     14290
## 339  GO:0006955         IBA          BP     14291
## 340  GO:0006955         IBA          BP     14293
## 341  GO:0006955         IBA          BP     14294
## 342  GO:0006955         IMP          BP     14347
## 343  GO:0006955         IBA          BP     14360
## 344  GO:0006955         IEA          BP     14360
## 345  GO:0006955         ISO          BP     14360
## 346  GO:0006955         ISO          BP     14367
## 347  GO:0006955         IEA          BP     14375
## 348  GO:0006955         ISO          BP     14375
## 349  GO:0006955         IMP          BP     14389
## 350  GO:0006955         ISO          BP     14433
## 351  GO:0006955         IMP          BP     14456
## 352  GO:0006955         ISO          BP     14461
## 353  GO:0006955         IDA          BP     14462
## 354  GO:0006955         IEA          BP     14462
## 355  GO:0006955         IMP          BP     14462
## 356  GO:0006955         IBA          BP     14468
## 357  GO:0006955         IDA          BP     14468
## 358  GO:0006955         IBA          BP     14469
## 359  GO:0006955         IDA          BP     14469
## 360  GO:0006955         ISO          BP     14469
## 361  GO:0006955         ISO          BP     14525
## 362  GO:0006955         ISO          BP     14528
## 363  GO:0006955         IBA          BP     14747
## 364  GO:0006955         ISO          BP     14756
## 365  GO:0006955         IBA          BP     14762
## 366  GO:0006955         IGI          BP     14775
## 367  GO:0006955         IGI          BP     14776
## 368  GO:0006955         IMP          BP     14824
## 369  GO:0006955         ISO          BP     14824
## 370  GO:0006955         IBA          BP     14825
## 371  GO:0006955         IMP          BP     14939
## 372  GO:0006955         IDA          BP     14960
## 373  GO:0006955         IEA          BP     14960
## 374  GO:0006955         IDA          BP     14961
## 375  GO:0006955         IEA          BP     14961
## 376  GO:0006955         IMP          BP     14961
## 377  GO:0006955         ISO          BP     14961
## 378  GO:0006955         IEA          BP     14962
## 379  GO:0006955         IMP          BP     14962
## 380  GO:0006955         ISO          BP     14962
## 381  GO:0006955         TAS          BP     14962
## 382  GO:0006955         IBA          BP     14963
## 383  GO:0006955         IBA          BP     14964
## 384  GO:0006955         IDA          BP     14964
## 385  GO:0006955         IDA          BP     14969
## 386  GO:0006955         IEA          BP     14969
## 387  GO:0006955         IBA          BP     14972
## 388  GO:0006955         IDA          BP     14972
## 389  GO:0006955         IBA          BP     14980
## 390  GO:0006955         IBA          BP     14985
## 391  GO:0006955         IBA          BP     14990
## 392  GO:0006955         IBA          BP     14991
## 393  GO:0006955         IDA          BP     14991
## 394  GO:0006955         IMP          BP     14991
## 395  GO:0006955         ISO          BP     14991
## 396  GO:0006955         IBA          BP     14997
## 397  GO:0006955         IEA          BP     14998
## 398  GO:0006955         IMP          BP     14998
## 399  GO:0006955         IEA          BP     14999
## 400  GO:0006955         IBA          BP     15006
## 401  GO:0006955         IBA          BP     15007
## 402  GO:0006955         IBA          BP     15013
## 403  GO:0006955         IBA          BP     15015
## 404  GO:0006955         IBA          BP     15018
## 405  GO:0006955         IDA          BP     15018
## 406  GO:0006955         IBA          BP     15019
## 407  GO:0006955         IBA          BP     15024
## 408  GO:0006955         IBA          BP     15039
## 409  GO:0006955         IBA          BP     15040
## 410  GO:0006955         IDA          BP     15040
## 411  GO:0006955         ISO          BP     15040
## 412  GO:0006955         IBA          BP     15042
## 413  GO:0006955         IBA          BP     15043
## 414  GO:0006955         IBA          BP     15061
## 415  GO:0006955         IDA          BP     15061
## 416  GO:0006955         IBA          BP     15064
## 417  GO:0006955         IEA          BP     15064
## 418  GO:0006955         IMP          BP     15064
## 419  GO:0006955         IDA          BP     15101
## 420  GO:0006955         IEA          BP     15139
## 421  GO:0006955         IEA          BP     15162
## 422  GO:0006955         IGI          BP     15170
## 423  GO:0006955         IMP          BP     15170
## 424  GO:0006955         IEA          BP     15216
## 425  GO:0006955         ISO          BP     15216
## 426  GO:0006955         IMP          BP     15223
## 427  GO:0006955         IMP          BP     15227
## 428  GO:0006955         IDA          BP     15275
## 429  GO:0006955         IGI          BP     15284
## 430  GO:0006955         IMP          BP     15284
## 431  GO:0006955         IBA          BP     15289
## 432  GO:0006955         IDA          BP     15289
## 433  GO:0006955         IMP          BP     15289
## 434  GO:0006955         IBA          BP     15354
## 435  GO:0006955         IEA          BP     15354
## 436  GO:0006955         ISO          BP     15368
## 437  GO:0006955         IMP          BP     15452
## 438  GO:0006955         IMP          BP     15458
## 439  GO:0006955         IMP          BP     15461
## 440  GO:0006955         ISO          BP     15481
## 441  GO:0006955         ISO          BP     15510
## 442  GO:0006955         IDA          BP     15894
## 443  GO:0006955         ISO          BP     15894
## 444  GO:0006955         IMP          BP     15900
## 445  GO:0006955         ISO          BP     15900
## 446  GO:0006955         IMP          BP     15930
## 447  GO:0006955         IDA          BP     15944
## 448  GO:0006955         IEA          BP     15944
## 449  GO:0006955         IMP          BP     15944
## 450  GO:0006955         IBA          BP     15945
## 451  GO:0006955         ISO          BP     15945
## 452  GO:0006955         IEA          BP     15950
## 453  GO:0006955         IBA          BP     15951
## 454  GO:0006955         IEA          BP     15957
## 455  GO:0006955         IEA          BP     15958
## 456  GO:0006955         IEA          BP     15959
## 457  GO:0006955         IBA          BP     15962
## 458  GO:0006955         IDA          BP     15962
## 459  GO:0006955         IBA          BP     15964
## 460  GO:0006955         IBA          BP     15965
## 461  GO:0006955         IBA          BP     15967
## 462  GO:0006955         IDA          BP     15967
## 463  GO:0006955         IBA          BP     15968
## 464  GO:0006955         IBA          BP     15969
## 465  GO:0006955         IBA          BP     15970
## 466  GO:0006955         IBA          BP     15972
## 467  GO:0006955         IDA          BP     15972
## 468  GO:0006955         IBA          BP     15974
## 469  GO:0006955         IDA          BP     15975
## 470  GO:0006955         IMP          BP     15975
## 471  GO:0006955         ISO          BP     15975
## 472  GO:0006955         IBA          BP     15976
## 473  GO:0006955         ISO          BP     15976
## 474  GO:0006955         IBA          BP     15977
## 475  GO:0006955         IDA          BP     15977
## 476  GO:0006955         IMP          BP     15977
## 477  GO:0006955         ISO          BP     15977
## 478  GO:0006955         IBA          BP     15978
## 479  GO:0006955         IDA          BP     15978
## 480  GO:0006955         IEA          BP     15978
## 481  GO:0006955         ISO          BP     15978
## 482  GO:0006955         IBA          BP     15985
## 483  GO:0006955         IDA          BP     15985
## 484  GO:0006955         IEA          BP     15985
## 485  GO:0006955         ISO          BP     16001
## 486  GO:0006955         ISO          BP     16002
## 487  GO:0006955         IBA          BP     16016
## 488  GO:0006955         IDA          BP     16016
## 489  GO:0006955         IBA          BP     16017
## 490  GO:0006955         IDA          BP     16017
## 491  GO:0006955         IBA          BP     16019
## 492  GO:0006955         IDA          BP     16019
## 493  GO:0006955         IMP          BP     16019
## 494  GO:0006955         IDA          BP     16020
## 495  GO:0006955         IDA          BP     16021
## 496  GO:0006955         IBA          BP     16033
## 497  GO:0006955         IBA          BP     16061
## 498  GO:0006955         IBA          BP     16068
## 499  GO:0006955         ISO          BP     16068
## 500  GO:0006955         ISO          BP     16069
## 501  GO:0006955         ISS          BP     16069
## 502  GO:0006955         IBA          BP     16071
## 503  GO:0006955         IBA          BP     16098
## 504  GO:0006955         IBA          BP     16136
## 505  GO:0006955         IBA          BP     16142
## 506  GO:0006955          IC          BP     16149
## 507  GO:0006955         IDA          BP     16149
## 508  GO:0006955         IEA          BP     16149
## 509  GO:0006955         IMP          BP     16149
## 510  GO:0006955         NAS          BP     16149
## 511  GO:0006955         IMP          BP     16153
## 512  GO:0006955         ISO          BP     16153
## 513  GO:0006955         IEA          BP     16159
## 514  GO:0006955         IGI          BP     16159
## 515  GO:0006955         ISO          BP     16159
## 516  GO:0006955         IDA          BP     16160
## 517  GO:0006955         IGI          BP     16160
## 518  GO:0006955         IMP          BP     16160
## 519  GO:0006955         ISO          BP     16160
## 520  GO:0006955         ISO          BP     16161
## 521  GO:0006955         IEA          BP     16163
## 522  GO:0006955         IGI          BP     16163
## 523  GO:0006955         IMP          BP     16163
## 524  GO:0006955         IMP          BP     16165
## 525  GO:0006955         IEA          BP     16168
## 526  GO:0006955         IMP          BP     16168
## 527  GO:0006955         IDA          BP     16173
## 528  GO:0006955         IGI          BP     16173
## 529  GO:0006955         IMP          BP     16173
## 530  GO:0006955         ISO          BP     16173
## 531  GO:0006955         ISS          BP     16173
## 532  GO:0006955         TAS          BP     16173
## 533  GO:0006955         IMP          BP     16174
## 534  GO:0006955         IEA          BP     16175
## 535  GO:0006955         IEA          BP     16176
## 536  GO:0006955         ISO          BP     16176
## 537  GO:0006955         ISO          BP     16177
## 538  GO:0006955         IBA          BP     16179
## 539  GO:0006955         IEP          BP     16179
## 540  GO:0006955         ISO          BP     16179
## 541  GO:0006955         IEA          BP     16180
## 542  GO:0006955         IEA          BP     16181
## 543  GO:0006955         IMP          BP     16182
## 544  GO:0006955         ISO          BP     16182
## 545  GO:0006955         IEA          BP     16183
## 546  GO:0006955         IGI          BP     16183
## 547  GO:0006955         IMP          BP     16183
## 548  GO:0006955         ISO          BP     16183
## 549  GO:0006955         ISO          BP     16184
## 550  GO:0006955         IEA          BP     16187
## 551  GO:0006955         IDA          BP     16189
## 552  GO:0006955         IEA          BP     16189
## 553  GO:0006955         IGI          BP     16189
## 554  GO:0006955         IMP          BP     16189
## 555  GO:0006955         ISO          BP     16189
## 556  GO:0006955         IGI          BP     16190
## 557  GO:0006955         IMP          BP     16190
## 558  GO:0006955         IEA          BP     16191
## 559  GO:0006955         IMP          BP     16192
## 560  GO:0006955         IDA          BP     16193
## 561  GO:0006955         IEA          BP     16193
## 562  GO:0006955         IMP          BP     16193
## 563  GO:0006955         ISO          BP     16193
## 564  GO:0006955         IBA          BP     16194
## 565  GO:0006955         IEA          BP     16196
## 566  GO:0006955         IMP          BP     16197
## 567  GO:0006955         IEA          BP     16198
## 568  GO:0006955         IMP          BP     16331
## 569  GO:0006955         ISO          BP     16334
## 570  GO:0006955         IEA          BP     16362
## 571  GO:0006955         IMP          BP     16362
## 572  GO:0006955         TAS          BP     16362
## 573  GO:0006955         IMP          BP     16364
## 574  GO:0006955         IDA          BP     16365
## 575  GO:0006955         IEA          BP     16365
## 576  GO:0006955         ISO          BP     16365
## 577  GO:0006955         IEA          BP     16396
## 578  GO:0006955         ISO          BP     16408
## 579  GO:0006955         ISO          BP     16409
## 580  GO:0006955         ISO          BP     16414
## 581  GO:0006955         ISO          BP     16423
## 582  GO:0006955         IBA          BP     16428
## 583  GO:0006955         IMP          BP     16428
## 584  GO:0006955         IMP          BP     16431
## 585  GO:0006955         ISO          BP     16449
## 586  GO:0006955         IEA          BP     16452
## 587  GO:0006955         ISO          BP     16452
## 588  GO:0006955         IEA          BP     16453
## 589  GO:0006955         IMP          BP     16453
## 590  GO:0006955         ISO          BP     16534
## 591  GO:0006955         IDA          BP     16558
## 592  GO:0006955         IDA          BP     16573
## 593  GO:0006955         IMP          BP     16590
## 594  GO:0006955         ISO          BP     16590
## 595  GO:0006955         ISO          BP     16643
## 596  GO:0006955         IMP          BP     16666
## 597  GO:0006955         ISO          BP     16678
## 598  GO:0006955         IMP          BP     16687
## 599  GO:0006955         IDA          BP     16768
## 600  GO:0006955         IEA          BP     16768
## 601  GO:0006955         IMP          BP     16768
## 602  GO:0006955         ISO          BP     16783
## 603  GO:0006955         IBA          BP     16797
## 604  GO:0006955         IEA          BP     16797
## 605  GO:0006955         ISO          BP     16797
## 606  GO:0006955         IEA          BP     16800
## 607  GO:0006955         IBA          BP     16803
## 608  GO:0006955         IDA          BP     16803
## 609  GO:0006955         IMP          BP     16803
## 610  GO:0006955         ISO          BP     16803
## 611  GO:0006955         IBA          BP     16818
## 612  GO:0006955         IDA          BP     16818
## 613  GO:0006955         IMP          BP     16819
## 614  GO:0006955         ISO          BP     16822
## 615  GO:0006955         IDA          BP     16842
## 616  GO:0006955         ISO          BP     16846
## 617  GO:0006955         IMP          BP     16848
## 618  GO:0006955         IDA          BP     16852
## 619  GO:0006955         IEA          BP     16854
## 620  GO:0006955         IMP          BP     16854
## 621  GO:0006955         IMP          BP     16859
## 622  GO:0006955         IEA          BP     16878
## 623  GO:0006955         IDA          BP     16904
## 624  GO:0006955         IMP          BP     16950
## 625  GO:0006955         IBA          BP     16952
## 626  GO:0006955         IEA          BP     16952
## 627  GO:0006955         ISO          BP     16952
## 628  GO:0006955         IBA          BP     16963
## 629  GO:0006955          IC          BP     16963
## 630  GO:0006955         IDA          BP     16963
## 631  GO:0006955         IEA          BP     16963
## 632  GO:0006955         ISO          BP     16963
## 633  GO:0006955         NAS          BP     16963
## 634  GO:0006955         IGI          BP     16971
## 635  GO:0006955         IMP          BP     16975
## 636  GO:0006955         IEA          BP     16988
## 637  GO:0006955         IEA          BP     16992
## 638  GO:0006955         IGI          BP     16992
## 639  GO:0006955         IMP          BP     16992
## 640  GO:0006955         IEA          BP     16994
## 641  GO:0006955         IEA          BP     17000
## 642  GO:0006955         ISO          BP     17002
## 643  GO:0006955         IDA          BP     17059
## 644  GO:0006955         IBA          BP     17079
## 645  GO:0006955         IEA          BP     17079
## 646  GO:0006955         IMP          BP     17079
## 647  GO:0006955         IGI          BP     17082
## 648  GO:0006955         IEA          BP     17084
## 649  GO:0006955         IEA          BP     17085
## 650  GO:0006955         ISO          BP     17085
## 651  GO:0006955         IEA          BP     17087
## 652  GO:0006955         IBA          BP     17096
## 653  GO:0006955         IDA          BP     17096
## 654  GO:0006955         IEA          BP     17096
## 655  GO:0006955         IGI          BP     17096
## 656  GO:0006955         IMP          BP     17096
## 657  GO:0006955         ISO          BP     17096
## 658  GO:0006955         IMP          BP     17101
## 659  GO:0006955         ISO          BP     17101
## 660  GO:0006955         IMP          BP     17127
## 661  GO:0006955         ISO          BP     17127
## 662  GO:0006955         ISO          BP     17130
## 663  GO:0006955         IMP          BP     17131
## 664  GO:0006955         IEA          BP     17167
## 665  GO:0006955         IBA          BP     17174
## 666  GO:0006955         IEA          BP     17174
## 667  GO:0006955         IMP          BP     17174
## 668  GO:0006955         IDA          BP     17175
## 669  GO:0006955         IEA          BP     17175
## 670  GO:0006955         ISO          BP     17175
## 671  GO:0006955         IEA          BP     17184
## 672  GO:0006955         ISO          BP     17184
## 673  GO:0006955         IDA          BP     17194
## 674  GO:0006955         IEA          BP     17194
## 675  GO:0006955         IGI          BP     17194
## 676  GO:0006955         ISO          BP     17194
## 677  GO:0006955         IDA          BP     17195
## 678  GO:0006955         IEA          BP     17195
## 679  GO:0006955         IGI          BP     17195
## 680  GO:0006955         IMP          BP     17195
## 681  GO:0006955         ISO          BP     17195
## 682  GO:0006955         ISO          BP     17221
## 683  GO:0006955         IMP          BP     17242
## 684  GO:0006955         IMP          BP     17260
## 685  GO:0006955         IMP          BP     17305
## 686  GO:0006955         IEA          BP     17319
## 687  GO:0006955         IMP          BP     17319
## 688  GO:0006955         ISO          BP     17319
## 689  GO:0006955         NAS          BP     17319
## 690  GO:0006955         IBA          BP     17329
## 691  GO:0006955         IGI          BP     17350
## 692  GO:0006955         IMP          BP     17350
## 693  GO:0006955         IMP          BP     17381
## 694  GO:0006955         IDA          BP     17390
## 695  GO:0006955         IMP          BP     17393
## 696  GO:0006955         IBA          BP     17441
## 697  GO:0006955         IEA          BP     17470
## 698  GO:0006955         IDA          BP     17472
## 699  GO:0006955         IDA          BP     17474
## 700  GO:0006955         IMP          BP     17474
## 701  GO:0006955         IEA          BP     17476
## 702  GO:0006955         IDA          BP     17533
## 703  GO:0006955         IBA          BP     17685
## 704  GO:0006955         IGI          BP     17685
## 705  GO:0006955         IMP          BP     17685
## 706  GO:0006955         IGI          BP     17688
## 707  GO:0006955         IMP          BP     17688
## 708  GO:0006955         IBA          BP     17857
## 709  GO:0006955         IDA          BP     17857
## 710  GO:0006955         TAS          BP     17857
## 711  GO:0006955         IBA          BP     17858
## 712  GO:0006955         ISO          BP     17863
## 713  GO:0006955         IBA          BP     17874
## 714  GO:0006955         IMP          BP     17874
## 715  GO:0006955         ISO          BP     17874
## 716  GO:0006955         TAS          BP     17874
## 717  GO:0006955         IDA          BP     17913
## 718  GO:0006955         IMP          BP     17916
## 719  GO:0006955         IEA          BP     17948
## 720  GO:0006955         IEA          BP     17951
## 721  GO:0006955         IEA          BP     17952
## 722  GO:0006955         IMP          BP     17999
## 723  GO:0006955         ISO          BP     18019
## 724  GO:0006955         IEA          BP     18030
## 725  GO:0006955         IMP          BP     18034
## 726  GO:0006955         IMP          BP     18089
## 727  GO:0006955         IEA          BP     18106
## 728  GO:0006955         IMP          BP     18106
## 729  GO:0006955         ISO          BP     18106
## 730  GO:0006955         IMP          BP     18124
## 731  GO:0006955         IDA          BP     18126
## 732  GO:0006955         IGI          BP     18128
## 733  GO:0006955         IGI          BP     18129
## 734  GO:0006955         IMP          BP     18129
## 735  GO:0006955         ISO          BP     18168
## 736  GO:0006955         IDA          BP     18173
## 737  GO:0006955         IMP          BP     18173
## 738  GO:0006955         IMP          BP     18176
## 739  GO:0006955         ISO          BP     18387
## 740  GO:0006955         IEA          BP     18413
## 741  GO:0006955         IMP          BP     18439
## 742  GO:0006955         IMP          BP     18477
## 743  GO:0006955         IBA          BP     18489
## 744  GO:0006955         IEA          BP     18521
## 745  GO:0006955         IEA          BP     18566
## 746  GO:0006955         IMP          BP     18566
## 747  GO:0006955         ISO          BP     18578
## 748  GO:0006955         IEA          BP     18602
## 749  GO:0006955         IEA          BP     18605
## 750  GO:0006955         IEA          BP     18606
## 751  GO:0006955         IMP          BP     18607
## 752  GO:0006955         IEA          BP     18636
## 753  GO:0006955         IMP          BP     18636
## 754  GO:0006955         IDA          BP     18646
## 755  GO:0006955         IMP          BP     18646
## 756  GO:0006955         ISO          BP     18673
## 757  GO:0006955         ISO          BP     18703
## 758  GO:0006955         IEA          BP     18707
## 759  GO:0006955         IEA          BP     18733
## 760  GO:0006955         IMP          BP     18733
## 761  GO:0006955         IEA          BP     18751
## 762  GO:0006955         IMP          BP     18751
## 763  GO:0006955         IMP          BP     18753
## 764  GO:0006955         IMP          BP     18754
## 765  GO:0006955         ISO          BP     18755
## 766  GO:0006955         IEA          BP     18760
## 767  GO:0006955         IMP          BP     18761
## 768  GO:0006955         IMP          BP     18762
## 769  GO:0006955         ISO          BP     18778
## 770  GO:0006955         IDA          BP     18803
## 771  GO:0006955         ISO          BP     18806
## 772  GO:0006955         ISO          BP     18826
## 773  GO:0006955         IBA          BP     18829
## 774  GO:0006955         IEA          BP     18829
## 775  GO:0006955         IMP          BP     18843
## 776  GO:0006955         ISO          BP     18843
## 777  GO:0006955         IBA          BP     18854
## 778  GO:0006955         IDA          BP     18854
## 779  GO:0006955         ISO          BP     18854
## 780  GO:0006955         IMP          BP     18858
## 781  GO:0006955         IGI          BP     18861
## 782  GO:0006955         IMP          BP     18861
## 783  GO:0006955         IBA          BP     18938
## 784  GO:0006955         IMP          BP     18950
## 785  GO:0006955         ISO          BP     18983
## 786  GO:0006955         IMP          BP     18987
## 787  GO:0006955         IEA          BP     19011
## 788  GO:0006955         IMP          BP     19014
## 789  GO:0006955         ISO          BP     19016
## 790  GO:0006955         IMP          BP     19056
## 791  GO:0006955         IEA          BP     19074
## 792  GO:0006955         IEA          BP     19090
## 793  GO:0006955         ISO          BP     19090
## 794  GO:0006955         IEA          BP     19106
## 795  GO:0006955         IMP          BP     19122
## 796  GO:0006955         IGI          BP     19164
## 797  GO:0006955         ISO          BP     19164
## 798  GO:0006955         IGI          BP     19165
## 799  GO:0006955         IMP          BP     19172
## 800  GO:0006955         IEA          BP     19200
## 801  GO:0006955         ISO          BP     19204
## 802  GO:0006955         IDA          BP     19219
## 803  GO:0006955         IEA          BP     19229
## 804  GO:0006955         IMP          BP     19229
## 805  GO:0006955         IMP          BP     19255
## 806  GO:0006955         ISO          BP     19255
## 807  GO:0006955         IEA          BP     19260
## 808  GO:0006955         IMP          BP     19260
## 809  GO:0006955         ISO          BP     19260
## 810  GO:0006955         ISO          BP     19261
## 811  GO:0006955         IGI          BP     19264
## 812  GO:0006955         IMP          BP     19264
## 813  GO:0006955         ISO          BP     19264
## 814  GO:0006955         IMP          BP     19266
## 815  GO:0006955         IDA          BP     19271
## 816  GO:0006955         IGI          BP     19271
## 817  GO:0006955         ISO          BP     19271
## 818  GO:0006955         IBA          BP     19288
## 819  GO:0006955         ISO          BP     19288
## 820  GO:0006955         ISO          BP     19294
## 821  GO:0006955         IDA          BP     19328
## 822  GO:0006955         IMP          BP     19329
## 823  GO:0006955         IDA          BP     19332
## 824  GO:0006955         IMP          BP     19354
## 825  GO:0006955         IBA          BP     19368
## 826  GO:0006955         IBA          BP     19369
## 827  GO:0006955         IDA          BP     19369
## 828  GO:0006955         IBA          BP     19370
## 829  GO:0006955         IBA          BP     19373
## 830  GO:0006955         IMP          BP     19373
## 831  GO:0006955         ISO          BP     19401
## 832  GO:0006955         IMP          BP     19419
## 833  GO:0006955         ISO          BP     19419
## 834  GO:0006955         IMP          BP     19664
## 835  GO:0006955         IBA          BP     19692
## 836  GO:0006955         IBA          BP     19693
## 837  GO:0006955         IBA          BP     19694
## 838  GO:0006955         IBA          BP     19695
## 839  GO:0006955         IDA          BP     19695
## 840  GO:0006955         ISO          BP     19695
## 841  GO:0006955         ISO          BP     19697
## 842  GO:0006955         IMP          BP     19698
## 843  GO:0006955         IDA          BP     19720
## 844  GO:0006955         ISO          BP     19720
## 845  GO:0006955         IDA          BP     19824
## 846  GO:0006955         IEA          BP     19882
## 847  GO:0006955         IMP          BP     19883
## 848  GO:0006955         IDA          BP     19885
## 849  GO:0006955         IMP          BP     19885
## 850  GO:0006955         ISO          BP     19946
## 851  GO:0006955         ISO          BP     20085
## 852  GO:0006955         IGI          BP     20104
## 853  GO:0006955         IMP          BP     20104
## 854  GO:0006955         IEA          BP     20128
## 855  GO:0006955         IEA          BP     20186
## 856  GO:0006955         IEA          BP     20201
## 857  GO:0006955         IEA          BP     20202
## 858  GO:0006955         ISO          BP     20202
## 859  GO:0006955         IBA          BP     20219
## 860  GO:0006955         ISO          BP     20219
## 861  GO:0006955         ISO          BP     20248
## 862  GO:0006955         IBA          BP     20290
## 863  GO:0006955         IEA          BP     20290
## 864  GO:0006955         IBA          BP     20292
## 865  GO:0006955         IEA          BP     20292
## 866  GO:0006955         IBA          BP     20293
## 867  GO:0006955         IEA          BP     20293
## 868  GO:0006955         IBA          BP     20295
## 869  GO:0006955         IBA          BP     20296
## 870  GO:0006955         IDA          BP     20296
## 871  GO:0006955         IEA          BP     20296
## 872  GO:0006955         ISO          BP     20296
## 873  GO:0006955         IBA          BP     20297
## 874  GO:0006955         IEA          BP     20297
## 875  GO:0006955         IBA          BP     20299
## 876  GO:0006955         IEA          BP     20299
## 877  GO:0006955         IBA          BP     20300
## 878  GO:0006955         IEA          BP     20300
## 879  GO:0006955         IBA          BP     20302
## 880  GO:0006955         IEA          BP     20302
## 881  GO:0006955         IBA          BP     20303
## 882  GO:0006955         IEA          BP     20303
## 883  GO:0006955         IBA          BP     20304
## 884  GO:0006955         IEA          BP     20304
## 885  GO:0006955         ISO          BP     20304
## 886  GO:0006955         IBA          BP     20305
## 887  GO:0006955         IEA          BP     20305
## 888  GO:0006955         IBA          BP     20306
## 889  GO:0006955         IEA          BP     20306
## 890  GO:0006955         IBA          BP     20307
## 891  GO:0006955         IEA          BP     20307
## 892  GO:0006955         IBA          BP     20308
## 893  GO:0006955         IEA          BP     20308
## 894  GO:0006955         IBA          BP     20309
## 895  GO:0006955         IBA          BP     20310
## 896  GO:0006955         IBA          BP     20311
## 897  GO:0006955         ISO          BP     20311
## 898  GO:0006955         IBA          BP     20312
## 899  GO:0006955         IEA          BP     20312
## 900  GO:0006955         IEA          BP     20315
## 901  GO:0006955         IEA          BP     20351
## 902  GO:0006955         IMP          BP     20351
## 903  GO:0006955         IBA          BP     20361
## 904  GO:0006955         IDA          BP     20361
## 905  GO:0006955         IMP          BP     20371
## 906  GO:0006955         ISO          BP     20371
## 907  GO:0006955         IEA          BP     20390
## 908  GO:0006955         ISO          BP     20390
## 909  GO:0006955         IEA          BP     20400
## 910  GO:0006955         IGI          BP     20400
## 911  GO:0006955         IMP          BP     20400
## 912  GO:0006955         ISO          BP     20466
## 913  GO:0006955         IMP          BP     20568
## 914  GO:0006955         ISO          BP     20568
## 915  GO:0006955         IDA          BP     20592
## 916  GO:0006955         ISO          BP     20617
## 917  GO:0006955         ISO          BP     20619
## 918  GO:0006955         IDA          BP     20706
## 919  GO:0006955         IEA          BP     20715
## 920  GO:0006955         IMP          BP     20723
## 921  GO:0006955         ISO          BP     20723
## 922  GO:0006955         IMP          BP     20737
## 923  GO:0006955         ISO          BP     20737
## 924  GO:0006955         ISO          BP     20821
## 925  GO:0006955         IBA          BP     20846
## 926  GO:0006955         IDA          BP     20846
## 927  GO:0006955         IMP          BP     20846
## 928  GO:0006955         ISO          BP     20846
## 929  GO:0006955         IBA          BP     20847
## 930  GO:0006955         IMP          BP     20847
## 931  GO:0006955         ISO          BP     20847
## 932  GO:0006955         IMP          BP     20848
## 933  GO:0006955         IMP          BP     20850
## 934  GO:0006955         IMP          BP     20851
## 935  GO:0006955         IGI          BP     20852
## 936  GO:0006955         IGI          BP     20869
## 937  GO:0006955         IMP          BP     20869
## 938  GO:0006955         IDA          BP     20909
## 939  GO:0006955         ISO          BP     20909
## 940  GO:0006955         IDA          BP     20910
## 941  GO:0006955         ISO          BP     20910
## 942  GO:0006955         IDA          BP     20911
## 943  GO:0006955         ISO          BP     20911
## 944  GO:0006955         IDA          BP     20912
## 945  GO:0006955         IDA          BP     20913
## 946  GO:0006955         IMP          BP     20926
## 947  GO:0006955         IDA          BP     20947
## 948  GO:0006955         ISO          BP     20955
## 949  GO:0006955         ISS          BP     20955
## 950  GO:0006955         IBA          BP     20963
## 951  GO:0006955         IDA          BP     20963
## 952  GO:0006955         IMP          BP     20963
## 953  GO:0006955         ISO          BP     20963
## 954  GO:0006955         IEA          BP     21354
## 955  GO:0006955         ISO          BP     21354
## 956  GO:0006955         IDA          BP     21355
## 957  GO:0006955         IEA          BP     21355
## 958  GO:0006955         IMP          BP     21355
## 959  GO:0006955         ISO          BP     21355
## 960  GO:0006955         IEA          BP     21425
## 961  GO:0006955         IMP          BP     21425
## 962  GO:0006955         IEA          BP     21632
## 963  GO:0006955         ISO          BP     21667
## 964  GO:0006955         IBA          BP     21682
## 965  GO:0006955         ISO          BP     21682
## 966  GO:0006955         IDA          BP     21687
## 967  GO:0006955         IDA          BP     21803
## 968  GO:0006955         ISO          BP     21803
## 969  GO:0006955         TAS          BP     21803
## 970  GO:0006955         ISO          BP     21808
## 971  GO:0006955         ISO          BP     21809
## 972  GO:0006955         ISO          BP     21814
## 973  GO:0006955         IDA          BP     21822
## 974  GO:0006955         IBA          BP     21838
## 975  GO:0006955         IDA          BP     21838
## 976  GO:0006955         ISO          BP     21838
## 977  GO:0006955         IDA          BP     21849
## 978  GO:0006955         IGI          BP     21849
## 979  GO:0006955         ISO          BP     21849
## 980  GO:0006955         IEA          BP     21897
## 981  GO:0006955         IDA          BP     21898
## 982  GO:0006955         IMP          BP     21898
## 983  GO:0006955         ISO          BP     21898
## 984  GO:0006955         TAS          BP     21898
## 985  GO:0006955         IEA          BP     21899
## 986  GO:0006955         IMP          BP     21906
## 987  GO:0006955         IEA          BP     21926
## 988  GO:0006955         IGI          BP     21926
## 989  GO:0006955         IMP          BP     21926
## 990  GO:0006955         ISO          BP     21926
## 991  GO:0006955          IC          BP     21929
## 992  GO:0006955         IMP          BP     21929
## 993  GO:0006955         NAS          BP     21929
## 994  GO:0006955         ISO          BP     21934
## 995  GO:0006955         IEA          BP     21935
## 996  GO:0006955         IGI          BP     21938
## 997  GO:0006955         IMP          BP     21938
## 998  GO:0006955         ISO          BP     21938
## 999  GO:0006955         IDA          BP     21939
## 1000 GO:0006955         IEA          BP     21943
## 1001 GO:0006955         IEA          BP     21944
## 1002 GO:0006955         IBA          BP     21946
## 1003 GO:0006955         IEA          BP     21946
## 1004 GO:0006955         IMP          BP     21946
## 1005 GO:0006955         ISO          BP     21946
## 1006 GO:0006955         IDA          BP     21947
## 1007 GO:0006955         IEA          BP     21947
## 1008 GO:0006955         ISO          BP     21947
## 1009 GO:0006955         IEA          BP     21948
## 1010 GO:0006955         ISO          BP     21948
## 1011 GO:0006955         IEA          BP     21949
## 1012 GO:0006955         IEA          BP     21950
## 1013 GO:0006955         ISO          BP     22030
## 1014 GO:0006955         IEA          BP     22031
## 1015 GO:0006955         IMP          BP     22034
## 1016 GO:0006955         ISO          BP     22034
## 1017 GO:0006955         IEA          BP     22035
## 1018 GO:0006955         IMP          BP     22038
## 1019 GO:0006955         ISO          BP     22038
## 1020 GO:0006955         IMP          BP     22040
## 1021 GO:0006955         ISO          BP     22042
## 1022 GO:0006955         IGI          BP     22059
## 1023 GO:0006955         IMP          BP     22059
## 1024 GO:0006955         IDA          BP     22121
## 1025 GO:0006955         ISO          BP     22121
## 1026 GO:0006955         IMP          BP     22122
## 1027 GO:0006955         IDA          BP     22164
## 1028 GO:0006955         IEA          BP     22164
## 1029 GO:0006955         IMP          BP     22164
## 1030 GO:0006955         NAS          BP     22164
## 1031 GO:0006955         IBA          BP     22165
## 1032 GO:0006955         IMP          BP     22165
## 1033 GO:0006955         ISO          BP     22165
## 1034 GO:0006955         IGI          BP     22174
## 1035 GO:0006955         IMP          BP     22177
## 1036 GO:0006955         ISO          BP     22217
## 1037 GO:0006955         IGI          BP     22256
## 1038 GO:0006955         ISO          BP     22284
## 1039 GO:0006955         ISO          BP     22318
## 1040 GO:0006955         IDA          BP     22319
## 1041 GO:0006955         IDA          BP     22320
## 1042 GO:0006955         ISO          BP     22320
## 1043 GO:0006955         IGI          BP     22324
## 1044 GO:0006955         IMP          BP     22324
## 1045 GO:0006955         ISO          BP     22339
## 1046 GO:0006955         ISO          BP     22350
## 1047 GO:0006955         IDA          BP     22352
## 1048 GO:0006955         IDA          BP     22361
## 1049 GO:0006955         IBA          BP     22362
## 1050 GO:0006955         IPI          BP     22362
## 1051 GO:0006955         IBA          BP     22363
## 1052 GO:0006955         IBA          BP     22364
## 1053 GO:0006955         IEA          BP     22370
## 1054 GO:0006955         IDA          BP     22376
## 1055 GO:0006955         ISO          BP     22376
## 1056 GO:0006955         ISO          BP     22418
## 1057 GO:0006955         ISO          BP     22433
## 1058 GO:0006955         IEA          BP     22596
## 1059 GO:0006955         ISO          BP     22596
## 1060 GO:0006955         ISO          BP     22631
## 1061 GO:0006955         IEA          BP     22637
## 1062 GO:0006955         IMP          BP     22637
## 1063 GO:0006955         ISO          BP     22637
## 1064 GO:0006955         ISO          BP     22670
## 1065 GO:0006955         IMP          BP     22694
## 1066 GO:0006955         IMP          BP     22724
## 1067 GO:0006955         IDA          BP     22788
## 1068 GO:0006955         ISO          BP     22788
## 1069 GO:0006955         IDA          BP     22793
## 1070 GO:0006955         IBA          BP     23832
## 1071 GO:0006955         IBA          BP     23845
## 1072 GO:0006955         IDA          BP     23845
## 1073 GO:0006955         ISO          BP     23845
## 1074 GO:0006955         IBA          BP     23855
## 1075 GO:0006955         IBA          BP     23880
## 1076 GO:0006955         IEA          BP     23880
## 1077 GO:0006955         IEA          BP     23881
## 1078 GO:0006955         TAS          BP     23882
## 1079 GO:0006955         IEA          BP     23900
## 1080 GO:0006955         IBA          BP     23921
## 1081 GO:0006955         IDA          BP     23921
## 1082 GO:0006955         IMP          BP     23921
## 1083 GO:0006955         ISO          BP     23947
## 1084 GO:0006955         IEA          BP     23962
## 1085 GO:0006955         IBA          BP     23993
## 1086 GO:0006955         ISO          BP     23993
## 1087 GO:0006955         IBA          BP     24047
## 1088 GO:0006955         IDA          BP     24047
## 1089 GO:0006955         IDA          BP     24088
## 1090 GO:0006955         IMP          BP     24088
## 1091 GO:0006955         ISO          BP     24088
## 1092 GO:0006955         TAS          BP     24088
## 1093 GO:0006955         IEA          BP     24099
## 1094 GO:0006955         IMP          BP     24099
## 1095 GO:0006955         ISO          BP     24105
## 1096 GO:0006955         IBA          BP     24108
## 1097 GO:0006955         IEP          BP     24108
## 1098 GO:0006955         IEA          BP     26362
## 1099 GO:0006955         IMP          BP     26365
## 1100 GO:0006955         IEA          BP     26408
## 1101 GO:0006955         IEA          BP     26412
## 1102 GO:0006955         IDA          BP     26413
## 1103 GO:0006955         IMP          BP     26416
## 1104 GO:0006955         IMP          BP     26417
## 1105 GO:0006955         IDA          BP     26437
## 1106 GO:0006955         IMP          BP     26440
## 1107 GO:0006955         TAS          BP     26440
## 1108 GO:0006955         IEA          BP     26888
## 1109 GO:0006955         IMP          BP     26903
## 1110 GO:0006955         ISO          BP     26903
## 1111 GO:0006955         IDA          BP     26904
## 1112 GO:0006955         IEA          BP     26904
## 1113 GO:0006955         IGI          BP     26904
## 1114 GO:0006955         IMP          BP     26904
## 1115 GO:0006955         IMP          BP     26909
## 1116 GO:0006955         IEA          BP     26939
## 1117 GO:0006955         IEA          BP     26940
## 1118 GO:0006955         ISO          BP     26943
## 1119 GO:0006955         IEA          BP     26971
## 1120 GO:0006955         IBA          BP     27007
## 1121 GO:0006955         IDA          BP     27007
## 1122 GO:0006955         IEA          BP     27007
## 1123 GO:0006955         IMP          BP     27007
## 1124 GO:0006955         ISO          BP     27007
## 1125 GO:0006955         IBA          BP     27028
## 1126 GO:0006955         IEA          BP     27041
## 1127 GO:0006955         ISO          BP     27050
## 1128 GO:0006955         IEA          BP     27056
## 1129 GO:0006955         IMP          BP     27060
## 1130 GO:0006955         IPI          BP     27061
## 1131 GO:0006955         IEA          BP     27103
## 1132 GO:0006955         IMP          BP     27103
## 1133 GO:0006955         IDA          BP     27218
## 1134 GO:0006955         IEA          BP     27218
## 1135 GO:0006955         ISO          BP     27218
## 1136 GO:0006955         IMP          BP     27223
## 1137 GO:0006955         ISO          BP     27223
## 1138 GO:0006955         IDA          BP     27354
## 1139 GO:0006955         IMP          BP     27361
## 1140 GO:0006955         ISO          BP     27401
## 1141 GO:0006955         ISO          BP     28040
## 1142 GO:0006955         IBA          BP     30053
## 1143 GO:0006955         IEA          BP     30925
## 1144 GO:0006955         ISO          BP     30925
## 1145 GO:0006955         IBA          BP     50701
## 1146 GO:0006955         IDA          BP     50701
## 1147 GO:0006955         IGI          BP     50701
## 1148 GO:0006955         IMP          BP     50701
## 1149 GO:0006955         ISO          BP     50701
## 1150 GO:0006955         IBA          BP     50723
## 1151 GO:0006955         IEA          BP     50723
## 1152 GO:0006955         NAS          BP     50723
## 1153 GO:0006955         IEA          BP     50908
## 1154 GO:0006955         IEA          BP     50909
## 1155 GO:0006955         IEA          BP     50928
## 1156 GO:0006955         IEA          BP     50930
## 1157 GO:0006955         IGI          BP     50931
## 1158 GO:0006955         IMP          BP     50931
## 1159 GO:0006955         IMP          BP     51869
## 1160 GO:0006955         IDA          BP     52055
## 1161 GO:0006955         IMP          BP     52065
## 1162 GO:0006955         ISO          BP     52065
## 1163 GO:0006955         IBA          BP     52118
## 1164 GO:0006955         IMP          BP     53314
## 1165 GO:0006955         ISO          BP     53323
## 1166 GO:0006955         IDA          BP     53330
## 1167 GO:0006955         ISO          BP     53331
## 1168 GO:0006955         ISO          BP     53357
## 1169 GO:0006955         ISO          BP     53603
## 1170 GO:0006955         IEA          BP     53610
## 1171 GO:0006955         ISO          BP     53610
## 1172 GO:0006955         IEA          BP     53791
## 1173 GO:0006955         IEA          BP     53856
## 1174 GO:0006955         IDA          BP     53859
## 1175 GO:0006955         IEA          BP     54123
## 1176 GO:0006955         IMP          BP     54123
## 1177 GO:0006955         ISO          BP     54123
## 1178 GO:0006955         TAS          BP     54123
## 1179 GO:0006955         IEA          BP     54131
## 1180 GO:0006955         IMP          BP     54131
## 1181 GO:0006955         IBA          BP     54199
## 1182 GO:0006955         IDA          BP     54215
## 1183 GO:0006955         IEA          BP     54215
## 1184 GO:0006955         IMP          BP     54215
## 1185 GO:0006955         ISO          BP     54215
## 1186 GO:0006955         IEA          BP     54390
## 1187 GO:0006955         IDA          BP     54396
## 1188 GO:0006955         IMP          BP     54396
## 1189 GO:0006955         ISO          BP     54396
## 1190 GO:0006955         IEA          BP     54445
## 1191 GO:0006955         IEA          BP     54448
## 1192 GO:0006955         IEA          BP     54450
## 1193 GO:0006955         ISO          BP     54450
## 1194 GO:0006955         IEA          BP     54473
## 1195 GO:0006955         IBA          BP     54483
## 1196 GO:0006955         IEA          BP     54483
## 1197 GO:0006955         ISO          BP     54483
## 1198 GO:0006955         IDA          BP     54519
## 1199 GO:0006955         IEA          BP     54633
## 1200 GO:0006955         ISO          BP     54633
## 1201 GO:0006955         IMP          BP     54644
## 1202 GO:0006955         IEA          BP     54652
## 1203 GO:0006955         IDA          BP     54698
## 1204 GO:0006955         IEA          BP     54698
## 1205 GO:0006955         ISO          BP     54698
## 1206 GO:0006955         ISS          BP     54698
## 1207 GO:0006955         IBA          BP     54725
## 1208 GO:0006955         IDA          BP     54725
## 1209 GO:0006955         ISO          BP     54725
## 1210 GO:0006955         IBA          BP     55932
## 1211 GO:0006955         IDA          BP     55932
## 1212 GO:0006955         IDA          BP     55943
## 1213 GO:0006955         IMP          BP     55982
## 1214 GO:0006955         IBA          BP     55985
## 1215 GO:0006955         IBA          BP     56045
## 1216 GO:0006955         IEA          BP     56045
## 1217 GO:0006955         IMP          BP     56045
## 1218 GO:0006955         ISO          BP     56045
## 1219 GO:0006955         IDA          BP     56048
## 1220 GO:0006955         IBA          BP     56066
## 1221 GO:0006955         IEA          BP     56200
## 1222 GO:0006955         IMP          BP     56200
## 1223 GO:0006955         IBA          BP     56221
## 1224 GO:0006955         IEA          BP     56221
## 1225 GO:0006955         IBA          BP     56275
## 1226 GO:0006955         IEA          BP     56275
## 1227 GO:0006955         ISO          BP     56275
## 1228 GO:0006955         IMP          BP     56310
## 1229 GO:0006955         ISO          BP     56335
## 1230 GO:0006955         IEA          BP     56399
## 1231 GO:0006955         ISO          BP     56403
## 1232 GO:0006955         IEA          BP     56417
## 1233 GO:0006955         IMP          BP     56417
## 1234 GO:0006955         IDA          BP     56468
## 1235 GO:0006955         IMP          BP     56480
## 1236 GO:0006955         ISO          BP     56480
## 1237 GO:0006955         IDA          BP     56489
## 1238 GO:0006955         IMP          BP     56489
## 1239 GO:0006955         IEA          BP     56501
## 1240 GO:0006955         IGI          BP     56532
## 1241 GO:0006955         IBA          BP     56554
## 1242 GO:0006955         IDA          BP     56554
## 1243 GO:0006955         IDA          BP     56619
## 1244 GO:0006955         IMP          BP     56619
## 1245 GO:0006955         IDA          BP     56620
## 1246 GO:0006955         IEA          BP     56620
## 1247 GO:0006955         IMP          BP     56632
## 1248 GO:0006955         IDA          BP     56699
## 1249 GO:0006955         IDA          BP     56708
## 1250 GO:0006955         NAS          BP     56708
## 1251 GO:0006955         IDA          BP     56715
## 1252 GO:0006955         IMP          BP     56715
## 1253 GO:0006955         IMP          BP     56717
## 1254 GO:0006955         IEA          BP     56743
## 1255 GO:0006955         ISO          BP     56743
## 1256 GO:0006955         ISS          BP     56743
## 1257 GO:0006955         IBA          BP     56744
## 1258 GO:0006955         IMP          BP     56744
## 1259 GO:0006955         ISO          BP     56744
## 1260 GO:0006955         ISO          BP     56792
## 1261 GO:0006955         IEA          BP     56838
## 1262 GO:0006955         ISO          BP     57257
## 1263 GO:0006955         IEA          BP     57266
## 1264 GO:0006955         IMP          BP     57320
## 1265 GO:0006955         IBA          BP     57349
## 1266 GO:0006955         IEA          BP     57444
## 1267 GO:0006955         IBA          BP     57757
## 1268 GO:0006955         IMP          BP     57757
## 1269 GO:0006955         IDA          BP     57765
## 1270 GO:0006955         IMP          BP     57765
## 1271 GO:0006955         IDA          BP     57914
## 1272 GO:0006955         IEA          BP     57916
## 1273 GO:0006955         IEA          BP     58185
## 1274 GO:0006955         IMP          BP     58185
## 1275 GO:0006955         IBA          BP     58203
## 1276 GO:0006955         IEA          BP     58203
## 1277 GO:0006955         IMP          BP     58203
## 1278 GO:0006955         IBA          BP     58205
## 1279 GO:0006955         IEA          BP     58205
## 1280 GO:0006955         IEA          BP     58210
## 1281 GO:0006955         IGI          BP     58217
## 1282 GO:0006955         IDA          BP     58218
## 1283 GO:0006955         IGI          BP     58218
## 1284 GO:0006955         IMP          BP     58230
## 1285 GO:0006955         IMP          BP     58861
## 1286 GO:0006955         IEA          BP     59025
## 1287 GO:0006955         IMP          BP     59032
## 1288 GO:0006955         IBA          BP     59289
## 1289 GO:0006955         IEA          BP     60440
## 1290 GO:0006955         IDA          BP     60505
## 1291 GO:0006955         IEA          BP     60505
## 1292 GO:0006955         ISO          BP     60505
## 1293 GO:0006955         IBA          BP     60533
## 1294 GO:0006955         IEA          BP     60533
## 1295 GO:0006955         ISO          BP     60533
## 1296 GO:0006955         IMP          BP     63953
## 1297 GO:0006955         IMP          BP     64297
## 1298 GO:0006955         IEA          BP     64435
## 1299 GO:0006955         TAS          BP     64435
## 1300 GO:0006955         IDA          BP     64685
## 1301 GO:0006955         IEA          BP     64685
## 1302 GO:0006955         IMP          BP     64930
## 1303 GO:0006955         IEA          BP     65099
## 1304 GO:0006955         IMP          BP     65113
## 1305 GO:0006955         IBA          BP     65956
## 1306 GO:0006955         ISO          BP     66102
## 1307 GO:0006955         IBA          BP     66141
## 1308 GO:0006955         IDA          BP     66141
## 1309 GO:0006955         IEA          BP     66141
## 1310 GO:0006955         ISO          BP     66141
## 1311 GO:0006955         ISO          BP     66214
## 1312 GO:0006955         IDA          BP     66222
## 1313 GO:0006955         ISO          BP     66294
## 1314 GO:0006955         IBA          BP     66298
## 1315 GO:0006955         IMP          BP     66362
## 1316 GO:0006955         IMP          BP     66406
## 1317 GO:0006955         ISO          BP     66552
## 1318 GO:0006955         ISO          BP     66592
## 1319 GO:0006955         ISO          BP     66597
## 1320 GO:0006955         IEA          BP     66645
## 1321 GO:0006955         ISO          BP     66645
## 1322 GO:0006955         IGI          BP     66713
## 1323 GO:0006955         IBA          BP     66755
## 1324 GO:0006955         IMP          BP     66755
## 1325 GO:0006955         IEA          BP     66824
## 1326 GO:0006955         IMP          BP     66824
## 1327 GO:0006955         ISO          BP     66824
## 1328 GO:0006955         ISO          BP     66854
## 1329 GO:0006955         IBA          BP     66873
## 1330 GO:0006955         IEA          BP     66873
## 1331 GO:0006955         ISO          BP     66873
## 1332 GO:0006955         IEA          BP     66878
## 1333 GO:0006955         ISO          BP     66878
## 1334 GO:0006955         IBA          BP     66949
## 1335 GO:0006955         IDA          BP     66949
## 1336 GO:0006955         IEA          BP     67005
## 1337 GO:0006955         IEA          BP     67065
## 1338 GO:0006955         ISO          BP     67065
## 1339 GO:0006955         ISO          BP     67067
## 1340 GO:0006955         IDA          BP     67070
## 1341 GO:0006955         IMP          BP     67116
## 1342 GO:0006955         ISO          BP     67116
## 1343 GO:0006955         IDA          BP     67133
## 1344 GO:0006955         IMP          BP     67133
## 1345 GO:0006955         IEA          BP     67138
## 1346 GO:0006955         ISO          BP     67248
## 1347 GO:0006955         IMP          BP     67278
## 1348 GO:0006955         ISO          BP     67313
## 1349 GO:0006955         IEA          BP     67486
## 1350 GO:0006955         ISO          BP     67486
## 1351 GO:0006955         ISO          BP     67525
## 1352 GO:0006955         IBA          BP     67596
## 1353 GO:0006955         IMP          BP     67596
## 1354 GO:0006955         IEA          BP     67664
## 1355 GO:0006955         IMP          BP     67742
## 1356 GO:0006955         IEA          BP     67781
## 1357 GO:0006955         IEA          BP     67857
## 1358 GO:0006955         IEA          BP     67917
## 1359 GO:0006955         IMP          BP     67917
## 1360 GO:0006955         ISO          BP     67917
## 1361 GO:0006955         IMP          BP     68002
## 1362 GO:0006955         IBA          BP     68009
## 1363 GO:0006955         IDA          BP     68009
## 1364 GO:0006955         ISO          BP     68024
## 1365 GO:0006955         IEA          BP     68038
## 1366 GO:0006955         IDA          BP     68119
## 1367 GO:0006955         IMP          BP     68137
## 1368 GO:0006955         IEA          BP     68279
## 1369 GO:0006955         ISO          BP     68350
## 1370 GO:0006955         IMP          BP     68585
## 1371 GO:0006955         IEA          BP     68667
## 1372 GO:0006955         ISO          BP     68667
## 1373 GO:0006955         IBA          BP     68668
## 1374 GO:0006955         ISO          BP     68668
## 1375 GO:0006955         IBA          BP     68713
## 1376 GO:0006955         IEA          BP     68713
## 1377 GO:0006955         IMP          BP     68767
## 1378 GO:0006955         IEA          BP     68891
## 1379 GO:0006955         ISO          BP     68891
## 1380 GO:0006955         IBA          BP     69068
## 1381 GO:0006955         ISO          BP     69068
## 1382 GO:0006955         IDA          BP     69091
## 1383 GO:0006955         ISO          BP     69097
## 1384 GO:0006955         IEA          BP     69146
## 1385 GO:0006955         ISO          BP     69150
## 1386 GO:0006955         IBA          BP     69317
## 1387 GO:0006955         IEA          BP     69379
## 1388 GO:0006955         IBA          BP     69550
## 1389 GO:0006955         IDA          BP     69550
## 1390 GO:0006955         IMP          BP     69550
## 1391 GO:0006955         IEA          BP     69583
## 1392 GO:0006955         IMP          BP     69583
## 1393 GO:0006955         ISO          BP     69583
## 1394 GO:0006955         IEA          BP     69601
## 1395 GO:0006955         IMP          BP     69635
## 1396 GO:0006955         ISO          BP     69635
## 1397 GO:0006955         IEA          BP     69677
## 1398 GO:0006955         ISO          BP     69727
## 1399 GO:0006955         IEA          BP     69769
## 1400 GO:0006955         ISO          BP     69807
## 1401 GO:0006955         IDA          BP     69834
## 1402 GO:0006955         IMP          BP     70238
## 1403 GO:0006955         IEA          BP     70312
## 1404 GO:0006955         ISO          BP     70312
## 1405 GO:0006955         IEA          BP     70408
## 1406 GO:0006955         ISO          BP     70408
## 1407 GO:0006955         IEA          BP     70428
## 1408 GO:0006955         ISO          BP     70428
## 1409 GO:0006955         IMP          BP     70450
## 1410 GO:0006955         ISO          BP     70450
## 1411 GO:0006955         ISO          BP     70481
## 1412 GO:0006955         ISO          BP     70789
## 1413 GO:0006955         IBA          BP     71183
## 1414 GO:0006955         ISO          BP     71183
## 1415 GO:0006955         IMP          BP     71481
## 1416 GO:0006955         ISO          BP     71481
## 1417 GO:0006955         IEA          BP     71514
## 1418 GO:0006955         ISO          BP     71514
## 1419 GO:0006955         IMP          BP     71538
## 1420 GO:0006955         IMP          BP     71586
## 1421 GO:0006955         IEA          BP     71648
## 1422 GO:0006955         IBA          BP     71660
## 1423 GO:0006955         ISO          BP     71660
## 1424 GO:0006955         IEA          BP     71693
## 1425 GO:0006955         ISO          BP     71693
## 1426 GO:0006955         IEA          BP     71733
## 1427 GO:0006955         IEA          BP     71779
## 1428 GO:0006955         ISO          BP     71890
## 1429 GO:0006955         IBA          BP     71956
## 1430 GO:0006955         IEA          BP     71956
## 1431 GO:0006955         ISO          BP     71956
## 1432 GO:0006955         IEA          BP     72029
## 1433 GO:0006955         IEA          BP     72049
## 1434 GO:0006955         IMP          BP     72049
## 1435 GO:0006955         IMP          BP     72077
## 1436 GO:0006955         IMP          BP     72103
## 1437 GO:0006955         IEA          BP     72162
## 1438 GO:0006955         IMP          BP     72162
## 1439 GO:0006955         IEA          BP     72169
## 1440 GO:0006955         IBA          BP     72349
## 1441 GO:0006955         ISO          BP     72349
## 1442 GO:0006955         IMP          BP     72432
## 1443 GO:0006955         IMP          BP     72508
## 1444 GO:0006955         IBA          BP     72512
## 1445 GO:0006955         IMP          BP     72512
## 1446 GO:0006955         ISO          BP     72512
## 1447 GO:0006955         IMP          BP     72544
## 1448 GO:0006955         IBA          BP     72699
## 1449 GO:0006955         IDA          BP     72699
## 1450 GO:0006955         IEA          BP     72699
## 1451 GO:0006955         IDA          BP     72925
## 1452 GO:0006955         ISO          BP     72925
## 1453 GO:0006955         IMP          BP     72993
## 1454 GO:0006955         IEA          BP     73174
## 1455 GO:0006955         ISO          BP     73218
## 1456 GO:0006955         IBA          BP     73368
## 1457 GO:0006955         IEA          BP     73670
## 1458 GO:0006955         ISO          BP     73747
## 1459 GO:0006955         IMP          BP     73914
## 1460 GO:0006955         IEA          BP     73945
## 1461 GO:0006955         IDA          BP     74039
## 1462 GO:0006955         IMP          BP     74039
## 1463 GO:0006955         IDA          BP     74048
## 1464 GO:0006955         IGI          BP     74117
## 1465 GO:0006955         IBA          BP     74131
## 1466 GO:0006955         IMP          BP     74131
## 1467 GO:0006955         IEA          BP     74136
## 1468 GO:0006955         IMP          BP     74256
## 1469 GO:0006955         ISO          BP     74256
## 1470 GO:0006955         IEA          BP     74414
## 1471 GO:0006955         ISO          BP     74414
## 1472 GO:0006955         IBA          BP     74482
## 1473 GO:0006955         IBA          BP     74556
## 1474 GO:0006955         IDA          BP     74585
## 1475 GO:0006955         ISO          BP     74585
## 1476 GO:0006955         IDA          BP     74732
## 1477 GO:0006955         IMP          BP     74732
## 1478 GO:0006955         ISO          BP     74735
## 1479 GO:0006955         IMP          BP     74748
## 1480 GO:0006955         IEA          BP     75234
## 1481 GO:0006955         IMP          BP     75234
## 1482 GO:0006955         IEA          BP     75345
## 1483 GO:0006955         IEA          BP     75400
## 1484 GO:0006955         ISO          BP     75454
## 1485 GO:0006955         ISO          BP     75698
## 1486 GO:0006955         IDA          BP     75863
## 1487 GO:0006955         IMP          BP     75863
## 1488 GO:0006955         IMP          BP     75974
## 1489 GO:0006955         IBA          BP     76074
## 1490 GO:0006955         IDA          BP     76074
## 1491 GO:0006955         IMP          BP     76438
## 1492 GO:0006955         ISO          BP     76438
## 1493 GO:0006955         IEA          BP     76527
## 1494 GO:0006955         IEA          BP     76681
## 1495 GO:0006955         IEA          BP     76854
## 1496 GO:0006955         IDA          BP     77125
## 1497 GO:0006955         IGI          BP     77125
## 1498 GO:0006955         IEA          BP     77647
## 1499 GO:0006955         ISO          BP     77647
## 1500 GO:0006955         IEA          BP     77673
## 1501 GO:0006955         IEA          BP     77674
## 1502 GO:0006955         IEA          BP     77727
## 1503 GO:0006955         IMP          BP     77727
## 1504 GO:0006955         IEA          BP     77772
## 1505 GO:0006955         ISO          BP     77772
## 1506 GO:0006955         IBA          BP     77777
## 1507 GO:0006955         IDA          BP     77777
## 1508 GO:0006955         ISO          BP     77777
## 1509 GO:0006955         IEA          BP     77799
## 1510 GO:0006955         IBA          BP     78128
## 1511 GO:0006955         IDA          BP     78416
## 1512 GO:0006955         ISO          BP     78416
## 1513 GO:0006955         IEA          BP     78473
## 1514 GO:0006955         ISO          BP     78473
## 1515 GO:0006955         IEA          BP     78781
## 1516 GO:0006955         IMP          BP     78801
## 1517 GO:0006955         IEA          BP     78903
## 1518 GO:0006955         IEA          BP     78929
## 1519 GO:0006955         IEA          BP     80285
## 1520 GO:0006955         IMP          BP     80285
## 1521 GO:0006955         ISO          BP     80285
## 1522 GO:0006955         IEA          BP     80287
## 1523 GO:0006955         IDA          BP     80782
## 1524 GO:0006955         IGI          BP     80782
## 1525 GO:0006955         IMP          BP     80859
## 1526 GO:0006955         IEA          BP     80861
## 1527 GO:0006955         IMP          BP     80861
## 1528 GO:0006955         ISO          BP     80861
## 1529 GO:0006955         IBA          BP     80876
## 1530 GO:0006955         IEA          BP     80876
## 1531 GO:0006955         ISO          BP     80876
## 1532 GO:0006955         IEA          BP     80898
## 1533 GO:0006955         IBA          BP     80901
## 1534 GO:0006955         NAS          BP     81600
## 1535 GO:0006955         IBA          BP     81702
## 1536 GO:0006955         ISO          BP     81702
## 1537 GO:0006955         IBA          BP     81897
## 1538 GO:0006955         IDA          BP     81897
## 1539 GO:0006955         IMP          BP     81897
## 1540 GO:0006955         TAS          BP     81897
## 1541 GO:0006955         IBA          BP     83430
## 1542 GO:0006955         IDA          BP     83430
## 1543 GO:0006955         IEA          BP     83430
## 1544 GO:0006955         ISO          BP     83430
## 1545 GO:0006955          IC          BP     83433
## 1546 GO:0006955         IMP          BP     83433
## 1547 GO:0006955         ISO          BP     83945
## 1548 GO:0006955         IMP          BP     83964
## 1549 GO:0006955         ISO          BP     84095
## 1550 GO:0006955         IMP          BP     84112
## 1551 GO:0006955         IMP          BP     84544
## 1552 GO:0006955         IBA          BP     85305
## 1553 GO:0006955         ISO          BP     85305
## 1554 GO:0006955         IEA          BP     93670
## 1555 GO:0006955         IMP          BP     93675
## 1556 GO:0006955         IDA          BP     93679
## 1557 GO:0006955         ISO          BP     93679
## 1558 GO:0006955         IDA          BP     93694
## 1559 GO:0006955         IGI          BP     93694
## 1560 GO:0006955         IMP          BP     93759
## 1561 GO:0006955         ISO          BP     93759
## 1562 GO:0006955         ISO          BP     93765
## 1563 GO:0006955         ISS          BP     93765
## 1564 GO:0006955         IMP          BP     94088
## 1565 GO:0006955         ISO          BP     94088
## 1566 GO:0006955         IDA          BP     94091
## 1567 GO:0006955         ISO          BP     94091
## 1568 GO:0006955         IMP          BP     94175
## 1569 GO:0006955         IMP          BP     94176
## 1570 GO:0006955         IEA          BP     94178
## 1571 GO:0006955         IBA          BP     94185
## 1572 GO:0006955         IMP          BP     94185
## 1573 GO:0006955         IEA          BP     94212
## 1574 GO:0006955         IEA          BP     94242
## 1575 GO:0006955         IEA          BP     96875
## 1576 GO:0006955         ISO          BP     96935
## 1577 GO:0006955         IBA          BP     97165
## 1578 GO:0006955         IEA          BP     97165
## 1579 GO:0006955         IMP          BP     97165
## 1580 GO:0006955         IEA          BP     98682
## 1581 GO:0006955         IEA          BP     99571
## 1582 GO:0006955         IBA          BP     99899
## 1583 GO:0006955         IEA          BP    100340
## 1584 GO:0006955         TAS          BP    100340
## 1585 GO:0006955         IEA          BP    100535
## 1586 GO:0006955         IDA          BP    100689
## 1587 GO:0006955         IMP          BP    100689
## 1588 GO:0006955         IBA          BP    100702
## 1589 GO:0006955         IDA          BP    100702
## 1590 GO:0006955         IMP          BP    101142
## 1591 GO:0006955         ISO          BP    101476
## 1592 GO:0006955         IEA          BP    101540
## 1593 GO:0006955         IMP          BP    101540
## 1594 GO:0006955         ISO          BP    101540
## 1595 GO:0006955         IEA          BP    101613
## 1596 GO:0006955         IMP          BP    101613
## 1597 GO:0006955         IBA          BP    102657
## 1598 GO:0006955         IMP          BP    102657
## 1599 GO:0006955         IBA          BP    103213
## 1600 GO:0006955         IMP          BP    103213
## 1601 GO:0006955         IDA          BP    103743
## 1602 GO:0006955         IDA          BP    104252
## 1603 GO:0006955         ISO          BP    104709
## 1604 GO:0006955         IEA          BP    104721
## 1605 GO:0006955         IMP          BP    104721
## 1606 GO:0006955         IMP          BP    105352
## 1607 GO:0006955         ISO          BP    105855
## 1608 GO:0006955         IEA          BP    106759
## 1609 GO:0006955         IMP          BP    106759
## 1610 GO:0006955         IEA          BP    107035
## 1611 GO:0006955         IEA          BP    107260
## 1612 GO:0006955         IBA          BP    107321
## 1613 GO:0006955         IDA          BP    107321
## 1614 GO:0006955         ISO          BP    107321
## 1615 GO:0006955         ISO          BP    107338
## 1616 GO:0006955         IDA          BP    107508
## 1617 GO:0006955         ISO          BP    107508
## 1618 GO:0006955         IEA          BP    107515
## 1619 GO:0006955         IEA          BP    107527
## 1620 GO:0006955         IEA          BP    107607
## 1621 GO:0006955         ISO          BP    107746
## 1622 GO:0006955         IMP          BP    107823
## 1623 GO:0006955         IEA          BP    107831
## 1624 GO:0006955         IBA          BP    108004
## 1625 GO:0006955         IBA          BP    108005
## 1626 GO:0006955         IBA          BP    108022
## 1627 GO:0006955         IBA          BP    108024
## 1628 GO:0006955         IBA          BP    108037
## 1629 GO:0006955         ISO          BP    108037
## 1630 GO:0006955         ISO          BP    108067
## 1631 GO:0006955         IMP          BP    108138
## 1632 GO:0006955         IDA          BP    108655
## 1633 GO:0006955         IMP          BP    108723
## 1634 GO:0006955         IBA          BP    108857
## 1635 GO:0006955         IEA          BP    109032
## 1636 GO:0006955         IEA          BP    109305
## 1637 GO:0006955         ISO          BP    109815
## 1638 GO:0006955         ISO          BP    109820
## 1639 GO:0006955         IDA          BP    109880
## 1640 GO:0006955         ISO          BP    109905
## 1641 GO:0006955         IGI          BP    109934
## 1642 GO:0006955         IEA          BP    110135
## 1643 GO:0006955         ISO          BP    110135
## 1644 GO:0006955         IGI          BP    110279
## 1645 GO:0006955         IEA          BP    110382
## 1646 GO:0006955         IBA          BP    110557
## 1647 GO:0006955         IBA          BP    110558
## 1648 GO:0006955         IDA          BP    110558
## 1649 GO:0006955         IEA          BP    110612
## 1650 GO:0006955         IBA          BP    110696
## 1651 GO:0006955         IBA          BP    110785
## 1652 GO:0006955         IBA          BP    110786
## 1653 GO:0006955         IBA          BP    110787
## 1654 GO:0006955         IEA          BP    114643
## 1655 GO:0006955         IMP          BP    114774
## 1656 GO:0006955         IEA          BP    117149
## 1657 GO:0006955         IMP          BP    117149
## 1658 GO:0006955         NAS          BP    117149
## 1659 GO:0006955         ISO          BP    140474
## 1660 GO:0006955         IDA          BP    140792
## 1661 GO:0006955         ISO          BP    140795
## 1662 GO:0006955         ISO          BP    140806
## 1663 GO:0006955         IDA          BP    142980
## 1664 GO:0006955         TAS          BP    142980
## 1665 GO:0006955         IBA          BP    170743
## 1666 GO:0006955         IEA          BP    170743
## 1667 GO:0006955         IBA          BP    170744
## 1668 GO:0006955         IEA          BP    170744
## 1669 GO:0006955         ISO          BP    170744
## 1670 GO:0006955         IEA          BP    171285
## 1671 GO:0006955         IMP          BP    171285
## 1672 GO:0006955         ISO          BP    171285
## 1673 GO:0006955         ISO          BP    171429
## 1674 GO:0006955         IBA          BP    192194
## 1675 GO:0006955         IEA          BP    192231
## 1676 GO:0006955         ISO          BP    192231
## 1677 GO:0006955         IBA          BP    192656
## 1678 GO:0006955         IMP          BP    192656
## 1679 GO:0006955         ISO          BP    192656
## 1680 GO:0006955         IEA          BP    195046
## 1681 GO:0006955         IBA          BP    195176
## 1682 GO:0006955         IBA          BP    195180
## 1683 GO:0006955         IBA          BP    195297
## 1684 GO:0006955         IBA          BP    195564
## 1685 GO:0006955         IEA          BP    208154
## 1686 GO:0006955         IMP          BP    208154
## 1687 GO:0006955         IMP          BP    208650
## 1688 GO:0006955         ISO          BP    208650
## 1689 GO:0006955         IEA          BP    209200
## 1690 GO:0006955         ISO          BP    209354
## 1691 GO:0006955         IEA          BP    209446
## 1692 GO:0006955         IMP          BP    209446
## 1693 GO:0006955         IEA          BP    209558
## 1694 GO:0006955         IMP          BP    209558
## 1695 GO:0006955         IEA          BP    209588
## 1696 GO:0006955         IEA          BP    209590
## 1697 GO:0006955         ISO          BP    209590
## 1698 GO:0006955         IMP          BP    210293
## 1699 GO:0006955         IBA          BP    210757
## 1700 GO:0006955         IEA          BP    210757
## 1701 GO:0006955         IMP          BP    210757
## 1702 GO:0006955         IBA          BP    211331
## 1703 GO:0006955         IBA          BP    211550
## 1704 GO:0006955         ISO          BP    211550
## 1705 GO:0006955         ISO          BP    211948
## 1706 GO:0006955         IBA          BP    213002
## 1707 GO:0006955         IMP          BP    213208
## 1708 GO:0006955         ISO          BP    213541
## 1709 GO:0006955         IBA          BP    213570
## 1710 GO:0006955         IBA          BP    213684
## 1711 GO:0006955         IBA          BP    214763
## 1712 GO:0006955         IDA          BP    214763
## 1713 GO:0006955         IEA          BP    214763
## 1714 GO:0006955         IGI          BP    214763
## 1715 GO:0006955         IMP          BP    214763
## 1716 GO:0006955         ISO          BP    214763
## 1717 GO:0006955         IEA          BP    214855
## 1718 GO:0006955         IMP          BP    214855
## 1719 GO:0006955         IEA          BP    215257
## 1720 GO:0006955         IEA          BP    215274
## 1721 GO:0006955         IBA          BP    216161
## 1722 GO:0006955         IMP          BP    216161
## 1723 GO:0006955         ISO          BP    216161
## 1724 GO:0006955         IMP          BP    216190
## 1725 GO:0006955         IEA          BP    216799
## 1726 GO:0006955         IMP          BP    216799
## 1727 GO:0006955         ISO          BP    216869
## 1728 GO:0006955         IMP          BP    216892
## 1729 GO:0006955         IDA          BP    217069
## 1730 GO:0006955         ISO          BP    217069
## 1731 GO:0006955         IEA          BP    217203
## 1732 GO:0006955         IDA          BP    217303
## 1733 GO:0006955         ISO          BP    217303
## 1734 GO:0006955         IMP          BP    217370
## 1735 GO:0006955         ISO          BP    217715
## 1736 GO:0006955         IEA          BP    217845
## 1737 GO:0006955         ISO          BP    218442
## 1738 GO:0006955         IMP          BP    218624
## 1739 GO:0006955         ISO          BP    218832
## 1740 GO:0006955         IDA          BP    219033
## 1741 GO:0006955         IMP          BP    219131
## 1742 GO:0006955         IDA          BP    223601
## 1743 GO:0006955         ISO          BP    224045
## 1744 GO:0006955         IBA          BP    224109
## 1745 GO:0006955         IMP          BP    224109
## 1746 GO:0006955         IEA          BP    224647
## 1747 GO:0006955         ISO          BP    224727
## 1748 GO:0006955         IBA          BP    224753
## 1749 GO:0006955         IBA          BP    224754
## 1750 GO:0006955         IBA          BP    224756
## 1751 GO:0006955         IBA          BP    224761
## 1752 GO:0006955         IDA          BP    224762
## 1753 GO:0006955         ISO          BP    224762
## 1754 GO:0006955         IBA          BP    224840
## 1755 GO:0006955         IEA          BP    224840
## 1756 GO:0006955         IMP          BP    224840
## 1757 GO:0006955         IMP          BP    224860
## 1758 GO:0006955         ISO          BP    224938
## 1759 GO:0006955         IMP          BP    225160
## 1760 GO:0006955         IEA          BP    225471
## 1761 GO:0006955         IBA          BP    225825
## 1762 GO:0006955         IMP          BP    225825
## 1763 GO:0006955         ISO          BP    225825
## 1764 GO:0006955         ISO          BP    225913
## 1765 GO:0006955         IDA          BP    226421
## 1766 GO:0006955         ISO          BP    226422
## 1767 GO:0006955         IBA          BP    226695
## 1768 GO:0006955         IEA          BP    226866
## 1769 GO:0006955         IBA          BP    227059
## 1770 GO:0006955         IMP          BP    227059
## 1771 GO:0006955         IBA          BP    227288
## 1772 GO:0006955         IEA          BP    227525
## 1773 GO:0006955         IDA          BP    227753
## 1774 GO:0006955         IBA          BP    228607
## 1775 GO:0006955         IMP          BP    228607
## 1776 GO:0006955         ISO          BP    228607
## 1777 GO:0006955         IEA          BP    228801
## 1778 GO:0006955         ISO          BP    228801
## 1779 GO:0006955         IMP          BP    229096
## 1780 GO:0006955         IEA          BP    229603
## 1781 GO:0006955         IMP          BP    229603
## 1782 GO:0006955         IBA          BP    229898
## 1783 GO:0006955         IDA          BP    229898
## 1784 GO:0006955         IMP          BP    229898
## 1785 GO:0006955         IBA          BP    229900
## 1786 GO:0006955         IDA          BP    229900
## 1787 GO:0006955         IMP          BP    230073
## 1788 GO:0006955         ISO          BP    230073
## 1789 GO:0006955         IMP          BP    230126
## 1790 GO:0006955         IBA          BP    230396
## 1791 GO:0006955         IBA          BP    230398
## 1792 GO:0006955         IBA          BP    230405
## 1793 GO:0006955         IEA          BP    230558
## 1794 GO:0006955         ISO          BP    230558
## 1795 GO:0006955         IBA          BP    230613
## 1796 GO:0006955         IBA          BP    230622
## 1797 GO:0006955         IBA          BP    230623
## 1798 GO:0006955         IDA          BP    230738
## 1799 GO:0006955         IMP          BP    230738
## 1800 GO:0006955         ISO          BP    230738
## 1801 GO:0006955         IBA          BP    230787
## 1802 GO:0006955         IMP          BP    230787
## 1803 GO:0006955         ISO          BP    230899
## 1804 GO:0006955         IBA          BP    230979
## 1805 GO:0006955         IEA          BP    230979
## 1806 GO:0006955         IMP          BP    230979
## 1807 GO:0006955         ISO          BP    230979
## 1808 GO:0006955         IEA          BP    231655
## 1809 GO:0006955         IMP          BP    231712
## 1810 GO:0006955         IBA          BP    232065
## 1811 GO:0006955         IMP          BP    232341
## 1812 GO:0006955         ISO          BP    232345
## 1813 GO:0006955         IEA          BP    232371
## 1814 GO:0006955         ISO          BP    232413
## 1815 GO:0006955         IMP          BP    232790
## 1816 GO:0006955         IBA          BP    232836
## 1817 GO:0006955         ISO          BP    232836
## 1818 GO:0006955         IEA          BP    233001
## 1819 GO:0006955         IMP          BP    233079
## 1820 GO:0006955         ISO          BP    233079
## 1821 GO:0006955         IMP          BP    233080
## 1822 GO:0006955         IMP          BP    233726
## 1823 GO:0006955         IDA          BP    234199
## 1824 GO:0006955         IEA          BP    234199
## 1825 GO:0006955         IMP          BP    234695
## 1826 GO:0006955         IDA          BP    234779
## 1827 GO:0006955         IMP          BP    234779
## 1828 GO:0006955         IDA          BP    235047
## 1829 GO:0006955         IGI          BP    235047
## 1830 GO:0006955         IMP          BP    235587
## 1831 GO:0006955         IMP          BP    235623
## 1832 GO:0006955         IEA          BP    235626
## 1833 GO:0006955         ISO          BP    235626
## 1834 GO:0006955         IBA          BP    235952
## 1835 GO:0006955         IBA          BP    236047
## 1836 GO:0006955         IEA          BP    236312
## 1837 GO:0006955         IBA          BP    236573
## 1838 GO:0006955         IDA          BP    236573
## 1839 GO:0006955         IMP          BP    237625
## 1840 GO:0006955         IBA          BP    237754
## 1841 GO:0006955         IEA          BP    237868
## 1842 GO:0006955         IMP          BP    237877
## 1843 GO:0006955         IBA          BP    238412
## 1844 GO:0006955         IBA          BP    238418
## 1845 GO:0006955         IBA          BP    238427
## 1846 GO:0006955         IBA          BP    238447
## 1847 GO:0006955         IDA          BP    238447
## 1848 GO:0006955         IBA          BP    238448
## 1849 GO:0006955         IBA          BP    238555
## 1850 GO:0006955         IDA          BP    238555
## 1851 GO:0006955         IBA          BP    238875
## 1852 GO:0006955         IMP          BP    238875
## 1853 GO:0006955         IEA          BP    239081
## 1854 GO:0006955         IEA          BP    239739
## 1855 GO:0006955         IMP          BP    239743
## 1856 GO:0006955         IBA          BP    240095
## 1857 GO:0006955         IBA          BP    240354
## 1858 GO:0006955         IDA          BP    240354
## 1859 GO:0006955         IEP          BP    240354
## 1860 GO:0006955         IMP          BP    240354
## 1861 GO:0006955         ISO          BP    240354
## 1862 GO:0006955         IBA          BP    240754
## 1863 GO:0006955         IEA          BP    240754
## 1864 GO:0006955         IMP          BP    240754
## 1865 GO:0006955         ISO          BP    240754
## 1866 GO:0006955         IBA          BP    240873
## 1867 GO:0006955         IDA          BP    240873
## 1868 GO:0006955         IEA          BP    240873
## 1869 GO:0006955         IMP          BP    240873
## 1870 GO:0006955         IBA          BP    242100
## 1871 GO:0006955         IEA          BP    242100
## 1872 GO:0006955         IMP          BP    242100
## 1873 GO:0006955         ISO          BP    242100
## 1874 GO:0006955         IBA          BP    242122
## 1875 GO:0006955         IEA          BP    242122
## 1876 GO:0006955         IBA          BP    242517
## 1877 GO:0006955         IBA          BP    242519
## 1878 GO:0006955         IBA          BP    242594
## 1879 GO:0006955         ISO          BP    242594
## 1880 GO:0006955         IBA          BP    242627
## 1881 GO:0006955         IMP          BP    242700
## 1882 GO:0006955         IBA          BP    243420
## 1883 GO:0006955         IBA          BP    243423
## 1884 GO:0006955         IBA          BP    243428
## 1885 GO:0006955         IBA          BP    243431
## 1886 GO:0006955         IBA          BP    243433
## 1887 GO:0006955         IBA          BP    243439
## 1888 GO:0006955         IBA          BP    243451
## 1889 GO:0006955         IBA          BP    243453
## 1890 GO:0006955         IBA          BP    243461
## 1891 GO:0006955         IEA          BP    243461
## 1892 GO:0006955         IDA          BP    243655
## 1893 GO:0006955         IMP          BP    243655
## 1894 GO:0006955         ISO          BP    243655
## 1895 GO:0006955         IBA          BP    243864
## 1896 GO:0006955         ISO          BP    243864
## 1897 GO:0006955         IMP          BP    243874
## 1898 GO:0006955         IMP          BP    243910
## 1899 GO:0006955         IEA          BP    243958
## 1900 GO:0006955         IGI          BP    243958
## 1901 GO:0006955         IEA          BP    244202
## 1902 GO:0006955         IMP          BP    244202
## 1903 GO:0006955         IEA          BP    245126
## 1904 GO:0006955         IMP          BP    245860
## 1905 GO:0006955         IEA          BP    246082
## 1906 GO:0006955         IEA          BP    246084
## 1907 GO:0006955         IEA          BP    246177
## 1908 GO:0006955         IMP          BP    246177
## 1909 GO:0006955         IEA          BP    246700
## 1910 GO:0006955         IEA          BP    246727
## 1911 GO:0006955         IDA          BP    246728
## 1912 GO:0006955         IEA          BP    246728
## 1913 GO:0006955         IBA          BP    246779
## 1914 GO:0006955         IEA          BP    246779
## 1915 GO:0006955         ISO          BP    246779
## 1916 GO:0006955         IBA          BP    252837
## 1917 GO:0006955         IDA          BP    257632
## 1918 GO:0006955         IMP          BP    257632
## 1919 GO:0006955         ISO          BP    257632
## 1920 GO:0006955         IEA          BP    266620
## 1921 GO:0006955         IEA          BP    266632
## 1922 GO:0006955         IBA          BP    266815
## 1923 GO:0006955         IDA          BP    268564
## 1924 GO:0006955         IEA          BP    268564
## 1925 GO:0006955         ISO          BP    268749
## 1926 GO:0006955         IMP          BP    268857
## 1927 GO:0006955         IEA          BP    268973
## 1928 GO:0006955         IMP          BP    268973
## 1929 GO:0006955         ISO          BP    269378
## 1930 GO:0006955         NAS          BP    269855
## 1931 GO:0006955         IEA          BP    270151
## 1932 GO:0006955         IMP          BP    270151
## 1933 GO:0006955         IBA          BP    277146
## 1934 GO:0006955         ISO          BP    278180
## 1935 GO:0006955         IDA          BP    279572
## 1936 GO:0006955         IDA          BP    286940
## 1937 GO:0006955         IEA          BP    317677
## 1938 GO:0006955         IBA          BP    319146
## 1939 GO:0006955         ISO          BP    319179
## 1940 GO:0006955         ISO          BP    319180
## 1941 GO:0006955         ISO          BP    319181
## 1942 GO:0006955         ISO          BP    319184
## 1943 GO:0006955         ISO          BP    319185
## 1944 GO:0006955         ISO          BP    319190
## 1945 GO:0006955         ISO          BP    319278
## 1946 GO:0006955         IEA          BP    319352
## 1947 GO:0006955         IBA          BP    319430
## 1948 GO:0006955         IEA          BP    319579
## 1949 GO:0006955         IMP          BP    319583
## 1950 GO:0006955         IGI          BP    319817
## 1951 GO:0006955         IMP          BP    319817
## 1952 GO:0006955         IBA          BP    320148
## 1953 GO:0006955         IBA          BP    320640
## 1954 GO:0006955         IMP          BP    320795
## 1955 GO:0006955         IBA          BP    320913
## 1956 GO:0006955         IMP          BP    321019
## 1957 GO:0006955         IBA          BP    321020
## 1958 GO:0006955         IBA          BP    321021
## 1959 GO:0006955         IEA          BP    326623
## 1960 GO:0006955         IBA          BP    328483
## 1961 GO:0006955         IBA          BP    328505
## 1962 GO:0006955         IBA          BP    328795
## 1963 GO:0006955         IGI          BP    328795
## 1964 GO:0006955         IBA          BP    328829
## 1965 GO:0006955         IBA          BP    328830
## 1966 GO:0006955         IBA          BP    328833
## 1967 GO:0006955         IBA          BP    329260
## 1968 GO:0006955         IMP          BP    329260
## 1969 GO:0006955         ISO          BP    329260
## 1970 GO:0006955         IBA          BP    329547
## 1971 GO:0006955         ISO          BP    329547
## 1972 GO:0006955         IDA          BP    329693
## 1973 GO:0006955         IGI          BP    329693
## 1974 GO:0006955         IBA          BP    329918
## 1975 GO:0006955         IBA          BP    329919
## 1976 GO:0006955         IBA          BP    330122
## 1977 GO:0006955         IEA          BP    330490
## 1978 GO:0006955         IBA          BP    330496
## 1979 GO:0006955         IDA          BP    330496
## 1980 GO:0006955         IEA          BP    330496
## 1981 GO:0006955         IEA          BP    332579
## 1982 GO:0006955         IMP          BP    332579
## 1983 GO:0006955         IBA          BP    333715
## 1984 GO:0006955         IBA          BP    333883
## 1985 GO:0006955         IDA          BP    333883
## 1986 GO:0006955         ISO          BP    333883
## 1987 GO:0006955         IBA          BP    338374
## 1988 GO:0006955         IDA          BP    338374
## 1989 GO:0006955         IEA          BP    338374
## 1990 GO:0006955         IDA          BP    360013
## 1991 GO:0006955         IEA          BP    360211
## 1992 GO:0006955         IBA          BP    378460
## 1993 GO:0006955         IMP          BP    378460
## 1994 GO:0006955         IEA          BP    378700
## 1995 GO:0006955         IBA          BP    379043
## 1996 GO:0006955         IDA          BP    379043
## 1997 GO:0006955         IMP          BP    380732
## 1998 GO:0006955         IBA          BP    380792
## 1999 GO:0006955         IBA          BP    380793
## 2000 GO:0006955         IDA          BP    380793
## 2001 GO:0006955         IBA          BP    380794
## 2002 GO:0006955         IBA          BP    380795
## 2003 GO:0006955         IBA          BP    380797
## 2004 GO:0006955         IDA          BP    380797
## 2005 GO:0006955         IMP          BP    380797
## 2006 GO:0006955         IBA          BP    380808
## 2007 GO:0006955         IBA          BP    380809
## 2008 GO:0006955         IBA          BP    380823
## 2009 GO:0006955         IBA          BP    380824
## 2010 GO:0006955         IMP          BP    380924
## 2011 GO:0006955         IGI          BP    381305
## 2012 GO:0006955         IMP          BP    381305
## 2013 GO:0006955         IBA          BP    381308
## 2014 GO:0006955         IBA          BP    381776
## 2015 GO:0006955         IEA          BP    381776
## 2016 GO:0006955         IBA          BP    381777
## 2017 GO:0006955         IBA          BP    381778
## 2018 GO:0006955         IBA          BP    381782
## 2019 GO:0006955         IBA          BP    381783
## 2020 GO:0006955         IBA          BP    381784
## 2021 GO:0006955         IEA          BP    381812
## 2022 GO:0006955         IBA          BP    381831
## 2023 GO:0006955         IBA          BP    382000
## 2024 GO:0006955         IBA          BP    382059
## 2025 GO:0006955         IBA          BP    382692
## 2026 GO:0006955         IBA          BP    382695
## 2027 GO:0006955         IBA          BP    382696
## 2028 GO:0006955         IBA          BP    383619
## 2029 GO:0006955         IDA          BP    383619
## 2030 GO:0006955         IEA          BP    383619
## 2031 GO:0006955         ISO          BP    383619
## 2032 GO:0006955         IEA          BP    384059
## 2033 GO:0006955         IDA          BP    384309
## 2034 GO:0006955         IBA          BP    384410
## 2035 GO:0006955         IBA          BP    384411
## 2036 GO:0006955         IBA          BP    384417
## 2037 GO:0006955         IBA          BP    384419
## 2038 GO:0006955         IBA          BP    384514
## 2039 GO:0006955         IBA          BP    384515
## 2040 GO:0006955         IBA          BP    384997
## 2041 GO:0006955         IEA          BP    384997
## 2042 GO:0006955         IMP          BP    384997
## 2043 GO:0006955         ISO          BP    384997
## 2044 GO:0006955         IBA          BP    385047
## 2045 GO:0006955         IBA          BP    385109
## 2046 GO:0006955         IBA          BP    385120
## 2047 GO:0006955         IBA          BP    385253
## 2048 GO:0006955         IEA          BP    385253
## 2049 GO:0006955         IBA          BP    385291
## 2050 GO:0006955         IBA          BP    386446
## 2051 GO:0006955         IDA          BP    387140
## 2052 GO:0006955         IDA          BP    387173
## 2053 GO:0006955         IBA          BP    387510
## 2054 GO:0006955         IBA          BP    399549
## 2055 GO:0006955         IBA          BP    404549
## 2056 GO:0006955         IBA          BP    404711
## 2057 GO:0006955         IDA          BP    404711
## 2058 GO:0006955         IBA          BP    404736
## 2059 GO:0006955         IBA          BP    404743
## 2060 GO:0006955         IBA          BP    432701
## 2061 GO:0006955         IBA          BP    432702
## 2062 GO:0006955         IBA          BP    432708
## 2063 GO:0006955         IBA          BP    432709
## 2064 GO:0006955         IEA          BP    432763
## 2065 GO:0006955         IBA          BP    432940
## 2066 GO:0006955         ISO          BP    432940
## 2067 GO:0006955         IEA          BP    433693
## 2068 GO:0006955         IBA          BP    434024
## 2069 GO:0006955         IBA          BP    434025
## 2070 GO:0006955         IBA          BP    434028
## 2071 GO:0006955         IBA          BP    434031
## 2072 GO:0006955         IBA          BP    434033
## 2073 GO:0006955         IBA          BP    434034
## 2074 GO:0006955         IBA          BP    434036
## 2075 GO:0006955         IBA          BP    434039
## 2076 GO:0006955         IBA          BP    434040
## 2077 GO:0006955         IBA          BP    434041
## 2078 GO:0006955         IBA          BP    434341
## 2079 GO:0006955         IDA          BP    434341
## 2080 GO:0006955         IMP          BP    434341
## 2081 GO:0006955         ISO          BP    434341
## 2082 GO:0006955         IBA          BP    434586
## 2083 GO:0006955         IBA          BP    434609
## 2084 GO:0006955         IBA          BP    435321
## 2085 GO:0006955         IBA          BP    435328
## 2086 GO:0006955         IMP          BP    435653
## 2087 GO:0006955         IBA          BP    435791
## 2088 GO:0006955         IBA          BP    435900
## 2089 GO:0006955         IBA          BP    436468
## 2090 GO:0006955         IBA          BP    436539
## 2091 GO:0006955         IBA          BP    436545
## 2092 GO:0006955         IEA          BP    442835
## 2093 GO:0006955         IBA          BP    497114
## 2094 GO:0006955         IBA          BP    503491
## 2095 GO:0006955         IDA          BP    503491
## 2096 GO:0006955         IBA          BP    541307
## 2097 GO:0006955         IBA          BP    544896
## 2098 GO:0006955         IEA          BP    545378
## 2099 GO:0006955         IGI          BP    545378
## 2100 GO:0006955         IMP          BP    545378
## 2101 GO:0006955         IEA          BP    545384
## 2102 GO:0006955         IBA          BP    545645
## 2103 GO:0006955         IBA          BP    545648
## 2104 GO:0006955         IBA          BP    545649
## 2105 GO:0006955         IBA          BP    545650
## 2106 GO:0006955         IBA          BP    545652
## 2107 GO:0006955         IBA          BP    545847
## 2108 GO:0006955         IBA          BP    545848
## 2109 GO:0006955         IBA          BP    545849
## 2110 GO:0006955         IBA          BP    545850
## 2111 GO:0006955         IBA          BP    545851
## 2112 GO:0006955         ISO          BP    546038
## 2113 GO:0006955         IBA          BP    546213
## 2114 GO:0006955         IBA          BP    546244
## 2115 GO:0006955         IEA          BP    547253
## 2116 GO:0006955         IMP          BP    547253
## 2117 GO:0006955         ISO          BP    547253
## 2118 GO:0006955         IBA          BP    547329
## 2119 GO:0006955         IBA          BP    547424
## 2120 GO:0006955         IBA          BP    547431
## 2121 GO:0006955         IMP          BP    547431
## 2122 GO:0006955         IGI          BP    574402
## 2123 GO:0006955         IMP          BP    574402
## 2124 GO:0006955         IBA          BP    619806
## 2125 GO:0006955         IBA          BP    619833
## 2126 GO:0006955         IBA          BP    619846
## 2127 GO:0006955         IEA          BP    619846
## 2128 GO:0006955         IBA          BP    619916
## 2129 GO:0006955         IEA          BP    619916
## 2130 GO:0006955         IEA          BP    619960
## 2131 GO:0006955         IBA          BP    619994
## 2132 GO:0006955         IBA          BP    620017
## 2133 GO:0006955         IBA          BP    620050
## 2134 GO:0006955         IBA          BP    620088
## 2135 GO:0006955         IBA          BP    620105
## 2136 GO:0006955         IBA          BP    620126
## 2137 GO:0006955         IBA          BP    620191
## 2138 GO:0006955         IBA          BP    620240
## 2139 GO:0006955         IBA          BP    620297
## 2140 GO:0006955         IBA          BP    620400
## 2141 GO:0006955         IBA          BP    622728
## 2142 GO:0006955         IBA          BP    624681
## 2143 GO:0006955         IDA          BP    625018
## 2144 GO:0006955         IBA          BP    626347
## 2145 GO:0006955         IBA          BP    626545
## 2146 GO:0006955         IBA          BP    626578
## 2147 GO:0006955         IDA          BP    626578
## 2148 GO:0006955         IBA          BP    626583
## 2149 GO:0006955         IBA          BP    626682
## 2150 GO:0006955         IBA          BP    626708
## 2151 GO:0006955         IBA          BP    627394
## 2152 GO:0006955         IBA          BP    628027
## 2153 GO:0006955         IBA          BP    628056
## 2154 GO:0006955         IBA          BP    628072
## 2155 GO:0006955         IBA          BP    628098
## 2156 GO:0006955         IBA          BP    628127
## 2157 GO:0006955         IBA          BP    628144
## 2158 GO:0006955         IBA          BP    628268
## 2159 GO:0006955         IBA          BP    628398
## 2160 GO:0006955         IBA          BP    628541
## 2161 GO:0006955         IBA          BP    628571
## 2162 GO:0006955         IBA          BP    628614
## 2163 GO:0006955         IBA          BP    629812
## 2164 GO:0006955         IBA          BP    629818
## 2165 GO:0006955         IBA          BP    629822
## 2166 GO:0006955         IBA          BP    629826
## 2167 GO:0006955         IBA          BP    629833
## 2168 GO:0006955         IBA          BP    629842
## 2169 GO:0006955         IBA          BP    629845
## 2170 GO:0006955         IBA          BP    629849
## 2171 GO:0006955         IBA          BP    629859
## 2172 GO:0006955         IBA          BP    629860
## 2173 GO:0006955         IBA          BP    629865
## 2174 GO:0006955         IBA          BP    629866
## 2175 GO:0006955         IBA          BP    629871
## 2176 GO:0006955         IBA          BP    629884
## 2177 GO:0006955         IBA          BP    629893
## 2178 GO:0006955         IBA          BP    629897
## 2179 GO:0006955         IBA          BP    629906
## 2180 GO:0006955         IBA          BP    629908
## 2181 GO:0006955         IBA          BP    629915
## 2182 GO:0006955         IBA          BP    629919
## 2183 GO:0006955         IBA          BP    629925
## 2184 GO:0006955         IBA          BP    629930
## 2185 GO:0006955         IBA          BP    630086
## 2186 GO:0006955         IBA          BP    630294
## 2187 GO:0006955         IBA          BP    630486
## 2188 GO:0006955         IBA          BP    632126
## 2189 GO:0006955         IBA          BP    632654
## 2190 GO:0006955         IBA          BP    633457
## 2191 GO:0006955         IBA          BP    633568
## 2192 GO:0006955         IBA          BP    634650
## 2193 GO:0006955         IBA          BP    634825
## 2194 GO:0006955         IBA          BP    636260
## 2195 GO:0006955         IBA          BP    636462
## 2196 GO:0006955         IBA          BP    636752
## 2197 GO:0006955         IBA          BP    637227
## 2198 GO:0006955         IEA          BP    637515
## 2199 GO:0006955         IBA          BP    638605
## 2200 GO:0006955         IBA          BP    639510
## 2201 GO:0006955         IBA          BP    639774
## 2202 GO:0006955         IBA          BP    639781
## 2203 GO:0006955         IBA          BP    640046
## 2204 GO:0006955         IBA          BP    640340
## 2205 GO:0006955         IBA          BP    640506
## 2206 GO:0006955         IBA          BP    641178
## 2207 GO:0006955         IEA          BP    654458
## 2208 GO:0006955         IEA          BP    654459
## 2209 GO:0006955         IEA          BP    654460
## 2210 GO:0006955         IBA          BP    654836
## 2211 GO:0006955         IBA          BP    665927
## 2212 GO:0006955         IEA          BP    667277
## 2213 GO:0006955         IBA          BP    667281
## 2214 GO:0006955         IPI          BP    667281
## 2215 GO:0006955         IBA          BP    667435
## 2216 GO:0006955         IBA          BP    667449
## 2217 GO:0006955         IBA          BP    667481
## 2218 GO:0006955         IBA          BP    667550
## 2219 GO:0006955         IBA          BP    667681
## 2220 GO:0006955         IBA          BP    667683
## 2221 GO:0006955         IBA          BP    667859
## 2222 GO:0006955         IBA          BP    667865
## 2223 GO:0006955         IBA          BP    667881
## 2224 GO:0006955         IBA          BP    667899
## 2225 GO:0006955         IBA          BP    667914
## 2226 GO:0006955         IBA          BP    667924
## 2227 GO:0006955         IBA          BP    667928
## 2228 GO:0006955         IBA          BP    667940
## 2229 GO:0006955         IBA          BP    667946
## 2230 GO:0006955         IBA          BP    667977
## 2231 GO:0006955         IBA          BP    668389
## 2232 GO:0006955         IBA          BP    668395
## 2233 GO:0006955         IBA          BP    668421
## 2234 GO:0006955         IBA          BP    668438
## 2235 GO:0006955         IBA          BP    668469
## 2236 GO:0006955         IBA          BP    668474
## 2237 GO:0006955         IBA          BP    668478
## 2238 GO:0006955         IBA          BP    668497
## 2239 GO:0006955         IBA          BP    668517
## 2240 GO:0006955         IBA          BP    668544
## 2241 GO:0006955         IBA          BP    668549
## 2242 GO:0006955         IEA          BP    668549
## 2243 GO:0006955         IBA          BP    668589
## 2244 GO:0006955         IBA          BP    668591
## 2245 GO:0006955         IBA          BP    668597
## 2246 GO:0006955         IBA          BP    670558
## 2247 GO:0006955         IPI          BP    670558
## 2248 GO:0006955         IBA          BP    674018
## 2249 GO:0006955         IEA          BP    674018
## 2250 GO:0006955         IBA          BP    677858
## 2251 GO:0006955         IBA          BP    692152
## 2252 GO:0006955         IBA          BP    692154
## 2253 GO:0006955         IBA          BP    692161
## 2254 GO:0006955         IBA          BP    692165
## 2255 GO:0006955         IBA          BP    692169
## 2256 GO:0006955         IEA          BP    692182
## 2257 GO:0006955         IBA          BP    692187
## 2258 GO:0006955         IBA          BP    692245
## 2259 GO:0006955         IDA          BP    723834
## 2260 GO:0006955         IMP          BP    723834
## 2261 GO:0006955         IDA          BP    723840
## 2262 GO:0006955         IMP          BP    723840
## 2263 GO:0006955         IDA          BP    723890
## 2264 GO:0006955         IDA          BP    723903
## 2265 GO:0006955         IBA          BP    724035
## 2266 GO:0006955         IBA          BP    777685
## 2267 GO:0006955         IBA          BP    777686
## 2268 GO:0006955         IBA          BP    777688
## 2269 GO:0006955         IBA          BP    777780
## 2270 GO:0006955         IBA          BP    780792
## 2271 GO:0006955         IBA          BP    780793
## 2272 GO:0006955         IBA          BP    780794
## 2273 GO:0006955         IBA          BP    780799
## 2274 GO:0006955         IBA          BP    780800
## 2275 GO:0006955         IBA          BP    780801
## 2276 GO:0006955         IBA          BP    780802
## 2277 GO:0006955         IBA          BP    780803
## 2278 GO:0006955         IBA          BP    780804
## 2279 GO:0006955         IBA          BP    780818
## 2280 GO:0006955         IBA          BP    780825
## 2281 GO:0006955         IBA          BP    780829
## 2282 GO:0006955         IBA          BP    780831
## 2283 GO:0006955         IBA          BP    780864
## 2284 GO:0006955         IBA          BP    780883
## 2285 GO:0006955         IBA          BP    780884
## 2286 GO:0006955         IBA          BP    780885
## 2287 GO:0006955         IBA          BP    780891
## 2288 GO:0006955         IBA          BP    780929
## 2289 GO:0006955         IBA          BP    780931
## 2290 GO:0006955         IBA          BP    780932
## 2291 GO:0006955         IBA          BP    780938
## 2292 GO:0006955         IBA          BP    780939
## 2293 GO:0006955         IBA          BP    780956
## 2294 GO:0006955         IBA          BP    780960
## 2295 GO:0006955         IBA          BP    791089
## 2296 GO:0006955         IBA          BP    791090
## 2297 GO:0006955         IEA          BP 100033459
## 2298 GO:0006955         IBA          BP 100038862
## 2299 GO:0006955         ISO          BP 100038882
## 2300 GO:0006955         IBA          BP 100038927
## 2301 GO:0006955         IBA          BP 100040035
## 2302 GO:0006955         IBA          BP 100040462
## 2303 GO:0006955         IBA          BP 100041688
## 2304 GO:0006955         IBA          BP 100041759
## 2305 GO:0006955         IBA          BP 100041787
## 2306 GO:0006955         IBA          BP 100041811
## 2307 GO:0006955         IBA          BP 100041895
## 2308 GO:0006955         IBA          BP 100041952
## 2309 GO:0006955         IBA          BP 100042444
## 2310 GO:0006955         IBA          BP 100042493
## 2311 GO:0006955         IBA          BP 100042621
## 2312 GO:0006955         IBA          BP 100043177
## 2313 GO:0006955         IBA          BP 100043197
## 2314 GO:0006955         IBA          BP 100043322
## 2315 GO:0006955         IBA          BP 100101942
## 2316 GO:0006955         IBA          BP 100113413
## 2317 GO:0006955         IBA          BP 100114901
## 2318 GO:0006955         IBA          BP 100123473
## 2319 GO:0006955         IDA          BP 100124488
## 2320 GO:0006955         IBA          BP 100125262
## 2321 GO:0006955         IBA          BP 100125263
## 2322 GO:0006955         IBA          BP 100126451
## 2323 GO:0006955         IBA          BP 100126459
## 2324 GO:0006955         IBA          BP 100126463
## 2325 GO:0006955         IBA          BP 100126464
## 2326 GO:0006955         IBA          BP 100294660
## 2327 GO:0006955         IEA          BP 100503878
## 2328 GO:0006955         IMP          BP 100503878
## 2329 GO:0006955         IBA          BP 100503970
## 2330 GO:0006955         IEA          BP 100504362
## 2331 GO:0006955         IBA          BP 100529082
## 2332 GO:0006955         IBA          BP 100775172
## 2333 GO:0006955         IBA          BP 100775173
## 2334 GO:0006955         IBA          BP 100775174
## 2335 GO:0006955         IBA          BP 100775175
## 2336 GO:0006955         IBA          BP 102639802
## 2337 GO:0006955         IBA          BP 102640920
## 2338 GO:0006955         ISO          BP 102640920

Retrieving function groups

We can then filter our DE table, with this GO set of immune response GENES and write to file.

IRG_Entrez <- unique(ImmuneResponseGenes$ENTREZID)
IRG_Res <- Activated_minus_Resting[Activated_minus_Resting$ENTREZID %in% IRG_Entrez, 
    ]
write.table(IRG_Res, file = "data/ImmuneResponseGeneTable.csv", sep = ",", row.names = FALSE)
IRG_Res[1:3, ]
##      ENTREZID SYMBOL  baseMean log2FoldChange      lfcSE       stat
## 8   100033459 Ifi208 3282.6785     -0.0277477 0.09029354 -0.3073055
## 107 100038882  Isg15  738.5107      0.6976512 0.15748919  4.4298359
## 201 100040462  Mndal 7827.5532      0.1476855 0.06299482  2.3444076
##           pvalue         padj   newPadj
## 8   7.586109e-01 8.601547e-01 1.0000000
## 107 9.430483e-06 6.656254e-05 0.1686925
## 201 1.905733e-02 5.607844e-02 1.0000000

GSEA


GSEA

Another popular method for differential expression analysis is the Broad’s GSEA method.

GSEA tests whether our gene set is correlated with the ranking of genes by our differential expression analysis metric using a modified KS-test.

GSEA inputs

We have already seen how we can write gene set collections as gmt format files. The gmt format is the standard input format for GSEA gene sets.

We will also need to produce a ranked table of gene ids and write to a rnk format file. Here will rank by stat column to give sensible measure of differential expression. We could also use log2FoldChange column if we have modified log2 fold changes using lfsShrink() function.

forRNK <- data.frame(Activated_minus_Resting$ENTREZID, Activated_minus_Resting$stat)

forRNK[1:3, ]
##   Activated_minus_Resting.ENTREZID Activated_minus_Resting.stat
## 1                           100017                   -0.5422305
## 2                           100019                  -11.8960650
## 3                        100033459                   -0.3073055

rnk file

We can now write our results to a rnk file for use within GSEA.

write.table(forRNK, file = "data/Activated_minus_Resting.rnk", sep = "\t", col.names = FALSE, 
    row.names = FALSE)

fgsea

The fgsea package provides access to GSEA method within the R framework.

Once installed we can load library in standard way.

library(fgsea)

fgsea

We can make use of gmt files directly by using the gmtPathways() function to read our previous created gmt file of mouse translated gene sets.

mouse_Hallmarks <- gmtPathways("mouse_Hallmarks.gmt")
class(mouse_Hallmarks)
## [1] "list"
names(mouse_Hallmarks)
##  [1] "HALLMARK_TNFA_SIGNALING_VIA_NFKB"          
##  [2] "HALLMARK_HYPOXIA"                          
##  [3] "HALLMARK_CHOLESTEROL_HOMEOSTASIS"          
##  [4] "HALLMARK_MITOTIC_SPINDLE"                  
##  [5] "HALLMARK_WNT_BETA_CATENIN_SIGNALING"       
##  [6] "HALLMARK_TGF_BETA_SIGNALING"               
##  [7] "HALLMARK_IL6_JAK_STAT3_SIGNALING"          
##  [8] "HALLMARK_DNA_REPAIR"                       
##  [9] "HALLMARK_G2M_CHECKPOINT"                   
## [10] "HALLMARK_APOPTOSIS"                        
## [11] "HALLMARK_NOTCH_SIGNALING"                  
## [12] "HALLMARK_ADIPOGENESIS"                     
## [13] "HALLMARK_ESTROGEN_RESPONSE_EARLY"          
## [14] "HALLMARK_ESTROGEN_RESPONSE_LATE"           
## [15] "HALLMARK_ANDROGEN_RESPONSE"                
## [16] "HALLMARK_MYOGENESIS"                       
## [17] "HALLMARK_PROTEIN_SECRETION"                
## [18] "HALLMARK_INTERFERON_ALPHA_RESPONSE"        
## [19] "HALLMARK_INTERFERON_GAMMA_RESPONSE"        
## [20] "HALLMARK_APICAL_JUNCTION"                  
## [21] "HALLMARK_APICAL_SURFACE"                   
## [22] "HALLMARK_HEDGEHOG_SIGNALING"               
## [23] "HALLMARK_COMPLEMENT"                       
## [24] "HALLMARK_UNFOLDED_PROTEIN_RESPONSE"        
## [25] "HALLMARK_PI3K_AKT_MTOR_SIGNALING"          
## [26] "HALLMARK_MTORC1_SIGNALING"                 
## [27] "HALLMARK_E2F_TARGETS"                      
## [28] "HALLMARK_MYC_TARGETS_V1"                   
## [29] "HALLMARK_MYC_TARGETS_V2"                   
## [30] "HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION"
## [31] "HALLMARK_INFLAMMATORY_RESPONSE"            
## [32] "HALLMARK_XENOBIOTIC_METABOLISM"            
## [33] "HALLMARK_FATTY_ACID_METABOLISM"            
## [34] "HALLMARK_OXIDATIVE_PHOSPHORYLATION"        
## [35] "HALLMARK_GLYCOLYSIS"                       
## [36] "HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY"  
## [37] "HALLMARK_P53_PATHWAY"                      
## [38] "HALLMARK_UV_RESPONSE_UP"                   
## [39] "HALLMARK_UV_RESPONSE_DN"                   
## [40] "HALLMARK_ANGIOGENESIS"                     
## [41] "HALLMARK_HEME_METABOLISM"                  
## [42] "HALLMARK_COAGULATION"                      
## [43] "HALLMARK_IL2_STAT5_SIGNALING"              
## [44] "HALLMARK_BILE_ACID_METABOLISM"             
## [45] "HALLMARK_PEROXISOME"                       
## [46] "HALLMARK_ALLOGRAFT_REJECTION"              
## [47] "HALLMARK_SPERMATOGENESIS"                  
## [48] "HALLMARK_KRAS_SIGNALING_UP"                
## [49] "HALLMARK_KRAS_SIGNALING_DN"                
## [50] "HALLMARK_PANCREAS_BETA_CELLS"

fgsea

Similar to goseq package we need to provide a vector of our ranking metric named by gene id. We can create this from our rnk file.

Act_minus_Rest_rnk <- read.delim("data/Activated_minus_Resting.rnk", sep = "\t", 
    h = FALSE, row.names = 1)
Act_minus_Rest_gsea <- Act_minus_Rest_rnk[, 1]
names(Act_minus_Rest_gsea) <- rownames(Act_minus_Rest_rnk)
Act_minus_Rest_gsea[1:3]
##      100017      100019   100033459 
##  -0.5422305 -11.8960650  -0.3073055

fgsea

The fgsea() functions requires our gene sets, named vector of ranking metric, the minimum and maximum sizes of gene sets to be tested (to minSize and maxSize parameters respectively) and the number of permutations to run (nperm parameter).

Act_minus_Rest_gseaRes <- fgsea(mouse_Hallmarks, Act_minus_Rest_gsea, minSize = 15, 
    maxSize = 500, nperm = 1000)
Act_minus_Rest_gseaRes <- Act_minus_Rest_gseaRes[order(Act_minus_Rest_gseaRes$NES, 
    decreasing = T), ]
Act_minus_Rest_gseaRes[1:2, ]
##                               pathway        pval        padj        ES
## 1: HALLMARK_INTERFERON_GAMMA_RESPONSE 0.001060445 0.004676394 0.6602350
## 2: HALLMARK_INTERFERON_ALPHA_RESPONSE 0.001122334 0.004676394 0.6734605
##         NES nMoreExtreme size                              leadingEdge
## 1: 2.275092            0  247 14190,16412,20304,229900,55932,56045,...
## 2: 2.237251            0  144 12977,229900,55932,16149,12362,76933,...

fgsea

We can extract leading edge genes from leadingEdge column as a list. These are the genes driving your enrichment.

Act_minus_Rest_gseaRes$leadingEdge
## [[1]]
##   [1] "14190"     "16412"     "20304"     "229900"    "55932"     "56045"    
##   [7] "16154"     "12367"     "16149"     "15894"     "12362"     "16421"    
##  [13] "15251"     "76933"     "58203"     "16912"     "21354"     "17472"    
##  [19] "20846"     "22320"     "16185"     "108670"    "19188"     "15900"    
##  [25] "67775"     "231712"    "14964"     "15040"     "246727"    "80876"    
##  [31] "16913"     "12363"     "56791"     "15018"     "12010"     "16364"    
##  [37] "621823"    "16362"     "22169"     "19039"     "57444"     "78388"    
##  [43] "243771"    "68713"     "14972"     "21356"     "66141"     "66892"    
##  [49] "53620"     "100702"    "17069"     "70152"     "12575"     "22375"    
##  [55] "16414"     "547253"    "50523"     "14969"     "58185"     "19171"    
##  [61] "27056"     "72075"     "19106"     "626578"    "56421"     "16822"    
##  [67] "20847"     "327959"    "109552"    "18950"     "26445"     "434341"   
##  [73] "14960"     "17857"     "66552"     "18034"     "229003"    "236573"   
##  [79] "60533"     "19246"     "14998"     "19166"     "18577"     "12369"    
##  [85] "100038882" "667373"    "19186"     "64685"     "20821"     "22038"    
##  [91] "75345"     "14991"     "54721"     "17768"     "16391"     "16452"    
##  [97] "76074"     "230073"    "65972"     "22035"     "18712"    
## 
## [[2]]
##  [1] "12977"     "229900"    "55932"     "16149"     "12362"     "76933"    
##  [7] "14469"     "16912"     "21354"     "17472"     "212943"    "246730"   
## [13] "108670"    "19188"     "67775"     "231712"    "14964"     "15040"    
## [19] "80876"     "16913"     "56791"     "15018"     "12010"     "621823"   
## [25] "16362"     "22169"     "19039"     "57444"     "243771"    "67168"    
## [31] "68713"     "14972"     "80285"     "66141"     "100702"    "17069"    
## [37] "54199"     "22375"     "73711"     "547253"    "58185"     "72075"    
## [43] "20128"     "19106"     "16423"     "626578"    "20847"     "74153"    
## [49] "17857"     "229003"    "236573"    "23960"     "100038882" "19186"    
## [55] "64685"     "20821"     "22038"     "22201"     "14991"     "16391"    
## [61] "76074"     "65972"     "23961"     "12799"     "17454"     "71586"    
## [67] "13709"    
## 
## [[3]]
##  [1] "14939"  "12772"  "12766"  "16412"  "20304"  "17395"  "12774"  "12332" 
##  [9] "12977"  "229900" "15979"  "16149"  "16161"  "15894"  "19073"  "16421" 
## [17] "15251"  "14469"  "16174"  "21354"  "20846"  "12516"  "14537"  "20303" 
## [25] "14062"  "16185"  "16186"  "15900"  "12481"  "14964"  "16153"  "15040" 
## [33] "15163"  "15018"  "12010"  "16364"  "12504"  "12445"  "14972"  "21356" 
## [41] "12502"  "13867"  "12501"  "12189"  "56501"  "22375"  "17972"  "13244" 
## [49] "12519"  "12051"  "16414"  "12500"  "19171"  "21355"  "16423"  "11785" 
## [57] "16822"  "19264"  "192176" "17096"  "21899"  "20779"  "11651"  "13866" 
## [65] "13040"  "14960"  "14998"  "15978"  "14991"  "12768"  "54721"  "12444" 
## [73] "16452"  "12487"  "18125"  "14961"  "22376"  "14940"  "20299"  "26411" 
## [81] "234734" "17973"  "14423"  "21803"  "329165" "12503"  "50723"  "667803"
## [89] "13819" 
## 
## [[4]]
##   [1] "17345"  "21973"  "12531"  "12442"  "26934"  "15251"  "15511"  "16551" 
##   [9] "17219"  "12428"  "16906"  "233406" "16905"  "20460"  "16319"  "108907"
##  [17] "12534"  "12615"  "108000" "17218"  "76464"  "72119"  "16571"  "11799" 
##  [25] "110033" "105988" "193740" "23834"  "20877"  "12449"  "73804"  "68612" 
##  [33] "21335"  "19651"  "209737" "15366"  "107823" "12580"  "52033"  "19366" 
##  [41] "12445"  "229841" "107995" "54124"  "17215"  "27221"  "56150"  "18817" 
##  [49] "12544"  "15270"  "242705" "16765"  "71819"  "14211"  "20878"  "12051" 
##  [57] "22137"  "13555"  "18263"  "15481"  "14056"  "72391"  "78733"  "14828" 
##  [65] "18005"  "18973"  "94246"  "12235"  "19359"  "18141"  "73086"  "12649" 
##  [73] "231912" "12530"  "12444"  "17865"  "319166" "98386"  "21781"  "27214" 
##  [81] "21969"  "19891"  "26909"  "18128"  "19291"  "16573"  "19650"  "17118" 
##  [89] "16574"  "21803"  "18854"  "17216"  "77605"  "17748"  "19357"  "67052" 
##  [97] "13819"  "217232" "17127"  "20873"  "56452"  "71514"  "272551" "665433"
## 
## [[5]]
##  [1] "17345"  "20135"  "21973"  "12531"  "12442"  "26934"  "17219"  "16906" 
##  [9] "16905"  "52276"  "12534"  "17218"  "108961" "20492"  "16571"  "11799" 
## [17] "110033" "13178"  "105988" "20877"  "97165"  "73804"  "21335"  "15366" 
## [25] "12580"  "15201"  "67629"  "14793"  "17279"  "12236"  "54141"  "17217" 
## [33] "229841" "107995" "66929"  "12447"  "16881"  "54124"  "17215"  "13433" 
## [41] "12189"  "68275"  "12575"  "106795" "56150"  "18817"  "15270"  "21877" 
## [49] "12704"  "16765"  "20878"  "68298"  "53381"  "66442"  "70472"  "14056" 
## [57] "72391"  "19362"  "70218"  "22390"  "66570"  "18973"  "110074" "17121" 
## [65] "212377" "218977" "69639"  "12649"  "106618" "12530"  "17768"  "56419" 
## [73] "17865"  "76131"  "18538"  "319166" "98386"  "110052" "12419"  "19891" 
## [81] "55936"  "17216"  "77605"  "67967"  "19357"  "67951"  "66422"  "20873" 
## [89] "12578"  "69716"  "56452"  "114714" "665433" "67196"  "72107" 
## 
## [[6]]
##  [1] "16407"  "54167"  "17916"  "14190"  "17082"  "12332"  "66616"  "12977" 
##  [9] "21938"  "229900" "15979"  "19883"  "55932"  "16154"  "12367"  "12773" 
## [17] "12477"  "66395"  "12506"  "18671"  "17472"  "229521" "216233" "16178" 
## [25] "16182"  "22163"  "53314"  "11658"  "12334"  "21936"  "384009" "16185" 
## [33] "15900"  "56726"  "20430"  "16153"  "23834"  "80876"  "18030"  "11622" 
## [41] "17873"  "11746"  "16364"  "20973"  "20527"  "22779"  "225010" "12445" 
## [49] "68713"  "74318"  "66141"  "12447"  "100702" "12505"  "15258"  "14064" 
## [57] "21942"  "102626" "107702" "76884"  "18263"  "626578" "18810"  "17913" 
## [65] "100604" "11803"  "16188"  "18950"  "19347"  "17164"  "18451"  "17119" 
## [73] "12349"  "64138"  "13011"  "236573" "12048"  "381738" "68151"  "12333" 
## [81] "244962" "72729"  "69863"  "11520"  "22038"  "17829"  "16410"  "20893" 
## [89] "12444"  "76074"  "17760"  "57912"  "71602"  "22035"  "18712" 
## 
## [[7]]
##  [1] "14939"  "20304"  "16854"  "19141"  "12367"  "12362"  "15511"  "16912" 
##  [9] "240672" "16784"  "98878"  "13033"  "13030"  "13660"  "16409"  "70574" 
## [17] "193740" "12608"  "12363"  "73804"  "20196"  "16362"  "14678"  "12315" 
## [25] "14784"  "12313"  "63986"  "214531" "14702"  "56193"  "14462"  "56212" 
## [33] "13032"  "14693"  "71520"  "80287"  "19164"  "14688"  "15481"  "16822" 
## [41] "17096"  "14828"  "20779"  "18643"  "12349"  "19072"  "13040"  "11927" 
## [49] "170750" "11502"  "12842"  "19052"  "12369"  "18753"  "22038"  "54721" 
## [57] "16452"  "13007"  "22376"  "18712"  "56420"  "14940"  "18128"  "21858" 
## [65] "235584" "22041"  "50721"  "14945"  "16363"  "12259"  "30955"  "70675" 
## [73] "12262" 
## 
## [[8]]
##  [1] "93692"  "14190"  "16412"  "20135"  "19141"  "63913"  "20491"  "16421" 
##  [9] "13595"  "17113"  "12450"  "12317"  "26397"  "16828"  "22027"  "83671" 
## [17] "193740" "18030"  "18477"  "12449"  "23789"  "19324"  "20527"  "66286" 
## [25] "56248"  "17217"  "74117"  "14751"  "66713"  "68275"  "21991"  "12575" 
## [33] "18817"  "22375"  "13032"  "15357"  "20878"  "16414"  "26441"  "107513"
## [41] "15481"  "228033" "50527"  "14718"  "107272" "242894" "14828"  "103963"
## [49] "64136"  "12721"  "18950"  "18451"  "15452"  "20322"  "68465"  "26377" 
## [57] "13361"  "73834"  "12235"  "23997"  "14381"  "74192"  "50493"  "72661" 
## [65] "170439" "14782"  "26941"  "67895"  "20893"  "11674"  "12530"  "17768" 
## [73] "65972"  "112407" "54353"  "11938"  "14227"  "17216"  "12330"  "56418" 
## [81] "27053"  "100678" "72157"  "21753"  "59029"  "225363" "18036"  "15288" 
## [89] "56529"  "15275"  "100705" "19173"  "12745"  "23790" 
## 
## [[9]]
##  [1] "16854"  "21973"  "14676"  "12531"  "15979"  "12367"  "12362"  "14958" 
##  [9] "13595"  "19165"  "21354"  "16906"  "16905"  "14062"  "58801"  "12481" 
## [17] "80876"  "97165"  "12363"  "17873"  "12257"  "16362"  "57444"  "12445" 
## [25] "68713"  "227753" "66141"  "13867"  "12189"  "16952"  "12575"  "12505" 
## [33] "18797"  "17948"  "19164"  "228355" "15368"  "22390"  "13866"  "16478" 
## [41] "12048"  "223453" "12369"  "14775"  "12633"  "14782"  "20259"  "12444" 
## [49] "12122"  "27061"  "74256"  "22035"  "21858"  "18003"  "18611"  "19401" 
## [57] "11732" 
## 
## [[10]]
##  [1] "20304"  "12977"  "21938"  "14676"  "16154"  "15894"  "15251"  "12521" 
##  [9] "16174"  "12506"  "19219"  "80901"  "16182"  "54371"  "16185"  "67775" 
## [17] "218756" "16153"  "80876"  "11622"  "381290" "16362"  "14678"  "68713" 
## [25] "21356"  "66141"  "11540"  "17069"  "50498"  "54199"  "12575"  "20354" 
## [33] "56212"  "14767"  "26362"  "16491"  "21942"  "12493"  "19164"  "19106" 
## [41] "16822"  "16416"  "17096"  "109552" "21899" 
## 
## [[11]]
##  [1] "20715"  "93692"  "16412"  "17395"  "15902"  "21938"  "12142"  "16154" 
##  [9] "18826"  "16421"  "320139" "12521"  "11501"  "15483"  "17132"  "18671" 
## [17] "16792"  "238393" "16398"  "16186"  "15900"  "16913"  "12445"  "109700"
## [25] "14063"  "11491"  "94176"  "16414"  "211770" "17948"  "12493"  "58205" 
## [33] "50527"  "93695"  "16188"  "66390"  "12349"  "13040"  "71665"  "56743" 
## [41] "83397"  "240832" "12444"  "76816"  "26411"  "16573"  "14425"  "19224" 
## [49] "11732"  "235584" "16574" 
## 
## [[12]]
##  [1] "16412"  "16852"  "12332"  "15902"  "22352"  "326618" "226519" "16398" 
##  [9] "18074"  "17873"  "20650"  "12933"  "215280" "73690"  "109700" "12505" 
## [17] "20649"  "19035"  "20583"  "11839"  "16416"  "192176" "11803"  "18643" 
## [25] "104009" "16478"  "71665"  "12842"  "11461"  "16410"  "65112"  "16782" 
## 
## [[13]]
## [1] "20198" "21946" "12445" "19074" "14182" "12842" "16410" "12444"
## 
## [[14]]
##  [1] "17916"  "21973"  "12442"  "26934"  "16551"  "16906"  "233406" "16905" 
##  [9] "12540"  "277360" "12334"  "12345"  "16319"  "108907" "12534"  "108000"
## [17] "72119"  "16571"  "11799"  "110033" "105988" "12927"  "73804"  "16328" 
## [25] "209737" "109934" "22627"  "227753" "54141"  "229841" "217944" "68743" 
## [33] "208628" "18817"  "71819"  "94176"  "20878"  "50523"  "22137"  "208084"
## [41] "223254" "11845"  "192176" "74018"  "217866" "18005"  "12235"  "192662"
## [49] "13605"  "17974"  "218977" "12333"  "17698"  "259302" "81910"  "17886" 
## [57] "20259"  "16800"  "70799"  "330177" "231912" "69632"  "75786"  "71602" 
## [65] "22376"  "18128"  "56376"  "68724"  "18003"  "16573"  "17973"  "53860" 
## [73] "17118"  "16574"  "73341"  "67399"  "329165" "27373"  "67052"  "20739" 
## [81] "217232" "242687" "26382" 
## 
## [[15]]
##  [1] "20491"  "12317"  "26397"  "16186"  "12534"  "22027"  "19045"  "20111" 
##  [9] "56378"  "20527"  "14784"  "12631"  "13867"  "74117"  "67300"  "66713" 
## [17] "12575"  "17347"  "18797"  "71520"  "13555"  "54401"  "20847"  "17096" 
## [25] "242894" "19087"  "12283"  "18643"  "11651"  "13866"  "26377"  "11513" 
## [33] "192662" "13001"  "16438"  "26413"  "12326"  "17973"  "19353"  "14682" 
## [41] "110355" "26420"  "11840"  "266632" "17127"  "19247"  "72349"  "18036" 
## [49] "100705" "16189" 
## 
## [[16]]
##  [1] "93692"  "54371"  "18746"  "12534"  "12615"  "16828"  "193740" "73804" 
##  [9] "15366"  "12933"  "57444"  "56248"  "13867"  "11540"  "53618"  "21991" 
## [17] "21881"  "80879"  "12505"  "26362"  "16765"  "19348"  "26384"  "20878" 
## [25] "22166"  "21351"  "14719"  "56421"  "74246"  "15481"  "50527"  "83553" 
## [33] "14718"  "14828"  "20970"  "21802"  "18451"  "13866"  "104009" "23827" 
## [41] "57357"  "14381"  "12842"  "19052"  "69976"  "11674"  "54128"  "76131" 
## [49] "16164"  "12337"  "58810"  "17684"  "17449"  "17448"  "112407" "72727" 
## [57] "14583"  "12124"  "229782" "11727"  "109672" "15275"  "71653"  "54170" 
## [65] "66646"  "50799"  "50797"  "66681"  "233781" "216558" "78330"  "74241" 
## [73] "59046"  "239556" "66913"  "67005"  "100910" "15277"  "236900" "15512" 
## [81] "20856"  "27376"  "18655"  "12291"  "18194"  "110006" "56375"  "68137" 
## 
## [[17]]
##  [1] "12977" "21938" "15979" "16161" "20846" "16178" "16182" "16186" "57914"
## [10] "16362" "14784" "16199" "50498" "12505" "71520" "16416" "20847" "15368"
## [19] "16188" "19246" "16478" "12768" "54721" "16391" "16452" "16164" "18712"
## [28] "21803" "12018" "79201" "19247" "15975" "24088" "15945" "12402"
## 
## [[18]]
##  [1] "16854"  "20195"  "19141"  "63913"  "13595"  "11658"  "60599"  "18030" 
##  [9] "14678"  "11465"  "71914"  "15357"  "50762"  "11676"  "11461"  "22038" 
## [17] "51798"  "19016"  "230903"
## 
## [[19]]
##  [1] "17395"  "19141"  "16784"  "13030"  "12334"  "16398"  "20196"  "109700"
##  [9] "227753" "56193"  "16952"  "64383"  "14064"  "14693"  "22388"  "11844" 
## [17] "14688"  "16416"  "20779"  "19072"  "13040"  "11502"  "12333"  "20259" 
## [25] "13007"  "12337"  "18550"  "56405"  "19353"  "235584" "22041"  "12259" 
## [33] "14544"  "259277" "11727"  "14191" 
## 
## [[20]]
##  [1] "20715"  "21973"  "15902"  "19143"  "226519" "53314"  "238393" "20460" 
##  [9] "56460"  "14229"  "23834"  "225845" "20111"  "27375"  "381290" "20393" 
## [17] "57444"  "12445"  "107995" "11898"  "12505"  "217837" "54135"  "19348" 
## [25] "67784"  "74246"  "223254" "11839"  "192176" "13418"  "19087"  "18415" 
## [33] "225182" "12349"  "15452"  "114663" "20322"  "12017"  "26941"  "110826"
## [41] "54721"  "12864"  "12444"  "16452"  "16782"  "94249"  "13521"  "106572"
## [49] "320997" "12700"  "71982"  "22041" 
## 
## [[21]]
##  [1] "20198"  "20194"  "14667"  "12362"  "12521"  "21354"  "12795"  "19143" 
##  [9] "20181"  "22320"  "13033"  "12450"  "14062"  "231712" "20430"  "11688" 
## [17] "57444"  "12445"  "53421"  "75234"  "12575"  "17347"  "15270"  "11783" 
## [25] "102626" "12493"  "15254"  "76884"  "56702"  "29858"  "67784"  "15368" 
## [33] "21802"  "239273" "18415"  "13830"  "17164"  "17119"  "16478"  "71665" 
## [41] "217344" "17254"  "12444"  "18538"  "319166" "65972"  "18128"  "13663" 
## [49] "17988"  "70484"  "21803"  "67623"  "12018"  "22271"  "13650"  "17246" 
## [57] "22062"  "22401"  "79201"  "67941"  "12578"  "114714" "259277" "665433"
## [65] "16554"  "105501" "56437"  "19124"  "16449"  "15461"  "20698"  "12579" 
## [73] "21812"  "19734"  "17122" 
## 
## [[22]]
##  [1] "14958"  "17132"  "14229"  "12571"  "20111"  "12010"  "20393"  "14678" 
##  [9] "544963" "12445"  "67938"  "106869" "67268"  "26362"  "15357"  "69608" 
## [17] "107652" "239273" "192657" "11651"  "20322"  "333433" "83397"  "14782" 
## [25] "16410"  "65112"  "12444"  "20363"  "71817"  "328365" "13167"  "56376" 
## [33] "17988"  "13521"  "11732"  "19341"  "67399"  "72155"  "404710" "19342" 
## [41] "19229"  "20807"  "56228"  "70361"  "218294" "54608"  "20249"  "66065" 
## [49] "76687"  "11474"  "109785"
## 
## [[23]]
##  [1] "20198"  "93692"  "12306"  "19883"  "54371"  "22022"  "231507" "16828" 
##  [9] "193740" "18030"  "17035"  "12933"  "20527"  "57444"  "56248"  "13867" 
## [17] "11540"  "14751"  "21991"  "12575"  "21881"  "15212"  "56421"  "15481" 
## [25] "13008"  "50527"  "83553"  "14828"  "20970"  "15368"  "11676"  "18451" 
## [33] "13866"  "170750" "16478"  "12452"  "12842"  "83397"  "17886"  "11520" 
## [41] "20893"  "11674"  "18712"  "17684"  "17988"  "16573" 
## 
## [[24]]
##  [1] "16412"  "17395"  "17996"  "15894"  "226519" "22323"  "16398"  "11688" 
##  [9] "27375"  "12331"  "22793"  "14678"  "11465"  "67938"  "19354"  "109700"
## [17] "21873"  "13867"  "76709"  "67268"  "22629"  "11928"  "16331"  "19264" 
## [25] "192176" "12385"  "20970"  "20779"  "18643"  "13866"  "16332"  "11502" 
## [33] "60533"  "12842"  "17698"  "11461"  "12908"  "17886"  "330177" "16782" 
## [41] "20130"  "22376"  "18516"  "232975" "26411"  "14786"  "54353"  "73341" 
## [49] "69192"  "12798"  "11490"  "22329" 
## 
## [[25]]
##  [1] "93692"  "18477"  "16985"  "76650"  "53381"  "22166"  "56421"  "68576" 
##  [9] "239273" "11927"  "16478"  "14381"  "50493"  "14782"  "18104"  "76408" 
## 
## [[26]]
##  [1] "12442"  "15511"  "15925"  "15463"  "12534"  "215387" "193740" "73804" 
##  [9] "21881"  "20878"  "21351"  "22137"  "16162"  "110257" "15481"  "14056" 
## [17] "72391"  "83553"  "12672"  "14828"  "19087"  "18005"  "18415"  "231600"
## [25] "12235"  "12326"  "18125"  "27214"  "56292"  "18550"  "12330"  "74451" 
## [33] "17349"  "12745"  "11861"  "13404"  "22335" 
## 
## [[27]]
##  [1] "20304"  "12977"  "15902"  "15894"  "21354"  "240672" "98878"  "19219" 
##  [9] "26397"  "13660"  "20303"  "56722"  "12608"  "18030"  "17873"  "21847" 
## [17] "381290" "20393"  "16362"  "20527"  "12445"  "14063"  "56193"  "75234" 
## [25] "106869" "54199"  "12575"  "56336"  "12505"  "12519"  "21942"  "12051" 
## [33] "211770" "17948"  "11839"  "19347"  "55991"  "17119"  "18034"  "16478" 
## [41] "12045"  "18577"  "12633"  "18037"  "65112"  "20893"  "12444"  "230073"
## [49] "16596"  "56376"  "71586"  "19224"  "17118" 
## 
## [[28]]
##  [1] "21973"  "18671"  "20181"  "15925"  "67283"  "18477"  "20238"  "12257" 
##  [9] "78388"  "11739"  "22629"  "21355"  "11666"  "73836"  "239273" "433256"
## [17] "12908"  "16413"  "51798"  "55936"  "66437" 
## 
## [[29]]
##  [1] "67804"  "16784"  "17113"  "20111"  "208449" "13867"  "67300"  "11928" 
##  [9] "13032"  "69608"  "12757"  "22319"  "108664" "232910" "13866"  "14683" 
## [17] "15893"  "12725"  "26413"  "232975" "11487"  "11774"  "106572" "70349" 
## [25] "56418"  "11840"  "68365"  "67830"  "11764"  "50797"  "70361"  "271457"
## [33] "19063"  "68581" 
## 
## [[30]]
##  [1] "16828"  "12894"  "14751"  "67834"  "11739"  "12868"  "57279"  "12858" 
##  [9] "14719"  "228033" "11974"  "108664" "66916"  "67680"  "12856"  "16922" 
## [17] "73834"  "11973"  "12857"  "12369"  "66108"  "18104"  "110826" "11949" 
## [25] "66152"  "12864"  "51798"  "12866"  "67264"  "110323" "57423"  "66925" 
## [33] "17449"  "17448"  "18293"  "66694"  "11950"  "17992"  "21871"  "67126" 
## [41] "66046"  "68375"  "12861"  "66043"  "11946"  "13177"  "20930"  "109672"
## [49] "30057"  "66144"  "14661"  "22335"  "15159"  "50799"  "66335"  "211253"
## [57] "11957"  "12859"  "225887" "27060"  "22272"  "78830"  "97212"  "12028" 
## [65] "170731" "54405"  "66594"  "407785" "17993"  "170718" "66576"  "72900" 
## [73] "67003"  "11740"  "11958"  "68197"  "11947" 
## 
## [[31]]
##  [1] "16185"  "16186"  "16328"  "12189"  "14462"  "17096"  "68465"  "171171"
##  [9] "11487"  "21871"  "27060"  "21838"  "11630"  "237847" "432442" "13837" 
## 
## [[32]]
##  [1] "12367"  "15894"  "18671"  "21354"  "14964"  "15040"  "193740" "15018" 
##  [9] "66168"  "11891"  "16362"  "110213" "13350"  "12445"  "14972"  "12447" 
## [17] "11739"  "26362"  "15270"  "17075"  "12757"  "15481"  "17308"  "17096" 
## [25] "14828"  "103963" "15368"  "232910" "12349"  "16478"  "12842"  "18753" 
## [33] "12611"  "14991"  "11674"  "12444"  "11828"  "12122"  "216150" "319166"
## [41] "12799"  "19182"  "110920" "18550"  "12018"  "56418"  "27053"  "20364" 
## [49] "14156"  "81489"  "12215"  "665433" "14528"  "667977" "66144"  "56437" 
## [57] "12566"  "66335"  "19063"  "12579"  "246221" "22146"  "216869" "22275" 
## [65] "15512"  "22142"  "18670"  "18412"  "11740"  "319164" "106344" "15007" 
## [73] "630294" "319167" "20656"  "14590"  "66427"  "319172" "15024"  "15015" 
## [81] "13728"  "224860" "232440" "15370" 
## 
## [[33]]
##  [1] "26943"  "16852"  "20194"  "16828"  "22027"  "56791"  "12894"  "13476" 
##  [9] "22629"  "17025"  "18263"  "11363"  "109778" "68728"  "12349"  "433256"
## [17] "68465"  "19186"  "12908"  "11674"  "12892"  "51798"  "66925"  "17449" 
## [25] "17448"  "77605"  "170789" "11409"  "13177"  "22628"  "66357"  "56442" 
## 
## [[34]]
##  [1] "14958"     "68262"     "16784"     "212943"    "13030"     "26397"    
##  [7] "380711"    "18477"     "65107"     "20527"     "12445"     "100503605"
## [13] "140780"    "242705"    "53378"     "17025"     "110257"    "109778"   
## [19] "192657"    "53415"     "18451"     "12349"     "233489"    "224703"   
## [25] "14934"     "66943"     "22228"     "12725"     "107566"    "74136"    
## [31] "69632"     "12444"     "11828"     "12892"     "68591"     "15130"    
## [37] "17896"     "21969"     "16596"     "15467"     "56786"     "64898"    
## [43] "72674"     "71648"     "21871"     "219094"    "27053"     "21349"    
## [49] "12346"     "20739"     "217232"    "12215"     "74257"     "71946"    
## [55] "12183"     "15288"     "67608"     "54484"     "383295"    "19746"    
## [61] "74334"     "74645"     "22439"     "56209"     "20617"     "27060"    
## [67] "14055"     "18173"     "59125"     "11519"     "11656"    
## 
## [[35]]
##  [1] "16412"  "22352"  "19165"  "56726"  "16985"  "17873"  "20973"  "227753"
##  [9] "13867"  "53313"  "12575"  "64383"  "78286"  "67784"  "17913"  "56421" 
## [17] "16404"  "16416"  "29856"  "20399"  "13866"  "433256" "12017"  "12842" 
## [25] "11461"  "12908"  "17886"  "18104"  "20259"  "20893"  "18125"  "17896" 
## [33] "18128"  "11938"  "21803"  "67399"  "13144" 
## 
## [[36]]
##  [1] "15979"  "68262"  "217430" "11804"  "23943"  "109019" "12580"  "13476" 
##  [9] "13350"  "67834"  "21881"  "22629"  "12868"  "21351"  "20168"  "16404" 
## [17] "66148"  "11363"  "83553"  "66588"  "66092"  "66916"  "13830"  "68465" 
## [25] "26379"  "67680"  "11513"  "16922"  "22187"  "108954" "12452"  "12842" 
## [33] "12908"  "11520"  "170439" "22228"  "232941" "11674"  "110826" "66152" 
## [41] "51798"  "18712"  "17448"  "18606"  "26411"  "19016"  "268301" "12861" 
## [49] "72157"  "66375"  "11409" 
## 
## [[37]]
##  [1] "20135"     "27224"     "15163"     "22171"     "22169"     "54208"    
##  [7] "56248"     "18968"     "19361"     "53421"     "16881"     "53378"    
## [13] "59022"     "18950"     "15452"     "110074"    "11513"     "12856"    
## [19] "18577"     "27061"     "18538"     "19075"     "19891"     "330959"   
## [25] "100041294" "26370"     "50773"     "67967"     "14156"     "20930"    
## [31] "68092"     "66914"     "74414"     "19718"     "72151"     "16434"    
## [37] "67665"     "20018"     "18100"     "18969"    
## 
## [[38]]
##  [1] "15902"  "74134"  "15483"  "380711" "15900"  "20430"  "12927"  "110213"
##  [9] "14872"  "12846"  "19171"  "76884"  "29858"  "52585"  "11666"  "15368" 
## [17] "110172" "239273" "12349"  "15452"  "66054"  "110208" "14782"  "18104" 
## [25] "76408"  "51798"  "67437"  "56376"  "70484"  "50997"  "64898"  "11938" 
## [33] "66397"  "67399"  "22271"  "17748"  "69051"  "66375"  "79201"  "14528" 
## [41] "109900" "109672" "74114" 
## 
## [[39]]
##  [1] "12306"  "12393"  "12399"  "20181"  "226519" "14537"  "27375"  "11746" 
##  [9] "381290" "20238"  "21873"  "13867"  "11540"  "71973"  "20583"  "16416" 
## [17] "109552" "20779"  "217866" "19087"  "239273" "219140" "13866"  "18034" 
## [25] "12842"  "15893"  "76408"  "20893"  "23942"  "16782"  "14200"  "12978" 
## [33] "17684"  "328365" "18128"  "56376"  "19016"  "116871" "67399"  "17748" 
## 
## [[40]]
##  [1] "15902"  "11853"  "14225"  "19045"  "27375"  "21847"  "21873"  "15258" 
##  [9] "17948"  "94246"  "16478"  "232941" "65112"  "18550"  "21803"  "106572"
## 
## [[41]]
##  [1] "12317"  "22027"  "193740" "12608"  "109019" "66286"  "54124"  "15270" 
##  [9] "107513" "15481"  "50527"  "107272" "14828"  "67398"  "11972"  "226641"
## [17] "66482"  "667373" "72661"  "12611"  "17768"  "319166" "69019"  "22631" 
## [25] "16573"  "13685"  "16574"  "218343" "27053"  "67951"  "665433" "71853" 
## [33] "78943"  "56529"  "69065"  "18045"  "15957"  "70640"  "20624"  "13665" 
## [41] "66913"  "22154"  "76687"  "56454"  "15512"  "20856" 
## 
## [[42]]
##  [1] "17132"  "66286"  "239273" "69019"  "53626"  "20813"  "56529"  "18548" 
##  [9] "13482"  "16909"  "20910" 
## 
## [[43]]
##  [1] "12776"  "54371"  "212943" "12334"  "11688"  "20393"  "19271"  "27984" 
##  [9] "11928"  "12519"  "58185"  "17857"  "12842"  "12333"  "15978"  "11461" 
## [17] "21819"  "20363"  "18125" 
## 
## [[44]]
##  [1] "17219"  "12428"  "17218"  "16828"  "22027"  "22171"  "22627"  "17217" 
##  [9] "107995" "20133"  "56150"  "12544"  "57296"  "12858"  "53381"  "14719" 
## [17] "22384"  "26441"  "18263"  "26445"  "26440"  "15452"  "110074" "19359" 
## [25] "218236" "19166"  "22195"  "12461"  "18538"  "26444"  "110052" "21781" 
## [33] "55936"  "17216"  "12330"  "77605"  "69192"  "26446" 
## 
## [[45]]
## [1] "207521" "14534"  "18129"  "16450"  "18519"  "21416"  "14357"  "12234" 
## [9] "109689"
## 
## [[46]]
##  [1] "11303"  "19299"  "11669"  "66307"  "224824" "110784" "74043"  "76267" 
##  [9] "103737" "16890"  "72535"  "63959"  "76263" 
## 
## [[47]]
## [1] "16835" "16825" "14766" "21885" "18187" "12614"
## 
## [[48]]
##  [1] "12043"  "17869"  "107771" "101490" "16206"  "268903" "18432"  "22234" 
##  [9] "16001"  "20520"  "22151"  "16763"  "24056"  "14228"  "16195"  "58208" 
## [17] "16598"  "11518"  "20148"  "76199"  "11512"  "107094" "20539"  "20509" 
## [25] "16451"  "97998"  "12614"  "76459"  "21844" 
## 
## [[49]]
##  [1] "21414"  "17869"  "107771" "16842"  "13542"  "14534"  "15182"  "18129" 
##  [9] "212398" "22059" 
## 
## [[50]]
##  [1] "17869"  "107771" "18432"  "13537"  "75751"  "67134"  "72515"  "235036"
##  [9] "226169" "20810"  "27966"  "71974"  "59028"  "101612" "70683"  "67973" 
## [17] "107094" "110109" "76130"  "28126"  "21453"  "30877"  "107071" "20509" 
## [25] "68493"  "18148"  "338359" "70769"  "66942"

fgsea

We can use these leading edge genes to select genes strongly correlated with our condition and within an enriched gene set.

INTERFERON_Response_LE <- Act_minus_Rest_gseaRes$leadingEdge[[1]]
IR_LE <- Activated_minus_Resting[Activated_minus_Resting$ENTREZID %in% INTERFERON_Response_LE, 
    ]
IR_LE[1:2, ]
##       ENTREZID SYMBOL  baseMean log2FoldChange     lfcSE     stat       pvalue
## 107  100038882  Isg15  738.5107      0.6976512 0.1574892 4.429836 9.430483e-06
## 1236    100702   Gbp6 1308.0094      0.8984211 0.1192259 7.535452 4.866453e-14
##              padj      newPadj
## 107  6.656254e-05 1.686925e-01
## 1236 8.937247e-13 9.271079e-10

GSEA plots

We can also produce a GSEA style plot to visualize our enrichment in a pathway of interest using the plotEnrichment() function. We simply provide the pathway to plot and the ranking we used in test.

plotEnrichment(mouse_Hallmarks[["HALLMARK_INTERFERON_GAMMA_RESPONSE"]], Act_minus_Rest_gsea)

Time for an exercise

Link_to_exercises

Link_to_answers